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Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
Published in:
Nature Reviews Drug Discovery, 2014, v. 13, n. 9, p. 692, doi. 10.1038/nrd4308
By:
- Conn, P. Jeffrey;
- Lindsley, Craig W.;
- Meiler, Jens;
- Niswender, Colleen M.
Publication type:
Article
Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.076916
By:
- Coleman, Jeremy S;
- Capstick, Rory A;
- Rathnayake, Upendra A;
- Parr, Lauren;
- Chang, Sichen;
- Thompson, Analisa D;
- Qi, Aidong;
- Niswender, Colleen M;
- Boutaud, Olivier;
- Plumley, Hyekyung;
- Jones, Carrie K;
- Engers, Darren;
- Lindsley, Craig W
Publication type:
Article
RNA-editing of the 5-HT2C receptor alters agonist-receptor-effector coupling specificity.
Published in:
British Journal of Pharmacology, 2001, v. 134, n. 2, p. 386, doi. 10.1038/sj.bjp.0704255
By:
- Berg, Kelly A;
- Cropper, Jodie D;
- Niswender, Colleen M;
- Sanders-Bush, Elaine;
- Emeson, Ronald B;
- Clarke, William P
Publication type:
Article
Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.
Published in:
Frontiers in Molecular Neuroscience, 2018, p. N.PAG, doi. 10.3389/fnmol.2018.00387
By:
- Fisher, Nicole M.;
- Seto, Mabel;
- Lindsley, Craig W.;
- Niswender, Colleen M.
Publication type:
Article
Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators.
Published in:
Journal of Molecular Modeling, 2012, v. 18, n. 9, p. 4437, doi. 10.1007/s00894-012-1441-0
By:
- Mueller, Ralf;
- Dawson, Eric;
- Niswender, Colleen;
- Butkiewicz, Mariusz;
- Hopkins, Corey;
- Weaver, C.;
- Lindsley, Craig;
- Conn, P.;
- Meiler, Jens
Publication type:
Article
Discovery of a highly M5-preferring muscarinic acetylcholine receptor allosteric potentiator
Published in:
2009
By:
- Bridges, Thomas M.;
- Marlo, Joy E.;
- Niswender, Colleen M.;
- Gentry, Patrick R.;
- Weaver, C. David;
- Conn, P. Jeffrey;
- Lindsley, Craig W.
Publication type:
Abstract
Cre recombinase‐dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.
Published in:
Genesis: The Journal of Genetics & Development, 2005, v. 43, n. 3, p. 109, doi. 10.1002/gene.20159
By:
- Colleen M. Niswender;
- Brandon S. Willis;
- Angela Wallen;
- Ian R. Sweet;
- Thomas L. Jetton;
- Brian R. Thompson;
- Chaodong Wu;
- Alex J. Lange;
- G. Stanley McKnight
Publication type:
Article
Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model.
Published in:
Genes, Brain & Behavior, 2022, v. 21, n. 1, p. 1, doi. 10.1111/gbb.12752
By:
- Vermudez, Sheryl Anne D.;
- Gogliotti, Rocco G.;
- Arthur, Bright;
- Buch, Aditi;
- Morales, Clarissa;
- Moxley, Yuta;
- Rajpal, Hemangi;
- Conn, P. Jeffrey;
- Niswender, Colleen M.
Publication type:
Article
Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders.
Published in:
Genes, Brain & Behavior, 2020, v. 19, n. 7, p. 1, doi. 10.1111/gbb.12654
By:
- Fisher, Nicole M.;
- Gould, Robert W.;
- Gogliotti, Rocco G.;
- McDonald, Annalise J.;
- Badivuku, Hana;
- Chennareddy, Susmita;
- Buch, Aditi B.;
- Moore, Annah M.;
- Jenkins, Matthew T.;
- Robb, W. Hudson;
- Lindsley, Craig W.;
- Jones, Carrie K.;
- Conn, P. Jeffrey;
- Niswender, Colleen M.
Publication type:
Article
M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.
Published in:
Scientific Reports, 2015, v. 5, n. 1, p. 17555, doi. 10.1038/srep17555
By:
- Garcia, Raphael Caio Tamborelli;
- Dati, Livia Mendonça Munhoz;
- Torres, Larissa Helena;
- da Silva, Mariana Aguilera Alencar;
- Udo, Mariana Sayuri Berto;
- Abdalla, Fernando Maurício Francis;
- da Costa, José Luiz;
- Gorjão, Renata;
- Afeche, Solange Castro;
