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Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2.
Published in:
Angewandte Chemie International Edition, 2014, v. 53, n. 4, p. 1017, doi. 10.1002/anie.201308898
By:
- Schroeder, Christina I.;
- Rash, Lachlan D.;
- Vila‐Farrés, Xavier;
- Rosengren, K. Johan;
- Mobli, Mehdi;
- King, Glenn F.;
- Alewood, Paul F.;
- Craik, David J.;
- Durek, Thomas
Publication type:
Article
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.
Published in:
EMBO Journal, 2004, v. 23, n. 7, p. 1516, doi. 10.1038/sj.emboj.7600177
By:
- Diochot, Sylvie;
- Baron, Anne;
- Rash, Lachlan D.;
- Deval, Emmanuel;
- Escoubas, Pierre;
- Scarzello, Sabine;
- Salinas, Miguel;
- Lazdunski, Michel
Publication type:
Article
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.
Published in:
Journal of Physiology, 2006, v. 570, n. 2, p. 339, doi. 10.1113/jphysiol.2005.095810
By:
- Salinas, Miguel;
- Rash, Lachlan D.;
- Baron, Anne;
- Lambeau, Gérard;
- Escoubas, Pierre;
- Lazdunski, Michel
Publication type:
Article
Neurotoxic activity of venom from the Australian eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating.
Published in:
2000
By:
- Rash, Lachlan D;
- Birinyi-Strachan, Liesl C;
- Nicholson, Graham M;
- Hodgson, Wayne C;
- Rash, L D;
- Birinyi-Strachan, L C;
- Nicholson, G M;
- Hodgson, W C
Publication type:
journal article
Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy.
Published in:
Nature Genetics, 2015, v. 47, n. 3, p. 304, doi. 10.1038/ng0315-304b
By:
- Simons, Cas;
- Rash, Lachlan D;
- Crawford, Joanna;
- Ma, Linlin;
- Cristofori-Armstrong, Ben;
- Miller, David;
- Ru, Kelin;
- Baillie, Gregory J;
- Alanay, Yasemin;
- Jacquinet, Adeline;
- Debray, François-Guillaume;
- Verloes, Alain;
- Shen, Joseph;
- Yesil, Gözde;
- Guler, Serhat;
- Yuksel, Adnan;
- Cleary, John G;
- Grimmond, Sean M;
- McGaughran, Julie;
- King, Glenn F
Publication type:
Article
Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy.
Published in:
Nature Genetics, 2015, v. 47, n. 1, p. 73, doi. 10.1038/ng.3153
By:
- Simons, Cas;
- Rash, Lachlan D;
- Crawford, Joanna;
- Ma, Linlin;
- Cristofori-Armstrong, Ben;
- Ru, Kelin;
- Baillie, Gregory J;
- King, Glenn F;
- McGaughran, Julie;
- Gabbett, Michael T;
- Taft, Ryan J;
- Miller, David;
- Alanay, Yasemin;
- Jacquinet, Adeline;
- Debray, François-Guillaume;
- Verloes, Alain;
- Shen, Joseph;
- Yesil, Gözde;
- Guler, Serhat;
- Yuksel, Adnan
Publication type:
Article
Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2.
Published in:
Angewandte Chemie, 2014, v. 126, n. 4, p. 1035, doi. 10.1002/ange.201308898
By:
- Schroeder, Christina I.;
- Rash, Lachlan D.;
- Vila ‐ Farrés, Xavier;
- Rosengren, K. Johan;
- Mobli, Mehdi;
- King, Glenn F.;
- Alewood, Paul F.;
- Craik, David J.;
- Durek, Thomas
Publication type:
Article
Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.
Published in:
Scientific Reports, 2015, p. 1, doi. 10.1038/srep14763
By:
- Cristofori-Armstrong, Ben;
- Soh, Ming S.;
- Talwar, Sahil;
- Brown, Darren L.;
- Griffin, John D. O.;
- Dekan, Zoltan;
- Stow, Jennifer L.;
- King, Glenn F.;
- Lynch, Joseph W.;
- Rash, Lachlan D.
Publication type:
Article
Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063865
By:
- Klint, Julie K.;
- Senff, Sebastian;
- Saez, Natalie J.;
- Seshadri, Radha;
- Lau, Ho Yee;
- Bende, Niraj S.;
- Undheim, Eivind A. B.;
- Rash, Lachlan D.;
- Mobli, Mehdi;
- King, Glenn F.
Publication type:
Article
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction.
Published in:
European Heart Journal, 2024, v. 45, n. 17, p. 1571, doi. 10.1093/eurheartj/ehad793
By:
- Redd, Meredith A;
- Yoshikawa, Yusuke;
- Khan, Nemat;
- Waqar, Maleeha;
- Saez, Natalie J;
- Outhwaite, Jennifer E;
- Russell, Jake S;
- Hanna, Amy D;
- Chiu, Han S;
- Er, Sing Yan;
- Butcher, Neville J;
- Mardon, Karine;
- Fraser, John F;
- Smythe, Mark L;
- Rash, Lachlan D;
- Thomas, Walter G;
- King, Glenn F;
- Reichelt, Melissa E;
- Palpant, Nathan J
Publication type:
Article
Functional Expression in Escherichia coli of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3.
Published in:
Marine Drugs, 2012, v. 10, n. 7, p. 1605, doi. 10.3390/md10071605
By:
- Anangi, Raveendra;
- Rash, Lachlan D.;
- Mobli, Mehdi;
- King, Glenn F.
Publication type:
Article
Cyclisation Increases the Stability of the Sea Anemone Peptide APET×2 but Decreases Its Activity at Acid-Sensing Ion Channel 3.
Published in:
Marine Drugs, 2012, v. 10, n. 7, p. 1511, doi. 10.3390/md10071511
By:
- Jensen, Jonas E.;
- Mobli, Mehdi;
- Brust, Andreas;
- Alewood, Paul F.;
- King, Glenn F.;
- Rash, Lachlan D.
Publication type:
Article
Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans.
Published in:
Cellular & Molecular Life Sciences, 2018, v. 75, n. 23, p. 4465, doi. 10.1007/s00018-018-2893-x
By:
- Silva, Anjana;
- Cristofori-Armstrong, Ben;
- Rash, Lachlan D.;
