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A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.
Published in:
PLoS Biology, 2016, v. 14, n. 1, p. 1, doi. 10.1371/journal.pbio.1002344
By:
- de Jong, Rob N.;
- Beurskens, Frank J.;
- Verploegen, Sandra;
- Strumane, Kristin;
- van Kampen, Muriel D.;
- Voorhorst, Marleen;
- Horstman, Wendy;
- Engelberts, Patrick J.;
- Oostindie, Simone C.;
- Wang, Guanbo;
- Heck, Albert J. R.;
- Schuurman, Janine;
- Parren, Paul W. H. I.
Publication type:
Article
Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers.
Published in:
European Journal of Immunology, 2011, v. 41, n. 8, p. 2436, doi. 10.1002/eji.201041204
By:
- Beum, Paul V.;
- Lindorfer, Margaret A.;
- Peek, Elizabeth M.;
- Stukenberg, P. Todd;
- de Weers, Michel;
- Beurskens, Frank J.;
- Parren, Paul W. H. I.;
- van de Winkel, Jan G. J.;
- Taylor, Ronald P.
Publication type:
Article
Ig A EGFR antibodies mediate tumour killing in vivo.
Published in:
EMBO Molecular Medicine, 2013, v. 5, n. 8, p. 1213, doi. 10.1002/emmm.201201929
By:
- Boross, Peter;
- Lohse, Stefan;
- Nederend, Maaike;
- Jansen, Johannes Hendrik Marco;
- van Tetering, Geert;
- Dechant, Michael;
- Peipp, Matthias;
- Royle, Louise;
- Liew, Li Phing;
- Boon, Louis;
- van Rooijen, Nico;
- Bleeker, Wim K.;
- Parren, Paul W. H. I.;
- van de Winkel, Jan G. J.;
- Valerius, Thomas;
- Leusen, Jeanette H. W.
Publication type:
Article
N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG.
Published in:
Biotechnology Progress, 2009, v. 25, n. 1, p. 244, doi. 10.1002/btpr.92
By:
- van Berkel, Patrick H. C.;
- Gerritsen, Jolanda;
- Perdok, Gerrard;
- Valbjørn, Jesper;
- Vink, Tom;
- van de Winkel, Jan G. J.;
- Parren, Paul W. H. I.
Publication type:
Article
Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.915837
By:
- Saura-Esteller, José;
- de Jong, Milon;
- King, Lisa A.;
- Ensing, Erik;
- Winograd, Benjamin;
- de Gruijl, Tanja D.;
- Parren, Paul W. H. I.;
- van der Vliet, Hans J.
Publication type:
Article
Editorial: Antibody Therapeutics for the Treatment of Filoviral Infection.
Published in:
2022
By:
- Murin, Charles D.;
- Gunn, Bronwyn M.;
- Parren, Paul W. H. I.;
- Kobinger, Gary P.
Publication type:
Editorial
Anti-galactose-?-1,3-galactose IgE from allergic patients does not bind ?-galactosylated glycans on intact therapeutic antibody Fc domains.
Published in:
Nature Biotechnology, 2011, v. 29, n. 7, p. 574, doi. 10.1038/nbt.1912
By:
- van Bueren, Jeroen J Lammerts;
- Rispens, Theo;
- Verploegen, Sandra;
- van der Palen-Merkus, Tjitske;
- Turinsky, Andrei L;
- Stapel, Steven;
- Workman, Lisa J;
- James, Hayley;
- van Berkel, Patrick H C;
- van de Winkel, Jan G J;
- Platts-Mills, Thomas A E;
- Parren, Paul W H I
Publication type:
Article
Reply to Fab-arm exchange.
Published in:
2010
By:
- Labrijn, Aran F.;
- Schuurman, Janine;
- De Winkel, Jan G. J. van;
- Parren, Paul W. H. I.
Publication type:
Letter
Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo.
Published in:
Nature Biotechnology, 2009, v. 27, n. 8, p. 767, doi. 10.1038/nbt.1553
By:
- Labrijn, Aran F.;
- Buijsse, Antonio Ortiz;
- Van den Bremer, Ewald T. J.;
- Verwilligen, Annemiek Y. W.;
- Bleeker, Wim K.;
- Thorpe, Susan J.;
- Killestein, Joep;
- Polman, Chris H.;
