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Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-021-04126-6
By:
- Heshusius, Steven;
- Grech, Laura;
- Gillemans, Nynke;
- Brouwer, Rutger W. W.;
- den Dekker, Xander T.;
- van IJcken, Wilfred F. J.;
- Nota, Benjamin;
- Felice, Alex E.;
- van Dijk, Thamar B.;
- von Lindern, Marieke;
- Borg, Joseph;
- van den Akker, Emile;
- Philipsen, Sjaak
Publication type:
Article
Author Correction: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.
Published in:
2023
By:
- Lu, Hanlin;
- Yuan, Peidong;
- Ma, Xiaoping;
- Jiang, Xiuxin;
- Liu, Shaozhuang;
- Ma, Chang;
- Philipsen, Sjaak;
- Zhang, Qunye;
- Yang, Jianmin;
- Xu, Feng;
- Zhang, Cheng;
- Zhang, Yun;
- Zhang, Wencheng
Publication type:
Correction Notice
Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36409-z
By:
- Lu, Hanlin;
- Yuan, Peidong;
- Ma, Xiaoping;
- Jiang, Xiuxin;
- Liu, Shaozhuang;
- Ma, Chang;
- Philipsen, Sjaak;
- Zhang, Qunye;
- Yang, Jianmin;
- Xu, Feng;
- Zhang, Cheng;
- Zhang, Yun;
- Zhang, Wencheng
Publication type:
Article
Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36409-z
By:
- Lu, Hanlin;
- Yuan, Peidong;
- Ma, Xiaoping;
- Jiang, Xiuxin;
- Liu, Shaozhuang;
- Ma, Chang;
- Philipsen, Sjaak;
- Zhang, Qunye;
- Yang, Jianmin;
- Xu, Feng;
- Zhang, Cheng;
- Zhang, Yun;
- Zhang, Wencheng
Publication type:
Article
Erythroid overexpression of C/EBP? in transgenic mice affects ?-globin expression and fetal liver erythropoiesis.
Published in:
EMBO Journal, 2000, v. 19, n. 21, p. 5856, doi. 10.1093/emboj/19.21.5856
By:
- Zafarana, Gaetano;
- Rottier, Robbert;
- Grosveld, Frank;
- Philipsen, Sjaak
Publication type:
Article
Activation of the ß globin locus by transcription factors and chromatin modifiers.
Published in:
EMBO Journal, 2000, v. 19, n. 18, p. 4986, doi. 10.1093/emboj/19.18.4986
By:
- McMorrow, Tara;
- van den Wijngaard, Arthur;
- Wollenschlaeger, Alex;
- van de Corput, Mariëtte;
- Monkhorts, Kim;
- Trimborn, Tolleiv;
- Fraser, Peter;
- van Lohuizen, Maarten;
- Jenuwein, Thomas;
- Djabali, Malek;
- Philipsen, Sjaak;
- Grosveld, Frank;
- Milot, Eric
Publication type:
Article
Transcription factor Sp3 is essential for post-natal survival and late tooth development.
Published in:
EMBO Journal, 2000, v. 19, n. 4, p. 655, doi. 10.1093/emboj/19.4.655
By:
- Bowman, Peter;
- Göllner, Heike;
- Elsässer, Hans-Peter;
- Eckhoff, Gabriele;
- Karis, Alar;
- Grosveld, Frank;
- Philipsen, Sjaak;
- Suske, Guntram
Publication type:
Article
Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the ß-globin locus control region.
Published in:
EMBO Journal, 1998, v. 17, n. 8, p. 2334, doi. 10.1093/emboj/17.8.2334
By:
- Tewari, Rita;
- Gillemans, Nynke;
- Wijgerde, Mark;
- Nuez, Beatriz;
- von Lindern, Marieke;
- Grosveld, Frank;
- Philipsen, Sjaak
Publication type:
Article
The return of Romeo. Scientists' international mobility and the future of research in Europe.
Published in:
EMBO Reports, 2006, v. 7, n. 11, p. 1067, doi. 10.1038/sj.embor.7400845
By:
- Migliaccio, Anna Rita;
- Philipsen, Sjaak
Publication type:
Article
Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach.
Published in:
Nucleic Acids Research, 2017, v. 45, n. 1, p. 115, doi. 10.1093/nar/gkw820
By:
- Kin Tung Tam;
- Ping Kei Chan;
- Wei Zhang;
- Pui Pik Law;
- Zhipeng Tian;
- Chi Fung Chan, Godfrey;
- Philipsen, Sjaak;
- Festenstein, Richard;
- Kian Cheng Tan-Un
Publication type:
Article
Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA.
