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The epigenetic agents suberoylanilide hydroxamic acid and 5-AZA-2′ deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.
Published in:
International Journal of Oncology, 2015, v. 46, n. 5, p. 2223, doi. 10.3892/ijo.2015.2894
By:
- SUSANTO, JOHANA M.;
- COLVIN, EMILY K.;
- PINESE, MARK;
- CHANG, DAVID K.;
- PAJIC, MARINA;
- MAWSON, AMANDA;
- CALDON, C. ELIZABETH;
- MUSGROVE, ELIZABETH A.;
- HENSHALL, SUSAN M.;
- SUTHERLAND, ROBERT L.;
- BIANKIN, ANDREW V.;
- SCARLETT, CHRISTOPHER J.
Publication type:
Article
Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial.
Published in:
Journal of Personalized Medicine, 2023, v. 13, n. 7, p. 1033, doi. 10.3390/jpm13071033
By:
- Daly, Rebecca;
- Hetherington, Kate;
- Hazell, Emily;
- Wadling, Bethany R.;
- Tyrrell, Vanessa;
- Tucker, Katherine M.;
- Marshall, Glenn M.;
- Ziegler, David S.;
- Lau, Loretta M. S.;
- Trahair, Toby N.;
- O'Brien, Tracey A.;
- Collins, Kiri;
- Gifford, Andrew J.;
- Haber, Michelle;
- Pinese, Mark;
- Malkin, David;
- Cowley, Mark J.;
- Karpelowsky, Jonathan;
- Drew, Donna;
- Jacobs, Chris
Publication type:
Article
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer.
Published in:
EMBO Molecular Medicine, 2022, v. 14, n. 4, p. 1, doi. 10.15252/emmm.202114608
By:
- Lau, Loretta M S;
- Mayoh, Chelsea;
- Xie, Jinhan;
- Barahona, Paulette;
- MacKenzie, Karen L;
- Wong, Marie;
- Kamili, Alvin;
- Tsoli, Maria;
- Failes, Tim W;
- Kumar, Amit;
- Mould, Emily V A;
- Gifford, Andrew;
- Chow, Shu‐Oi;
- Pinese, Mark;
- Fletcher, Jamie I;
- Arndt, Greg M;
- Khuong‐Quang, Dong‐Anh;
- Wadham, Carol;
- Batey, Daniel;
- Eden, Georgina
Publication type:
Article
Targeting the LOX/ hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Published in:
EMBO Molecular Medicine, 2015, v. 7, n. 8, p. 1063, doi. 10.15252/emmm.201404827
By:
- Miller, Bryan W;
- Morton, Jennifer P;
- Pinese, Mark;
- Saturno, Grazia;
- Jamieson, Nigel B;
- McGhee, Ewan;
- Timpson, Paul;
- Leach, Joshua;
- McGarry, Lynn;
- Shanks, Emma;
- Bailey, Peter;
- Chang, David;
- Oien, Karin;
- Karim, Saadia;
- Au, Amy;
- Steele, Colin;
- Carter, Christopher Ross;
- McKay, Colin;
- Anderson, Kurt;
- Evans, Thomas R Jeffry
Publication type:
Article
PINA v2.0: mining interactome modules.
Published in:
Nucleic Acids Research, 2012, p. D862, doi. 10.1093/nar/gkr967
By:
- Cowley, Mark J.;
- Pinese, Mark;
- Kassahn, Karin S.;
- Waddell, Nic;
- Pearson, John V.;
- Grimmond, Sean M.;
- Biankin, Andrew V.;
- Hautaniemi, Sampsa;
- Wu, Jianmin
Publication type:
Article
ClinSV: clinical grade structural and copy number variant detection from whole genome sequencing data.
Published in:
Genome Medicine, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13073-021-00841-x
By:
- Minoche, Andre E.;
- Lundie, Ben;
- Peters, Greg B.;
- Ohnesorg, Thomas;
- Pinese, Mark;
- Thomas, David M.;
- Zankl, Andreas;
- Roscioli, Tony;
- Schonrock, Nicole;
- Kummerfeld, Sarah;
- Burnett, Leslie;
- Dinger, Marcel E.;
- Cowley, Mark J.
