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A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31408-y
By:
- Hamed, Akram A.;
- Kunz, Daniel J.;
- El-Hamamy, Ibrahim;
- Trinh, Quang M.;
- Subedar, Omar D.;
- Richards, Laura M.;
- Foltz, Warren;
- Bullivant, Garrett;
- Ware, Matthaeus;
- Vladoiu, Maria C.;
- Zhang, Jiao;
- Raj, Antony M.;
- Pugh, Trevor J.;
- Taylor, Michael D.;
- Teichmann, Sarah A.;
- Stein, Lincoln D.;
- Simons, Benjamin D.;
- Dirks, Peter B.
Publication type:
Article
Genome screening, reporting, and genetic counseling for healthy populations.
Published in:
Human Genetics, 2023, v. 142, n. 2, p. 181, doi. 10.1007/s00439-022-02480-7
By:
- Casalino, Selina;
- Frangione, Erika;
- Chung, Monica;
- MacDonald, Georgia;
- Chowdhary, Sunakshi;
- Mighton, Chloe;
- Faghfoury, Hanna;
- Bombard, Yvonne;
- Strug, Lisa;
- Pugh, Trevor J.;
- Simpson, Jared;
- Arnoldo, Saranya;
- Aujla, Navneet;
- Bearss, Erin;
- Binnie, Alexandra;
- Borgundvaag, Bjug;
- Chertkow, Howard;
- Clausen, Marc;
- Dagher, Marc;
- Devine, Luke
Publication type:
Article
Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation.
Published in:
Nucleic Acids Research, 2013, v. 41, n. 6, p. e67, doi. 10.1093/nar/gks1443
By:
- Costello, Maura;
- Pugh, Trevor J.;
- Fennell, Timothy J.;
- Stewart, Chip;
- Lichtenstein, Lee;
- Meldrim, James C.;
- Fostel, Jennifer L.;
- Friedrich, Dennis C.;
- Perrin, Danielle;
- Dionne, Danielle;
- Kim, Sharon;
- Gabriel, Stacey B.;
- Lander, Eric S.;
- Fisher, Sheila;
- Getz, Gad
Publication type:
Article
Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26598-w
By:
- Croucher, Danielle C.;
- Richards, Laura M.;
- Tsofack, Serges P.;
- Waller, Daniel;
- Li, Zhihua;
- Wei, Ellen Nong;
- Huang, Xian Fang;
- Chesi, Marta;
- Bergsagel, P. Leif;
- Sebag, Michael;
- Pugh, Trevor J.;
- Trudel, Suzanne
Publication type:
Article
The genetic landscape of high-risk neuroblastoma.
Published in:
Nature Genetics, 2013, v. 45, n. 3, p. 279, doi. 10.1038/ng.2529
By:
- Pugh, Trevor J;
- Morozova, Olena;
- Attiyeh, Edward F;
- Asgharzadeh, Shahab;
- Wei, Jun S;
- Auclair, Daniel;
- Carter, Scott L;
- Cibulskis, Kristian;
- Hanna, Megan;
- Kiezun, Adam;
- Kim, Jaegil;
- Lawrence, Michael S;
- Lichenstein, Lee;
- McKenna, Aaron;
- Pedamallu, Chandra Sekhar;
- Ramos, Alex H;
- Shefler, Erica;
- Sivachenko, Andrey;
- Sougnez, Carrie;
- Stewart, Chip
Publication type:
Article
Alternative expression analysis by RNA sequencing.
Published in:
Nature Methods, 2010, v. 7, n. 10, p. 843, doi. 10.1038/nmeth.1503
By:
- Griffith, Malachi;
- Griffith, Obi L.;
- Mwenifumbo, Jill;
- Goya, Rodrigo;
- Morrissy, A Sorana;
- Morin, Ryan D;
- Corbett, Richard;
- Tang, Michelle J.;
- Ying-Chen Hou;
- Pugh, Trevor J.;
- Robertson, Gordon;
- Chittaranjan, Suganthi;
- Ally, Adrian;
- Asano, Jennifer K.;
- Chan, Susanna Y.;
- Li, Haiyan I.;
- McDonald, Helen;
- Teague, Kevin;
- Yongjun Zhao;
- Zeng, Thomas
Publication type:
Article
Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma.