- Yonamine, Mauricio;
- Niswender, Colleen M.;
- Conn, P. Jeffrey;
- Camarini, Rosana;
- Sandoval, Maria Regina Lopes;
- Marcourakis, Tania
Publication type:
Article
Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice.
Published in:
PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018772
By:
- Willis, Brandon S.;
- Niswender, Colleen M.;
- Su, Thomas;
- Amieux, Paul S.;
- McKnight, G. Stanley
Publication type:
Article
Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network.
Published in:
Frontiers in Neural Circuits, 2016, p. 1, doi. 10.3389/fncir.2016.00031
By:
- Tassin, Valériane;
- Girard, Benoît;
- Chotte, Apolline;
- Fontanaud, Pierre;
- Rigault, Delphine;
- Kalinichev, Mikhail;
- Perroy, Julie;
- Acher, Francine;
- Fagni, Laurent;
- Bertaso, Federica;
- Polleux, Franck;
- Fioravante, Diasynou;
- Niswender, Colleen
Publication type:
Article
Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles.
Published in:
Neuropsychopharmacology, 2015, v. 40, n. 3, p. 755, doi. 10.1038/npp.2014.245
By:
- Rook, Jerri M;
- Tantawy, Mohammed N;
- Ansari, Mohammad S;
- Felts, Andrew S;
- Stauffer, Shaun R;
- Emmitte, Kyle A;
- Kessler, Robert M;
- Niswender, Colleen M;
- Daniels, J Scott;
- Jones, Carrie K;
- Lindsley, Craig W;
- Conn, P Jeffrey
Publication type:
Article
Development of Novel M4 Muscarinic Acetylcholine Receptor Antagonists for the Treatment of Movement Disorders.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.L8009
By:
- Rook, Jerri;
- Bender, Aaron;
- Dickerson, Jonathan;
- Foster, Daniel;
- Rodriguez, Alice;
- Niswender, Colleen;
- Hess, Ellen;
- Conn, Jeff;
- Lindsley, Craig
Publication type:
Article
Mechanisms of Orthosteric Agonist and Allosteric Modulator Activity at mGlu7.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0R397
By:
- Lei, Xia;
- Rodriguez, Alice;
- Niswender, Colleen
Publication type:
Article
Impact of MeCP2 Overexpression on Myelination Defects Found in Pitt‐Hopkins Syndrome Model Mice.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4772
By:
- Freitas, Geanne A.;
- Vermudez, Sheryl A. D.;
- Gogliotti, Rocco G.;
- Niswender, Colleen M.
Publication type:
Article
Phenotypic profiling of mGlu7 overexpressing mice and its implications for neurodevelopmental disorders such as Rett syndrome.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0R517
By:
- Buch, Aditi;
- Fisher, Nicole;
- Frietas, Geanne;
- Vermudez, Sheryl;
- Weiss, Kelly;
- Gogliotti, Rocco;
- Niswender, Colleen
Publication type:
Article
Effects of the M4 muscarinic receptor positive allosteric modulator VU0467154 on cognition and pyramidal cell firing properties in layer V of the mPFC (845.9).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.845.9
By:
- Grannan, Michael;
- Bubser, Michael;
- Bridges, Thomas;
- Gould, Robert;
- Dencker Thorbek, Ditte;
- Daniels, J;
- Noetzel, Meredith;
- Niswender, Colleen;
- Duggan, Mark;
- Brandon, Nicholas;
- Dunlop, John;
- Wood, Michael;
- Wess, Jurgen;
- Lindsley, Craig;
- Conn, P;
- Jones, Carrie
Publication type:
Article
mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.
Published in:
Science Translational Medicine, 2017, v. 9, n. 403, p. 1, doi. 10.1126/scitranslmed.aai7459
By:
- Gogliotti, Rocco G.;
- Senter, Rebecca K.;
- Fisher, Nicole M.;
- Adams, Jeffrey;
- Zamorano, Rocio;
- Walker, Adam G.;
- Blobaum, Anna L.;
- Engers, Darren W.;
- Hopkin, Corey R.;
- Daniels, J. Scott;
- Jones, Carrie K.;
- Lindsley, Craig W.;
- Zixiu Xiang;
- Conn, P. Jeffrey;
- Niswender, Colleen M.
Publication type:
Article
When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.
Published in:
Assay & Drug Development Technologies, 2017, v. 15, n. 8, p. 354, doi. 10.1089/adt.2017.821
By:
- Pulley, Jill M.;
- Jerome, Rebecca N.;
- Zaleski, Nicole M.;
- Shirey-Rice, Jana K.;
- Pruijssers, Andrea J.;
- Lavieri, Robert R.;
- Chettiar, Somsundaram N.;
- Naylor, Helen M.;
- Aronoff, David M.;
- Edwards, David A.;
- Niswender, Colleen M.;
- Dugan, Laura L.;
- Crofford, Leslie J.;
- Bernard, Gordon R.;
- Holroyd, Kenneth J.
Publication type:
Article
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.
Published in:
Assay & Drug Development Technologies, 2017, v. 15, n. 3, p. 113, doi. 10.1089/adt.2016.772
By:
- Pulley, Jill M.;
- Shirey-Rice, Jana K.;
- Lavieri, Robert R.;
- Jerome, Rebecca N.;
- Zaleski, Nicole M.;
- Aronoff, David M.;
- Bastarache, Lisa;
- Niu, Xinnan;
- Holroyd, Kenneth J.;
- Roden, Dan M.;
- Skaar, Eric P.;
- Niswender, Colleen M.;
- Marnett, Lawrence J.;
- Lindsley, Craig W.;
- Ekstrom, Leeland B.;
- Bentley, Alan R.;
- Bernard, Gordon R.;
- Hong, Charles C.;
- Denny, Joshua C.
Publication type:
Article
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 10, p. 1990, doi. 10.1093/hmg/ddw074
By:
- Gogliotti, Rocco G.;
- Senter, Rebecca K.;
- Rook, Jerri M.;
- Ghoshal, Ayan;
- Zamorano, Rocio;
- Malosh, Chrysa;
- Stauffer, Shaun R.;
- Bridges, Thomas M.;
- Bartolome, Jose M.;
- Daniels, J. Scott;
- Jones, Carrie K.;
- Lindsley, Craig W.;
- Conn, P. Jeffrey;
- Niswender, Colleen M.
Publication type:
Article
Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.
Published in:
Cerebral Cortex, 2018, v. 28, n. 12, p. 4291, doi. 10.1093/cercor/bhx282
By:
- Stansley, Branden J;
- Fisher, Nicole M;
- Gogliotti, Rocco G;
- Lindsley, Craig W;
- Conn, P Jeffrey;
- Niswender, Colleen M
Publication type:
Article
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers.
Published in:
Science Signaling, 2021, v. 14, n. 677, p. 1, doi. 10.1126/scisignal.abd2319
By:
- Xiang, Zixiu;
- Lv, Xiaohui;
- Lin, Xin;
- O'Brien, Daniel E.;
- Altman, Molly K.;
- Lindsley, Craig W.;
- Javitch, Jonathan A.;
- Niswender, Colleen M.;
- Conn, P. Jeffrey
Publication type:
Article
Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity.
Published in:
Science Signaling, 2019, v. 12, n. 610, p. 1, doi. 10.1126/scisignal.aax2057
By:
- Moran, Sean P.;
- Xiang, Zixiu;
- Doyle, Catherine A.;
- Maksymetz, James;
- Lv, Xiaohui;
- Faltin, Sehr;
- Fisher, Nicole M.;
- Niswender, Colleen M.;
- Rook, Jerri M.;
- Lindsley, Craig W.;
- Conn, P. Jeffrey
Publication type:
Article
The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia.
Published in:
Journal of NeuroImmune Pharmacology, 2016, v. 11, n. 2, p. 231, doi. 10.1007/s11481-016-9655-z
By:
- Ponnazhagan, Ranjani;
- Harms, Ashley;
- Thome, Aaron;
- Jurkuvenaite, Asta;
- Gogliotti, Rocco;
- Niswender, Colleen;
- Conn, P.;
- Standaert, David
Publication type:
Article
Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52822-4
By:
- Lin, Xin;
- Provasi, Davide;
- Niswender, Colleen M.;
- Asher, Wesley B.;
- Javitch, Jonathan A.
Publication type:
Article
Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements.
Published in:
Pigment Cell & Melanoma Research, 2008, v. 21, n. 1, p. 63, doi. 10.1111/j.1755-148X.2007.00425.x
By:
- Alizadeh, Azita;
- Fitch, Karen R.;
- Niswender, Colleen M.;
- McKnight, G. Stanley;
- Barsh, Gregory S.
Publication type:
Article
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe.
Published in:
ChemMedChem, 2014, v. 9, n. 8, p. 1677, doi. 10.1002/cmdc.201402051
By:
- Gentry, Patrick R.;
- Kokubo, Masaya;
- Bridges, Thomas M.;
- Cho, Hyekyung P.;
- Smith, Emery;
- Chase, Peter;
- Hodder, Peter S.;
- Utley, Thomas J.;
- Rajapakse, Anuruddha;
- Byers, Frank;
- Niswender, Colleen M.;
- Morrison, Ryan D.;
- Daniels, J. Scott;
- Wood, Michael R.;
- Conn, P. Jeffrey;
- Lindsley, Craig W.
Publication type:
Article
Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 406, doi. 10.1002/cmdc.201100510
By:
- Mueller, Ralf;
- Dawson, Eric S.;
- Meiler, Jens;
- Rodriguez, Alice L.;
- Chauder, Brian A.;
- Bates, Brittney S.;
- Felts, Andrew S.;
- Lamb, Jeffrey P.;
- Menon, Usha N.;
- Jadhav, Sataywan B.;
- Kane, Alexander S.;
- Jones, Carrie K.;
- Gregory, Karen J.;
- Niswender, Colleen M.;
- Conn, P. Jeffrey;
- Olsen, Christopher M.;
- Winder, Danny G.;
- Emmitte, Kyle A.;
- Lindsley, Craig W.
Publication type:
Article
Serotonin 5-HT 2C Receptor RNA Editing Alters Receptor Basal Activity: Implications for Serotonergic Signal Transduction.
Published in:
Journal of Neurochemistry, 1999, v. 73, n. 4, p. 1711, doi. 10.1046/j.1471-4159.1999.731711.x
By:
- Herrick-Davis, Katharine;
- Grinde, Ellinor;
- Niswender, Colleen M.
Publication type:
Article
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
Published in:
Nature Chemical Biology, 2008, v. 4, n. 1, p. 42, doi. 10.1038/nchembio.2007.55
By:
- Shirey, Jana K;
- Zixiu Xiang;
- Orton, Darren;
- Brady, Ashley E;
- Johnson, Kari A;
- Williams, Richard;
- Ayala, Jennifer E;
- Rodriguez, Alice L;
- Wess, Jürgen;
- Weaver, David;
- Niswender, Colleen M;
- Conn, P Jeffrey
Publication type:
Article
Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SCCA1 Synapses in the Hippocampus.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 19, p. 7600, doi. 10.1523/JNEUROSCI.4543-14.2015
By:
- Klar, Rebecca;
- Walker, Adam G.;
- Ghose, Dipanwita;
- Grueter, Brad A.;
- Engers, Darren W.;
- Hopkins, Corey R.;
- Lindsley, Craig W.;
- Zixiu Xiang;
- Conn, P. Jeffrey;
- Niswender, Colleen M.
Publication type:
Article
M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location.
Published in:
Journal of Neuroscience, 2014, v. 34, n. 9, p. 3253, doi. 10.1523/JNEUROSCI.4896-13.2014
By:
- Foster, Daniel J.;
- Gentry, Patrick R.;
- Lizardi-Ortiz, Jose E.;
- Bridges, Thomas M.;
- Wood, Michael R.;
- Niswender, Colleen M.;
- Sulzer, David;
- Lindsley, Craig W.;
- Zixiu Xiang;
- Conn, P. Jeffrey
Publication type:
Article
Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS.
Published in:
Journal of Neuroscience, 2014, v. 34, n. 1, p. 79, doi. 10.1523/JNEUROSCI.1129-13.2014
By:
- Shen Yin;
- Noetzel, Meredith J.;
- Johnson, Kari A.;
- Zamorano, Rocio;
- Jalan-Sakrikar, Nidhi;
- Gregory, Karen J.;
- Conn, P. Jeffrey;
- Niswender, Colleen M.
Publication type:
Article
Novel Allosteric Agonists of M1 Muscarinic Acetylcholine Receptors Induce Brain Region-Specific Responses That Correspond with Behavioral Effects in Animal Models.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 25, p. 8532, doi. 10.1523/JNEUROSCI.0337-12.2012
By:
- Digby, Gregory J.;
- Noetzel, Meredith J.;
- Bubser, Michael;
- Utley, Thomas J.;
- Walker, Adam G.;
- Byun, Nellie E.;
- Lebois, Evan P.;
- Xiang, Zixiu;
- Sheffler, Douglas J.;
- Cho, Hyekyung P.;
- Davis, Albert A.;
- Nemirovsky, Natali E.;
- Mennenga, Sarah E.;
- Camp, Bryan W.;
- Bimonte-Nelson, Heather A.;
- Bode, Jacob;
- Italiano, Kimberly;
- Morrison, Ryan;
- Daniels, J. Scott;
- Niswender, Colleen M.
Publication type:
Article

