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(S)-(–)-α,α-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography.
- Published in:
- Journal of Separation Science, 2007, v. 30, n. 1, p. 21
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- Publication type:
- Article
Targeting bile-acid signalling for metabolic diseases.
- Published in:
- Nature Reviews Drug Discovery, 2008, v. 7, n. 8, p. 678, doi. 10.1038/nrd2619
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- Publication type:
- Article
Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2439, doi. 10.3390/ijms24032439
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- Publication type:
- Article
Indole and quinoline derivatives of 2,3-dihydro-l-benzothiepin-4(5 H) one.
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- Journal of Heterocyclic Chemistry, 1978, v. 15, n. 6, p. 927, doi. 10.1002/jhet.5570150606
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- Publication type:
- Article
TGR5 reduces macrophage migration through mTOR-induced C/EBP[beta] differential translation.
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- 2014
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- Publication type:
- Journal Article
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.
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- Journal of Clinical Investigation, 2014, v. 124, n. 12, p. 5424, doi. 10.1172/JCI76289
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- Publication type:
- Article
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.
- Published in:
- Nature Biotechnology, 2012, v. 30, n. 3, p. 283, doi. 10.1038/nbt.2121
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- Publication type:
- Article
The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex.
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- Journal of Molecular Neuroscience, 2010, v. 40, n. 1/2, p. 204, doi. 10.1007/s12031-009-9235-2
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- Publication type:
- Article
Fast chromatographic determination of the bile salt critical micellar concentration.
- Published in:
- Analytical & Bioanalytical Chemistry, 2011, v. 401, n. 1, p. 267, doi. 10.1007/s00216-011-5082-4
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- Publication type:
- Article
Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.
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- Analytical & Bioanalytical Chemistry, 2010, v. 397, n. 5, p. 1997, doi. 10.1007/s00216-010-3669-9
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- Publication type:
- Article
Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids.
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- Analytical & Bioanalytical Chemistry, 2007, v. 388, n. 8, p. 1681, doi. 10.1007/s00216-007-1360-6
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- Publication type:
- Article
Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway.
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- Experimental Dermatology, 2007, v. 16, n. 5, p. 429, doi. 10.1111/j.1600-0625.2007.00545.x
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- Publication type:
- Article
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.
- Published in:
- Scientific Reports, 2015, p. 14086, doi. 10.1038/srep14086
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- Publication type:
- Article
Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition.
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- Proteins, 2009, v. 77, n. 3, p. 524, doi. 10.1002/prot.22464
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- Publication type:
- Article
The role of electrostatic interaction in the molecular recognition of selective agonists to metabotropic glutamate receptors.
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- Proteins, 2003, v. 50, n. 4, p. 609, doi. 10.1002/prot.10301
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- Publication type:
- Article
Homolytic Substitution and Carbenoidic Reactions in the Preparation of Benzimidazole Derivatives of Pharmaceutical Interest: Synthesis and Properties of (2-Cycloalkyl-1-benzimidazolyl)- N,N-diethylacetamides.
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- Archiv der Pharmazie, 1985, v. 318, n. 5, p. 393, doi. 10.1002/ardp.19853180503
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- Publication type:
- Article
Preparation of 1-(Aroylalkyl)-1 H-imidazole and -Benzimidazole Derivatives of Pharmaceutical Interest. A New Synthetic Procedure.
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- Archiv der Pharmazie, 1984, v. 317, n. 1, p. 38, doi. 10.1002/ardp.19843170108
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- Publication type:
- Article
BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects.
- Published in:
- Catalysts (2073-4344), 2018, v. 8, n. 12, p. 600, doi. 10.3390/catal8120600
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- Publication type:
- Article
Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory.
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- Neuropsychopharmacology, 2011, v. 36, n. 11, p. 2357, doi. 10.1038/npp.2011.127
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- Publication type:
- Article
Poly( ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling.
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- Journal of Cellular & Molecular Medicine, 2014, v. 18, n. 3, p. 468, doi. 10.1111/jcmm.12197
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- Publication type:
- Article
Human kynurenine aminotransferase II - reactivity with substrates and inhibitors.
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- FEBS Journal, 2011, v. 278, n. 11, p. 1882, doi. 10.1111/j.1742-4658.2011.08106.x
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- Publication type:
- Article
Tandem Mass Spectrometric Determination of Atypical 3β-Hydroxy-Δ<sup>5</sup>-Bile Acids in Patients with 3β-Hydroxy-Δ<sup>5</sup>-C<sub>27</sub>-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response.
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- Clinical Chemistry, 2015, v. 61, n. 7, p. 955, doi. 10.1373/clinchem.2015.238238
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- Publication type:
- Article
Carboxyfullerenes Protect Human Keratinocytes from Ultraviolet-B-Induced Apoptosis.
