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Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1040039
By:
- Ronzetti, Michael H.;
- Baljinnyam, Bolormaa;
- Itkin, Zina;
- Jain, Sankalp;
- Rai, Ganesha;
- Zakharov, Alexey V.;
- Pal, Utpal;
- Simeonov, Anton
Publication type:
Article
Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma.
Published in:
Brain: A Journal of Neurology, 2023, v. 146, n. 4, p. 1697, doi. 10.1093/brain/awac342
By:
- Laraba, Liyam;
- Hillson, Lily;
- Guibert, Julio Grimm de;
- Hewitt, Amy;
- Jaques, Maisie R;
- Tang, Tracy T;
- Post, Leonard;
- Ercolano, Emanuela;
- Rai, Ganesha;
- Yang, Shyh-Ming;
- Jagger, Daniel J;
- Woznica, Waldemar;
- Edwards, Philip;
- Shivane, Aditya G;
- Hanemann, C Oliver;
- Parkinson, David B
Publication type:
Article
KDM5 histone demethylases repress immune response via suppression of STING.
Published in:
PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2006134
By:
- Wu, Lizhen;
- Cao, Jian;
- Cai, Wesley L.;
- Lang, Sabine M.;
- Horton, John R.;
- Jansen, Daniel J.;
- Liu, Zongzhi Z.;
- Chen, Jocelyn F.;
- Zhang, Meiling;
- Mott, Bryan T.;
- Pohida, Katherine;
- Rai, Ganesha;
- Kales, Stephen C.;
- Henderson, Mark J.;
- Hu, Xin;
- Jadhav, Ajit;
- Maloney, David J.;
- Simeonov, Anton;
- Zhu, Shu;
- Iwasaki, Akiko
Publication type:
Article
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.
Published in:
Diabetologia, 2015, v. 58, n. 3, p. 549, doi. 10.1007/s00125-014-3452-0
By:
- Taylor-Fishwick, David;
- Weaver, Jessica;
- Glenn, Lindsey;
- Kuhn, Norine;
- Rai, Ganesha;
- Jadhav, Ajit;
- Simeonov, Anton;
- Dudda, Angela;
- Schmoll, Dieter;
- Holman, Theodore;
- Maloney, David;
- Nadler, Jerry
Publication type:
Article
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40537-x
By:
- Yan, Wenjing;
- Zhong, Yongwang;
- Hu, Xin;
- Xu, Tuan;
- Zhang, Yinghua;
- Kales, Stephen;
- Qu, Yanyan;
- Talley, Daniel C.;
- Baljinnyam, Bolormaa;
- LeClair, Christopher A.;
- Simeonov, Anton;
- Polster, Brian M.;
- Huang, Ruili;
- Ye, Yihong;
- Rai, Ganesha;
- Henderson, Mark J.;
- Tao, Dingyin;
- Fang, Shengyun
Publication type:
Article
Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065928
By:
- Hoobler, Eric K.;
- Rai, Ganesha;
- Warrilow, Andrew G. S.;
- Perry, Steven C.;
- Smyrniotis, Christopher J.;
- Jadhav, Ajit;
- Simeonov, Anton;
- Parker, Josie E.;
- Kelly, Diane E.;
- Maloney, David J.;
- Kelly, S. L.;
- Holman, Theodore R.
Publication type:
Article
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors.
Published in:
PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0015535
By:
- King, Oliver N. F.;
- Li, Xuan Shirley;
- Sakurai, Masaaki;
- Kawamura, Akane;
- Rose, Nathan R.;
- Ng, Stanley S.;
- Quinn, Amy M.;
- Rai, Ganesha;
- Mott, Bryan T.;
- Beswick, Paul;
- Klose, Robert J.;
- Oppermann, Udo;
- Jadhav, Ajit;
- Heightman, Tom D.;
- Maloney, David J.;
- Schofield, Christopher J.;
- Simeonov, Anton
Publication type:
Article
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy.
Published in:
Cancers, 2020, v. 12, n. 8, p. 2121, doi. 10.3390/cancers12082121
By:
- Jose, Anmi;
- Shenoy, Gautham G.;
- Sunil Rodrigues, Gabriel;
- Kumar, Naveena A. N.;
- Munisamy, Murali;
- Thomas, Levin;
- Kolesar, Jill;
- Rai, Ganesha;
- Rao, Praveen P. N.;
- Rao, Mahadev
Publication type:
Article
A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology.
