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STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy.
Published in:
EMBO Molecular Medicine, 2013, v. 5, n. 4, p. 572, doi. 10.1002/emmm.201201876
By:
- Camporeale, Annalisa;
- Marino, Francesca;
- Papageorgiou, Anna;
- Carai, Paolo;
- Fornero, Sara;
- Fletcher, Steven;
- Page, Brent D. G.;
- Gunning, Patrick;
- Forni, Marco;
- Chiarle, Roberto;
- Morello, Mara;
- Jensen, Ole;
- Levi, Renzo;
- Heymans, Stephane;
- Poli, Valeria
Publication type:
Article
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.
Published in:
Metabolites (2218-1989), 2023, v. 13, n. 2, p. 151, doi. 10.3390/metabo13020151
By:
- Brown, Jennifer I.;
- Wang, Peng;
- Wong, Alan Y. L.;
- Petrova, Boryana;
- Persaud, Rosanne;
- Soukhtehzari, Sepideh;
- Lopez McDonald, Melanie;
- Hanke, Danielle;
- Christensen, Josephine;
- Iliev, Petar;
- Wang, Weiyuan;
- Everton, Daniel K.;
- Williams, Karla C.;
- Frank, David A.;
- Kanarek, Naama;
- Page, Brent D. G.
Publication type:
Article
Dynamic Reprogramming of Signaling Upon Met Inhibition Reveals a Mechanism of Drug Resistance in Gastric Cancer.
Published in:
Science Signaling, 2014, v. 7, n. 322, p. 1, doi. 10.1126/scisignal.2004839
By:
- Lai, Andrea Z.;
- Cory, Sean;
- Hong Zhao;
- Gigoux, Mathieu;
- Monast, Anie;
- Guiot, Marie-Christine;
- Sidong Huang;
- Tofigh, Ali;
- Thompson, Crista;
- Naujokas, Monica;
- Marcus, Victoria A.;
- Bertos, Nicholas;
- Sehat, Bita;
- Perera, Rushika M.;
- Bell, Emily S.;
- Page, Brent D. G.;
- Gunning, Patrick T.;
- Ferri, Lorenzo E.;
- Hallett, Michael;
- Park, Morag
Publication type:
Article
Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Published in:
2019
By:
- Page, Brent D. G.;
- Valerie, Nicholas C. K.;
- Wright, Roni H. G.;
- Wallner, Olov;
- Isaksson, Rebecka;
- Carter, Megan;
- Rudd, Sean G.;
- Loseva, Olga;
- Jemth, Ann-Sofie;
- Almlöf, Ingrid;
- Font-Mateu, Jofre;
- Llona-Minguez, Sabin;
- Baranczewski, Pawel;
- Jeppsson, Fredrik;
- Homan, Evert;
- Almqvist, Helena;
- Axelsson, Hanna;
- Regmi, Shruti;
- Gustavsson, Anna-Lena;
- Lundbäck, Thomas
Publication type:
Correction Notice
Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition.
Published in:
Cancers, 2021, v. 13, n. 14, p. 3464, doi. 10.3390/cancers13143464
By:
- Pons, Miriam;
- Zeyn, Yanira;
- Zahn, Stella;
- Mahendrarajah, Nisintha;
- Page, Brent D. G.;
- Gunning, Patrick T.;
- Moriggl, Richard;
- Brenner, Walburgis;
- Butter, Falk;
- Krämer, Oliver H.
Publication type:
Article
Investigating Protein Binding with the Isothermal Ligand‐induced Resolubilization Assay.
Published in:
ChemBioChem, 2024, v. 25, n. 6, p. 1, doi. 10.1002/cbic.202300773
By:
- Prout‐Holm, Riley A.;
- van Walstijn, Cerissa C.;
- Hitsman, Alana;
- Rowley, Michael J.;
- Olsen, Jonas E.;
- Page, Brent D. G.;
- Frankel, Adam
Publication type:
Article
STAT Protein Thermal Shift Assays to Monitor Protein‐Inhibitor Interactions.
Published in:
ChemBioChem, 2022, v. 23, n. 20, p. 1, doi. 10.1002/cbic.202200039
By:
- Iliev, Petar;
- Hanke, Danielle;
- Page, Brent D. G.
Publication type:
Article
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Published in:
Nature Communications, 2015, v. 6, n. 8, p. 7871, doi. 10.1038/ncomms8871
By:
- Carter, Megan;
- Jemth, Ann-Sofie;
- Hagenkort, Anna;
- Page, Brent D. G.;
- Gustafsson, Robert;
- Griese, Julia J.;
- Gad, Helge;
- Valerie, Nicholas C. K.;
- Desroses, Matthieu;
- Boström, Johan;
- Warpman Berglund, Ulrika;
- Helleday, Thomas;
- Stenmark, Pål
Publication type:
Article
3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.