Published in:
American Journal of Hematology, 2022, v. 97, n. 12, p. 1538, doi. 10.1002/ajh.26726
By:
- Lackraj, Tracy;
- Ben Barouch, Sharon;
- Medeiros, Jessie J. F.;
- Pedersen, Stephanie;
- Danesh, Arnavaz;
- Bakhtiari, Mehran;
- Hong, Michael;
- Tong, Kit;
- Joynt, Jesse;
- Arruda, Andrea;
- Minden, Mark D.;
- Kuruvilla, John;
- Bhella, Sita;
- Kukreti, Vishal;
- Crump, Michael;
- Prica, Anca;
- Chen, Christine;
- Deng, Yangqing;
- Xu, Wei;
- Pugh, Trevor J.
Publication type:
Article
MEDIPIPE: an automated and comprehensive pipeline for cfMeDIP-seq data quality control and analysis.
Published in:
Bioinformatics, 2023, v. 39, n. 7, p. 1, doi. 10.1093/bioinformatics/btad423
By:
- Zeng, Yong;
- Ye, Wenbin;
- Stutheit-Zhao, Eric Y;
- Han, Ming;
- Bratman, Scott V;
- Pugh, Trevor J;
- He, Housheng Hansen
Publication type:
Article
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45449-y
By:
- Lien, Scott C.;
- Ly, Dalam;
- Yang, S. Y. Cindy;
- Wang, Ben X.;
- Clouthier, Derek L.;
- St. Paul, Michael;
- Gadalla, Ramy;
- Noamani, Babak;
- Garcia-Batres, Carlos R.;
- Boross-Harmer, Sarah;
- Bedard, Philippe L.;
- Pugh, Trevor J.;
- Spreafico, Anna;
- Hirano, Naoto;
- Razak, Albiruni R. A.;
- Ohashi, Pamela S.
Publication type:
Article
Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40966-8
By:
- Coffey, David G.;
- Maura, Francesco;
- Gonzalez-Kozlova, Edgar;
- Diaz-Mejia, J. Javier;
- Luo, Ping;
- Zhang, Yong;
- Xu, Yuexin;
- Warren, Edus H.;
- Dawson, Travis;
- Lee, Brian;
- Xie, Hui;
- Smith, Eric;
- Ciardiello, Amanda;
- Cho, Hearn J.;
- Rahman, Adeeb;
- Kim-Schulze, Seunghee;
- Diamond, Benjamin;
- Lesokhin, Alexander;
- Kazandjian, Dickran;
- Pugh, Trevor J.
Publication type:
Article
Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38432-6
By:
- Suppiah, Suganth;
- Mansouri, Sheila;
- Mamatjan, Yasin;
- Liu, Jeffrey C.;
- Bhunia, Minu M.;
- Patil, Vikas;
- Rath, Prisni;
- Mehani, Bharati;
- Heir, Pardeep;
- Bunda, Severa;
- Velez-Reyes, German L.;
- Singh, Olivia;
- Ijad, Nazanin;
- Pirouzmand, Neda;
- Dalcourt, Tatyana;
- Meng, Ying;
- Karimi, Shirin;
- Wei, Qingxia;
- Nassiri, Farshad;
- Pugh, Trevor J.
Publication type:
Article
Applications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy.
Published in:
JNCI Cancer Spectrum, 2021, v. 5, n. 3, p. 1, doi. 10.1093/jncics/pkaa122
By:
- Araujo, Daniel V;
- Wang, Ao;
- Torti, Dax;
- Leon, Alberto;
- Marsh, Kayla;
- McCarthy, Aoife;
- Berman, Hal;
- Spreafico, Anna;
- Hansen, Aaron R;
- Razak, Albiruni-Abdul;
- Bedard, Philippe L;
- Wang, Lisa;
- Plackmann, Eric;
- Chow, Helen;
- Bao, Hua;
- Wu, Xue;
- Pugh, Trevor J;
- Siu, Lillian L
Publication type:
Article
Predicting Toxicity and Response to Pembrolizumab Through Germline Genomic HLA Class 1 Analysis.