- Aalberse, Rob C.;
- Schuurman, Janine;
- Van De Winkel, Jan G. J.;
- Parren, Paul W. H. I.
Publication type:
Article
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques.
Published in:
Nature Medicine, 2009, v. 15, n. 8, p. 951, doi. 10.1038/nm.1974
By:
- Hessell, Ann J.;
- Poignard, Pascal;
- Hunter, Meredith;
- Hangartner, Lars;
- Tehrani, David M.;
- Bleeker, Wim K.;
- Parren, Paul W. H. I.;
- Marx, Preston A.;
- Burton, Dennis R.
Publication type:
Article
Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0039706
By:
- Bangsgaard, Nannie;
- Houtkamp, Mischa;
- Schuurhuis, Danita H.;
- Parren, Paul W. H. I.;
- Baadsgaard, Ole;
- Niessen, Hans W. M.;
- Skov, Lone
Publication type:
Article
A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein.
Published in:
PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0020927
By:
- Sean X. Du;
- Li Xu;
- Wenge Zhang;
- Susan Tang;
- Rebecca I. Boenig;
- Helen Chen;
- Ellaine B. Mariano;
- Michael B. Zwick;
- Paul W. H. I. Parren;
- Dennis R. Burton;
- Terri Wrin;
- Christos J. Petropoulos;
- John A. Ballantyne;
- Michael Chambers;
- Robert G. Whalen
Publication type:
Article
Novel human antibody therapeutics: The age of the Umabs.
Published in:
Biotechnology Journal, 2008, v. 3, n. 9/10, p. 1157, doi. 10.1002/biot.200800110
By:
- Ruuls, Sigrid R.;
- Lammerts van Bueren, Jeroen J.;
- van de Winkel, Jan G. J.;
- Parren, Paul W. H. I.
Publication type:
Article
Characterization of a Fully Human IgG1 Reconstructed from an Anti-AChR Fab.
Published in:
Annals of the New York Academy of Sciences, 2003, v. 998, n. 1, p. 399, doi. 10.1196/annals.1254.050
By:
- STASSEN, MAURICE H. W.;
- MACHIELS, BARBIE M.;
- FOSTIERI, EFROSINI;
- TZARTOS, SOCRATES J.;
- BERRIH-AKNIN, SONIA;
- BOSMANS, EUGÈNE;
- PARREN, PAUL W. H. I.;
- BAETS, MARC H.
Publication type:
Article
Epidermal Growth Factor Receptor as Target for Perioperative Elimination of Circulating Colorectal Cancer Cells.
Published in:
Journal of Oncology, 2022, p. 1, doi. 10.1155/2022/3577928
By:
- Gruijs, Mandy;
- Braster, Rens;
- Overdijk, Marije B.;
- Hellingman, Tessa;
- Verploegen, Sandra;
- Korthouwer, Rianne;
- van der Wilk, Berend J.;
- Parren, Paul W. H. I.;
- van der Vliet, Hans J.;
- Bögels, Marijn;
- van Egmond, Marjolein
Publication type:
Article
Fc receptor but not complement binding is important in antibody protection against HIV.
Published in:
2007
By:
- Hessell, Ann J.;
- Hangartner, Lars;
- Hunter, Meredith;
- Havenith, Carin E. G.;
- Beurskens, Frank J.;
- Bakker, Joost M.;
- Lanigan, Caroline M. S.;
- Landucci, Gary;
- Forthal, Donald N.;
- Parren, Paul W. H. I.;
- Marx, Preston A.;
- Burton, Dennis R.
Publication type:
Letter
Monoclonal antibodies targeting CD38 in hematological malignancies and beyond.
Published in:
Immunological Reviews, 2016, v. 270, n. 1, p. 95, doi. 10.1111/imr.12389
By:
- Donk, Niels W. C. J.;
- Janmaat, Maarten L.;
- Mutis, Tuna;
- Lammerts van Bueren, Jeroen J.;
- Ahmadi, Tahamtan;
- Sasser, A. Kate;
- Lokhorst, Henk M.;
- Parren, Paul W. H. I.
Publication type:
Article
Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1183914
By:
- van der Wulp, Willemijn;
- Gram, Anna M.;
- Bleijlevens, Boris;
- Hagedoorn, Renate S.;
- Araman, Can;
- Kim, Robbert Q.;
