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Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice.
Published in:
2017
By:
- Miller, Brendyn;
- Spevak, Lyudmila;
- Lukashova, Lyudmila;
- Javaheri, Behzad;
- Pitsillides, Andrew;
- Boskey, Adele;
- Bou-Gharios, George;
- Carriero, Alessandra;
- Pitsillides, Andrew A
Publication type:
journal article
Expression of semaphorin‐3A in the joint and role in osteoarthritis.
Published in:
Cell Biochemistry & Function, 2024, v. 42, n. 3, p. 1, doi. 10.1002/cbf.4012
By:
- Li, Xiang;
- Martinez‐Ramos, Sara;
- Heedge, Freija T.;
- Pitsillides, Andrew;
- Bou‐Gharios, George;
- Poulet, Blandine;
- Chenu, Chantal
Publication type:
Article
Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery.
Published in:
Cell Biochemistry & Function, 2023, v. 41, n. 2, p. 189, doi. 10.1002/cbf.3772
By:
- Houston, Dean A.;
- Stephen, Louise A.;
- Jayash, Soher N.;
- Myers, Katherine;
- Little, Kirsty;
- Hopkinson, Mark;
- Pitsillides, Andrew A.;
- MacRae, Vicky E.;
- Millan, Jose Luis;
- Staines, Katherine A.;
- Farquharson, Colin
Publication type:
Article
High bone mass in mice can be linked to lower osteoclast formation, resorptive capacity, and restricted in vitro sensitivity to inhibition by stable sulforaphane.
Published in:
Cell Biochemistry & Function, 2022, v. 40, n. 7, p. 683, doi. 10.1002/cbf.3734
By:
- Louka, Polymnia;
- Orriss, Isabel R.;
- Pitsillides, Andrew A.
Publication type:
Article
Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes.
Published in:
Cell Biochemistry & Function, 2017, v. 35, n. 4, p. 244, doi. 10.1002/cbf.3268
By:
- Suswillo, Rosemary F.L.;
- Javaheri, Behzad;
- Rawlinson, Simon C.F.;
- Dowthwaite, Gary P.;
- Lanyon, Lance E.;
- Pitsillides, Andrew A.
Publication type:
Article
Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes.
Published in:
Cell Biochemistry & Function, 2017, v. 35, n. 1, p. 56, doi. 10.1002/cbf.3245
By:
- Suswillo, Rosemary F.L.;
- Javaheri, Behzad;
- Rawlinson, Simon C.F.;
- Dowthwaite, Gary P.;
- Lanyon, Lance E.;
- Pitsillides, Andrew A.
Publication type:
Article
Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-10600-6
By:
- Ajami, Sara;
- Javaheri, Behzad;
- Chang, Y.-M.;
- Maruthainar, Nimalan;
- Khan, Tahir;
- Donaldson, James;
- Pitsillides, Andrew A.;
- Liu, Chaozong
Publication type:
Article
Correction to: Aging and Mechanoadaptive Responsiveness of Bone.
Published in:
2022
By:
- Javaheri, Behzad;
- Pitsillides, Andrew A.
Publication type:
Correction Notice
Aging and Mechanoadaptive Responsiveness of Bone.
Published in:
Current Osteoporosis Reports, 2019, v. 17, n. 6, p. 560, doi. 10.1007/s11914-019-00553-7
By:
- Javaheri, Behzad;
- Pitsillides, Andrew A.
Publication type:
Article
Restraint upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction between Quasi-Static Load and the mTOR Pathway.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13220, doi. 10.3390/ijms222413220
By:
- Caetano-Silva, Soraia;
- Simbi, Bigboy H.;
- Marr, Neil;
- Hibbert, Andrew;
- Allen, Steve P.;
- Pitsillides, Andrew A.
Publication type:
Article
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 9729, doi. 10.3390/ijms22189729
By:
- Marr, Neil;
- Meeson, Richard;
- Kelly, Elizabeth F.;
- Fang, Yongxiang;
- Peffers, Mandy J.;
- Pitsillides, Andrew A.;
- Dudhia, Jayesh;
- Thorpe, Chavaunne T.
Publication type:
Article
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.