Published in:
JNCI Cancer Spectrum, 2021, v. 5, n. 1, p. 1, doi. 10.1093/jncics/pkaa115
By:
- Iafolla, Marco A. J.;
- Yang, Cindy;
- Chandran, Vinod;
- Pintilie, Melania;
- Quan Li;
- Bedard, Philippe L.;
- Hansen, Aaron;
- Lheureux, Stephanie;
- Spreafico, Anna;
- Razak, Albiruni A.;
- Hakgor, Sevan;
- Giesler, Amanda;
- Pugh, Trevor J.;
- Siu, Lillian L.
Publication type:
Article
Prospective observational study and serosurvey of SARS-CoV-2 infection in asymptomatic healthcare workers at a Canadian tertiary care center.
Published in:
PLoS ONE, 2021, v. 16, n. 2, p. 1, doi. 10.1371/journal.pone.0247258
By:
- Ferreira, Victor H.;
- Chruscinski, Andrzej;
- Kulasingam, Vathany;
- Pugh, Trevor J.;
- Dus, Tamara;
- Wouters, Brad;
- Oza, Amit;
- Ierullo, Matthew;
- Ku, Terrance;
- Majchrzak-Kita, Beata;
- Humar, Sonika T.;
- Bahinskaya, Ilona;
- Pinzon, Natalia;
- Zhang, Jianhua;
- Heisler, Lawrence E.;
- Krzyzanowski, Paul M.;
- Lam, Bernard;
- Lungu, Ilinca M.;
- Manase, Dorin;
- Pace, Krista M.
Publication type:
Article
Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing.
Published in:
Life Science Alliance, 2023, v. 6, n. 1, p. 1, doi. 10.26508/lsa.202201543
By:
- Chow, Signy;
- Kis, Olena;
- Mulder, David T.;
- Danesh, Arnavaz;
- Bruce, Jeff;
- Wang, Ting Ting;
- Reece, Donna;
- Bhalis, Nizar;
- Neri, Paola;
- Sabatini, Peter J. B.;
- Keats, Jonathan;
- Trudel, Suzanne;
- Pugh, Trevor J.
Publication type:
Article
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first‐line platinum chemotherapy in high grade serous ovarian cancer.
Published in:
Cancer Medicine, 2021, v. 10, n. 9, p. 3045, doi. 10.1002/cam4.3831
By:
- Weberpals, Johanne I.;
- Pugh, Trevor J.;
- Marco‐Casanova, Paola;
- Goss, Glenwood D.;
- Andrews Wright, Natalie;
- Rath, Prisni;
- Torchia, Jonathon;
- Fortuna, Alexander;
- Jones, Gemma N.;
- Roudier, Martine P.;
- Bernard, Laurence;
- Lo, Bryan;
- Torti, Dax;
- Leon, Alberto;
- Marsh, Kayla;
- Hodgson, Darren;
- Duciaume, Marc;
- Howat, William J.;
- Lukashchuk, Natalia;
- Lazic, Stanley E.
Publication type:
Article
Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.
Published in:
Neuro-Oncology, 2020, v. 22, n. 10, p. 1474, doi. 10.1093/neuonc/noaa077
By:
- Fukuoka, Kohei;
- Mamatjan, Yasin;
- Tatevossian, Ruth;
- Zapotocky, Michal;
- Ryall, Scott;
- Stucklin, Ana Guerreiro;
- Bennett, Julie;
- Nobre, Liana Figueiredo;
- Arnoldo, Anthony;
- Luu, Betty;
- Wen, Ji;
- Zhu, Kaicen;
- Leon, Alberto;
- Torti, Dax;
- Pugh, Trevor J;
- Hazrati, Lili-Naz;
- Laperriere, Normand;
- Drake, James;
- Rutka, James T;
- Dirks, Peter
Publication type:
Article
A Comprehensive Assay for CFTR Mutational Analysis Using Next-Generation Sequencing.
Published in:
Clinical Chemistry, 2013, v. 59, n. 10, p. 1481, doi. 10.1373/clinchem.2013.206466
By:
- Tayoun, Ahmad N. Abou;
- Tunkey, Christopher D.;
- Pugh, Trevor J.;
- Ross, Tristen;
- Shah, Minita;
- Lee, Clarence C.;
- Harkins, Timothy T.;
- Wells, Wendy A.;
- Tafe, Laura J.;
- Amos, Christopher I.;
- Tsongalis, Gregory J.
Publication type:
Article
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment.