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- Journal of Investigative Dermatology, 2000, v. 115, n. 5, p. 835, doi. 10.1046/j.1523-1747.2000.00140.x
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- Publication type:
- Article
Insights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP).
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- Journal of Computer-Aided Molecular Design, 2010, v. 24, n. 11, p. 943, doi. 10.1007/s10822-010-9386-9
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- Publication type:
- Article
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia.
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- European Journal of Neuroscience, 1999, v. 11, n. 10, p. 3637, doi. 10.1046/j.1460-9568.1999.00786.x
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- Publication type:
- Article
Type 2 Metabotropic Glutamate (mGlu) Receptors Tonically Inhibit Transmitter Release in Rat Caudate Nucleus: In Vivo Studies with (2 S,1′ S,2′ S,3′ R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a New Potent and Selective Antagonist
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- European Journal of Neuroscience, 1997, v. 9, n. 7, p. 1350, doi. 10.1111/j.1460-9568.1997.tb01489.x
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- Publication type:
- Article
Ursodeoxycholic acid attenuates colonic epithelial secretory function.
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- Journal of Physiology, 2013, v. 591, n. 9, p. 2307, doi. 10.1113/jphysiol.2013.252544
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- Publication type:
- Article
Comparison of the Neurochemical and Behavioral Effects Resulting from the Inhibition of Kynurenine Hydroxylase and/or Kynureninase.
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- Journal of Neurochemistry, 1995, v. 65, n. 3, p. 1176, doi. 10.1046/j.1471-4159.1995.65031176.x
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- Publication type:
- Article
Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine.
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- Journal of Neurochemistry, 1991, v. 57, n. 5, p. 1630, doi. 10.1111/j.1471-4159.1991.tb06361.x
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- Publication type:
- Article
Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography.
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- Chirality, 2004, v. 16, n. 5, p. 314
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- Publication type:
- Article
Synthesis and Quantitative Structure-Property Relationships of Side Chain-Modified Hyodeoxycholic Acid Derivatives.
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- Molecules, 2013, v. 18, n. 9, p. 10497, doi. 10.3390/molecules180910497
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- Publication type:
- Article
Attrition in the Pharmaceutical Industry - Reasons, Implications, and Pathways Forward. Edited by Alexander Alex, C. John Harris, Dennis A. Smith.
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- ChemMedChem, 2017, v. 12, n. 13, p. 1097, doi. 10.1002/cmdc.201600621
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- Publication type:
- Article
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.
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- ChemMedChem, 2016, v. 11, n. 12, p. 1219, doi. 10.1002/cmdc.201500391
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- Publication type:
- Article
Sequence Variants in Kynurenine Aminotransferase II (KAT II) Orthologs Determine Different Potencies of the Inhibitor S-ESBA.
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- ChemMedChem, 2008, v. 3, n. 8, p. 1199, doi. 10.1002/cmdc.200800109
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- Publication type:
- Article
On the Way to Selective PARP-2 Inhibitors. Design, Synthesis, and Preliminary Evaluation of a Series of Isoquinolinone Derivatives.
- Published in:
- ChemMedChem, 2008, v. 3, n. 6, p. 914, doi. 10.1002/cmdc.200800010
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- Publication type:
- Article
Poly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD<sup>+</sup>: QM/MM Simulation of the Enzyme Reaction.
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- ChemMedChem, 2006, v. 1, n. 5, p. 533, doi. 10.1002/cmdc.200500061
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- Publication type:
- Article
Cover Picture: Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of ( S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor (ChemMedChem 5/2006)
- Published in:
- ChemMedChem, 2006, v. 1, n. 5, p. 493, doi. 10.1002/cmdc.200690014
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- Publication type:
- Article
Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of ( S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor.
- Published in:
- ChemMedChem, 2006, v. 1, n. 5, p. 528, doi. 10.1002/cmdc.200500095
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- Publication type:
- Article
Synthesis and Preliminary Biological Evaluation of 2′-Substituted 2-(3′-Carboxybicyclo[1.1.1]pentyl)glycine Derivatives as Group I Selective Metabotropic Glutamate Receptor Ligands.
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- ChemMedChem, 2006, v. 1, n. 3, p. 358, doi. 10.1002/cmdc.200500071
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- Publication type:
- Article
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo.
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- Journal of Neurochemistry, 2009, v. 109, n. 2, p. 316, doi. 10.1111/j.1471-4159.2009.05893.x
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- Publication type:
- Article
Cyclobutanones via the (1-Oxycyclopropyl)methanol Route.
- Published in:
- Helvetica Chimica Acta, 1977, v. 60, n. 1, p. 1, doi. 10.1002/hlca.19770600102
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- Publication type:
- Article