Published in:
International Journal of Molecular Sciences, 2017, v. 18, n. 1, p. 29, doi. 10.3390/ijms18010029
By:
- Al-Jazzar, Ahmed;
- Javaheri, Behzad;
- Prideaux, Matt;
- Boyde, Alan;
- Scudamore, Cheryl L.;
- Cherifi, Chahrazad;
- Hay, Eric;
- Hopkinson, Mark;
- Boyd, Michael;
- Cohen-Solal, Martine;
- Farquharson, Colin;
- Pitsillides, Andrew A.
Publication type:
Article
Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-10600-6
By:
- Ajami, Sara;
- Javaheri, Behzad;
- Chang, Y.-M.;
- Maruthainar, Nimalan;
- Khan, Tahir;
- Donaldson, James;
- Pitsillides, Andrew A.;
- Liu, Chaozong
Publication type:
Article
Effects of oral propylthiouracil treatment on nitric oxide production in rat aorta.
Published in:
British Journal of Pharmacology, 1999, v. 127, n. 1, p. 1, doi. 10.1038/sj.bjp.0702501
By:
- Grieve, David J;
- Fletcher, Sara;
- Pitsillides, Andrew A;
- Botham, Kathleen M;
- Elliott, Jonathan
Publication type:
Article
Osteocytes Use Estrogen Receptor α to Respond to Strain but Their ERα Content Is Regulated by Estrogen.
Published in:
Journal of Bone & Mineral Research, 2006, v. 21, n. 8, p. 1297, doi. 10.1359/jbmr.060504
By:
- Zaman, Gul;
- Jessop, Helen L;
- Muzylak, Mariusz;
- De Souza, Roberto L;
- Pitsillides, Andrew A;
- Price, Joanna S;
- Lanyon, Lance L
Publication type:
Article
Sympathetic Nervous System Does Not Mediate the Load-Induced Cortical New Bone Formation.
Published in:
Journal of Bone & Mineral Research, 2005, v. 20, n. 12, p. 2159, doi. 10.1359/JBMR.050812
By:
- de Souza, Roberto L;
- Pitsillides, Andrew A;
- Lanyon, Lance E;
- Skerry, Timothy M;
- Chenu, Chantal
Publication type:
Article
Osteocytic Expression of Constitutive NO Synthase Isoforms in the Femoral Neck Cortex: A Case-Control Study of Intracapsular Hip Fracture.
Published in:
Journal of Bone & Mineral Research, 2005, v. 20, n. 2, p. 268, doi. 10.1359/JBMR.041103
By:
- Caballero-Alías, Ana Maria;
- Loveridge, Nigel;
- Pitsillides, Andrew;
- Parker, Martyn;
- Kaptoge, Stephen;
- Lyon, Alan;
- Reeve, Jonathan
Publication type:
Article
Osteoblast-Like Cells From Estrogen Receptor α Knockout Mice Have Deficient Responses to Mechanical Strain.
Published in:
Journal of Bone & Mineral Research, 2004, v. 19, n. 6, p. 938, doi. 10.1359/jbmr.2004.19.6.938
By:
- Jessop, Helen L;
- Suswillo, Rosemary FL;
- Rawlinson, Simon CF;
- Zaman, Gul;
- Lee, Karla;
- Das-Gupta, Vicky;
- Pitsillides, Andrew A;
- Lanyon, Lance E
Publication type:
Article
Human Osteoblasts' Proliferative Responses to Strain and 17β-Estradiol Are Mediated by the Estrogen Receptor and the Receptor for Insulin-Like Growth Factor I.
Published in:
Journal of Bone & Mineral Research, 2002, v. 17, n. 4, p. 593, doi. 10.1359/jbmr.2002.17.4.593
By:
- Cheng, Ming Zhao;
- Rawlinson, Simon C. F.;
- Pitsillides, Andrew A.;
- Zaman, Gul;
- Mohan, Subburaman;
- Baylink, David J.;
- Lanyon, Lance E.
Publication type:
Article
Bone's Early Responses to Mechanical Loading Differ in Distinct Genetic Strains of Chick: Selection for Enhanced Growth Reduces Skeletal Adaptability.
Published in:
Journal of Bone & Mineral Research, 1999, v. 14, n. 6, p. 980, doi. 10.1359/jbmr.1999.14.6.980
By:
- Pitsillides, Andrew A.;
- Rawlinson, Simon C. F.;
- Mosley, John R.;
- Lanyon, Lance E.