Published in:
Science Immunology, 2019, v. 4, n. 42, p. 1, doi. 10.1126/sciimmunol.aax8189
By:
- Halaby, Marie Jo;
- Hezaveh, Kebria;
- Lamorte, Sara;
- Ciudad, M. Teresa;
- Kloetgen, Andreas;
- MacLeod, Bethany L.;
- Mengdi Guo;
- Chakravarthy, Ankur;
- Da Silva Medina, Tiago;
- Ugel, Stefano;
- Tsirigos, Aristotelis;
- Bronte, Vincenzo;
- Munn, David H.;
- Pugh, Trevor J.;
- De Carvalho, Daniel D.;
- Butler, Marcus O.;
- Ohashi, Pamela S.;
- Brooks, David G.;
- McGaha, Tracy L.
Publication type:
Article
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00174-7
By:
- Agnihotri, Sameer;
- Suppiah, Suganth;
- Tonge, Peter D.;
- Jalali, Shahrzad;
- Danesh, Arnavaz;
- Bruce, Jeffery P.;
- Mamatjan, Yasin;
- Klironomos, George;
- Gonen, Lior;
- Au, Karolyn;
- Mansouri, Sheila;
- Karimi, Sharin;
- Sahm, Felix;
- Deimling, Andreasvon;
- Taylor, Michael D.;
- Laperriere, Normand J.;
- Pugh, Trevor J.;
- Aldape, Kenneth D.;
- Zadeh, Gelareh
Publication type:
Article
Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.
Published in:
Nature Communications, 2017, v. 8, n. 5, p. 15086, doi. 10.1038/ncomms15086
By:
- Kis, Olena;
- Kaedbey, Rayan;
- Chow, Signy;
- Danesh, Arnavaz;
- Dowar, Mark;
- Li, Tiantian;
- Li, Zhihua;
- Liu, Jessica;
- Mansour, Mark;
- Masih-Khan, Esther;
- Zhang, Tong;
- Bratman, Scott V.;
- Oza, Amit M.;
- Kamel-Reid, Suzanne;
- Trudel, Suzanne;
- Pugh, Trevor J.
Publication type:
Article
Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.
Published in:
British Journal of Cancer, 2019, v. 121, n. 4, p. 318, doi. 10.1038/s41416-019-0517-3
By:
- Veitch, Zachary W.;
- Cescon, David W.;
- Denny, Trisha;
- Yonemoto, Lisa-Maria;
- Fletcher, Graham;
- Brokx, Richard;
- Sampson, Peter;
- Li, Sze-Wan;
- Pugh, Trevor J.;
- Bruce, Jeffrey;
- Bray, Mark R.;
- Slamon, Dennis J.;
- Mak, Tak W.;
- Wainberg, Zev A.;
- Bedard, Philippe L.
Publication type:
Article
Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.
Published in:
2019
By:
- Veitch, Zachary W;
- Cescon, David W;
- Denny, Trisha;
- Yonemoto, Lisa-Maria;
- Fletcher, Graham;
- Brokx, Richard;
- Sampson, Peter;
- Li, Sze-Wan;
- Pugh, Trevor J;
- Bruce, Jeffrey;
- Bray, Mark R;
- Slamon, Dennis J;
- Mak, Tak W;
- Wainberg, Zev A;
- Bedard, Philippe L
Publication type:
journal article
Next generation sequencing-based copy number analysis reveals low prevalence of deletions and duplications in 46 genes associated with genetic cardiomyopathies.
Published in:
Molecular Genetics & Genomic Medicine, 2016, v. 4, n. 2, p. 143, doi. 10.1002/mgg3.187
By:
- Ceyhan‐Birsoy, Ozge;
- Pugh, Trevor J.;
- Bowser, Mark J.;
- Hynes, Elizabeth;
- Frisella, Ashley L.;
- Mahanta, Lisa M.;
- Lebo, Matt S.;
- Amr, Sami S.;
- Funke, Birgit H.
