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TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 4, p. 1368, doi. 10.1172/JCI60893
By:
- Reinert, Line S.;
- Harder, Louis;
- Holm, Christian K.;
- Iversen, Marie B.;
- Horan, Kristy A.;
- Dagnæs-Hansen, Frederik;
- Ulhøi, Benedicte P.;
- Holm, Thomas H.;
- Mogensen, Trine H.;
- Owens, Trevor;
- Nyengaard, Jens R.;
- Thomsen, Allan R.;
- Paludan, Søren R.
Publication type:
Article
Innate recognition of intracellular pathogens: detection and activation of the first line of defense.
Published in:
APMIS, 2009, v. 117, n. 5/6, p. 323, doi. 10.1111/j.1600-0463.2009.02456.x
By:
- RASMUSSEN, SIMON B.;
- REINERT, LINE S.;
- PALUDAN, SØREN R.
Publication type:
Article
ER stress induces caspase‐2‐tBID‐GSDME‐dependent cell death in neurons lytically infected with herpes simplex virus type 2.
Published in:
EMBO Journal, 2023, v. 42, n. 19, p. 1, doi. 10.15252/embj.2022113118
By:
- Ren, Fanghui;
- Narita, Ryo;
- Rashidi, Ahmad S;
- Fruhwürth, Stefanie;
- Gao, Zongliang;
- Bak, Rasmus O;
- Thomsen, Martin K;
- Verjans, Georges MGM;
- Reinert, Line S;
- Paludan, Søren R
Publication type:
Article
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection.
Published in:
EMBO Journal, 2022, v. 41, n. 10, p. 1, doi. 10.15252/embj.2021109622
By:
- van der Sluis, Renée M;
- Cham, Lamin B;
- Gris‐Oliver, Albert;
- Gammelgaard, Kristine R;
- Pedersen, Jesper G;
- Idorn, Manja;
- Ahmadov, Ulvi;
- Hernandez, Sabina Sanches;
- Cémalovic, Ena;
- Godsk, Stine H;
- Thyrsted, Jacob;
- Gunst, Jesper D;
- Nielsen, Silke D;
- Jørgensen, Janni J;
- Bjerg, Tobias Wang;
- Laustsen, Anders;
- Reinert, Line S;
- Olagnier, David;
- Bak, Rasmus O;
- Kjolby, Mads
Publication type:
Article
Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice.
Published in:
EMBO Reports, 2024, v. 25, n. 9, p. 3777, doi. 10.1038/s44319-024-00216-4
By:
- Macht, Anna;
- Huang, Yiqi;
- Reinert, Line S;
- Grass, Vincent;
- Lohmer, Kristin;
- Aristizabal Prada, Elke Tatjana;
- Babel, Eveline;
- Semmler, Alexandra;
- Zhang, Wen;
- Wegner, Andrea;
- Lichtenegger-Hartl, Eva;
- Haas, Sonja;
- Hasenpusch, Günther;
- Meyer, Steffen;
- Paludan, Søren R;
- Pichlmair, Andreas;
- Rudolph, Carsten;
- Langenickel, Thomas
Publication type:
Article
The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.70002
By:
- Bayarri-Olmos, Rafael;
- Johnsen, Laust Bruun;
- Idorn, Manja;
- Reinert, Line S.;
- Rosbjerg, Anne;
- Vang, Søren;
- Hansen, Cecilie Bo;
- Helgstrand, Charlotte;
- Bjelke, Jais Rose;
- Bak-Thomsen, Theresa;
- Paludan, Søren R.;
- Garred, Peter;
- Skjoedt, Mikkel-Ole
Publication type:
Article
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.
Published in:
EMBO Journal, 2016, v. 35, n. 13, p. 1385, doi. 10.15252/embj.201593458
By:
- Christensen, Maria H;
- Jensen, Søren B;
- Miettinen, Juho J;
- Luecke, Stefanie;
- Prabakaran, Thaneas;
- Reinert, Line S;
- Mettenleiter, Thomas;
- Chen, Zhijian J;
- Knipe, David M;
- Sandri‐Goldin, Rozanne M;
- Enquist, Lynn W;
- Hartmann, Rune;
- Mogensen, Trine H;
- Rice, Stephen A;
- Nyman, Tuula A;
- Matikainen, Sampsa;
- Paludan, Søren R
Publication type:
Article
STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice.
