Found: 17
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GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.
- Published in:
- Clinical Hemorheology & Microcirculation, 2018, v. 70, n. 1, p. 95, doi. 10.3233/CH-170340
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- Article
The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia.
- Published in:
- Physiological Reports, 2019, v. 7, n. 6, p. N.PAG, doi. 10.14814/phy2.14027
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- Article
Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis.
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- Physiological Reports, 2016, v. 4, n. 17, p. n/a, doi. 10.14814/phy2.12965
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- Article
GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro.
- Published in:
- Hematology Reports, 2018, v. 10, n. 2, p. 1, doi. 10.4081/hr.2018.7419
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- Article
GBT440 inhibits sickling of sickle cell trait blood under in vitro conditions mimicking strenuous exercise.
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- Hematology Reports, 2016, v. 8, n. 3, p. 37, doi. 10.4081/hr.2016.6637
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- Article
GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model.
- Published in:
- British Journal of Haematology, 2023, v. 202, n. 1, p. 173, doi. 10.1111/bjh.18771
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- Article
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
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- British Journal of Haematology, 2016, v. 175, n. 1, p. 141, doi. 10.1111/bjh.14214
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- Article
A single amino-acid difference confers major pharmacological variation between human and rodent...
- Published in:
- Nature, 1992, v. 360, n. 6400, p. 161, doi. 10.1038/360161a0
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- Article
A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke.
- Published in:
- PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069233
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- Article
Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease.
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- British Journal of Clinical Pharmacology, 2019, v. 85, n. 6, p. 1290, doi. 10.1111/bcp.13896
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- Article
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.
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- Brain: A Journal of Neurology, 2011, v. 134, n. 3, p. 732, doi. 10.1093/brain/awq367
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- Article
Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers.
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- Drug Design, Development & Therapy, 2018, v. 12, p. 1599, doi. 10.2147/DDDT.S157570
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- Article
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia.
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- European Journal of Neuroscience, 2008, v. 27, n. 9, p. 2444, doi. 10.1111/j.1460-9568.2008.06209.x
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- Article
Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP).
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- European Journal of Neuroscience, 2006, v. 23, n. 11, p. 2847, doi. 10.1111/j.1460-9568.2006.04837.x
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- Article
The Third Intracellular Loop of the 5-Hydroxytryptamine<sub>2A</sub> Receptor Determines Effector Coupling Specificity.
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- Journal of Neurochemistry, 1995, v. 64, n. 4, p. 1440, doi. 10.1046/j.1471-4159.1995.64041440.x
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- Article
Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model.
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- Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.742784
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- Article
Anti-Migraine Drug Interactions with Cloned Human 5-Hydroxytryptamine <sub>1</sub> , Receptor Subtypes.
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- Headache: The Journal of Head & Face Pain, 1993, v. 33, n. 7, p. 347, doi. 10.1111/j.1526-4610.1993.hed3307347.x
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- Article