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A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria.
- Published in:
- 2021
- By:
- Publication type:
- journal article
Selective targeting and protection against toxic amyloid‐beta oligomers by PMN310, a monoclonal antibody rationally designed for greater therapeutic potency in Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.079734
- By:
- Publication type:
- Article
Rational design of a vaccine for Alzheimer's disease using a computationally‐derived conformational epitope to selectively target toxic amyloid‐beta oligomers.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.079769
- By:
- Publication type:
- Article
Selective targeting of intracellular, misfolded, pathogenic TDP‐43 with rationally designed intrabodies.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055269
- By:
- Publication type:
- Article
Conformational epitopes exposed on misfolded toxic forms of amyloid‐beta, tau and alpha‐synuclein directly contribute to their seeding activity.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055254
- By:
- Publication type:
- Article
Epitope prediction for oligomer‐selective antibodies in tau and Aβ: Molecular and cell biology/tau.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045757
- By:
- Publication type:
- Article
Rationally designed antibodies selective for pathogenic tau aggregates: Nonhuman: Preclinical immunotherapeutic studies.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045461
- By:
- Publication type:
- Article
Targeting of misfolded, pathogenic TDP‐43 with rationally designed antibodies: Nonhuman/Target identification and validation studies: Proteostasis.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045221
- By:
- Publication type:
- Article
O5‐06‐01: SELECTIVE TARGETING OF AMYLOID‐BETA OLIGOMER SPECIES BY PMN310, A MONOCLONAL ANTIBODY RATIONALLY DESIGNED FOR GREATER THERAPEUTIC POTENCY IN ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1628, doi. 10.1016/j.jalz.2019.06.4864
- By:
- Publication type:
- Article
P4‐163: THE PATHOLOGICAL INTERACTOME OF TDP‐43 INCLUDES HUMAN WILDTYPE SOD1.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1336, doi. 10.1016/j.jalz.2019.06.3825
- By:
- Publication type:
- Article
P2‐048: HUMANIZED PMN310 SHOWS ENHANCED THERAPEUTIC POTENTIAL BY BINDING TOXIC LOW MOLECULAR WEIGHT Aβ OLIGOMERS WHILE AVOIDING ARIA‐RELATED BINDING TO Aβ DEPOSITS IN AD PATIENT BRAINS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P685, doi. 10.1016/j.jalz.2018.06.732
- By:
- Publication type:
- Article
Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
- Published in:
- Frontiers in Molecular Neuroscience, 2019, p. 1, doi. 10.3389/fnmol.2019.00262
- By:
- Publication type:
- Article
TARGETING OF TOXIC AMYLOID-BETA OLIGOMER SPECIES BY MONOCLONAL ANTIBODY PMN310: PRECISION DRUG DESIGN FOR ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P592, doi. 10.1016/j.jalz.2017.07.225
- By:
- Publication type:
- Article
PROPAGATIVE TOXIC Aβ OLIGOMER SUBCLASS IDENTIFIED AND DEFINED BY SOLVENT ORIENTATION OF THE LYSINE 28 SIDE CHAIN.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1003, doi. 10.1016/j.jalz.2017.06.1394
- By:
- Publication type:
- Article
A COMPUTATIONAL METHOD TO PREDICT DISEASE-SPECIFIC EPITOPES IN Aβ, AND ITS APPLICATION TO OLIGOMER-SELECTIVE ANTIBODIES FOR ALZHEIMER’S IMMUNOTHERAPY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1148, doi. 10.1016/j.jalz.2016.07.042
- By:
- Publication type:
- Article
Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways.
- Published in:
- PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0053642
- By:
- Publication type:
- Article
Speeding protein folding beyond the Gō model: How a little frustration sometimes helps.
- Published in:
- Proteins, 2001, v. 45, n. 4, p. 337, doi. 10.1002/prot.1154
- By:
- Publication type:
- Article
Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases.
- Published in:
- 2019
- By:
- Publication type:
- journal article
A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46306-5
- By:
- Publication type:
- Article
Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
- Published in:
- 2020
- By:
- Publication type:
- Correction Notice
Understanding protein folding with energy landscape theory Part I: Basic concepts.
- Published in:
- Quarterly Reviews of Biophysics, 2002, v. 35, n. 2, p. 111, doi. 10.1017/S0033583502003761
- By:
- Publication type:
- Article
Understanding protein folding with energy landscape theory Part II: Quantitative aspects.
- Published in:
- Quarterly Reviews of Biophysics, 2002, v. 35, n. 3, p. 205, doi. 10.1017/S0033583502003785
- By:
- Publication type:
- Article
As Simple As Possible, but Not Simpler: Exploring the Fidelity of Coarse-Grained Protein Models for Simulated Force Spectroscopy.
- Published in:
- PLoS Computational Biology, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.pcbi.1005211
- By:
- Publication type:
- Article
Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein.
- Published in:
- Biomedicines, 2022, v. 10, n. 9, p. 2168, doi. 10.3390/biomedicines10092168
- By:
- Publication type:
- Article
The effects of nonnative interactions on protein folding rates: Theory and simulation.
- Published in:
- Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 7, p. 1750, doi. 10.1110/ps.03580104
- By:
- Publication type:
- Article
Structural alignment using the generalized Euclidean distance between conformations.
- Published in:
- International Journal of Quantum Chemistry, 2009, v. 109, n. 14, p. 3217, doi. 10.1002/qua.22347
- By:
- Publication type:
- Article
Electrostatics in the stability and misfolding of the prion protein: salt bridges, self energy, and solvation.
- Published in:
- Biochemistry & Cell Biology, 2010, v. 88, n. 2, p. 371, doi. 10.1139/O09-180
- By:
- Publication type:
- Article
Immunological mimicry of PrPC–PrPSc interactions: antibody-induced PrP misfolding.
- Published in:
- PEDS: Protein Engineering, Design & Selection, 2009, v. 22, n. 8, p. 523, doi. 10.1093/protein/gzp038
- By:
- Publication type:
- Article