Published in:
PLoS Pathogens, 2018, v. 14, n. 4, p. 1, doi. 10.1371/journal.ppat.1006976
By:
- Skouboe, Morten K.;
- Knudsen, Alice;
- Reinert, Line S.;
- Boularan, Cedric;
- Lioux, Thierry;
- Perouzel, Eric;
- Thomsen, Martin K.;
- Paludan, Søren R.
Publication type:
Article
STING is redundant for host defense and pathology of COVID-19-like disease in mice.
Published in:
Life Science Alliance, 2023, v. 6, n. 8, p. 1, doi. 10.26508/lsa.202301997
By:
- Marino, Giorgia;
- Baocun Zhang;
- Schmitz, Alexander;
- Schwensen, Hanna V. F.;
- Reinert, Line S.;
- Paludan, Søren R.
Publication type:
Article
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production.
Published in:
2021
By:
- Reinert, Line S.;
- Rashidi, Ahmad S.;
- Tran, Diana N.;
- Katzilieris-Petras, Georgios;
- Hvidt, Astrid K.;
- Gohr, Mette;
- Fruhwürth, Stefanie;
- Bodda, Chiranjeevi;
- Thomsen, Martin K.;
- Vendelbo, Mikkel H.;
- Khan, Ahmad R.;
- Hansen, Brian;
- Bergström, Petra;
- Agholme, Lotta;
- Mogensen, Trine H.;
- Christensen, Maria H.;
- Nyengaard, Jens R.;
- Sen, Ganes C.;
- Zetterberg, Henrik;
- Verjans, Georges MGM
Publication type:
journal article
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
Published in:
Nature Communications, 2016, v. 7, n. 11, p. 13348, doi. 10.1038/ncomms13348
By:
- Reinert, Line S.;
- Lopušná, Katarína;
- Winther, Henriette;
- Sun, Chenglong;
- Thomsen, Martin K.;
- Nandakumar, Ramya;
- Mogensen, Trine H.;
- Meyer, Morten;
- Vægter, Christian;
- Nyengaard, Jens R.;
- Fitzgerald, Katherine A.;
- Paludan, Søren R.
Publication type:
Article
The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice.
Published in:
PLoS ONE, 2024, v. 19, n. 9, p. 1, doi. 10.1371/journal.pone.0310915
By:
- Ben Abdallah, Hakim;
- Marino, Giorgia;
- Idorn, Manja;
- S. Reinert, Line;
- Bregnhøj, Anne;
- Paludan, Søren Riis;
- Johansen, Claus
Publication type:
Article
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Published in:
2020
By:
- Olagnier, David;
- Farahani, Ensieh;
- Thyrsted, Jacob;
- Blay-Cadanet, Julia;
- Herengt, Angela;
- Idorn, Manja;
- Hait, Alon;
- Hernaez, Bruno;
- Knudsen, Alice;
- Iversen, Marie Beck;
- Schilling, Mirjam;
- Jørgensen, Sofie E.;
- Thomsen, Michelle;
- Reinert, Line S.;
- Lappe, Michael;
- Hoang, Huy-Dung;
- Gilchrist, Victoria H.;
- Hansen, Anne Louise;
- Ottosen, Rasmus;
- Nielsen, Camilla G.
Publication type:
Correction Notice
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18764-3
By:
- Olagnier, David;
- Farahani, Ensieh;
- Thyrsted, Jacob;
- Blay-Cadanet, Julia;
- Herengt, Angela;
- Idorn, Manja;
- Hait, Alon;
- Hernaez, Bruno;
- Knudsen, Alice;
- Iversen, Marie Beck;
- Schilling, Mirjam;
- Jørgensen, Sofie E.;
- Thomsen, Michelle;
- Reinert, Line S.;
- Lappe, Michael;
- Hoang, Huy-Dung;
- Gilchrist, Victoria H.;
- Hansen, Anne Louise;
- Ottosen, Rasmus;
- Nielsen, Camilla G.
Publication type:
Article

Found: 14