Publication type:
Article
Enhancement by Sex Hormones of the Osteoregulatory Effects of Mechanical Loading and Prostaglandins in Explants of Rat Ulnae.
Published in:
Journal of Bone & Mineral Research, 1997, v. 12, n. 9, p. 1424, doi. 10.1359/jbmr.1997.12.9.1424
By:
- Cheng, Ming Zhao;
- Zaman, Gul;
- Rawlinson, Simon C. F.;
- Pitsillides, Andrew A.;
- Suswillo, Rosemary F. L.;
- Lanyon, Lance E.
Publication type:
Article
Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain.
Published in:
Journal of Bone & Mineral Research, 1995, v. 10, n. 8, p. 1225, doi. 10.1002/jbmr.5650100813
By:
- Rawlinson, Simon C. F.;
- Mosley, John R.;
- Suswillo, Rosemary F. L.;
- Pitsillides, Andrew A.;
- Lanyon, Lance E.
Publication type:
Article
Effect of Inflammatory Signaling on Human Articular Chondrocyte Hypertrophy: Potential Involvement of Tissue Repair Macrophages.
Published in:
Cartilage, 2021, v. 13, p. 168S, doi. 10.1177/19476035211021907
By:
- Ferrao Blanco, Mauricio N.;
- Bastiaansen-Jenniskens, Yvonne M.;
- Chambers, Mark G.;
- Pitsillides, Andrew A.;
- Narcisi, Roberto;
- van Osch, Gerjo J.V.M.
Publication type:
Article
Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036786
By:
- Prideaux, Matthew;
- Loveridge, Nigel;
- Pitsillides, Andrew A.;
- Farquharson, Colin
Publication type:
Article
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.
Published in:
Bioscience Reports, 2020, v. 40, n. 1, p. 1, doi. 10.1042/BSR20190329
By:
- Staines, Katherine A.;
- Hopkinson, Mark;
- Dillon, Scott;
- Stephen, Louise A.;
- Fleming, Robert;
- Sophocleous, Antonia;
- Buttle, David J.;
- Pitsillides, Andrew A.;
- Farquharson, Colin
Publication type:
Article
A new method for segmentation and analysis of bone callus in rodent fracture models using micro‐CT.
Published in:
Journal of Orthopaedic Research, 2023, v. 41, n. 8, p. 1717, doi. 10.1002/jor.25507
By:
- Hopkinson, Mark;
- Jones, Gareth;
- Evans, Lucinda;
- Gohin, Stephanie;
- Magnusdottir, Ran;
- Salmon, Phil;
- Chenu, Chantal;
- Meeson, Richard;
- Javaheri, Behzad;
- Pitsillides, Andrew A.
Publication type:
Article
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.
Published in:
2019
By:
- Staines, Katherine A.;
- Ikpegbu, Ekele;
- Törnqvist, Anna E.;
- Dillon, Scott;
- Javaheri, Behzad;
- Amin, Anish K.;
- Clements, Dylan N.;
- Buttle, David J.;
- Pitsillides, Andrew A.;
- Farquharson, Colin
Publication type:
journal article
Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography.
Published in:
Biological Procedures Online, 2020, v. 22, n. 1, p. 1, doi. 10.1186/s12575-020-00126-4
By:
- Marr, Neil;
- Hopkinson, Mark;
- Hibbert, Andrew P.;
- Pitsillides, Andrew A.;
- Thorpe, Chavaunne T.
Publication type:
Article
Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq.
Published in:
Advanced Genetics, 2023, v. 4, n. 2, p. 1, doi. 10.1002/ggn2.202200024
By:
- Stokes, Tanner;
- Cen, Haoning Howard;
- Kapranov, Philipp;
- Gallagher, Iain J;
- Pitsillides, Andrew A.;
- Volmar, Claude‐Henry;
- Kraus, William E;
- Johnson, James D.;
- Phillips, Stuart M.;
- Wahlestedt, Claes;
- Timmons, James A.
Publication type:
Article
A synoptic literature review of animal models for investigating the biomechanics of knee osteoarthritis.
