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Design, synthesis, in vitro evaluation, and molecular modeling studies of N‐substituted benzomorphans, analogs of LP2, as novel MOR ligands.
- Published in:
- Chemical Biology & Drug Design, 2023, v. 101, n. 6, p. 1382, doi. 10.1111/cbdd.14220
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- Article
Novel N -normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain.
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- Molecules, 2022, v. 27, n. 16, p. 5135, doi. 10.3390/molecules27165135
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- Article
LP1 and LP2: Dual-Target MOPr/DOPr Ligands as Drug Candidates for Persistent Pain Relief.
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- Molecules, 2021, v. 26, n. 14, p. 4168, doi. 10.3390/molecules26144168
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- Article
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.
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- Molecules, 2018, v. 23, n. 3, p. 677, doi. 10.3390/molecules23030677
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- Article
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 5864, doi. 10.3390/ijms23115864
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- Article
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain.
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- Molecular Neurobiology, 2024, v. 61, n. 5, p. 2672, doi. 10.1007/s12035-023-03717-w
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- Article
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain.
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- Molecular Neurobiology, 2019, v. 56, n. 11, p. 7338, doi. 10.1007/s12035-019-1607-1
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- Article
In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate.
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- Applied Sciences (2076-3417), 2019, v. 9, n. 5, p. 845, doi. 10.3390/app9050845
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- Article
Solid Lipid Nanoparticles as Carriers for the Synthetic Opioid LP2: Characterization and In Vitro Release.
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- Applied Sciences (2076-3417), 2021, v. 11, n. 21, p. 10250, doi. 10.3390/app112110250
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- Article
From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design.
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- Molecules, 2024, v. 29, n. 4, p. 815, doi. 10.3390/molecules29040815
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- Article
From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design.
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- Molecules, 2023, v. 28, n. 20, p. 7089, doi. 10.3390/molecules28207089
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- Article
New Insights into the Opioid Analgesic Profile of cis -(−)- N -Normetazocine-derived Ligands.
- Published in:
- Molecules, 2023, v. 28, n. 12, p. 4827, doi. 10.3390/molecules28124827
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- Article
Intercellular communication and ion channels in neuropathic pain chronicization.
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- Inflammation Research, 2020, v. 69, n. 9, p. 841, doi. 10.1007/s00011-020-01363-9
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- Article
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.
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- Inflammation Research, 2014, v. 63, n. 3, p. 231, doi. 10.1007/s00011-013-0692-2
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- Article
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling.
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- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.749365
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- Article
Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.
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- Nanomaterials (2079-4991), 2018, v. 8, n. 2, p. 87, doi. 10.3390/nano8020087
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- Article
In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations.
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- Pharmaceutics, 2018, v. 10, n. 1, p. 27, doi. 10.3390/pharmaceutics10010027
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- Article
Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.
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- Pharmaceutics, 2017, v. 9, n. 4, p. 58, doi. 10.3390/pharmaceutics9040058
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- Article
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles.
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- Pharmaceutics, 2017, v. 9, n. 4, p. 48, doi. 10.3390/pharmaceutics9040048
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- Article
Synthesis and Structure-Activity Relationships of (−)-cis-N-Normetazocine-Based LP1 Derivatives.
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- Pharmaceuticals (14248247), 2018, v. 11, n. 2, p. 40, doi. 10.3390/ph11020040
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- Article