Published in:
Frontiers in Oncology, 2022, v. 11, p. 1, doi. 10.3389/fonc.2021.790037
By:
- Kagan, Amanda B.;
- Moses, Blake S.;
- Mott, Bryan T.;
- Rai, Ganesha;
- Anders, Nicole M.;
- Rudek, Michelle A.;
- Civin, Curt I.
Publication type:
Article
A 12‐lipoxygenase‐Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
Published in:
FASEB Journal, 2020, v. 34, n. 11, p. 14850, doi. 10.1096/fj.201902308RR
By:
- Hernandez‐Perez, Marimar;
- Kulkarni, Abhishek;
- Samala, Niharika;
- Sorrell, Cody;
- El, Kimberly;
- Haider, Isra;
- Mukhtar Aleem, Ansari;
- Holman, Theodore R.;
- Rai, Ganesha;
- Tersey, Sarah A.;
- Mirmira, Raghavendra G.;
- Anderson, Ryan M.
Publication type:
Article
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.
Published in:
Nature Communications, 2014, v. 5, n. 11, p. 5165, doi. 10.1038/ncomms6165
By:
- Gormally, Michael V.;
- Dexheimer, Thomas S.;
- Marsico, Giovanni;
- Sanders, Deborah A.;
- Lowe, Christopher;
- Matak-Vinković, Dijana;
- Michael, Sam;
- Jadhav, Ajit;
- Rai, Ganesha;
- Maloney, David J.;
- Simeonov, Anton;
- Balasubramanian, Shankar
Publication type:
Article
A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators Via High-Throughput Screening and CETSA.
Published in:
Assay & Drug Development Technologies, 2021, v. 19, n. 8, p. 539, doi. 10.1089/adt.2021.059
By:
- Larson, Hunter G.;
- Zakharov, Alexey V.;
- Sarkar, Sukumar;
- Yang, Shyh-Ming;
- Rai, Ganesha;
- Larner, James M.;
- Simeonov, Anton;
- Martinez, Natalia J.
Publication type:
Article
A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoniThioredoxin Glutathione Reductase.
Published in:
Assay & Drug Development Technologies, 2008, v. 6, n. 4, p. 551, doi. 10.1089/adt.2008.149
By:
- Wendy A. Lea;
- Ajit Jadhav;
- Ganesha Rai;
- Ahmed A. Sayed;
- Cynthia L. Cass;
- James Inglese;
- David L. Williams;
- Christopher P. Austin;
- Anton Simeonov
Publication type:
Article
ART714 is a best-in-class antileukemic 2-carbon-linked dimeric artemisinin derivative.
Published in:
Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 1, p. 39, doi. 10.1007/s00280-023-04539-2
By:
- Kagan, Amanda B.;
- Moses, Blake S.;
- Lapidus, Rena;
- Mott, Bryan T.;
- Rai, Ganesha;
- Anders, Nicole M.;
- Hoag, Stephen W.;
- Rudek, Michelle A.;
- Civin, Curt I.
Publication type:
Article
XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6.
Published in:
Human Molecular Genetics, 2022, v. 31, n. 15, p. 2639, doi. 10.1093/hmg/ddac010
By:
- Zhong, Yongwang;
- Yan, Wenjing;
- Ruan, Jingjing;
- Fang, Mike;
- Yu, Changjun;
- Du, Shaojun;
- Rai, Ganesha;
- Tao, Dingyin;
- Henderson, Mark J;
- Fang, Shengyun
Publication type:
Article
Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency.
Published in:
Science Translational Medicine, 2013, v. 5, n. 167, p. 1, doi. 10.1126/scitranslmed.3005145
By:
- Yu Liang;
- Vogel, Jodi L.;
- Arbuckle, Jesse H.;
- Rai, Ganesha;
- Jadhav, Ajit;
- Simeonov, Anton;
- Maloney, David J.;
- Kristie, Thomas M.
Publication type:
Article
Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.
