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Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02770-2
By:
- Bajrami, Ilirjana;
- Walker, Callum;
- Krastev, Dragomir B.;
- Weekes, Daniel;
- Song, Feifei;
- Wicks, Andrew J.;
- Alexander, John;
- Haider, Syed;
- Brough, Rachel;
- Pettitt, Stephen J.;
- Tutt, Andrew N. J.;
- Lord, Christopher J.
Publication type:
Article
Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system.
Published in:
Nucleic Acids Research, 2012, v. 40, n. 3, p. e21, doi. 10.1093/nar/gkr908
By:
- Huang, Yue;
- Pettitt, Stephen J.;
- Guo, Ge;
- Liu, Guang;
- Li, Meng Amy;
- Yang, Fengtang;
- Bradley, Allan
Publication type:
Article
Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Published in:
Nature Methods, 2009, v. 6, n. 7, p. 493, doi. 10.1038/nmeth.1342
By:
- Pettitt, Stephen J.;
- Qi Liang;
- Rairdan, Xin Y.;
- Moran, Jennifer L.;
- Prosser, Haydn M.;
- Beier, David R.;
- Lloyd, Kent C.;
- Bradley, Allan;
- Skarnes, William C.
Publication type:
Article
A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies <i>Parp1</i> as a Mediator of Olaparib Toxicity.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061520
By:
- Pettitt, Stephen J.;
- Rehman, Farah L.;
- Bajrami, Ilirjana;
- Brough, Rachel;
- Wallberg, Fredrik;
- Kozarewa, Iwanka;
- Fenwick, Kerry;
- Assiotis, Ioannis;
- Chen, Lina;
- Campbell, James;
- Lord, Christopher J.;
- Ashworth, Alan
Publication type:
Article
Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.
Published in:
Molecular Oncology, 2024, v. 18, n. 2, p. 369, doi. 10.1002/1878-0261.13537
By:
- Baxter, Joseph S.;
- Brough, Rachel;
- Krastev, Dragomir B.;
- Song, Feifei;
- Sridhar, Sandhya;
- Gulati, Aditi;
- Alexander, John;
- Roumeliotis, Theodoros I.;
- Kozik, Zuza;
- Choudhary, Jyoti S.;
- Haider, Syed;
- Pettitt, Stephen J.;
- Tutt, Andrew N. J.;
- Lord, Christopher J.
Publication type:
Article
Resistance to DNA repair inhibitors in cancer.
Published in:
Molecular Oncology, 2022, v. 16, n. 21, p. 3811, doi. 10.1002/1878-0261.13224
By:
- Baxter, Joseph S.;
- Zatreanu, Diana;
- Pettitt, Stephen J.;
- Lord, Christopher J.
Publication type:
Article
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.
Published in:
2019
By:
- Chabanon, Roman M.;
- Muirhead, Gareth;
- Krastev, Dragomir B.;
- Adam, Julien;
- Morel, Daphné;
- Garrido, Marlène;
- Lamb, Andrew;
- Hénon, Clémence;
- Dorvault, Nicolas;
- Rouanne, Mathieu;
- Marlow, Rebecca;
- Bajrami, Ilirjana;
- Cardeñosa, Marta Llorca;
- Konde, Asha;
- Besse, Benjamin;
- Ashworth, Alan;
- Pettitt, Stephen J.;
- Haider, Syed;
- Marabelle, Aurélien;
- Tutt, Andrew N. J.
Publication type:
journal article
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Published in:
British Journal of Cancer, 2017, v. 117, n. 1, p. 113, doi. 10.1038/bjc.2017.133
By:
- Nikkilä, Jenni;
- Kumar, Rahul;
- Campbell, James;
- Brandsma, Inger;
- Pemberton, Helen N;
- Wallberg, Fredrik;
- Nagy, Kinga;
- Scheer, Ildikó;
- Vertessy, Beata G;
- Serebrenik, Artur A;
- Monni, Valentina;
- Harris, Reuben S;
- Pettitt, Stephen J;
- Ashworth, Alan;
- Lord, Christopher J
Publication type:
Article
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Published in:
2017
By:
- Nikkilä, Jenni;
- Kumar, Rahul;
- Campbell, James;
- Brandsma, Inger;
- Pemberton, Helen N;
- Wallberg, Fredrik;
- Nagy, Kinga;
- Scheer, Ildikó;
- Vertessy, Beata G;
- Serebrenik, Artur A;
- Monni, Valentina;
- Harris, Reuben S;
- Pettitt, Stephen J;
- Ashworth, Alan;
- Lord, Christopher J
Publication type:
journal article
Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR.
Published in:
Journal of Pathology: Clinical Research, 2020, v. 6, n. 1, p. 3, doi. 10.1002/cjp2.146
By:
- Khalique, Saira;
- Pettitt, Stephen J;
- Kelly, Ger;
- Tunariu, Nina;
- Natrajan, Rachael;
- Banerjee, Susana;
- Lord, Christopher J
Publication type:
Article
Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04466-4
By:
- Krastev, Dragomir B.;
- Pettitt, Stephen J.;
- Campbell, James;
- Feifei Song;
- Tanos, Barbara E.;
- Stoynov, Stoyno S.;
- Ashworth, Alan;
- Lord, Christopher J.
Publication type:
Article
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03917-2
By:
- Pettitt, Stephen J.;
- Krastev, Dragomir B.;
- Brandsma, Inger;
- Dréan, Amy;
- Feifei Song;
- Aleksandrov, Radoslav;
- Harrell, Maria I.;
- Menon, Malini;
- Brough, Rachel;
- Campbell, James;
- Frankum, Jessica;
- Ranes, Michael;
- Pemberton, Helen N.;
- Rafiq, Rumana;
- Fenwick, Kerry;
- Swain, Amanda;
- Guettler, Sebastian;
- Jung-Min Lee;
- Swisher, Elizabeth M.;
- Stoynov, Stoyno
Publication type:
Article

Found: 12