Published in:
Frontiers in Bioengineering & Biotechnology, 2024, p. 1, doi. 10.3389/fbioe.2024.1408015
By:
- Luyang Xu;
- Kazezian, Zepur;
- Pitsillides, Andrew A.;
- Bull, Anthony M. J.
Publication type:
Article
Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between histological and micro-CT bone markers in rat models of osteoarthritis.
Published in:
FASEB Journal, 2021, v. 35, n. 4, p. 1, doi. 10.1096/fj.202002009R
By:
- Yu-Mei Chang;
- Menges, Stephanie;
- Westhof, Andreas;
- Kleinschmidt-Doerr, Kerstin;
- Brenneis, Christian;
- Pitsillides, Andrew A.
Publication type:
Article
A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele.
Published in:
Human Molecular Genetics, 2023, v. 32, n. 17, p. 2681, doi. 10.1093/hmg/ddad094
By:
- Crane-Smith, Zoe;
- Castro, Sandra C P De;
- Nikolopoulou, Evanthia;
- Wolujewicz, Paul;
- Smedley, Damian;
- Lei, Yunping;
- Mather, Emma;
- Santos, Chloe;
- Hopkinson, Mark;
- Pitsillides, Andrew A;
- Consortium, Genomics England Research;
- Finnell, Richard H;
- Ross, M Elisabeth;
- Copp, Andrew J;
- Greene, Nicholas D E
Publication type:
Article
Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting.
Published in:
Journal of Tissue Engineering, 2022, v. 13, p. 1, doi. 10.1177/20417314221133480
By:
- Santos-Beato, Patricia;
- Midha, Swati;
- Pitsillides, Andrew A;
- Miller, Aline;
- Torii, Ryo;
- Kalaskar, Deepak M
Publication type:
Article
Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting.
Published in:
Journal of Tissue Engineering, 2022, v. 13, p. 1, doi. 10.1177/20417314221133480
By:
- Santos-Beato, Patricia;
- Midha, Swati;
- Pitsillides, Andrew A.;
- Miller, Aline;
- Torii, Ryo;
- Kalaskar, Deepak M.
Publication type:
Article
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.
Published in:
PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0167971
By:
- Poulet, Blandine;
- Liu, Ke;
- Plumb, Darren;
- Vo, Phoung;
- Shah, Mittal;
- Staines, Katherine;
- Sampson, Alexandra;
- Nakamura, Hiroyuki;
- Nagase, Hideaki;
- Carriero, Alessandra;
- Shefelbine, Sandra;
- Pitsillides, Andrew A.;
- Bou-Gharios, George
Publication type:
Article
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo.
Published in:
PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0159657
By:
- Javaheri, Behzad;
- Hopkinson, Mark;
- Poulet, Blandine;
- Pollard, Andrea S.;
- Shefelbine, Sandra J.;
- Chang, Yu-Mei;
- Francis-West, Philippa;
- Bou-Gharios, George;
- Pitsillides, Andrew A.
Publication type:
Article
FGF‐2 promotes osteocyte differentiation through increased E11/podoplanin expression.
Published in:
Journal of Cellular Physiology, 2018, v. 233, n. 7, p. 5334, doi. 10.1002/jcp.26345
By:
- Ikpegbu, Ekele;
- Basta, Lena;
- Clements, Dylan N.;
- Fleming, Robert;
- Vincent, Tonia L.;
- Buttle, David J.;
- Pitsillides, Andrew A.;
- Staines, Katherine A.;
- Farquharson, Colin
Publication type:
Article
Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.
Published in:
Journal of Cellular Physiology, 2017, v. 232, n. 11, p. 3006, doi. 10.1002/jcp.25999
By:
- Staines, Katherine A.;
- Javaheri, Behzad;
- Hohenstein, Peter;
- Fleming, Robert;
- Ikpegbu, Ekele;
- Unger, Erin;
- Hopkinson, Mark;
- Buttle, David J.;
- Pitsillides, Andrew A.;
- Farquharson, Colin
Publication type:
Article
E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.
Published in:
Journal of Cellular Physiology, 2016, v. 231, n. 6, p. 1392, doi. 10.1002/jcp.25282
By:
- Staines, Katherine A.;
- Prideaux, Matt;
- Allen, Steve;
- Buttle, David J.;
- Pitsillides, Andrew A.;
- Farquharson, Colin
Publication type:
Article
Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis.