Publication type:
Article
Adar3 Is Involved in Learning and Memory in Mice.
Published in:
Frontiers in Neuroscience, 2018, p. 1, doi. 10.3389/fnins.2018.00243
By:
- Mladenova, Dessislava;
- Barry, Guy;
- Konen, Lyndsey M.;
- Pineda, Sandy S.;
- Guennewig, Boris;
- Avesson, Lotta;
- Zinn, Raphael;
- Schonrock, Nicole;
- Bitar, Maina;
- Jonkhout, Nicky;
- Crumlish, Lauren;
- Kaczorowski, Dominik C.;
- Gong, Andrew;
- Pinese, Mark;
- Franco, Gloria R.;
- Walkley, Carl R.;
- Vissel, Bryce;
- Mattick, John S.
Publication type:
Article
The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.
Published in:
Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0412-3
By:
- Tactacan, Carole M.;
- Yu Wei Phua;
- Ling Liu;
- Luxi Zhang;
- Humphrey, Emily S.;
- Cowley, Mark;
- Pinese, Mark;
- Biankin, Andrew V.;
- Daly, Roger J.
Publication type:
Article
The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
Published in:
Molecular Cancer, 2015, v. 14, n. 1, p. 139, doi. 10.1186/s12943-015-0412-3
By:
- Tactacan, Carole M.;
- Phua, Yu Wei;
- Ling Liu;
- Luxi Zhang;
- Humphrey, Emily S.;
- Cowley, Mark;
- Pinese, Mark;
- Biankin, Andrew V.;
- Daly, Roger J.
Publication type:
Article
The Effect of Resveratrol on a Cell Model of Human Aging.
Published in:
Annals of the New York Academy of Sciences, 2007, v. 1114, p. 407, doi. 10.1196/annals.1396.001
By:
- STEFANI, MAURIZIO;
- MARKUS, M. ANDREA;
- LIN, RUBY C. Y.;
- PINESE, MARK;
- DAWES, IAN W.;
- MORRIS, BRIAN J.
Publication type:
Article
Translating genomic risk into an early detection strategy for sarcoma.
Published in:
Genes, Chromosomes & Cancer, 2019, v. 58, n. 2, p. 130, doi. 10.1002/gcc.22697
By:
- Ballinger, Mandy L.;
- Pinese, Mark;
- Thomas, David M.
Publication type:
Article
qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles.
Published in:
PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045835
By:
- Song, Sarah;
- Nones, Katia;
- Miller, David;
- Harliwong, Ivon;
- Kassahn, Karin S.;
- Pinese, Mark;
- Pajic, Marina;
- Gill, Anthony J.;
- Johns, Amber L.;
- Anderson, Matthew;
- Holmes, Oliver;
- Leonard, Conrad;
- Taylor, Darrin;
- Wood, Scott;
- Xu, Qinying;
- Newell, Felicity;
- Cowley, Mark J.;
- Wu, Jianmin;
- Wilson, Peter;
- Fink, Lynn
Publication type:
Article
Retinoid Signaling in Pancreatic Cancer, Injury and Regeneration.
Published in:
PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0029075
By:
- Colvin, Emily K.;
- Susanto, Johana M.;
- Kench, James G.;
- Ong, Vivienna N.;
- Mawson, Amanda;
- Pinese, Mark;
- Chang, David K.;
- Rooman, Ilse;
- O'Toole, Sandra A.;
- Segara, Davendra;
- Musgrove, Elizabeth A.;
- Sutherland, Robert L.;
- Apte, Minoti V.;
- Scarlett, Christopher J.;
- Biankin, Andrew V.
Publication type:
Article
Recruitment and Activation of Pancreatic Stellate Cells from the Bone Marrow in Pancreatic Cancer: A Model of Tumor-Host Interaction.
Published in:
PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026088
By:
- Scarlett, Christopher J.;
- Colvin, Emily K.;
- Pinese, Mark;
- Chang, David K.;
- Morey, Adrienne L.;
- Musgrove, Elizabeth A.;
- Pajic, Marina;
- Apte, Minoti;
- Henshall, Susan M.;
- Sutherland, Robert L.;
- Kench, James G.;
- Biankin, Andrew V.