- Drijfhout, Jan Wouter;
- Parren, Paul W. H. I.;
- Hibbert, Richard G.;
- Hoeben, Rob C.;
- van Kasteren, Sander I.;
- Schuurman, Janine;
- Ressing, Maaike E.;
- Heemskerk, Mirjam H. M.
Publication type:
Article
Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys.
Published in:
PLoS Pathogens, 2007, v. 3, n. 1, p. 62, doi. 10.1371/journal.ppat.0030009
By:
- Oswald, Wendelien B.;
- Geisbert, Thomas W.;
- Davis, Kelly J.;
- Geisbert, Joan B.;
- Sullivan, Nancy J.;
- Jahrling, Peter B.;
- Parren, Paul W. H. I.;
- Burton, Dennis R.
Publication type:
Article
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Published in:
Nature, 2002, v. 420, n. 6916, p. 678, doi. 10.1038/nature01188
By:
- Kwong, Peter D.;
- Doyle, Michael L.;
- Casper, David J.;
- Cicala, Claudia;
- Leavitt, Stephanie A.;
- Majeed, Shahzad;
- Steenbeke, Tavis D.;
- Venturi, Miro;
- Chaiken, Irwin;
- Fung, Michael;
- Katinger, Hermann;
- Parren, Paul W. I. H.;
- Robinson, James;
- Van Ryk, Donald;
- Wang, Liping;
- Burton, Dennis R.;
- Freire, Ernesto;
- Wyatt, Richard;
- Sodroski, Joseph
Publication type:
Article
Fighting the Ebola virus.
Published in:
Nature, 2000, v. 408, n. 6812, p. 527, doi. 10.1038/35046176
By:
- Burton, Dennis R.;
- Parren, Paul W. H. I.
Publication type:
Article
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies.
Published in:
Blood Cancer Journal, 2020, v. 10, n. 3, p. 1, doi. 10.1038/s41408-020-0292-7
By:
- Oostindie, Simone C.;
- van der Horst, Hilma J.;
- Kil, Laurens P.;
- Strumane, Kristin;
- Overdijk, Marije B.;
- van den Brink, Edward N.;
- van den Brakel, Jeroen H. N.;
- Rademaker, Hendrik J.;
- van Kessel, Berris;
- van den Noort, Juliette;
- Chamuleau, Martine E. D.;
- Mutis, Tuna;
- Lindorfer, Margaret A.;
- Taylor, Ronald P.;
- Schuurman, Janine;
- Parren, Paul W. H. I.;
- Beurskens, Frank J.;
- Breij, Esther C. W.
Publication type:
Article
Celebrating Antibody Therapeutics.
Published in:
PEDS: Protein Engineering, Design & Selection, 2017, v. 30, n. 9, p. 573, doi. 10.1093/protein/gzx053
By:
- PARREN, PAUL W. H. I.;
- HUSTON, JAMES S.
Publication type:
Article
Genetic Vaccination: One-Shot Shopping for Immediate and Sustained Protection.
Published in:
Molecular Therapy, 2008, v. 16, n. 1, p. 6, doi. 10.1038/sj.mt.6300368
By:
- Boot, Elmieke P. J.;
- Parren, Paul W. H. I.
Publication type:
Article
Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor‐specific antibodies.
Published in:
HLA: Immune Response Genetics, 2019, v. 94, n. 5, p. 415, doi. 10.1111/tan.13664
By:
- Kramer, Cynthia S. M.;
- Franke‐van Dijk, Marry E. I.;
- Priddey, Ashley J.;
- Pongrácz, Tamás;
- Gnudi, Elena;
- Car, Helena;
- Karahan, Gonca E.;
- Beelen, Els;
- Zilvold‐van den Oever, Chalana C. C.;
- Rademaker, Hendrik J.;
- Haan, Noortje;
- Wuhrer, Manfred;
- Kosmoliaptsis, Vasilis;
- Parren, Paul W. H. I.;
- Mulder, Arend;
- Roelen, Dave L.;
- Claas, Frans H. J.;
- Heidt, Sebastiaan
Publication type:
Article
Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody.
Published in:
British Journal of Haematology, 2008, v. 140, n. 3, p. 303, doi. 10.1111/j.1365-2141.2007.06916.x
By:
- Bleeker, Wim K.;
- Munk, Martin E.;
- Mackus, Wendy J. M.;
- van den Brakel, Jeroen H. N.;
- Pluyter, Marielle;