Published in:
Nucleic Acids Research, 2016, v. 44, n. 20, p. 9847, doi. 10.1093/nar/gkw831
By:
- Keiichi Izumikawa;
- Harunori Yoshikawa;
- Hideaki Ishikawa;
- Yuko Nobe;
- Yoshio Yamauchi;
- Philipsen, Sjaak;
- Simpson, Richard J.;
- Toshiaki Isobe;
- Nobuhiro Takahashi
Publication type:
Article
Targeted Protein Degradation as a Promising Tool for Epigenetic Upregulation of Fetal Hemoglobin.
Published in:
ChemMedChem, 2020, v. 15, n. 24, p. 2436, doi. 10.1002/cmdc.202000574
By:
- J. Verheul, Thijs C.;
- Trinh, Van Tuan;
- Vázquez, Olalla;
- Philipsen, Sjaak
Publication type:
Article
Reflections on the European Union Eurythron Network Meeting "Molecular Control of Erythropoiesis," September 22-23, 2005, Istituto Superiore Di Sanità, Rome, Italy.
Published in:
Stem Cells, 2006, v. 24, n. 11, p. 2478, doi. 10.1634/stemcells.2006-0121
By:
- Migliaccio, Anna Rita;
- Philipsen, Sjaak
Publication type:
Article
ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus.
Published in:
British Journal of Haematology, 2016, v. 175, n. 3, p. 525, doi. 10.1111/bjh.14256
By:
- Breton, Amandine;
- Theodorou, Andria;
- Aktuna, Suleyman;
- Sonzogni, Laura;
- Darling, David;
- Chan, Lucas;
- Menzel, Stephan;
- Spek, Peter J.;
- Swagemakers, Sigrid M.A.;
- Grosveld, Frank;
- Philipsen, Sjaak;
- Thein, Swee Lay
Publication type:
Article
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.
Published in:
Nature Genetics, 2011, v. 43, n. 6, p. 607, doi. 10.1038/ng.825
By:
- Engelen, Erik;
- Akinci, Umut;
- Bryne, Jan Christian;
- Hou, Jun;
- Gontan, Cristina;
- Moen, Maaike;
- Szumska, Dorota;
- Kockx, Christel;
- van IJcken, Wilfred;
- Dekkers, Dick H. W.;
- Demmers, Jeroen;
- Rijkers, Erik-Jan;
- Bhattacharya, Shoumo;
- Philipsen, Sjaak;
- Pevny, Larysa H.;
- Grosveld, Frank G.;
- Rottier, Robbert J.;
- Lenhard, Boris;
- Poot, Raymond A.
Publication type:
Article
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.
Published in:
Nature Genetics, 2011, v. 43, n. 4, p. 295, doi. 10.1038/ng.785
By:
- Giardine, Belinda;
- Borg, Joseph;
- Higgs, Douglas R.;
- Peterson, Kenneth R.;
- Philipsen, Sjaak;
- Maglott, Donna;
- Singleton, Belinda K.;
- Anstee, David J.;
- Basak, A. Nazli;
- Clark, Barnaby;
- Costa, Flavia C.;
- Faustino, Paula;
- Fedosyuk, Halyna;
- Felice, Alex E.;
- Francina, Alain;
- Galanello, Renzo;
- Gallivan, Monica V. E.;
- Georgitsi, Marianthi;
- Gibbons, Richard J.;
- Giordano, Piero C.
Publication type:
Article
c AMP response element-binding protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2012, v. 39, n. 6, p. 510, doi. 10.1111/j.1440-1681.2012.05702.x
By:
- Banan, Mehdi;
- Esmaeilzadeh-Gharehdaghi, Elika;
- Nezami, Majid;
- Deilami, Zahra;
- Farashi, Samaneh;
- Philipsen, Sjaak;
- Esteghamat, Fatemehsadat;
- Pourfarzad, Farzin;
- Ali Imam, AM;
- Najmabadi, Hossein
Publication type:
Article
Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41567-1
By:
- Lu, Hanlin;
- Jiang, Xiuxin;
- He, Lifan;
- Ji, Xuyang;
- Li, Xinyun;
- Liu, Shaozhuang;
- Sun, Yuanyuan;
- Qin, Xiaoteng;
- Xiong, Xiwen;
- Philipsen, Sjaak;
- Xi, Bo;
- Zhang, Meng;
- Yang, Jianmin;
- Zhang, Cheng;
- Zhang, Yun;
- Zhang, Wencheng
Publication type:
Article
A Dual Reporter Mouse Model of the Human β-Globin Locus: Applications and Limitations.