Publication type:
Article
Messina: A Novel Analysis Tool to Identify Biologically Relevant Molecules in Disease.
Published in:
PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005337
By:
- Pinese, Mark;
- Scarlett, Christopher J.;
- Kench, James G.;
- Colvin, Emily K.;
- Segara, Davendra;
- Henshall, Susan M.;
- Sutherland, Robert L.;
- Biankin, Andrew V.
Publication type:
Article
Identification of Functional Networks of Estrogen- and c-Myc-Responsive Genes and Their Relationship to Response to Tamoxifen Therapy in Breast Cancer.
Published in:
PLoS ONE, 2008, v. 3, n. 8, p. 1, doi. 10.1371/journal.pone.0002987
By:
- Musgrove, Elizabeth A.;
- Sergio, C. Marcelo;
- Loi, Sherene;
- Inman, Claire K.;
- Anderson, Luke R.;
- Alles, M. Chehani;
- Pinese, Mark;
- Caldon, C. Elizabeth;
- Schütte, Judith;
- Gardiner-Garden, Margaret;
- Ormandy, Christopher J.;
- McArthur, Grant;
- Butt, Alison J.;
- Sutherland, Robert L.
Publication type:
Article
Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
Published in:
Cancer & Metabolism, 2017, v. 5, p. 1, doi. 10.1186/s40170-017-0164-1
By:
- Hardie, Rae-Anne;
- van Dam, Ellen;
- Cowley, Mark;
- Ting-Li Han;
- Balaban, Seher;
- Pajic, Marina;
- Pinese, Mark;
- Iconomou, Mary;
- Shearer, Robert F.;
- McKenna, Jessie;
- Miller, David;
- Waddell, Nicola;
- Pearson, John V.;
- Grimmond, Sean M.;
- Sazanov, Leonid;
- Biankin, Andrew V.;
- Villas-Boas, Silas;
- Hoy, Andrew J.;
- Turner, Nigel;
- Saunders, Darren N.
Publication type:
Article
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10968-6
By:
- Vennin, Claire;
- Mélénec, Pauline;
- Rouet, Romain;
- Nobis, Max;
- Cazet, Aurélie S.;
- Murphy, Kendelle J.;
- Herrmann, David;
- Reed, Daniel A.;
- Lucas, Morghan C.;
- Warren, Sean C.;
- Elgundi, Zehra;
- Pinese, Mark;
- Kalna, Gabriella;
- Roden, Daniel;
- Samuel, Monisha;
- Zaratzian, Anaiis;
- Grey, Shane T.;
- Da Silva, Andrew;
- Leung, Wilfred;
- Mathivanan, Suresh
Publication type:
Article
Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts.
Published in:
BMC Medical Genetics, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12881-019-0808-9
By:
- Jones, Rachel M.;
- Melton, Phillip E.;
- Pinese, Mark;
- Rea, Alexander J.;
- Ingley, Evan;
- Ballinger, Mandy L.;
- Wood, David J.;
- Thomas, David M.;
- Moses, Eric K.
Publication type:
Article
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signaling networks and conserved oncogenic pathways.
Published in:
Breast Cancer Research, 2014, v. 16, n. 5, p. 1, doi. 10.1186/s13058-014-0437-3
By:
- Ali, Naveid A.;
- Jianmin Wu;
- Hochgräfe, Falko;
- Chan, Howard;
- Nair, Radhika;
- Ye, Sunny;
- Luxi Zhang;
- Lyons, Ruth J.;
- Pinese, Mark;
- Hong Ching Lee;
- Armstrong, Nicola;
- Ormandy, Christopher J.;
- Clark, Susan J.;
- Swarbrick, Alexander;
- Daly, Roger J.
Publication type:
Article
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.
Published in:
2014
By:
- Ali, Naveid A;
- Wu, Jianmin;
- Hochgräfe, Falko;
- Chan, Howard;
- Nair, Radhika;
- Ye, Sunny;
- Zhang, Luxi;
- Lyons, Ruth J;
- Pinese, Mark;
- Lee, Hong Ching;
- Armstrong, Nicola;
- Ormandy, Christopher J;
- Clark, Susan J;
- Swarbrick, Alexander;
- Daly, Roger J
Publication type:
journal article
High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype.
