Found: 29
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Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.
- Published in:
- PLoS Pathogens, 2018, v. 14, n. 2, p. 1, doi. 10.1371/journal.ppat.1006850
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- Publication type:
- Article
Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.
- Published in:
- PLoS Pathogens, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.ppat.1005971
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- Publication type:
- Article
A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market.
- Published in:
- Molecules, 2021, v. 26, n. 5, p. 1396, doi. 10.3390/molecules26051396
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- Publication type:
- Article
Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform.
- Published in:
- 2022
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- Publication type:
- journal article
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.
- Published in:
- Nature Communications, 2016, v. 7, n. 11, p. 13312, doi. 10.1038/ncomms13312
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- Publication type:
- Article
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.
- Published in:
- Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0520-5
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- Publication type:
- Article
Sperm Toolbox—A selection of small molecules to study human spermatozoa.
- Published in:
- PLoS ONE, 2024, v. 19, n. 2, p. 1, doi. 10.1371/journal.pone.0297666
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- Publication type:
- Article
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.09744
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- Publication type:
- Article
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
- Published in:
- PLoS Pathogens, 2020, v. 16, n. 11, p. N.PAG, doi. 10.1371/journal.ppat.1008932
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- Publication type:
- Article
Targeting N-myristoylation for therapy of B-cell lymphomas.
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- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18998-1
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- Publication type:
- Article
Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.
- Published in:
- PLoS Neglected Tropical Diseases, 2015, v. 9, n. 9, p. 1, doi. 10.1371/journal.pntd.0004014
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- Publication type:
- Article
Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat PPAR b/d - Mediated Psoriasis-Like Skin Disease In Vivo.
- Published in:
- PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037097
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- Publication type:
- Article
Automated design of ligands to polypharmacological profiles.
- Published in:
- Nature, 2012, v. 492, n. 7428, p. 215, doi. 10.1038/nature11691
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- Publication type:
- Article
Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei.
- Published in:
- Microorganisms, 2022, v. 10, n. 7, p. N.PAG, doi. 10.3390/microorganisms10071287
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- Publication type:
- Article
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
- Published in:
- Scientific Reports, 2016, p. 35351, doi. 10.1038/srep35351
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- Publication type:
- Article
The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis.
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- Science Translational Medicine, 2012, v. 4, n. 119, p. 1, doi. 10.1126/scitranslmed.3003326
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- Publication type:
- Article
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.
- Published in:
- ChemMedChem, 2015, v. 10, n. 11, p. 1809, doi. 10.1002/cmdc.201500300
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- Publication type:
- Article
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
- Published in:
- ChemMedChem, 2015, v. 10, n. 11, p. 1821, doi. 10.1002/cmdc.201500301
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- Publication type:
- Article
Cover Picture: Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015).
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- ChemMedChem, 2015, v. 10, n. 11, p. 1769, doi. 10.1002/cmdc.201500397
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- Publication type:
- Article
Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents.
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- ChemMedChem, 2013, v. 8, n. 9, p. 1537, doi. 10.1002/cmdc.201300177
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- Publication type:
- Article
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors.
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- ChemMedChem, 2012, v. 7, n. 1, p. 95, doi. 10.1002/cmdc.201100420
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- Publication type:
- Article
Optimisation of the Anti- Trypanosoma brucei Activity of the Opioid Agonist U50488.
- Published in:
- ChemMedChem, 2011, v. 6, n. 10, p. 1832, doi. 10.1002/cmdc.201100278
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- Publication type:
- Article
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1.
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- ChemMedChem, 2011, v. 6, n. 2, p. 302, doi. 10.1002/cmdc.201000450
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- Publication type:
- Article
Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)
- Published in:
- ChemMedChem, 2011, v. 6, n. 2, p. 209, doi. 10.1002/cmdc.201190000
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- Publication type:
- Article
C-reactive protein is essential for innate resistance to pneumococcal infection.
- Published in:
- Immunology, 2014, v. 142, n. 3, p. 414, doi. 10.1111/imm.12266
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- Publication type:
- Article
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.
- Published in:
- ChemBioChem, 2018, v. 19, n. 5, p. 425, doi. 10.1002/cbic.201700500
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- Publication type:
- Article
Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat.
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- Epilepsia (Series 4), 2010, v. 51, n. 8, p. 1543, doi. 10.1111/j.1528-1167.2009.02482.x
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- Publication type:
- Article
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
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- Malaria Journal, 2011, v. 10, n. Suppl 1, p. 150, doi. 10.1186/1475-2875-10-150
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- Publication type:
- Article
Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs.
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- Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 5, p. 874, doi. 10.1038/jcbfm.2012.1
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- Publication type:
- Article