Published in:
Journal of Cellular Physiology, 2011, v. 226, n. 3, p. 749, doi. 10.1002/jcp.22393
By:
- Clarkin, Claire E.;
- Allen, Steve;
- Kuiper, Nikki J.;
- Wheeler, Benjamin T.;
- Wheeler-Jones, Caroline P.;
- Pitsillides, Andrew A.
Publication type:
Article
Evaluation of VEGF-mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.
Published in:
Journal of Cellular Physiology, 2008, v. 214, n. 2, p. 537, doi. 10.1002/jcp.21234
By:
- Clarkin, Claire E.;
- Emery, Roger J.;
- Pitsillides, Andrew A.;
- Wheeler-Jones, Caroline P. D.
Publication type:
Article
Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis.
Published in:
Arthritis & Rheumatology, 2019, v. 71, n. 4, p. 571, doi. 10.1002/art.40765
By:
- Kanakis, Ioannis;
- Liu, Ke;
- Poulet, Blandine;
- Javaheri, Behzad;
- Hof, Rob J.;
- Pitsillides, Andrew A.;
- Bou‐Gharios, George
Publication type:
Article
Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice.
Published in:
Arthritis & Rheumatology, 2014, v. 66, n. 7, p. 1832, doi. 10.1002/art.38616
By:
- Poulet, Blandine;
- Souza, Roberto;
- Knights, Chancie B.;
- Gentry, Clive;
- Wilson, Alan M.;
- Bevan, Stuart;
- Chang, Yu‐Mei;
- Pitsillides, Andrew A.
Publication type:
Article
Stable Sulforaphane Targets the Early Stages of Osteoclast Formation to Engender a Lasting Functional Blockade of Osteoclastogenesis.
Published in:
Cells (2073-4409), 2024, v. 13, n. 2, p. 165, doi. 10.3390/cells13020165
By:
- Louka, Polymnia;
- Orriss, Isabel R.;
- Pitsillides, Andrew A.
Publication type:
Article
3D profiling of mouse epiphyses across ages reveals new potential imaging biomarkers of early spontaneous osteoarthritis.
Published in:
Journal of Anatomy, 2023, v. 242, n. 6, p. 1037, doi. 10.1111/joa.13834
By:
- Herbst, Eva C.;
- Evans, Lucinda A. E.;
- Felder, Alessandro A.;
- Javaheri, Behzad;
- Pitsillides, Andrew A.
Publication type:
Article
Structural clues to articular calcified cartilage function: A descriptive review of this crucial interface tissue.
Published in:
Journal of Anatomy, 2022, v. 241, n. 4, p. 875, doi. 10.1111/joa.13728
By:
- Evans, Lucinda A. E.;
- Pitsillides, Andrew A.
Publication type:
Article
A distinctive patchy osteomalacia characterises Phospho1-deficient mice.
Published in:
Journal of Anatomy, 2017, v. 231, n. 2, p. 298, doi. 10.1111/joa.12628
By:
- Boyde, Alan;
- Staines, Katherine A.;
- Javaheri, Behzad;
- Millan, Jose Luis;
- Pitsillides, Andrew A.;
- Farquharson, Colin
Publication type:
Article
Anatomy, morphology and evolution of the patella in squamate lizards and tuatara (Sphenodon punctatus).
Published in:
Journal of Anatomy, 2016, v. 228, n. 5, p. 864, doi. 10.1111/joa.12435
By:
- Regnault, Sophie;
- Jones, Marc E. H.;
- Pitsillides, Andrew A.;
- Hutchinson, John R.
Publication type:
Article
Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.
Published in:
Journal of Anatomy, 2015, v. 226, n. 6, p. 560, doi. 10.1111/joa.12304
By:
- Akbareian, Sophia E.;
- Pitsillides, Andrew A.;
- Macharia, Raymond G.;
- McGonnell, Imelda M.
Publication type:
Article
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.
Published in:
Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0153-4
By:
- Berwick, Daniel C.;
- Javaheri, Behzad;
- Wetzel, Andrea;
- Hopkinson, Mark;
- Nixon-Abell, Jonathon;
- Grannò, Simone;
- Pitsillides, Andrew A.;
- Harvey, Kirsten
Publication type:
Article

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