Published in:
Histopathology, 2010, v. 56, n. 3, p. 286, doi. 10.1111/j.1365-2559.2009.03475.x
By:
- Zardawi, Sarah J.;
- Zardawi, Ibrahim;
- McNeil, Catriona M.;
- Millar, Ewan K. A.;
- McLeod, Duncan;
- Morey, Adrienne L.;
- Crea, Paul;
- Murphy, Niamh C.;
- Pinese, Mark;
- Lopez-Knowles, Elena;
- Oakes, Samantha R.;
- Ormandy, Christopher J.;
- Min Ru Qiu;
- Hamilton, Anne;
- Spillane, Andrew;
- Cheok Soon Lee;
- Sutherland, Robert L.;
- Musgrove, Elizabeth A.;
- O'Toole, Sandra A.
Publication type:
Article
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.
Published in:
Science Translational Medicine, 2017, v. 9, n. 384, p. 1, doi. 10.1126/scitranslmed.aai8504
By:
- Vennin, Claire;
- Chin, Venessa T.;
- Warren, Sean C.;
- Lucas, Morghan C.;
- Herrmann, David;
- Magenau, Astrid;
- Melenec, Pauline;
- Walters, Stacey N.;
- del Monte-Nieto, Gonzalo;
- Conway, James R. W.;
- Nobis, Max;
- Allam, Amr H.;
- McCloy, Rachael A.;
- Currey, Nicola;
- Pinese, Mark;
- Boulghourjian, Alice;
- Zaratzian, Anaiis;
- Adam, Arne A. S.;
- Heu, Celine;
- Nagrial, Adnan M.
Publication type:
Article
Introme accurately predicts the impact of coding and noncoding variants on gene splicing, with clinical applications.
Published in:
Genome Biology, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s13059-023-02936-7
By:
- Sullivan, Patricia J.;
- Gayevskiy, Velimir;
- Davis, Ryan L.;
- Wong, Marie;
- Mayoh, Chelsea;
- Mallawaarachchi, Amali;
- Hort, Yvonne;
- McCabe, Mark J.;
- Beecroft, Sarah;
- Jackson, Matilda R.;
- Arts, Peer;
- Dubowsky, Andrew;
- Laing, Nigel;
- Dinger, Marcel E.;
- Scott, Hamish S.;
- Oates, Emily;
- Pinese, Mark;
- Cowley, Mark J.
Publication type:
Article
Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma.
Published in:
2018
By:
- Ziegler, David S.;
- Wong, Marie;
- Mayoh, Chelsea;
- Kumar, Amit;
- Tsoli, Maria;
- Mould, Emily;
- Tyrrell, Vanessa;
- Khuong-Quang, Dong-Anh;
- Pinese, Mark;
- Gayevskiy, Velimir;
- Cohn, Richard J.;
- Lau, Loretta M. S.;
- Reynolds, Mark;
- Cox, Michael C.;
- Gifford, Andrew;
- Rodriguez, Michael;
- Cowley, Mark J.;
- Ekert, Paul G.;
- Marshall, Glenn M.;
- Haber, Michelle
Publication type:
journal article
Clinical and pathologic features of familial pancreatic cancer.
Published in:
Cancer (0008543X), 2014, v. 120, n. 23, p. 3669, doi. 10.1002/cncr.28863
By:
- Humphris, Jeremy L.;
- Johns, Amber L.;
- Simpson, Skye H.;
- Cowley, Mark J.;
- Pajic, Marina;
- Chang, David K.;
- Nagrial, Adnan M.;
- Chin, Venessa T.;
- Chantrill, Lorraine A.;
- Pinese, Mark;
- Mead, R. Scott;
- Gill, Anthony J.;
- Samra, Jaswinder S.;
- Kench, James G.;
- Musgrove, Elizabeth A.;
- Tucker, Katherine M.;
- Spigelman, Allan D.;
- Waddell, Nic;
- Grimmond, Sean M.;
- Biankin, Andrew V.
Publication type:
Article
Clinical and molecular characterization of HER2 amplified-pancreatic cancer.