Found: 36

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.

Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer's Disease.

RNA-editing of the 5-HT<sub>2C</sub> receptor alters agonist-receptor-effector coupling specificity.

Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.

Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators.

Discovery of a highly M5-preferring muscarinic acetylcholine receptor allosteric potentiator

Cre recombinase‐dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model.

Phenotypic profiling of mGlu<sub>7</sub> knockout mice reveals new implications for neurodevelopmental disorders.

M<sub>1</sub> and M<sub>3</sub> muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice.

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network.

Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles.

Development of Novel M4 Muscarinic Acetylcholine Receptor Antagonists for the Treatment of Movement Disorders.

Mechanisms of Orthosteric Agonist and Allosteric Modulator Activity at mGlu<sub>7</sub>.

Impact of MeCP2 Overexpression on Myelination Defects Found in Pitt‐Hopkins Syndrome Model Mice.

Phenotypic profiling of mGlu<sub>7</sub> overexpressing mice and its implications for neurodevelopmental disorders such as Rett syndrome.

Effects of the M4 muscarinic receptor positive allosteric modulator VU0467154 on cognition and pyramidal cell firing properties in layer V of the mPFC (845.9).

mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

mGlu<sub>5</sub> positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.

Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu<sub>2</sub>/mGlu<sub>4</sub> receptor heterodimers.

Biased M<sub>1</sub> receptor–positive allosteric modulators reveal role of phospholipase D in M<sub>1</sub>-dependent rodent cortical plasticity.

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia.

Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer.

Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements.

Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M<sub>5</sub>-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe.

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.

Serotonin 5-HT 2C Receptor RNA Editing Alters Receptor Basal Activity: Implications for Serotonergic Signal Transduction.

An allosteric potentiator of M<sub>4</sub> mAChR modulates hippocampal synaptic transmission.

Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SCCA1 Synapses in the Hippocampus.

M<sub>5</sub> Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location.

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS.

Novel Allosteric Agonists of M<sub>1</sub> Muscarinic Acetylcholine Receptors Induce Brain Region-Specific Responses That Correspond with Behavioral Effects in Animal Models.