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A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial of CX-8998, a Selective Modulator of the T-Type Calcium Channel in Inadequately Treated Moderate to Severe Essential Tremor: T-CALM Study Design and Methodology for Efficacy Endpoint and Digital Biomarker Selection
Published in:
Frontiers in Neurology, 2019, p. N.PAG, doi. 10.3389/fneur.2019.00597
By:
- Papapetropoulos, Spyros;
- Lee, Margaret S.;
- Boyer, Stacey;
- Newbold, Evan J.
Publication type:
Article
Phenotypic features of adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): presenting symptoms and clinical course.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 7, p. 1, doi. 10.1002/alz.063194
By:
- Papapetropoulos, Spyros;
- Portius, Angela;
- Zappia, Samantha;
- Brennan, Matthew;
- Leahy, Leslie
Publication type:
Article
VGL101 Rescues CSF1R Dysfunction in Human Microglia And Macrophages: Evaluation of In Vitro Trem2 Agonism in Models Of A CSF1R‐Dependent Leukodystrophy.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.061595
By:
- Larson, Kelley C.;
- Gergits, Frederick;
- Tchessalova, Daria;
- Renoux, Abigail;
- Figley, Matthew;
- Fisher, Richard;
- Papapetropoulos, Spyros;
- Mirescu, Christian
Publication type:
Article
Clinical presentation and diagnosis of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: a literature analysis of case studies.
Published in:
Frontiers in Neurology, 2024, p. 1, doi. 10.3389/fneur.2024.1320663
By:
- Papapetropoulos, Spyros;
- Gelfand, Jeffrey M.;
- Konno, Takuya;
- Ikeuchi, Takeshi;
- Pontius, Angela;
- Meier, Andreas;
- Foroutan, Farid;
- Wszolek, Zbigniew K.
Publication type:
Article
Patient Diaries As a Clinical Endpoint in Parkinson's Disease Clinical Trials.
Published in:
CNS Neuroscience & Therapeutics, 2012, v. 18, n. 5, p. 380, doi. 10.1111/j.1755-5949.2011.00253.x
By:
- Papapetropoulos, Spyridon (Spyros)
Publication type:
Article
LANDSCAPE ANALYSIS OF BIOMETRIC MONITORING DEVICES (BMDS) UTILIZED IN ASSESSING COGNITION, SLEEP AND MOBILITY IN ALZHEIMER’S DISEASE AND OTHER AGE-RELATED NEUROLOGICAL DISEASES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1322, doi. 10.1016/j.jalz.2017.06.2029
By:
- Kern, Volker D.;
- Rhodes, Jane;
- Karlin, Daniel R.;
- Fitzer-Attas, Cheryl;
- Ropacki, Michael T.;
- Kaye, Jeffrey;
- Hill, Derek L.;
- Dacks, Penny A.;
- Papapetropoulos, Spyros;
- Vradenburg, George;
- Hudson, Lynn D.;
- Arneric, Stephen P.
Publication type:
Article
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.
Published in:
Scientific Reports, 2016, p. 31652, doi. 10.1038/srep31652
By:
- Garcia-Miralles, Marta;
- Hong, Xin;
- Tan, Liang Juin;
- Caron, Nicholas S.;
- Huang, Yihui;
- To, Xuan Vinh;
- Lin, Rachel Yanping;
- Franciosi, Sonia;
- Papapetropoulos, Spyros;
- Hayardeny, Liat;
- Hayden, Michael R.;
- Chuang, Kai-Hsiang;
- Pouladi, Mahmoud A.
Publication type:
Article
Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development.
Published in:
Frontiers in Neurology, 2022, v. 12, p. 1, doi. 10.3389/fneur.2021.788168
By:
- Papapetropoulos, Spyros;
- Pontius, Angela;
- Finger, Elizabeth;
- Karrenbauer, Virginija;
- Lynch, David S.;
- Brennan, Matthew;
- Zappia, Samantha;
- Koehler, Wolfgang;
- Schoels, Ludger;
- Hayer, Stefanie N.;
- Takuya Konno;
- Takeshi Ikeuchi;
- Lund, Troy;
- Orthmann-Murphy, Jennifer;
- Eichler, Florian;
- Wszolek, Zbigniew K.
Publication type:
Article
Evaluation of D<sub>1</sub>/D<sub>5</sub> Partial Agonist PF-06412562 in Parkinson's Disease following Oral Administration.
Published in:
Neurodegenerative Diseases, 2018, v. 18, n. 5/6, p. 262, doi. 10.1159/000492498
By:
- Papapetropoulos, Spyros;
- Liu, Wenlei;
- Duvvuri, Sridhar;
- Thayer, Kathleen;
- Gray, David L.
Publication type:
Article
Unmet clinical needs in chronic migraine: Rationale for study and design of COMPEL, an open-label, multicenter study of the long-term efficacy, safety, and tolerability of onabotulinumtoxinA for headache prophylaxis in adults with chronic migraine.
Published in:
BMC Neurology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12883-015-0353-x
By:
- Blumenfeld, Andrew M.;
- Aurora, Sheena K.;
- Laranjo, Karen;
- Papapetropoulos, Spyros
Publication type:
Article
Unmet clinical needs in chronic migraine: Rationale for study and design of COMPEL, an open-label, multicenter study of the long-term efficacy, safety, and tolerability of onabotulinumtoxinA for headache prophylaxis in adults with chronic migraine.
Published in:
BMC Neurology, 2015, v. 15, n. 1, p. 100, doi. 10.1186/s12883-015-0353-x
By:
- Blumenfeld, Andrew M.;
- Aurora, Sheena K.;
- Laranjo, Karen;
- Papapetropoulos, Spyros
Publication type:
Article
Unmet clinical needs in chronic migraine: Rationale for study and design of COMPEL, an open-label, multicenter study of the long-term efficacy, safety, and tolerability of onabotulinumtoxinA for headache prophylaxis in adults with chronic migraine.