Published in:
Metallomics, 2014, v. 6, n. 2, p. 249, doi. 10.1039/c3mt00135k
By:
- Telpoukhovskaia, Maria A.;
- Rodríguez-Rodríguez, Cristina;
- Cawthray, Jacqueline F.;
- Scott, Lauren E.;
- Page, Brent D. G.;
- Alí-Torres, Jorge;
- Sodupe, Mariona;
- Bailey, Gwendolyn A.;
- Patrick, Brian O.;
- Orvig, Chris
Publication type:
Article
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-017-02293-7
By:
- Page, Brent D. G.;
- Valerie, Nicholas C. K.;
- Wright, Roni H. G.;
- Wallner, Olov;
- Isaksson, Rebecka;
- Carter, Megan;
- Rudd, Sean G.;
- Loseva, Olga;
- Jemth, Ann-Sofie;
- Almlöf, Ingrid;
- Font-Mateu, Jofre;
- Llona-Minguez, Sabin;
- Baranczewski, Pawel;
- Jeppsson, Fredrik;
- Homan, Evert;
- Almqvist, Helena;
- Axelsson, Hanna;
- Regmi, Shruti;
- Gustavsson, Anna-Lena;
- Lundbäck, Thomas
Publication type:
Article
Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules.
Published in:
ChemMedChem, 2011, v. 6, n. 8, p. 1459, doi. 10.1002/cmdc.201100194
By:
- Fletcher, Steven;
- Page, Brent D. G.;
- Zhang, Xialoei;
- Yue, Peibin;
- Li, Zhi Hua;
- Sharmeen, Sumaiya;
- Singh, Jagdeep;
- Zhao, Wei;
- Schimmer, Aaron D.;
- Trudel, Suzanne;
- Turkson, James;
- Gunning, Patrick T.
Publication type:
Article
Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities.
Published in:
ChemBioChem, 2009, v. 10, n. 12, p. 1959, doi. 10.1002/cbic.200900172
By:
- Fletcher, Steven;
- Singh, Jardeep;
- Zhang, Xiaolei;
- Yue, Peibin;
- Page, Brent D. G.;
- Sharmeen, Sumaiya;
- Shahani, Vijay M.;
- Zhao, Wei;
- Schimmer, Aaron D.;
- Turkson, James;
- Gunning, Patrick T.
Publication type:
Article
Inside Cover: Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities (ChemBioChem 12/2009).
Published in:
ChemBioChem, 2009, v. 10, n. 12, p. 1906, doi. 10.1002/cbic.200990048
By:
- Fletcher, Steven;
- Singh, Jardeephi;
- Zhang, Xiaolei;
- Yue, Peibin;
- Page, Brent D. G.;
- Sharmeen, Sumaiya;
- Shahani, Vijay M.;
- Zhao, Wei;
- Schimmer, Aaron D.;
- Turkson, James;
- Gunning, Patrick T.
Publication type:
Article
Correction: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth.
Published in:
Breast Cancer Research, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13058-024-01814-9
By:
- Qian, Jing;
- Ma, Yanxia;
- Tahaney, William M.;
- Moyer, Cassandra L.;
- Lanier, Amanda;
- Hill, Jamal;
- Coleman, Darian;
- Koupaei, Negar;
- Hilsenbeck, Susan G.;
- Savage, Michelle I.;
- Page, Brent D. G.;
- Mazumdar, Abhijit;
- Brown, Powel H.
Publication type:
Article
The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth.
Published in:
Breast Cancer Research, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13058-024-01778-w
By:
- Qian, Jing;
- Ma, Yanxia;
- Tahaney, William M.;
- Moyer, Cassandra L.;
- Lanier, Amanda;
- Hill, Jamal;
- Coleman, Darian;
- Koupaei, Negar;
- Hilsenbeck, Susan G.;
- Savage, Michelle I.;
- Page, Brent D. G.;
- Mazumdar, Abhijit;
- Brown, Powel H.
Publication type:
Article
Identification of novel small molecules that inhibit STAT3-dependent transcription and function.
Published in:
PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0178844
By:
- Kolosenko, Iryna;
- Yu, Yasmin;
- Busker, Sander;
- Dyczynski, Matheus;
- Palm Apergi, Caroline;
- Tamm, Katja Pokrovskaja;
- Grander, Dan;
- Liu, Jianping;
- Haraldsson, Martin;
- Helleday, Thomas;
- Page, Brent D. G.
Publication type:
Article
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein.
Published in:
Biochemistry & Cell Biology, 2009, v. 87, n. 6, p. 825, doi. 10.1139/O09-044
By:
- Fletcher, Steven;
- Drewry, Joel A.;
- Shahani, Vijay M.;
- Page, Brent D. G.;
- Gunning, Patrick T.
Publication type:
Article

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