Publication type:
Article
Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83366-y
By:
- Kwan, Jennifer Yin Yee;
- Lin, Liang-Tzung;
- Bell, Rachel;
- Bruce, Jeffrey P.;
- Richardson, Christopher;
- Pugh, Trevor J.;
- Liu, Fei-Fei
Publication type:
Article
A shower of second hit events as the cause of multifocal renal cell carcinoma in tuberous sclerosis complex.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 7, p. 1836, doi. 10.1093/hmg/ddu597
By:
- Tyburczy, Magdalena E.;
- Jozwiak, Sergiusz;
- Malinowska, Izabela A.;
- Chekaluk, Yvonne;
- Pugh, Trevor J.;
- Chin-Lee Wu;
- Nussbaum, Robert L.;
- Seepo, Sara;
- Dzik, Tomasz;
- Kotulska, Katarzyna;
- Kwiatkowski, David J.
Publication type:
Article
Considerations for the use of circulating tumor DNA sequencing as a screening tool in cancer predisposition syndromes.
Published in:
Pediatric Blood & Cancer, 2020, v. 67, n. 12, p. 1, doi. 10.1002/pbc.28758
By:
- Paramathas, Sangeetha;
- Guha, Tanya;
- Pugh, Trevor J.;
- Malkin, David;
- Villani, Anita
Publication type:
Article
Germline whole genome sequencing in adults with multiple primary tumors.
Published in:
Familial Cancer, 2023, v. 22, n. 4, p. 513, doi. 10.1007/s10689-023-00343-2
By:
- Wang, Yiming;
- Ding, Qiliang;
- Prokopec, Stephenie;
- Farncombe, Kirsten M.;
- Bruce, Jeffrey;
- Casalino, Selina;
- McCuaig, Jeanna;
- Szybowska, Marta;
- van Engelen, Kalene;
- Lerner-Ellis, Jordan;
- Pugh, Trevor J.;
- Kim, Raymond H.
Publication type:
Article
Pugh et al. reply.
Published in:
Nature, 2015, v. 520, n. 7547, p. E12, doi. 10.1038/nature14266
By:
- Pugh, Trevor J.;
- Banerji, Shantanu;
- Meyerson, Matthew
Publication type:
Article
Landscape of genomic alterations in cervical carcinomas.
Published in:
Nature, 2014, v. 506, n. 7488, p. 371, doi. 10.1038/nature12881
By:
- Ojesina, Akinyemi I.;
- Lichtenstein, Lee;
- Freeman, Samuel S.;
- Pedamallu, Chandra Sekhar;
- Imaz-Rosshandler, Ivan;
- Pugh, Trevor J.;
- Cherniack, Andrew D.;
- Ambrogio, Lauren;
- Cibulskis, Kristian;
- Bertelsen, Bjørn;
- Romero-Cordoba, Sandra;
- Treviño, Victor;
- Vazquez-Santillan, Karla;
- Guadarrama, Alberto Salido;
- Wright, Alexi A.;
- Rosenberg, Mara W.;
- Duke, Fujiko;
- Kaplan, Bethany;
- Wang, Rui;
- Nickerson, Elizabeth
Publication type:
Article
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Published in:
Nature, 2013, v. 499, n. 7457, p. 214, doi. 10.1038/nature12213
By:
- Lawrence, Michael S.;
- Stojanov, Petar;
- Polak, Paz;
- Kryukov, Gregory V.;
- Cibulskis, Kristian;
- Sivachenko, Andrey;
- Carter, Scott L.;
- Stewart, Chip;
- Mermel, Craig H.;
- Roberts, Steven A.;
- Kiezun, Adam;
- Hammerman, Peter S.;
- McKenna, Aaron;
- Drier, Yotam;
- Zou, Lihua;
- Ramos, Alex H.;
- Pugh, Trevor J.;
- Stransky, Nicolas;
- Helman, Elena;
- Kim, Jaegil
Publication type:
Article
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Published in:
Nature, 2012, v. 488, n. 7409, p. 106, doi. 10.1038/nature11329
By:
- Pugh, Trevor J.;
- Weeraratne, Shyamal Dilhan;
- Archer, Tenley C.;
- Pomeranz Krummel, Daniel A.;
- Auclair, Daniel;
- Bochicchio, James;
- Carneiro, Mauricio O.;
- Carter, Scott L.;
- Cibulskis, Kristian;
- Erlich, Rachel L.;
- Greulich, Heidi;
- Lawrence, Michael S.;
- Lennon, Niall J.;
- McKenna, Aaron;
- Meldrim, James;
- Ramos, Alex H.;
- Ross, Michael G.;
- Russ, Carsten;
- Shefler, Erica;
- Sivachenko, Andrey
Publication type:
Article
Dissecting the genomic complexity underlying medulloblastoma.