- Glennie, Martin J.;
- van de Winkel, Jan G. J.;
- Parren, Paul W. H. I.
Publication type:
Article
Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators.
Published in:
Frontiers in Immunology, 2024, p. 01, doi. 10.3389/fimmu.2024.1288597
By:
- Haiyu Wang;
- van de Bovenkamp, Fleur S.;
- Dijkstra, Douwe J.;
- Abendstein, Leoni;
- Borggreven, Nicole V.;
- Pool, Jos;
- Zuijderduijn, Rob;
- Gstöttner, Christoph;
- Gelderman, Kyra A.;
- Damelang, Timon;
- Vidarsson, Gestur;
- Blom, Anna M.;
- Domínguez-Vega, Elena;
- Parren, Paul W. H. I.;
- Sharp, Thomas H.;
- Trouw, Leendert A.
Publication type:
Article
Controlled Fab-arm exchange for the generation of stable bispecific IgG1.
Published in:
Nature Protocols, 2014, v. 9, n. 10, p. 2450, doi. 10.1038/nprot.2014.169
By:
- Labrijn, Aran F.;
- Meesters, Joyce I.;
- Priem, Patrick;
- de Jong, Rob N.;
- van den Bremer, Ewald T. J.;
- van Kampen, Muriel D.;
- Gerritsen, Arnout F.;
- Schuurman, Janine;
- Parren, Paul W. H. I.
Publication type:
Article
Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).
Published in:
Cancer Science, 2011, v. 102, n. 10, p. 1761, doi. 10.1111/j.1349-7006.2011.02019.x
By:
- Katja Klausz;
- Berger, Sven;
- Lammerts van Bueren, Jeroen J.;
- Derer, Stefanie;
- Lohse, Stefan;
- Dechant, Michael;
- van de Winkel, Jan G. J.;
- Peipp, Matthias;
- Parren, Paul W. H. I.;
- Valerius, Thomas
Publication type:
Article

Found: 29

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca<sup>2+</sup> influx and induces streamers.

Ig A EGFR antibodies mediate tumour killing in vivo.

N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG.

Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future.

Editorial: Antibody Therapeutics for the Treatment of Filoviral Infection.

Anti-galactose-?-1,3-galactose IgE from allergic patients does not bind ?-galactosylated glycans on intact therapeutic antibody Fc domains.

Reply to Fab-arm exchange.

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo.

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques.

Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor.

A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein.

Novel human antibody therapeutics: The age of the Umabs.

Characterization of a Fully Human IgG1 Reconstructed from an Anti-AChR F<sub>ab</sub>.

Epidermal Growth Factor Receptor as Target for Perioperative Elimination of Circulating Colorectal Cancer Cells.

Fc receptor but not complement binding is important in antibody protection against HIV.

Monoclonal antibodies targeting CD38 in hematological malignancies and beyond.

Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells.

Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys.

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.

Fighting the Ebola virus.

DuoHexaBody-CD37<sup>®</sup>, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies.

Celebrating Antibody Therapeutics.

Genetic Vaccination: One-Shot Shopping for Immediate and Sustained Protection.

Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor‐specific antibodies.

Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody.

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators.

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).