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Integrated stress response and immune cell infiltration in an ibrutinib‐refractory mantle cell lymphoma patient following ONC201 treatment.
Published in:
Angewandte Chemie, 2019, v. 131, n. 15, p. 133, doi. 10.1111/bjh.15271
By:
- Romaguera, Jorge E.;
- Lee, Hun J.;
- Tarapore, Rohinton;
- Prabhu, Varun;
- Allen, Joshua;
- Schalop, Lee;
- Zloza, Andrew;
- Ok, Chi Y.;
- Sadimin, Evita T.;
- Schenkel, Jason;
- Badillo, Maria;
- Wang, Michael
Publication type:
Article
Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2021, v. 40, n. 1, p. 1, doi. 10.1186/s13046-021-01842-9
By:
- Pierce, Stuart R.;
- Fang, Ziwei;
- Yin, Yajie;
- West, Lindsay;
- Asher, Majdouline;
- Hao, Tianran;
- Zhang, Xin;
- Tucker, Katherine;
- Staley, Allison;
- Fan, Yali;
- Sun, Wenchuan;
- Moore, Dominic T.;
- Xu, Chang;
- Tsai, Yi-Hsuan;
- Parker, Joel;
- Prabhu, Varun Vijay;
- Allen, Joshua E.;
- Lee, Douglas;
- Zhou, Chunxiao;
- Bae-Jump, Victoria
Publication type:
Article
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.
Published in:
Science Signaling, 2016, v. 9, n. 415, p. 1, doi. 10.1126/scisignal.aac4374
By:
- Kline, C. Leah B.;
- Van den Heuvel, A. Pieter J.;
- Allen, Joshua E.;
- Prabhu, Varun V.;
- Dicker, David T.;
- El-Deiry, Wafik S.
Publication type:
Article
Integrated stress response and immune cell infiltration in an ibrutinib‐refractory mantle cell lymphoma patient following ONC201 treatment.
Published in:
British Journal of Haematology, 2019, v. 185, n. 1, p. 133, doi. 10.1111/bjh.15271
By:
- Romaguera, Jorge E.;
- Lee, Hun J.;
- Tarapore, Rohinton;
- Prabhu, Varun;
- Allen, Joshua;
- Schalop, Lee;
- Zloza, Andrew;
- Ok, Chi Y.;
- Sadimin, Evita T.;
- Schenkel, Jason;
- Badillo, Maria;
- Wang, Michael
Publication type:
Article
Simulator-Based Assessment of Haptic Surgical Skill: A Comparative Study.
Published in:
Surgical Innovation, 2015, v. 22, n. 2, p. 183, doi. 10.1177/1553350614537119
By:
- Singapogu, Ravikiran B.;
- Long, Lindsay O.;
- Smith, Dane E.;
- Burg, Timothy C.;
- Pagano, Christopher C.;
- Prabhu, Varun V.;
- Burg, Karen J. L.
Publication type:
Article
Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors.
Published in:
Neuro-Oncology, 2021, v. 23, n. 3, p. 400, doi. 10.1093/neuonc/noaa188
By:
- He, Yuyu;
- Li, Jie;
- Koga, Tomoyuki;
- Ma, Jun;
- Dhawan, Sanjay;
- Suzuki, Yuta;
- Furnari, Frank;
- Prabhu, Varun V;
- Allen, Joshua E;
- Chen, Clark C
Publication type:
Article
Biological activity of weekly ONC201 in adult recurrent glioblastoma patients.
Published in:
Neuro-Oncology, 2020, v. 22, n. 1, p. 94, doi. 10.1093/neuonc/noz164
By:
- Arrillaga-Romany, Isabel;
- Odia, Yazmin;
- Prabhu, Varun V;
- Tarapore, Rohinton S;
- Merdinger, Krystal;
- Stogniew, Martin;
- Oster, Wolfgang;
- Allen, Joshua E;
- Mehta, Minesh;
- Batchelor, Tracy T;
- Wen, Patrick Y
Publication type:
Article
ACTR-33. TUMOR TISSUE PENETRATION AND PHARMACODYNAMICS OF ONC201 IN ADULT RECURRENT GLIOBLASTOMA PATIENTS.
Published in:
Neuro-Oncology, 2018, v. 20, p. vi18, doi. 10.1093/neuonc/noy148.066
By:
- Arrillaga-Romany, Isabel;
- Odia, Yazmin;
- Allen, Joshua;
- Prabhu, Varun Vijay;
- Tarapore, Rohinton;
- Costa, Debora Vendramini;
- Shah, Neelima;
- Cukierman, Edna;
- Oster, Wolfgang;
- Mehta, Minesh
Publication type:
Article
EXTH-26. MOLECULAR DETERMINANT OF CLINICAL RESPONSE TO ONC201, AN INHIBITOR OF DOPAMINE RECEPTOR 2 (DRD2) SIGNALING, IN GLIOBLASTOMA PATIENT.
Published in:
Neuro-Oncology, 2018, v. 20, p. vi90, doi. 10.1093/neuonc/noy148.375
By:
- Li, Jie;
- Ma, Jun;
- He, Yuyu;
- Prabhu, Varun Vijay;
- Allen, Joshua;
- Chen, Clark
Publication type:
Article
EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION.
