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KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.
Published in:
Arthritis Research & Therapy, 2019, v. 21, n. 1, p. N.PAG, doi. 10.1186/s13075-018-1783-9
By:
- Tanner, Mark R.;
- Pennington, Michael W.;
- Chauhan, Satendra S.;
- Laragione, Teresina;
- Gulko, Pércio S.;
- Beeton, Christine
Publication type:
Article
Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl.
Published in:
Angewandte Chemie International Edition, 2014, v. 53, n. 11, p. 2931, doi. 10.1002/anie.201310103
By:
- Dekan, Zoltan;
- Mobli, Mehdi;
- Pennington, Michael W.;
- Fung, Eileen;
- Nemeth, Elizabeta;
- Alewood, Paul F.
Publication type:
Article
Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia.
Published in:
Glia, 2020, v. 68, n. 11, p. 2377, doi. 10.1002/glia.23847
By:
- Nguyen, Hai M.;
- Lucente, Jacopo;
- Chen, Yi‐Je;
- Cui, Yanjun;
- Ibrahim, Rania H.;
- Pennington, Michael W.;
- Jin, Lee‐Way;
- Maezawa, Izumi;
- Wulff, Heike
Publication type:
Article
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.
Published in:
PLoS ONE, 2023, v. 17, n. 4, p. 1, doi. 10.1371/journal.pone.0283996
By:
- Wang, Yuqing;
- Hurley, Ayrea;
- De Giorgi, Marco;
- Tanner, Mark R.;
- Hu, Rong-Chi;
- Pennington, Michael W.;
- Lagor, William R.;
- Beeton, Christine
Publication type:
Article
Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl.
Published in:
Angewandte Chemie, 2014, v. 126, n. 11, p. 2975, doi. 10.1002/ange.201310103
By:
- Dekan, Zoltan;
- Mobli, Mehdi;
- Pennington, Michael W.;
- Fung, Eileen;
- Nemeth, Elizabeta;
- Alewood, Paul F.
Publication type:
Article
Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.714841
By:
- Markakis, Ioannis;
- Charitakis, Ioannis;
- Beeton, Christine;
- Galani, Melpomeni;
- Repousi, Elpida;
- Aggeloglou, Stella;
- Sfikakis, Petros P.;
- Pennington, Michael W.;
- Chandy, K. George;
- Poulopoulou, Cornelia
Publication type:
Article
A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation.
Published in:
PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0078712
By:
- Rashid, M. Harunur;
- Heinzelmann, Germano;
- Huq, Redwan;
- Tajhya, Rajeev B.;
- Chang, Shih Chieh;
- Chhabra, Sandeep;
- Pennington, Michael W.;
- Beeton, Christine;
- Norton, Raymond S.;
- Kuyucak, Serdar
Publication type:
Article
Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes.
Published in:
PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076740
By:
- Koshy, Shyny;
- Wu, Danli;
- Hu, Xueyou;
- Tajhya, Rajeev B.;
- Huq, Redwan;
- Khan, Fatima S.;
- Pennington, Michael W.;
- Wulff, Heike;
- Yotnda, Patricia;
- Beeton, Christine
Publication type:
Article
Targeted tyrosine iodination in a multi-tyrosine vasopressin analog.
Published in:
Journal of Peptide Science, 2007, v. 13, n. 11, p. 756, doi. 10.1002/psc.890
By:
- Durr, Jacques A.;
- Blankenship, Mary;
- Chauhan, Satendra S.;
- Pennington, Michael W.
Publication type:
Article
Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK.
Published in:
Marine Drugs, 2015, v. 13, n. 1, p. 529, doi. 10.3390/md13010529
By:
- Pennington, Michael W.;
- Shih Chieh Chang;
- Chauhan, Satendra;
- Huq, Redwan;
- Tajhya, Rajeev B.;
- Chhabra, Sandeep;
- Norton, Raymond S.;
- Beeton, Christine
Publication type:
Article
KCa1.1 channels regulate β1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.
Published in:
FASEB Journal, 2017, v. 31, n. 8, p. 3309, doi. 10.1096/fj.201601097R
By:
- Tanner, Mark R.;
- Pennington, Michael W.;
- Laragione, Teresina;
- Gulko, Pércio S.;
- Beeton, Christine
Publication type:
Article