Published in:
Nature, 2012, v. 488, n. 7409, p. 100, doi. 10.1038/nature11284
By:
- Jones, David T. W.;
- Jäger, Natalie;
- Kool, Marcel;
- Zichner, Thomas;
- Hutter, Barbara;
- Sultan, Marc;
- Cho, Yoon-Jae;
- Pugh, Trevor J.;
- Hovestadt, Volker;
- Stütz, Adrian M.;
- Rausch, Tobias;
- Warnatz, Hans-Jörg;
- Ryzhova, Marina;
- Bender, Sebastian;
- Sturm, Dominik;
- Pleier, Sabrina;
- Cin, Huriye;
- Pfaff, Elke;
- Sieber, Laura;
- Wittmann, Andrea
Publication type:
Article
CReSCENT: CanceR Single Cell ExpressioN Toolkit.
Published in:
Nucleic Acids Research, 2020, v. 48, n. W1, p. W372, doi. 10.1093/nar/gkaa437
By:
- Mohanraj, Suluxan;
- Díaz-Mejía, J Javier;
- Pham, Martin D;
- Elrick, Hillary;
- Husić, Mia;
- Rashid, Shaikh;
- Luo, Ping;
- Bal, Prabnur;
- Lu, Kevin;
- Patel, Samarth;
- Mahalanabis, Alaina;
- Naidas, Alaine;
- Christensen, Erik;
- Croucher, Danielle;
- Richards, Laura M;
- Shooshtari, Parisa;
- Brudno, Michael;
- Ramani, Arun K;
- Pugh, Trevor J
Publication type:
Article
High efficiency error suppression for accurate detection of low-frequency variants.
Published in:
Nucleic Acids Research, 2019, v. 47, n. 15, p. e87, doi. 10.1093/nar/gkz474
By:
- Wang, Ting Ting;
- Abelson, Sagi;
- Zou, Jinfeng;
- Li, Tiantian;
- Zhao, Zhen;
- Dick, John E;
- Shlush, Liran I;
- Pugh, Trevor J;
- Bratman, Scott V
Publication type:
Article
ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.
Published in:
2012
By:
- Jäger, Natalie;
- Jones, David T. W.;
- Kool, Marcel;
- Zichner, Thomas;
- Hutter, Barbara;
- Sultan, Marc;
- Yoon-Jae Cho;
- Pugh, Trevor J.;
- Hovestadt, Volker;
- Stütz, Adrian M.;
- Rausch, Tobias;
- Warnatz, Hans-Jörg;
- Brors, Benedikt;
- Northcott, Paul A.;
- Taylor, Michael D.;
- Meyerson, Matthew;
- Pomeroy, Scott L.;
- Yaspo, Marie-Laure;
- Korbel, Jan O.;
- Korshunov, Andrey
Publication type:
Abstract
Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.
Published in:
Human Mutation, 2015, v. 36, n. 11, p. 1080, doi. 10.1002/humu.22834
By:
- Cordeddu, Viviana;
- Yin, Jiani C.;
- Gunnarsson, Cecilia;
- Virtanen, Carl;
- Drunat, Séverine;
- Lepri, Francesca;
- Luca, Alessandro;
- Rossi, Cesare;
- Ciolfi, Andrea;
- Pugh, Trevor J.;
- Bruselles, Alessandro;
- Priest, James R.;
- Pennacchio, Len A.;
- Lu, Zhibin;
- Danesh, Arnavaz;
- Quevedo, Rene;
- Hamid, Alaa;
- Martinelli, Simone;
- Pantaleoni, Francesca;
- Gnazzo, Maria
Publication type:
Article
Oncotator: Cancer Variant Annotation Tool.
Published in:
Human Mutation, 2015, v. 36, n. 4, p. E2423, doi. 10.1002/humu.22771
By:
- Ramos, Alex H.;
- Lichtenstein, Lee;
- Gupta, Manaswi;
- Lawrence, Michael S.;
- Pugh, Trevor J.;
- Saksena, Gordon;
- Meyerson, Matthew;
- Getz, Gad
Publication type:
Article
Single-cell profiling of multiple myeloma reveals molecular response to FGFR3 inhibitor despite clinical progression.