Published in:
Neuro-Oncology, 2018, v. 20, p. vi88, doi. 10.1093/neuonc/noy148.366
By:
- Prabhu, Varun Vijay;
- Madhukar, Neel;
- Tarapore, Rohinton;
- Garnett, Mathew;
- McDermott, Ultan;
- Benes, Cyril;
- Anantharaman, Lakshmi;
- Charter, Neil;
- Deacon, Sean;
- VanEngelenburg, Alexander
Publication type:
Article
DRES-10. DRD5 IS A MODULATOR OF GLIOMA SUSCEPTIBILITY TO DRD2 ANTAGONISM BY ONC201.
Published in:
Neuro-Oncology, 2018, v. 20, p. vi77, doi. 10.1093/neuonc/noy148.317
By:
- Prabhu, Varun Vijay;
- Madhukar, Neel;
- Gilvary, Coryandar;
- Kline, C Leah B;
- Tarapore, Rohinton;
- El-Deiry, Wafik;
- Doherty, Faye;
- VanEngelenburg, Alexander;
- Durrant, Jessica;
- Benes, Cyril
Publication type:
Article
DDIS-12. ONC201: THE FIRST SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONIST FOR CLINICAL NEURO-ONCOLOGY.
Published in:
Neuro-Oncology, 2018, v. 20, p. vi71, doi. 10.1093/neuonc/noy148.291
By:
- Prabhu, Varun Vijay;
- Madhukar, Neel;
- Anantharaman, Lakshmi;
- Sulli, Chidananda;
- Davidson, Edgar;
- Deacon, Sean;
- Tarapore, Rohinton;
- Rucker, Joseph;
- Charter, Neil;
- Doranz, Benjamin
Publication type:
Article
Synergistic imipridone‐based drug combinations for treatment of pediatric H3K27M mutant diffuse intrinsic pontine glioma (DIPG).
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04856
By:
- Borsuk, Robyn;
- Zhou, Lanlan;
- Zheng, Yiqun;
- Prabhu, Varun;
- Allen, Joshua;
- Tapinos, Nikos;
- Lulla, Rishi;
- Wafik, El‐Deiry
Publication type:
Article
Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer.
Published in:
Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.789450
By:
- Fan, Yali;
- Wang, Jiandong;
- Fang, Ziwei;
- Pierce, Stuart R.;
- West, Lindsay;
- Staley, Allison;
- Tucker, Katherine;
- Yin, Yajie;
- Sun, Wenchuan;
- Kong, Weimin;
- Prabhu, Varun;
- Allen, Joshua E.;
- Zhou, Chunxiao;
- Bae-Jump, Victoria L.
Publication type:
Article
Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors (Adv. Mater. 2/2022).
Published in:
Advanced Materials, 2022, v. 34, n. 2, p. 1, doi. 10.1002/adma.202270014
By:
- Mosquera, Matthew J.;
- Kim, Sungwoong;
- Bareja, Rohan;
- Fang, Zhou;
- Cai, Shuangyi;
- Pan, Heng;
- Asad, Muhammad;
- Martin, Maria Laura;
- Sigouros, Michael;
- Rowdo, Florencia M.;
- Ackermann, Sarah;
- Capuano, Jared;
- Bernheim, Jacob;
- Cheung, Cynthia;
- Doane, Ashley;
- Brady, Nicholas;
- Singh, Richa;
- Rickman, David S.;
- Prabhu, Varun;
- Allen, Joshua E.
Publication type:
Article
Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors.
Published in:
Advanced Materials, 2022, v. 34, n. 2, p. 1, doi. 10.1002/adma.202100096
By:
- Mosquera, Matthew J.;
- Kim, Sungwoong;
- Bareja, Rohan;
- Fang, Zhou;
- Cai, Shuangyi;
- Pan, Heng;
- Asad, Muhammad;
- Martin, Maria Laura;
- Sigouros, Michael;
- Rowdo, Florencia M.;
- Ackermann, Sarah;
- Capuano, Jared;
- Bernheim, Jacob;
- Cheung, Cynthia;
- Doane, Ashley;
- Brady, Nicholas;
- Singh, Richa;
- Rickman, David S.;
- Prabhu, Varun;
- Allen, Joshua E.
Publication type:
Article
ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro.
Published in:
Frontiers in Oncology, 2020, v. 11, p. N.PAG, doi. 10.3389/fonc.2020.577141
By:
- Zhang, Yingao;
- Huang, Yu;
- Yin, Yajie;
- Fan, Yali;
- Sun, Wenchuan;
- Zhao, Xiaoling;
- Tucker, Katherine;
- Staley, Allison;
- Paraghamian, Sarah;
- Hawkins, Gabrielle;
- Prabhu, Varun;
- Allen, Joshua E.;
- Zhou, Chunxiao;
- Bae-Jump, Victoria
Publication type:
Article
Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.
Published in:
PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0180541
By:
- Prabhu, Varun V.;
- Lulla, Amriti R.;
- Madhukar, Neel S.;
- Ralff, Marie D.;
- Zhao, Dan;
- Kline, Christina Leah B.;
- Van den Heuvel, A. Pieter J.;
- Lev, Avital;
- Garnett, Mathew J.;
- McDermott, Ultan;
- Benes, Cyril H.;
- Batchelor, Tracy T.;
- Chi, Andrew S.;
- Elemento, Olivier;
- Allen, Joshua E.;
- El-Deiry, Wafik S.
Publication type:
Article

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