Published in:
PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051272
By:
- Papadopoulos, Petros;
- Gutiérrez, Laura;
- van der Linden, Reinier;
- Kong-A-San, John;
- Maas, Alex;
- Drabek, Dubravka;
- Patrinos, George P.;
- Philipsen, Sjaak;
- Grosveld, Frank
Publication type:
Article
Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction.
Published in:
PLoS ONE, 2010, v. 5, n. 4, p. 1, doi. 10.1371/journal.pone.0010312
By:
- Jun Hou;
- Aerts, Joachim;
- den Hamer, Bianca;
- van IJcken, Wilfred;
- den Bakker, Michael;
- Riegman, Peter;
- van der Leest, Cor;
- van der Spek, Peter;
- Foekens, John A.;
- Hoogsteden, Henk C.;
- Grosveld, Frank;
- Philipsen, Sjaak
Publication type:
Article
Specificity Protein 2 (Sp2) Is Essential for Mouse Development and Autonomous Proliferation of Mouse Embryonic Fibroblasts.
Published in:
PLoS ONE, 2010, v. 5, n. 3, p. 1, doi. 10.1371/journal.pone.0009587
By:
- Baur, Frank;
- Nau, Kerstin;
- Sadic, Dennis;
- Allweiss, Lena;
- sser, Hans-Peter Elsä;
- Gillemans, Nynke;
- de Wit, Ton;
- ger, Imme Krü;
- Vollmer, Marion;
- Philipsen, Sjaak;
- Suske, Guntram
Publication type:
Article
5'HS5 of the Human β-globin Locus Control Region Is Dispensable for the Formation of the β-globin Active Chromatin Hub.
Published in:
PLoS ONE, 2008, v. 3, n. 5, p. 1, doi. 10.1371/journal.pone.0002134
By:
- Ping Kei Chan;
- Albert Wai;
- Sjaak Philipsen;
- Kian-Cheng Tan-Un
Publication type:
Article
Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.
Published in:
Genes to Cells, 2001, v. 6, n. 8, p. 689, doi. 10.1046/j.1365-2443.2001.00455.x
By:
- Göllner, Heike;
- Bouwman, Peter;
- Mangold, Monika;
- Karis, Alar;
- Braun, Harald;
- Rohner, Iris;
- Del Rey, Adriana;
- Besedovsky, Hugo-Oskar;
- Meinhardt, Andreas;
- van den Broek, Marion;
- Cutforth, Tyler;
- Grosveld, Frank;
- Philipsen, Sjaak;
- Suske, Guntram
Publication type:
Article
Nucleotide changes in the γ-globin promoter and the (AT)xNy(AT)z polymorphic sequence of βLCRHS-2 region associated with altered levels of HbF.
Published in:
European Journal of Human Genetics, 1999, v. 7, n. 3, p. 345, doi. 10.1038/sj.ejhg.5200284
By:
- Samakoglu, Selda;
- Philipsen, Sjaak;
- Grosveld, Frank;
- Lüleci, Güven;
- Bagci, Hüseyin
Publication type:
Article
Chtop is a component of the dynamic TREX mRNA export complex.
Published in:
EMBO Journal, 2013, v. 32, n. 3, p. 473, doi. 10.1038/emboj.2012.342
By:
- Chang, Chung‐Te;
- Hautbergue, Guillaume M;
- Walsh, Matthew J;
- Viphakone, Nicolas;
- van Dijk, Thamar B;
- Philipsen, Sjaak;
- Wilson, Stuart A
Publication type:
Article
A tissue‐specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse.
Published in:
Nucleic Acids Research, 2003, v. 31, n. 18, p. 5405, doi. 10.1093/nar/gkg723
By:
- Lindeboom, Fokke;
- Gillemans, Nynke;
- Karis, Alar;
- Jaegle, Martine;
- Meijer, Dies;
- Grosveld, Frank;
- Philipsen, Sjaak
Publication type:
Article
SURVEY AND SUMMARY A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.