Published in:
Cold Spring Harbor Molecular Case Studies, 2023, v. 9, n. 2, p. 1, doi. 10.1101/mcs.a006249
By:
- Croucher, Danielle C.;
- Devasia, Anup Joseph;
- Abelman, D.;
- Mahdipour-Shirayeh, Ali;
- Zhihua Li;
- Erdmann, Natalie;
- Tiedemann, Rodger;
- Pugh, Trevor J.;
- Trudel, Suzanne
Publication type:
Article
"Game Changer": Health Professionals' Views on the Clinical Utility of Circulating Tumor DNA Testing in Hereditary Cancer Syndrome Management.
Published in:
Oncologist, 2022, v. 27, n. 5, p. e393, doi. 10.1093/oncolo/oyac039
By:
- Shickh, Salma;
- Oldfield, Leslie E;
- Clausen, Marc;
- Mighton, Chloe;
- Sebastian, Agnes;
- Calvo, Alessia;
- Baxter, Nancy N;
- Dawson, Lesa;
- Penney, Lynette S;
- Foulkes, William;
- Basik, Mark;
- Sun, Sophie;
- Schrader, Kasmintan A;
- Regier, Dean A;
- Karsan, Aly;
- Pollett, Aaron;
- Pugh, Trevor J;
- Kim, Raymond H;
- Bombard, Yvonne;
- Consortium, CHARM
Publication type:
Article
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52009-x
By:
- Barbulescu, Philip;
- Chana, Chetan K.;
- Wong, Matthew K.;
- Ben Makhlouf, Ines;
- Bruce, Jeffrey P.;
- Feng, Yuqing;
- Keszei, Alexander F. A.;
- Wong, Cassandra;
- Mohamad-Ramshan, Rukshana;
- McGary, Laura C.;
- Kashem, Mohammad A.;
- Ceccarelli, Derek F.;
- Orlicky, Stephen;
- Fang, Yifei;
- Kuang, Huihui;
- Mazhab-Jafari, Mohammad;
- Pezo, Rossanna C.;
- Bhagwat, Ashok S.;
- Pugh, Trevor J.;
- Gingras, Anne-Claude
Publication type:
Article
Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51529-w
By:
- Wong, Derek;
- Tageldein, Maha;
- Luo, Ping;
- Ensminger, Erik;
- Bruce, Jeffrey;
- Oldfield, Leslie;
- Gong, Haifan;
- Fischer, Nicholas William;
- Laverty, Brianne;
- Subasri, Vallijah;
- Davidson, Scott;
- Khan, Reem;
- Villani, Anita;
- Shlien, Adam;
- Kim, Raymond H.;
- Malkin, David;
- Pugh, Trevor J.
Publication type:
Article
Molecular Genetic Characteristics of FANCI , a Proposed New Ovarian Cancer Predisposing Gene.
Published in:
Genes, 2023, v. 14, n. 2, p. 277, doi. 10.3390/genes14020277
By:
- Fierheller, Caitlin T.;
- Alenezi, Wejdan M.;
- Serruya, Corinne;
- Revil, Timothée;
- Amuzu, Setor;
- Bedard, Karine;
- Subramanian, Deepak N.;
- Fewings, Eleanor;
- Bruce, Jeffrey P.;
- Prokopec, Stephenie;
- Bouchard, Luigi;
- Provencher, Diane;
- Foulkes, William D.;
- El Haffaf, Zaki;
- Mes-Masson, Anne-Marie;
- Tischkowitz, Marc;
- Campbell, Ian G.;
- Pugh, Trevor J.;
- Greenwood, Celia M. T.;
- Ragoussis, Jiannis
Publication type:
Article
Maximizing cancer prevention through genetic navigation for Lynch syndrome detection in women with newly diagnosed endometrial and nonserous/nonmucinous epithelial ovarian cancer.
Published in:
Cancer (0008543X), 2021, v. 127, n. 17, p. 3082, doi. 10.1002/cncr.33625
By:
- Kim, Soyoun Rachel;
- Tone, Alicia;
- Kim, Raymond H.;
- Cesari, Matthew;
- Clarke, Blaise A.;
- Eiriksson, Lua;
- Hart, Tae L.;
- Aronson, Melyssa;
- Holter, Spring;
- Lytwyn, Alice;
- Maganti, Manjula;
- Oldfield, Leslie;
- Gallinger, Steven;
- Bernardini, Marcus Q.;
- Oza, Amit M.;
- Djordjevic, Bojana;
- Lerner‐Ellis, Jordan;
- Van de Laar, Emily;
- Vicus, Danielle;
- Pugh, Trevor J.