Kv1.3 channel-blocking immunomodulatory pep tides from parasitic worms: implications for autoimmune diseases.
Published in:
FASEB Journal, 2014, v. 28, n. 9, p. 3952, doi. 10.1096/fj.14-251967
By:
- Chhabra, Sandeep;
- Shih Chieh Chang;
- Hai M. Nguyen;
- Huq, Redwan;
- Tanner, Mark R.;
- Londono, Luz M.;
- Estrada, Rosendo;
- Dhawan, Vikas;
- Chauhan, Satendra;
- Upadhyay, Sanjeev K.;
- Gindin, Mariel;
- Hotez, Peter J.;
- Valenzuela, Jesus G.;
- Mohanty, Biswaranjan;
- Swarbrick, James D.;
- Wulff, Heike;
- Iadonato, Shawn P.;
- Gutman, George A.;
- Beeton, Christine;
- Pennington, Michael W.
Publication type:
Article
N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.
Published in:
2015
By:
- Chang, Shih C.;
- Huq, Redwan;
- Chhabra, Sandeep;
- Beeton, Christine;
- Pennington, Michael W.;
- Smith, Brian J.;
- Norton, Raymond S.
Publication type:
Editorial
Potassium channels Kv1.3 and Kv1.5 are expressed on blood‐derived dendritic cells in the central nervous system.
Published in:
Annals of Neurology, 2006, v. 60, n. 1, p. 118
By:
- Katherine M. Mullen;
- Monika Rozycka;
- Horea Rus;
- Lina Hu;
- Cornelia Cudrici;
- Ekaterina Zafranskaia;
- Michael W. Pennington;
- David C. Johns;
- Susan I. V. Judge;
- Peter A. Calabresi
Publication type:
Article
Live imaging of effector memory T cells at a site of inflammation -a Kv1.3 blocker suppresses T cell motility.
Published in:
FASEB Journal, 2007, v. 21, n. 6, p. A770, doi. 10.1096/fasebj.21.6.a770-a
By:
- Beeton, Christine;
- Matheu, Melanie P.;
- Uemura, Marc;
- Pennington, Michael W.;
- Fluegel, Alexander;
- Parker, Ian;
- Cahalan, Michael D.;
- Chandy, K. George
Publication type:
Article
A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.
Published in:
2017
By:
- Rangaraju, Srikant;
- Raza, Syed Ali;
- Pennati, Andrea;
- Qiudong Deng;
- Dammer, Eric B.;
- Duc Duong;
- Pennington, Michael W.;
- Tansey, Malu G.;
- Lah, James J.;
- Betarbet, Ranjita;
- Seyfried, Nicholas T.;
- Levey, Allan I.;
- Deng, Qiudong;
- Duong, Duc
Publication type:
journal article
Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.81727
By:
- Phuong T. Nguyen;
- Hai M. Nguyen;
- Wagner, Karen M.;
- Stewart, Robert G.;
- Singh, Vikrant;
- Thapa, Parashar;
- Yi-Je Chen;
- Lillya, Mark W.;
- Anh Tuan Ton;
- Kondo, Richard;
- Ghetti, Andre;
- Pennington, Michael W.;
- Hammock, Bruce;
- Griffith, Theanne N.;
- Sack, Jon T.;
- Wulff, Heike;
- Yarov-Yarovoy, Vladimir
Publication type:
Article
KV1.3 channels are novel determinants of macrophage‐dependent endothelial dysfunction in angiotensin II‐induced hypertension in mice.
Published in:
British Journal of Pharmacology, 2021, v. 178, n. 8, p. 1836, doi. 10.1111/bph.15407
By:
- Olivencia, Miguel A.;
- Martínez‐Casales, Marta;
- Peraza, Diego A.;
- García‐Redondo, Ana B.;
- Mondéjar‐Parreño, Gema;
- Hernanz, Raquel;
- Salaices, Mercedes;
- Cogolludo, Angel;
- Pennington, Michael W.;
- Valenzuela, Carmen;
- Briones, Ana M.
Publication type:
Article
A helical capping motif in ShK toxin and its role in helix stabilization.
Published in:
Biopolymers, 2001, v. 58, n. 4, p. 422, doi. 10.1002/1097-0282(20010405)58:4<422::AID-BIP1018>3.0.CO;2-T
By:
- Lanigan, Mark D.;
- Tudor, Jane E.;
- Pennington, Michael W.;
- Norton, Raymond S.
Publication type:
Article
Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: Structure-based drug design and the resistance problem.
Published in:
Biopolymers, 1999, v. 51, n. 1, p. 69, doi. 10.1002/(SICI)1097-0282(1999)51:1<69::AID-BIP8>3.0.CO;2-#
By:
- Dunn, Ben M.;
- Pennington, Michael W.;
- Frase, D. Constanza;
- Nash, Kevin
Publication type:
Article
A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death.