Published in:
Nucleic Acids Research, 1999, v. 27, n. 15, p. 2991, doi. 10.1093/nar/27.15.2991
By:
- Philipsen, Sjaak;
- Suske, Guntram;
- Li, E.;
- Macleod, D.;
- Brandeis, M.;
- Kadonaga, J.T.;
- Hagen, G.;
- Sogawa, K.;
- Cook, T.;
- Kingsley, C.;
- Crossley, M.;
- Matsumoto, N.;
- Feng, W.C.;
- Miller, I.J.;
- Matera, A.G.;
- Scohy, S.;
- Kalff-Suske, M.;
- Imataka, H.;
- Imhof, A.;
- Ohe, N.
Publication type:
Article
Effects of three Sp1 motifs on the transcription of the FGF-4 gene.
Published in:
Molecular Reproduction & Development, 2000, v. 57, n. 1, p. 4, doi. 10.1002/1098-2795(200009)57:1<4::AID-MRD3>3.0.CO;2-I
By:
- Luster, Troy A.;
- Johnson, Lance R.;
- Nowling, Tamara K.;
- Lamb, Kimberly A.;
- Philipsen, Sjaak;
- Rizzino, Angie
Publication type:
Article
Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
Published in:
Journal of Neurochemistry, 2017, v. 140, n. 2, p. 245, doi. 10.1111/jnc.13908
By:
- Wegener, Amélie;
- Küspert, Melanie;
- Sock, Elisabeth;
- Philipsen, Sjaak;
- Suske, Guntram;
- Wegner, Michael
Publication type:
Article
Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B.
Published in:
Human Genomics, 2020, v. 14, n. 1, p. N.PAG, doi. 10.1186/s40246-020-00283-3
By:
- Papadopoulos, Petros;
- Kafasi, Athanassia;
- De Cuyper, Iris M.;
- Barroca, Vilma;
- Lewandowski, Daniel;
- Kadri, Zahra;
- Veldthuis, Martijn;
- Berghuis, Jeffrey;
- Gillemans, Nynke;
- Cuesta, Celina María Benavente;
- Grosveld, Frank G.;
- van Zwieten, Rob;
- Philipsen, Sjaak;
- Vernet, Muriel;
- Gutiérrez, Laura;
- Patrinos, George P.
Publication type:
Article
Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects.
Published in:
Developmental Dynamics, 2007, v. 236, n. 10, p. 2970, doi. 10.1002/dvdy.21322
By:
- Krüger, Imme;
- Vollmer, Marion;
- Simmons, David G.;
- Elsässer, Hans-Peter;
- Philipsen, Sjaak;
- Suske, Guntram
Publication type:
Article
Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects.
Published in:
Developmental Dynamics, 2007, v. 236, n. 8, p. 2235, doi. 10.1002/dvdy.21222
By:
- Imme Krüger;
- Marion Vollmer;
- David Simmons;
- Hans‐Peter Elsässer;
- Sjaak Philipsen;
- Guntram Suske
Publication type:
Article
An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.
Published in:
Nature, 2000, v. 406, n. 6795, p. 519, doi. 10.1038/35020086
By:
- Whyatt, David;
- Lindeboom, Fokke;
- Karis, Alar;
- Ferreira, Rita;
- Milot, Eric;
- Hendriks, Rudi;
- De Bruijn, Marella;
- Langeveld, An;
- Gribnau, Joost;
- Grosveld, Frank;
- Philipsen, Sjaak
Publication type:
Article
Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells.
Published in:
Journal of Leukocyte Biology, 2021, v. 110, n. 4, p. 735, doi. 10.1002/JLB.6A1219-711RRR
By:
- Scheenstra, Maaike R.;
- Martínez‐Botía, Patricia;
- Acebes‐Huerta, Andrea;
- Brouwer, Rutger W.W.;
- Caballero‐Sánchez, Noemí;
- Gillemans, Nynke;
- De Bleser, Pieter;
- Nota, Benjamin;
- De Cuyper, Iris M.;
- Salunkhe, Vishal;
- Woltman, Andrea M.;
- van de Laar, Lianne;
- Rijkers, Erikjan;
- Demmers, Jeroen A.A.;
- van IJcken, Wilfred F.J.;
- Philipsen, Sjaak;
- van den Berg, Timo K.;
- Kuijpers, Taco W.;
- Gutiérrez, Laura
Publication type:
Article
Hereditary persistence of fetal hemoglobin in two patients with KLF1 haploinsufficiency due to 19p13.2-p13.12/13 deletion.