Publication type:
Article
Performance characteristics of screening strategies to identify Lynch syndrome in women with ovarian cancer.
Published in:
Cancer (0008543X), 2020, v. 126, n. 22, p. 4886, doi. 10.1002/cncr.33144
By:
- Kim, Soyoun Rachel;
- Tone, Alicia;
- Kim, Raymond H.;
- Cesari, Matthew;
- Clarke, Blaise A.;
- Eiriksson, Lua;
- Hart, Tae;
- Aronson, Melyssa;
- Holter, Spring;
- Lytwyn, Alice;
- Maganti, Manjula;
- Oldfield, Leslie;
- Gallinger, Steven;
- Bernardini, Marcus Q.;
- Oza, Amit M.;
- Djordjevic, Bojana;
- Lerner‐Ellis, Jordan;
- Van de Laar, Emily;
- Vicus, Danielle;
- Pugh, Trevor J.
Publication type:
Article
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04828-9
By:
- Kondratyev, Maria;
- Pesic, Aleksandra;
- Ketela, Troy;
- Stickle, Natalie;
- Beswick, Christine;
- Shalev, Zvi;
- Marastoni, Stefano;
- Samadian, Soroush;
- Dvorkin-Gheva, Anna;
- Sayad, Azin;
- Bashkurov, Mikhail;
- Boasquevisque, Pedro;
- Datti, Alessandro;
- Pugh, Trevor J.;
- Virtanen, Carl;
- Moffat, Jason;
- Grénman, Reidar A.;
- Koritzinsky, Marianne;
- Wouters, Bradly G.
Publication type:
Article
Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor.
Published in:
Genome Medicine, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13073-020-00730-9
By:
- Quevedo, Rene;
- Spreafico, Anna;
- Bruce, Jeff;
- Danesh, Arnavaz;
- El Ghamrasni, Samah;
- Giesler, Amanda;
- Hanna, Youstina;
- Have, Cherry;
- Li, Tiantian;
- Yang, S. Y. Cindy;
- Zhang, Tong;
- Asa, Sylvia L.;
- Haibe-Kains, Benjamin;
- Krzyzanowska, Monika;
- Smith, Adam C.;
- Singh, Simron;
- Siu, Lillian L.;
- Pugh, Trevor J.
Publication type:
Article
Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients.
Published in:
BMC Cancer, 2007, v. 7, p. 1, doi. 10.1186/1471-2407-7-128
By:
- Pugh, Trevor J.;
- Bebb, Gwyn;
- Barclay, Lorena;
- Sutcliffe, Margaret;
- Fee, John;
- Salski, Chris;
- O'Connor, Robert;
- Ho, Cheryl;
- Murray, Nevin;
- Melosky, Barbara;
- English, John;
- Vielkind, Jeurgen;
- Horsman, Doug;
- Laskin, Janessa J.;
- Marra, Marco A.
Publication type:
Article
Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.
Published in:
PLoS Genetics, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.pgen.1006242
By:
- Giannikou, Krinio;
- Malinowska, Izabela A.;
- Pugh, Trevor J.;
- Yan, Rachel;
- Tseng, Yuen-Yi;
- Oh, Coyin;
- Kim, Jaegil;
- Tyburczy, Magdalena E.;
- Chekaluk, Yvonne;
- Liu, Yang;
- Alesi, Nicola;
- Finlay, Geraldine A.;
- Wu, Chin-Lee;
- Signoretti, Sabina;
- Meyerson, Matthew;
- Getz, Gad;
- Boehm, Jesse S.;
- Henske, Elizabeth P.;
- Kwiatkowski, David J.
Publication type:
Article
Bamgineer: Introduction of simulated allele-specific copy number variants into exome and targeted sequence data sets.
Published in:
PLoS Computational Biology, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.pcbi.1006080
By:
- Samadian, Soroush;
- Bruce, Jeff P.;
- Pugh, Trevor J.
Publication type:
Article

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