- Hodgson, Wayne C.;
- Isbister, Geoffrey K.
Publication type:
Article
The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution.
Published in:
Toxins, 2019, v. 11, n. 11, p. 666, doi. 10.3390/toxins11110666
By:
- Schendel, Vanessa;
- Rash, Lachlan D.;
- Jenner, Ronald A.;
- Undheim, Eivind A. B.
Publication type:
Article
D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.
Published in:
Toxins, 2019, v. 11, n. 4, p. 197, doi. 10.3390/toxins11040197
By:
- Kakumanu, Rahini;
- Kuruppu, Sanjaya;
- Rash, Lachlan D.;
- Isbister, Geoffrey K.;
- Hodgson, Wayne C.;
- Kemp-Harper, Barbara K.
Publication type:
Article
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.
Published in:
2018
By:
- Lee, Jia Yu Peppermint;
- Saez, Natalie J.;
- Cristofori‐Armstrong, Ben;
- Anangi, Raveendra;
- King, Glenn F.;
- Smith, Maree T.;
- Rash, Lachlan D.;
- Cristofori-Armstrong, Ben
Publication type:
journal article
The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.
Published in:
Toxins, 2017, v. 9, n. 11, p. 346, doi. 10.3390/toxins9110346
By:
- Wilson, David;
- Boyle, Glen M.;
- McIntyre, Lachlan;
- Nolan, Matthew J.;
- Parsons, Peter G.;
- Smith, Jennifer J.;
- Tribolet, Leon;
- Loukas, Alex;
- Liddell, Michael J.;
- Rash, Lachlan D.;
- Daly, Norelle L.
Publication type:
Article
Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Published in:
Toxins, 2015, v. 7, n. 7, p. 2494, doi. 10.3390/toxins7072494
By:
- Chun Yuen Chow;
- Cristofori-Armstrong, Ben;
- Undheim, Eivind A. B.;
- King, Glenn F.;
- Rash, Lachlan D.
Publication type:
Article
Spider-Venom Peptides as Therapeutics.
Published in:
Toxins, 2010, v. 2, n. 12, p. 2851, doi. 10.3390/toxins2122851
By:
- Saez, Natalie J.;
- Senff, Sebastian;
- Jensen, Jonas E.;
- Sing Yan Er;
- Herzig, Volker;
- Rash, Lachlan D.;
- King, Glenn F.
Publication type:
Article
Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.
Published in:
2015
By:
- Saez, Natalie J;
- Deplazes, Evelyne;
- Cristofori ‐ Armstrong, Ben;
- Chassagnon, Irène R;
- Lin, Xiaozhen;
- Mobli, Mehdi;
- Mark, Alan E;
- Rash, Lachlan D;
- King, Glenn F;
- Cristofori-Armstrong, Ben;
- Chassagnon, Irène R
Publication type:
journal article
Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.
Published in:
2012
By:
- Blanchard MG;
- Rash LD;
- Kellenberger S;
- Blanchard, Maxime G;
- Rash, Lachlan D;
- Kellenberger, Stephan
Publication type:
journal article
Inhibition of voltage-gated Na+ currents in sensory neurones by the sea anemone toxin APETx2.
Published in:
British Journal of Pharmacology, 2012, v. 165, n. 7, p. 2167, doi. 10.1111/j.1476-5381.2011.01674.x
By:
- Blanchard, Maxime G;
- Rash, Lachlan D;
- Kellenberger, Stephan
Publication type:
Article
Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System.
Published in:
Frontiers in Cellular Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fncel.2021.738043
By:
- Foster, Victoria S.;
- Rash, Lachlan D.;
- King, Glenn F.;
- Rank, Michelle M.
Publication type:
Article
The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
Published in:
PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173551
By:
- Rahnama, Sassan;
- Deuis, Jennifer R.;
- Cardoso, Fernanda C.;
- Ramanujam, Venkatraman;
- Lewis, Richard J.;
- Rash, Lachlan D.;
- King, Glenn F.;
- Vetter, Irina;
- Mobli, Mehdi
Publication type:
Article
ASIC3: First the Heartache, Now a Migraine!
Published in:
Headache: The Journal of Head & Face Pain, 2013, v. 53, n. 8, p. 1204, doi. 10.1111/head.12170
By:
- Rash, Lachlan D.
Publication type:
Article

Found: 25

Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2.

A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.

Neurotoxic activity of venom from the Australian eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating.

Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy.

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy.

Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.

Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of <i>E. coli</i>

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction.

Functional Expression in Escherichia coli of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3.

Cyclisation Increases the Stability of the Sea Anemone Peptide APET×2 but Decreases Its Activity at Acid-Sensing Ion Channel 3.

Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans.

The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution.

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.

Spider-Venom Peptides as Therapeutics.

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.

Inhibition of voltage-gated Na<sup>+</sup> currents in sensory neurones by the sea anemone toxin APETx2.

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System.

The structure, dynamics and selectivity profile of a Na<sub>V</sub>1.7 potency-optimised huwentoxin-IV variant.

ASIC3: First the Heartache, Now a Migraine!