Published in:
American Journal of Hematology, 2017, v. 92, n. 1, p. E2, doi. 10.1002/ajh.24574
By:
- Natiq, Abdelhafid;
- Lysy, Philippe A.;
- Gillemans, Nynke;
- Schaap, Rianne;
- Sefiani, Abdelaziz;
- Amzazi, Saaid;
- Chafai El-Alaoui, Siham;
- Cantú, Ileana;
- Banjanin, Bella;
- van Lom, Kirsten;
- Harteveld, Cornelis L.;
- Philipsen, Sjaak
Publication type:
Article
Identification and in silico structural analysis of Gallus gallus protein arginine methyltransferase 4 ( PRMT4).
Published in:
FEBS Open Bio, 2017, v. 7, n. 12, p. 1909, doi. 10.1002/2211-5463.12323
By:
- Berberich, Hannah;
- Terwesten, Felix;
- Rakow, Sinja;
- Sahu, Peeyush;
- Bouchard, Caroline;
- Meixner, Marion;
- Philipsen, Sjaak;
- Kolb, Peter;
- Bauer, Uta‐Maria
Publication type:
Article
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the α globin cluster.
Published in:
Human Molecular Genetics, 2001, v. 10, n. 4, p. 371, doi. 10.1093/hmg/10.4.371
By:
- Flint, Jonathan;
- Tufarelli, Cristina;
- Peden, John;
- Clark, Kevin;
- Daniels, Rachael J.;
- Hardison, Ross;
- Miller, Webb;
- Philipsen, Sjaak;
- Tan-Un, Kian Chen;
- McMorrow, Tara;
- Frampton, Jonathan;
- Alter, Blanche P.
Publication type:
Article
Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.
Published in:
Epigenetics & Chromatin, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13072-019-0282-9
By:
- Gilmour, Jane;
- O'Connor, Leigh;
- Middleton, Christopher P.;
- Keane, Peter;
- Gillemans, Nynke;
- Cazier, Jean-Baptiste;
- Philipsen, Sjaak;
- Bonifer, Constanze
Publication type:
Article
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
Published in:
PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0208659
By:
- Cantú, Ileana;
- van de Werken, Harmen J. G.;
- Gillemans, Nynke;
- Stadhouders, Ralph;
- Heshusius, Steven;
- Maas, Alex;
- Esteghamat, Fatemehsadat;
- Ozgur, Zeliha;
- van IJcken, Wilfred F. J.;
- Grosveld, Frank;
- von Lindern, Marieke;
- Philipsen, Sjaak;
- van Dijk, Thamar B.
Publication type:
Article
Transcription factor Sp4 is required for hyperalgesic state persistence.
Published in:
PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0211349
By:
- Sheehan, Kayla;
- Lee, Jessica;
- Chong, Jillian;
- Zavala, Kathryn;
- Sharma, Manohar;
- Philipsen, Sjaak;
- Maruyama, Tomoyuki;
- Xu, Zheyun;
- Guan, Zhonghui;
- Eilers, Helge;
- Kawamata, Tomoyuki;
- Schumacher, Mark
Publication type:
Article
Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells.
Published in:
BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-40
By:
- Leithner, Katharina;
- Wohlkoen, Christoph;
- Stacher, Elvira;
- Lindenmann, Jörg;
- Hofmann, Nicole A.;
- Gallé, Birgit;
- Guelly, Christian;
- Quehenberger, Franz;
- Stiegler, Philipp;
- Smolle-Jüttner, Freyja-Maria;
- Philipsen, Sjaak;
- Popper, Helmut H.;
- Hrzenjak, Andelko;
- Olschewski, Andrea;
- Olschewski, Horst
Publication type:
Article
Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells.
Published in:
2014
By:
- Leithner, Katharina;
- Wohlkoenig, Christoph;
- Stacher, Elvira;
- Lindenmann, Jörg;
- Hofmann, Nicole A;
- Gallé, Birgit;
- Guelly, Christian;
- Quehenberger, Franz;
- Stiegler, Philipp;
- Smolle-Jüttner, Freyja-Maria;
- Philipsen, Sjaak;
- Popper, Helmut H;
- Hrzenjak, Andelko;
- Olschewski, Andrea;
- Olschewski, Horst
Publication type:
journal article

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