Published in:
2015
By:
- Blumenfeld, Andrew M;
- Aurora, Sheena K;
- Laranjo, Karen;
- Papapetropoulos, Spyros
Publication type:
journal article
Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects.
Published in:
British Journal of Clinical Pharmacology, 2018, v. 84, n. 10, p. 2422, doi. 10.1111/bcp.13702
By:
- Schneider, Frank;
- Erisson, Lavi;
- Beygi, Hooman;
- Bradbury, Margaret;
- Cohen‐Barak, Orit;
- Grachev, Igor D.;
- Guzy, Serge;
- Loupe, Pippa S.;
- Levi, Micha;
- McDonald, Mirna;
- Savola, Juha‐Matti;
- Papapetropoulos, Spyros;
- Tracewell, William G.;
- Velinova, Maria;
- Spiegelstein, Ofer
Publication type:
Article
Reversal of Bortezomib-Induced Neurotoxicity by Suvecaltamide, a Selective T-Type Ca-Channel Modulator, in Preclinical Models.
Published in:
Cancers, 2021, v. 13, n. 19, p. 5013, doi. 10.3390/cancers13195013
By:
- Meregalli, Cristina;
- Maricich, Yuri;
- Cavaletti, Guido;
- Canta, Annalisa;
- Carozzi, Valentina A.;
- Chiorazzi, Alessia;
- Newbold, Evan;
- Marmiroli, Paola;
- Ceresa, Cecilia;
- Diani, Arthur;
- Papapetropoulos, Spyros;
- Lee, Margaret S.
Publication type:
Article
Psychiatric comorbidities of episodic and chronic migraine.
Published in:
Journal of Neurology, 2013, v. 260, n. 8, p. 1960, doi. 10.1007/s00415-012-6725-x
By:
- Buse, Dawn;
- Silberstein, Stephen;
- Manack, Aubrey;
- Papapetropoulos, Spyros;
- Lipton, Richard
Publication type:
Article
A Phase 2 Proof‐of‐Concept, Randomized, Placebo‐Controlled Trial of CX‐8998 in Essential Tremor.
Published in:
Movement Disorders, 2021, v. 36, n. 8, p. 1944, doi. 10.1002/mds.28584
By:
- Papapetropoulos, Spyros;
- Lee, Margaret S.;
- Versavel, Stacey;
- Newbold, Evan;
- Jinnah, Hyder A.;
- Pahwa, Rajesh;
- Lyons, Kelly E.;
- Elble, Rodger;
- Ondo, William;
- Zesiewicz, Theresa;
- Hedera, Peter;
- Handforth, Adrian;
- Elder, Jenna;
- Versavel, Mark
Publication type:
Article
Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
Published in:
2019
By:
- Johnston, Tom H.;
- Geva, Michal;
- Steiner, Lilach;
- Orbach, Aric;
- Papapetropoulos, Spyros;
- Savola, Juha‐Matti;
- Reynolds, Ian J.;
- Ravenscroft, Paula;
- Hill, Michael;
- Fox, Susan H.;
- Brotchie, Jonathan M.;
- Laufer, Ralph;
- Hayden, Michael R.;
- Savola, Juha-Matti
Publication type:
journal article
Post-stroke Spasticity: Predictors of Early Development and Considerations for Therapeutic Intervention.
Published in:
PM & R: Journal of Injury, Function & Rehabilitation, 2015, v. 7, n. 1, p. 60, doi. 10.1016/j.pmrj.2014.08.946
By:
- Wissel, Jörg;
- Verrier, Molly;
- Simpson, David M.;
- Charles, David;
- Guinto, Pia;
- Papapetropoulos, Spyros;
- Sunnerhagen, Katharina S.
Publication type:
Article
Digital health revolution: is it time for affordable remote monitoring for Parkinson's disease?
Published in:
Frontiers in Neurology, 2015, v. 6, p. 1, doi. 10.3389/fneur.2015.00034
By:
- Papapetropoulos, Spyros;
- Mitsi, Georgia;
- Espay, Alberto J.
Publication type:
Article
Characterizing patient compliance over six months in remote digital trials of Parkinson's and Huntington disease.
Published in:
2018
By:
- Cohen, Shani;
- Waks, Zeev;
- Elm, Jordan J.;
- Gordon, Mark Forrest;
- Grachev, Igor D.;
- Navon-Perry, Leehee;
- Fine, Shai;
- Grossman, Iris;
- Papapetropoulos, Spyros;
- Savola, Juha-Matti
Publication type:
journal article
Biometric Digital Health Technology for Measuring Motor Function in Parkinson's Disease: Results from a Feasibility and Patient Satisfaction Study.
Published in:
Frontiers in Neurology, 2017, p. 1, doi. 10.3389/fneur.2017.00273
By:
- Mitsi, Georgia;
- Mendoza, Enrique Urrea;
- Wissel, Benjamin D.;
- Barbopoulou, Elena;
- Dwivedi, Alok K.;
- Tsoulos, Ioannis;
- Stavrakoudis, Athanassios;
- Espay, Alberto J.;
- Papapetropoulos, Spyros
Publication type:
Article
Biomarkers Associated With Migraine and Their Potential Role in Migraine Management.
Published in:
Headache: The Journal of Head & Face Pain, 2013, v. 53, n. 8, p. 1262, doi. 10.1111/head.12174
By:
- Durham, Paul;
- Papapetropoulos, Spyros
Publication type:
Article

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