Published in:
2016
By:
- Martinez, Natalia J.;
- Rai, Ganesha;
- Yasgar, Adam;
- Lea, Wendy A.;
- Sun, Hongmao;
- Wang, Yuhong;
- Luci, Diane K.;
- Yang, Shyh-Ming;
- Nishihara, Kana;
- Takeda, Shunichi;
- Mohiuddin, null;
- Earnshaw, Irina;
- Okada, Tetsuya;
- Mori, Kazutoshi;
- Wilson, Kelli;
- Riggins, Gregory J.;
- Xia, Menghang;
- Grimaldi, Maurizio;
- Jadhav, Ajit;
- Maloney, David J.
Publication type:
Correction Notice
A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.
Published in:
PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0161486
By:
- Martinez, Natalia J.;
- Rai, Ganesha;
- Yasgar, Adam;
- Lea, Wendy A.;
- Sun, Hongmao;
- Wang, Yuhong;
- Luci, Diane K.;
- Yang, Shyh-Ming;
- Nishihara, Kana;
- Takeda, Shunichi;
- Sagor, Mohiuddin;
- Earnshaw, Irina;
- Okada, Tetsuya;
- Mori, Kazutoshi;
- Wilson, Kelli;
- Riggins, Gregory J.;
- Xia, Menghang;
- Grimaldi, Maurizio;
- Jadhav, Ajit;
- Maloney, David J.
Publication type:
Article
Short Report: In vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelmintic Susceptibility.
Published in:
American Journal of Tropical Medicine & Hygiene, 2014, v. 90, n. 1, p. 71, doi. 10.4269/ajtmh.12-0547
By:
- Treger, Rebecca S.;
- Otchere, Joseph;
- Keil, Martin F.;
- Quagraine, Josephine E.;
- Rai, Ganesha;
- Mott, Bryan T.;
- Humphries, Debbie L.;
- Wilson, Michael;
- Cappello, Michael;
- Vermeire, Jon J.
Publication type:
Article
ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression.
Published in:
NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00411-x
By:
- Lavudi, Kousalya;
- Banerjee, Ananya;
- Li, Na;
- Yang, Yajing;
- Cai, Shurui;
- Bai, Xuetao;
- Zhang, Xiaoli;
- Li, Aidan;
- Wani, Elsa;
- Yang, Shyh-Ming;
- Zhang, Junran;
- Rai, Ganesha;
- Backes, Floor;
- Patnaik, Srinivas;
- Guo, Peixuan;
- Wang, Qi-En
Publication type:
Article
A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1.
Published in:
ChemMedChem, 2014, v. 9, n. 3, p. 566, doi. 10.1002/cmdc.201300428
By:
- Schiller, Rachel;
- Scozzafava, Giuseppe;
- Tumber, Anthony;
- Wickens, James R.;
- Bush, Jacob T.;
- Rai, Ganesha;
- Lejeune, Clarisse;
- Choi, Hwanho;
- Yeh, Tzu‐Lan;
- Chan, Mun Chiang;
- Mott, Bryan T.;
- McCullagh, James S. O.;
- Maloney, David J.;
- Schofield, Christopher J.;
- Kawamura, Akane
Publication type:
Article
Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.
Published in:
Retrovirology, 2016, v. 13, p. 1, doi. 10.1186/s12977-016-0244-2
By:
- Smith, Steven J.;
- Pauly, Gary T.;
- Akram, Aamir;
- Melody, Kevin;
- Rai, Ganesha;
- Maloney, David J.;
- Ambrose, Zandrea;
- Thomas, Craig J.;
- Schneider, Joel T.;
- Hughes, Stephen H.
Publication type:
Article
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.
Published in:
Retrovirology, 2012, v. 9, n. 1, p. 99, doi. 10.1186/1742-4690-9-99
By:
- Johnson, Barry C.;
- Pauly, Gary T.;
- Rai, Ganesha;
- Patel, Disha;
- Bauman, Joseph D.;
- Baker, Heather L.;
- Das, Kalyan;
- Schneider, Joel P.;
- Maloney, David J.;
- Arnold, Eddy;
- Thomas, Craig J.;
- Hughes, Stephen H.
Publication type:
Article

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