Published in:
Biomedicines, 2022, v. 10, n. 10, p. N.PAG, doi. 10.3390/biomedicines10102605
By:
- Dardevet, Lucie;
- Najlaoui, Feten;
- Aroui, Sonia;
- Collot, Mayeul;
- Tisseyre, Céline;
- Pennington, Michael W.;
- Mallet, Jean-Maurice;
- De Waard, Michel
Publication type:
Article
A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases.
Published in:
Scientific Reports, 2014, p. 1, doi. 10.1038/srep04509
By:
- Rashid, M. Harunur;
- Huq, Redwan;
- Tanner, Mark R.;
- Chhabra, Sandeep;
- Khoo, Keith K.;
- Estrada, Rosendo;
- Dhawan, Vikas;
- Chauhan, Satendra;
- Pennington, Michael W.;
- Beeton, Christine;
- Kuyucak, Serdar;
- Norton, Raymond S.
Publication type:
Article
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3
Published in:
FEBS Letters, 2012, v. 586, n. 22, p. 3996, doi. 10.1016/j.febslet.2012.09.038
By:
- Pennington, Michael W.;
- Harunur Rashid, M.;
- Tajhya, Rajeev B.;
- Beeton, Christine;
- Kuyucak, Serdar;
- Norton, Raymond S.
Publication type:
Article
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.
Published in:
Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0254-8
By:
- Rangaraju, Srikant;
- Dammer, Eric B.;
- Raza, Syed Ali;
- Rathakrishnan, Priyadharshini;
- Xiao, Hailian;
- Gao, Tianwen;
- Duong, Duc M.;
- Pennington, Michael W.;
- Lah, James J.;
- Seyfried, Nicholas T.;
- Levey, Allan I.
Publication type:
Article
Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp.
Published in:
Peptide Science, 2018, v. 110, n. 4, p. 1, doi. 10.1002/pep2.24073
By:
- Sunanda, Punnepalli;
- Krishnarjuna, Bankala;
- Peigneur, Steve;
- Mitchell, Michela L.;
- Estrada, Rosendo;
- Villegas‐Moreno, Jessica;
- Pennington, Michael W.;
- Tytgat, Jan;
- Norton, Raymond S.
Publication type:
Article

Found: 25

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl.

Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia.

Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl.

Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis.

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation.

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes.

Targeted tyrosine iodination in a multi-tyrosine vasopressin analog.

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK.

KCa1.1 channels regulate β<sub>1</sub>-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.

Kv1.3 channel-blocking immunomodulatory pep tides from parasitic worms: implications for autoimmune diseases.

N-terminally extended analogues of the K<sup>+</sup> channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Potassium channels Kv1.3 and Kv1.5 are expressed on blood‐derived dendritic cells in the central nervous system.

Live imaging of effector memory T cells at a site of inflammation -a Kv1.3 blocker suppresses T cell motility.

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.

Computational design of peptides to target Na<sub>V</sub>1.7 channel with high potency and selectivity for the treatment of pain.

K<sub>V</sub>1.3 channels are novel determinants of macrophage‐dependent endothelial dysfunction in angiotensin II‐induced hypertension in mice.

A helical capping motif in ShK toxin and its role in helix stabilization.

Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: Structure-based drug design and the resistance problem.

A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death.

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases.

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Identification, chemical synthesis, structure, and function of a new K<sub>V</sub>1 channel blocking peptide from Oulactis sp.