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Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges.
- Published in:
- 2014
- By:
- Publication type:
- Journal Article
Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges.
- Published in:
- EP: Europace, 2014, v. 16, n. 5, p. 724
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- Publication type:
- Article
Das Ende des »Mythos« des sicheren Japans: Das Sicherheitsgefühl aus Sicht der japanischen privaten Sicherheitsindustrie.
- Published in:
- Jahrbuch der Vereinigung für Sozialwissenschaftliche Japanforschung, 2018, p. 211
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- Publication type:
- Article
Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets.
- Published in:
- Pharmaceutics, 2024, v. 16, n. 2, p. 259, doi. 10.3390/pharmaceutics16020259
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- Publication type:
- Article
A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning †.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 8, p. 2056, doi. 10.3390/pharmaceutics15082056
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- Publication type:
- Article
Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071514
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations.
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- Pharmaceutics, 2020, v. 12, n. 10, p. 942, doi. 10.3390/pharmaceutics12100942
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- Publication type:
- Article
Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating.
- Published in:
- Pharmaceuticals (14248247), 2022, v. 15, n. 3, p. 379, doi. 10.3390/ph15030379
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- Publication type:
- Article
Drug Therapy Optimization System Based on a Hybrid Approach Combining Clinical Data and In Silico Modeling - Perspective View and Concept Description.
- Published in:
- International Review on Modelling & Simulations, 2020, v. 13, n. 4, p. 234, doi. 10.15866/iremos.v13i4.19200
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- Publication type:
- Article
Artificial Intelligence That Predicts Sensitizing Potential of Cosmetic Ingredients with Accuracy Comparable to Animal and In Vitro Tests—How Does the Infotechnomics Compare to Other "Omics" in the Cosmetics Safety Assessment?
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6801, doi. 10.3390/ijms24076801
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- Publication type:
- Article
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2239, doi. 10.3390/ijms24032239
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- Publication type:
- Article
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part I.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12984, doi. 10.3390/ijms232112984
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- Publication type:
- Article
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11939, doi. 10.3390/ijms231911939
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- Publication type:
- Article
Magnetic Core–Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma—Material Characterization, Theoretical Analysis and Pharmacokinetics.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 7, p. 3665, doi. 10.3390/ijms22073665
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- Publication type:
- Article
Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 24, p. 9693, doi. 10.3390/ijms21249693
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- Publication type:
- Article
Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools.
- Published in:
- Computational & Mathematical Methods in Medicine, 2018, p. 1, doi. 10.1155/2018/3719703
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- Publication type:
- Article
Plasma vs heart tissue concentration in humans - literature data analysis of drugs distribution.
- Published in:
- Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 6, p. 337, doi. 10.1002/bdd.1944
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- Publication type:
- Article
Computational Methods as Part of Scientific Research in Cosmetic Sciences—Are We Using the Opportunity?
- Published in:
- Cosmetics (2079-9284), 2024, v. 11, n. 3, p. 79, doi. 10.3390/cosmetics11030079
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- Publication type:
- Article
A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application.
- Published in:
- Scientific Reports, 2017, p. 39494, doi. 10.1038/srep39494
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- Publication type:
- Article
Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium Summary.
- Published in:
- AAPS Journal, 2023, v. 25, n. 6, p. 1, doi. 10.1208/s12248-023-00862-x
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- Publication type:
- Article
Virtual Thorough QT (TQT) Trial—Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine.
- Published in:
- AAPS Journal, 2018, v. 20, n. 5, p. 1, doi. 10.1208/s12248-018-0244-3
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- Publication type:
- Article
Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.
- Published in:
- AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0199-4
- By:
- Publication type:
- Article
Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.
- Published in:
- AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0155-8
- By:
- Publication type:
- Article
Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates.
- Published in:
- 2015
- By:
- Publication type:
- Report
Population-Based Mechanistic Prediction of Oral Drug Absorption.
- Published in:
- AAPS Journal, 2009, v. 11, n. 2, p. 225, doi. 10.1208/s12248-009-9099-y
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- Publication type:
- Article
The impact of pharmaceutical care on patients with hypertension and their pharmacists.
- Published in:
- 2011
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- Publication type:
- Journal Article
The impact of pharmaceutical care on patients with hypertension and their pharmacists.
- Published in:
- Pharmacy Practice (1886-3655), 2011, v. 9, n. 2, p. 110, doi. 10.4321/S1886-36552011000200009
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- Publication type:
- Article
Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application.
