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Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 8, p. 1530, doi. 10.3390/pharmaceutics14081530
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- Article
A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain.
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- Pharmaceutical Research, 2016, v. 33, n. 5, p. 1093, doi. 10.1007/s11095-015-1853-5
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- Article
Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies.
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- AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0349-3
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- Article
Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models.
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- AAPS Journal, 2012, v. 14, n. 2, p. 176, doi. 10.1208/s12248-012-9327-8
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- Article
Optimal Design in Population Kinetic Experiments by Set-Valued Methods.
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- AAPS Journal, 2011, v. 13, n. 4, p. 495, doi. 10.1208/s12248-011-9291-8
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- Article
Properties of the full random‐effect modeling approach with missing covariate data.
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- Statistics in Medicine, 2024, v. 43, n. 5, p. 935, doi. 10.1002/sim.9979
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- Publication type:
- Article
Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism--the Hokusai-VTE phase 3 study.
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- British Journal of Clinical Pharmacology, 2015, v. 80, n. 6, p. 1374, doi. 10.1111/bcp.12727
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- Article
Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics studies.
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- British Journal of Clinical Pharmacology, 2015, v. 79, n. 1, p. 6, doi. 10.1111/bcp.12352
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- Article
Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials.
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- Orphanet Journal of Rare Diseases, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13023-023-02990-1
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- Article
Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors.
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- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 498, doi. 10.1002/cpt.3172
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- Article
Exposure-response analyses for the MET inhibitor tepotinib including patients in the pivotal VISION trial: support for dosage recommendations.
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- 2022
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- Publication type:
- journal article
Full random effects models (FREM): A practical usage guide.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 8, p. 1297, doi. 10.1002/psp4.13190
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- Article
Using forest plots to interpret covariate effects in pharmacometric models.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 5, p. 743, doi. 10.1002/psp4.13116
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- Publication type:
- Article
A quantitative approach to the choice of number of samples for percentile estimation in bootstrap and visual predictive check analyses.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 6, p. 673, doi. 10.1002/psp4.12790
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- Publication type:
- Article
An introduction to the full random effects model.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 2, p. 149, doi. 10.1002/psp4.12741
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- Publication type:
- Article
Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin.
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- Journal of Clinical Pharmacology, 2012, v. 52, n. 3, p. 347, doi. 10.1177/0091270010397731
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- Article
Ethically Attractive Dose-Finding Designs for Drugs With a Narrow Therapeutic Index.
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- Journal of Clinical Pharmacology, 2012, v. 52, n. 1, p. 29, doi. 10.1177/0091270010390041
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- Publication type:
- Article
Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2017, v. 44, n. 4, p. 325, doi. 10.1007/s10928-017-9522-4
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- Publication type:
- Article
Inter occasion variability in individual optimal design.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2015, v. 42, n. 6, p. 735, doi. 10.1007/s10928-015-9449-6
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- Publication type:
- Article
The effect of Fisher information matrix approximation methods in population optimal design calculations.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2016, v. 43, n. 6, p. 609, doi. 10.1007/s10928-016-9499-4
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- Publication type:
- Article
Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2014, v. 41, n. 6, p. 639, doi. 10.1007/s10928-014-9391-z
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- Publication type:
- Article
Optimizing disease progression study designs for drug effect discrimination.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2013, v. 40, n. 5, p. 587, doi. 10.1007/s10928-013-9331-3
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- Publication type:
- Article
Serial correlation in optimal design for nonlinear mixed effects models.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2012, v. 39, n. 3, p. 239, doi. 10.1007/s10928-012-9245-5
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- Publication type:
- Article
Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2009, v. 36, n. 3, p. 281, doi. 10.1007/s10928-009-9123-y
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- Publication type:
- Article
Simultaneous optimal experimental design on dose and sample times.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2009, v. 36, n. 2, p. 125, doi. 10.1007/s10928-009-9114-z
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- Publication type:
- Article
The lassoâa novel method for predictive covariate model building in nonlinear mixed effects models.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2007, v. 34, n. 4, p. 485, doi. 10.1007/s10928-007-9057-1
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- Publication type:
- Article
Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction.
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- Journal of Clinical Pharmacology, 2017, v. 57, n. 5, p. 573, doi. 10.1002/jcph.839
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- Publication type:
- Article