Published in:
Genome Medicine, 2013, v. 5, n. 8, p. 1, doi. 10.1186/gm482
By:
- Chou, Angela;
- Waddell, Nicola;
- Cowley, Mark J.;
- Gill, Anthony J.;
- Chang, David K.;
- Patch, Ann-Marie;
- Nones, Katia;
- Wu, Jianmin;
- Pinese, Mark;
- Johns, Amber L.;
- Miller, David K.;
- Kassahn, Karin S.;
- Nagrial, Adnan M.;
- Wasan, Harpreet;
- Goldstein, David;
- Toon, Christopher W.;
- Chin, Venessa;
- Chantrill, Lorraine;
- Humphris, Jeremy;
- Scott Mead, R.
Publication type:
Article
BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.
Published in:
PLoS ONE, 2018, v. 13, n. 8, p. 1, doi. 10.1371/journal.pone.0203003
By:
- Rath, Emma M.;
- Cheng, Yuen Yee;
- Pinese, Mark;
- Sarun, Kadir H.;
- Hudson, Amanda L.;
- Weir, Christopher;
- Wang, Yiwei D.;
- Håkansson, Anders P.;
- Howell, Viive M.;
- Liu, Guo Jun;
- Reid, Glen;
- Knott, Robert B.;
- Duff, Anthony P.;
- Church, W. Bret
Publication type:
Article
Parents' expectations, preferences, and recall of germline findings in a childhood cancer precision medicine trial.
Published in:
Cancer (0008543X), 2023, v. 129, n. 22, p. 3620, doi. 10.1002/cncr.34917
By:
- McGill, Brittany C.;
- Wakefield, Claire E.;
- Tucker, Katherine M.;
- Daly, Rebecca A.;
- Donoghoe, Mark W.;
- Vetsch, Janine;
- Warby, Meera;
- Fuentes‐Bolanos, Noemi A.;
- Barlow‐Stewart, Kristine;
- Kirk, Judy;
- Courtney, Eliza;
- O'Brien, Tracey A.;
- Marshall, Glenn M.;
- Pinese, Mark;
- Cowley, Mark J.;
- Tyrrell, Vanessa;
- Deyell, Rebecca J.;
- Ziegler, David S.;
- Hetherington, Kate
Publication type:
Article
Defining the genetic basis of early onset hereditary spastic paraplegia using whole genome sequencing.
Published in:
Neurogenetics, 2016, v. 17, n. 4, p. 265, doi. 10.1007/s10048-016-0495-z
By:
- Kumar, Kishore;
- Wali, G.M.;
- Kamate, Mahesh;
- Wali, Gautam;
- Minoche, André;
- Puttick, Clare;
- Pinese, Mark;
- Gayevskiy, Velimir;
- Dinger, Marcel;
- Roscioli, Tony;
- Sue, Carolyn;
- Cowley, Mark
Publication type:
Article
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-14079-0
By:
- Pinese, Mark;
- Lacaze, Paul;
- Rath, Emma M.;
- Stone, Andrew;
- Brion, Marie-Jo;
- Ameur, Adam;
- Nagpal, Sini;
- Puttick, Clare;
- Husson, Shane;
- Degrave, Dmitry;
- Cristina, Tina Navin;
- Kahl, Vivian F. S.;
- Statham, Aaron L.;
- Woods, Robyn L.;
- McNeil, John J.;
- Riaz, Moeen;
- Barr, Margo;
- Nelson, Mark R.;
- Reid, Christopher M.;
- Murray, Anne M.
Publication type:
Article
Lost in translation: returning germline genetic results in genome-scale cancer research.
Published in:
Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0430-4
By:
- Johns, Amber L.;
- McKay, Skye H.;
- Humphris, Jeremy L.;
- Pinese, Mark;
- Chantrill, Lorraine A.;
- Mead, R. Scott;
- Tucker, Katherine;
- Andrews, Lesley;
- Goodwin, Annabel;
- Leonard, Conrad;
- High, Hilda A.;
- Nones, Katia;
- Patch, Ann-Marie;
- Merrett, Neil D.;
- Pavlakis, Nick;
- Kassahn, Karin S.;
- Samra, Jaswinder S.;
- Miller, David K.;
- Chang, David K.;
- Pajic, Marina
Publication type:
Article

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