- Published in:
- British Journal of Clinical Pharmacology, 2024, v. 90, n. 6, p. 1428, doi. 10.1111/bcp.16029
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- Publication type:
- Article
open-access data set of pig skin anatomy and physiology for modelling purposes.
- Published in:
- Database: The Journal of Biological Databases & Curation, 2022, v. 2022, p. 1, doi. 10.1093/database/baac091
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- Publication type:
- Article
Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials.
- Published in:
- BMC Pharmacology & Toxicology, 2016, v. 17, p. 1, doi. 10.1186/s40360-016-0053-1
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- Publication type:
- Article
Tox-Database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition.
- Published in:
- BMC Pharmacology & Toxicology, 2012, v. 13, p. 1, doi. 10.1186/2050-6511-13-6
- By:
- Publication type:
- Article
The effect of increasing amitriptyline doses on cardiomyocytes' electrophysiology - simulation study.
- Published in:
- Bio-Algorithms & Med-Systems, 2016, v. 12, n. 1, p. 33, doi. 10.1515/bams-2015-0043
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- Publication type:
- Article
An analysis of cardiomyocytes' electrophysiology in the presence of the hERG gene mutations.
- Published in:
- Bio-Algorithms & Med-Systems, 2013, v. 9, n. 3, p. 135, doi. 10.1515/bams-2013-0017
- By:
- Publication type:
- Article
Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters.
- Published in:
- Journal of Clinical Pharmacy & Therapeutics, 2022, v. 47, n. 12, p. 2152, doi. 10.1111/jcpt.13762
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- Publication type:
- Article
Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study.
- Published in:
- Theoretical Biology & Medical Modelling, 2013, v. 10, n. 1, p. 1, doi. 10.1186/1742-4682-10-7
- By:
- Publication type:
- Article
Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems.
- Published in:
- Applied Sciences (2076-3417), 2020, v. 10, n. 20, p. 7109, doi. 10.3390/app10207109
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- Publication type:
- Article
DEVELOPMENT OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR THE IMMEDIATE RELEASE ROPINIROLE TABLETS.
- Published in:
- Acta Poloniae Pharmaceutica, 2021, v. 78, n. 3, p. 317, doi. 10.32383/appdr/137903
- By:
- Publication type:
- Article
How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 225, doi. 10.1002/cpt.3276
- By:
- Publication type:
- Article
Assessment of inter-individual variability in predicted phenytoin clearance.
- Published in:
- European Journal of Clinical Pharmacology, 2009, v. 65, n. 12, p. 1203, doi. 10.1007/s00228-009-0703-y
- By:
- Publication type:
- Article
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
- Published in:
- Journal of Applied Toxicology, 2018, v. 38, n. 4, p. 450, doi. 10.1002/jat.3552
- By:
- Publication type:
- Article
Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents.
- Published in:
- Journal of Applied Toxicology, 2015, v. 35, n. 9, p. 1030, doi. 10.1002/jat.3095
- By:
- Publication type:
- Article
Slow delayed rectifying potassium current ( I<sub>Ks</sub>) - analysis of the in vitro inhibition data and predictive model development.
- Published in:
- Journal of Applied Toxicology, 2013, v. 33, n. 8, p. 723, doi. 10.1002/jat.2719
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- Publication type:
- Article
Mechanistic modeling of drug products applied to the skin: A workshop summary report.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 5, p. 575, doi. 10.1002/psp4.12893
- By:
- Publication type:
- Article
Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 8, p. 1060, doi. 10.1002/psp4.12814
- By:
- Publication type:
- Article
Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks.
- Published in:
- Drug Design, Development & Therapy, 2013, v. 7, p. 223, doi. 10.2147/DDDT.S41401
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- Publication type:
- Article
In Vitro to Human In Vivo Translation – Pharmacokinetics and Pharmacodynamics of Quinidine.
- Published in:
- Altex, 2013, v. 30, n. 3, p. 309, doi. 10.14573/altex.2013.3.309
- By:
- Publication type:
- Article
How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case study.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2021, v. 48, n. 3, p. 387, doi. 10.1007/s10928-021-09744-1
- By:
- Publication type:
- Article
Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 3, p. 483, doi. 10.1007/s10928-018-9583-z
- By:
- Publication type:
- Article
Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 5, p. 663, doi. 10.1007/s10928-018-9597-6
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- Publication type:
- Article
Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 3, p. 457, doi. 10.1007/s10928-018-9580-2
- By:
- Publication type:
- Article