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Possible anaphylactic reaction to abciximab.
Published in:
Catheterization & Cardiovascular Interventions, 1999, v. 48, n. 1, p. 71, doi. 10.1002/(SICI)1522-726X(199909)48:1<71::AID-CCD14>3.0.CO;2-2
By:
- Guzzo, Joseph A.;
- Nichols, Timothy C.
Publication type:
Article
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector.
Published in:
Nature Medicine, 1999, v. 5, n. 1, p. 56, doi. 10.1038/4743
By:
- Herzog, Roland W.;
- Yang, Edmund Y.;
- Couto, Linda B.;
- Hagstrom, J. Nathan;
- Elwell, Dan;
- Fields, Paul A.;
- Burton, Melissa;
- Bellinger, Dwight A.;
- Read, Marjorie S.;
- Brinkhous, Kenneth M.;
- Podsakoff, Gregory M.;
- Nichols, Timothy C.;
- Kurtzman, Gary J.;
- High, Katherine A.
Publication type:
Article
Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11635, doi. 10.3390/ijms231911635
By:
- Taylor, James B.;
- Malone-Povolny, Maggie J.;
- Merricks, Elizabeth P.;
- Wimsey, Lauren E.;
- Soliman, Daniel;
- Nichols, Timothy C.;
- Wallet, Shannon M.;
- Maile, Robert;
- Schoenfisch, Mark H.
Publication type:
Article
γ-Glutamyl transpeptidase is up-regulated on memory T lymphocytes.
Published in:
International Immunology, 1999, v. 11, n. 11, p. 1791, doi. 10.1093/intimm/11.11.1791
By:
- Karp, David R.;
- Carlisle, Margaret L.;
- Mobley, Angela B.;
- Nichols, Timothy C.;
- Oppenheimer-Marks, Nancy;
- Brezinschek, Ruth I.;
- Holers, V. Michael
Publication type:
Article
Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies.
Published in:
Thrombosis, 2010, p. 1, doi. 10.1155/2010/461238
By:
- Nichols, Timothy C.;
- Bellinger, Dwight A.;
- Merricks, Elizabeth P.;
- Raymer, Robin A.;
- Kloos, Mark T.;
- DeFriess, Natalie;
- Ragni, Margaret V.;
- Griggs, Thomas R.
Publication type:
Article
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.
Published in:
Nature Biotechnology, 2021, v. 39, n. 1, p. 47, doi. 10.1038/s41587-020-0741-7
By:
- Nguyen, Giang N.;
- Everett, John K.;
- Kafle, Samita;
- Roche, Aoife M.;
- Raymond, Hayley E.;
- Leiby, Jacob;
- Wood, Christian;
- Assenmacher, Charles-Antoine;
- Merricks, Elizabeth P.;
- Long, C. Tyler;
- Kazazian, Haig H.;
- Nichols, Timothy C.;
- Bushman, Frederic D.;
- Sabatino, Denise E.
Publication type:
Article
Nuclear factor-kappaB activation in endothelium by Chlamydia pneumoniae without active infection.
Published in:
2003
By:
- Baer, Jefferson T;
- Du Laney, Tracey V;
- Wyrick, Priscilla B;
- McCain, Arlene S;
- Fischer, Thomas A;
- Merricks, Elizabeth P;
- Baldwin, Albert S;
- Nichols, Timothy C
Publication type:
journal article
Nuclear Factor--... B Activation in Endothelium by Chlamydia pneumoniae without Active Infection.
Published in:
2003
By:
- Baer, Jefferson T.;
- Dv Laney, Tracey V.;
- Wyrick, Priscilla B.;
- McCain, Arlene S.;
- Fischer, Thomas A.;
- Merricks, Elizabeth R.;
- Baldwin, Albert S.;
- Nichols, Timothy C.
Publication type:
Report
Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog.
Published in:
Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2022.815317
By:
- Shao, Wenwei;
- Sun, Junjiang;
- Chen, Xiaojing;
- Dobbins, Amanda;
- Merricks, Elizabeth P.;
- Samulski, R. Jude;
- Nichols, Timothy C.;
- Li, Chengwen
Publication type:
Article
Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132302
By:
- Nichols, Timothy C.;
- Merricks, Elizabeth P.;
- Bellinger, Dwight A.;
- Raymer, Robin A.;
- Yu, Jing;
- Lam, Diana;
- Koch, Gary G.;
- Jr.Busby, Walker H.;
- Clemmons, David R.
Publication type:
Article
Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs.
Published in:
PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0093457
By:
- Davis, Bryan T.;
- Wang, Xiao-Jun;
- Rohret, Judy A.;
- Struzynski, Jason T.;
- Merricks, Elizabeth P.;
- Bellinger, Dwight A.;
- Rohret, Frank A.;
- Nichols, Timothy C.;
- Rogers, Christopher S.
Publication type:
Article
Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.
Published in:
PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0240896
By:
- Nichols, Timothy C.;
- Levy, Howard;
- Merricks, Elizabeth P.;
- Raymer, Robin A.;
- Lee, Martin L.
Publication type:
Article
Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4-driven transcriptional state.
Published in:
Molecular Oncology, 2022, v. 16, n. 6, p. 1309, doi. 10.1002/1878-0261.13124
By:
- Wen Yan;
- Chi-Yeh Chung;
- Tao Xie;
- Ozeck, Mark;
- Nichols, Timothy C.;
- Frey, Jessica;
- Udyavar, Akshata R.;
- Sharma, Shikhar;
- Paul, Thomas A.
Publication type:
Article
The design and testing of a dual fiber textile matrix for accelerating surface hemostasis.
Published in:
Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2009, v. 91B, n. 1, p. 381, doi. 10.1002/jbm.b.31413
By:
- Fischer, Thomas H.;
- Vournakis, John N.;
- Manning, James E.;
- McCurdy, Shane L.;
- Rich, Preston B.;
- Nichols, Timothy C.;
- Scull, Christopher M.;
- McCord, Marian G.;
- Decorta, Joseph A.;
- Johnson, Peter C.;
- Smith, Carr J.
Publication type:
Article
Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models.
Published in:
2017
By:
- Markusic, David M.;
- Nichols, Timothy C.;
- Merricks, Elizabeth P.;
- Brett Palaschak;
- Zolotukhin, Irene;
- Marsic, Damien;
- Zolotukhin, Sergei;
- Srivastava, Arun;
- Herzog, Roland W.;
- Palaschak, Brett
Publication type:
journal article
Cardiovascular disease, inflammation, and periodontal infection.
Published in:
Periodontology 2000, 2007, v. 44, n. 1, p. 113, doi. 10.1111/j.1600-0757.2006.00196.x
By:
- Paquette, David W.;
- Brodala, Nadine;
- Nichols, Timothy C.
Publication type:
Article
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.
Published in:
Nature Communications, 2013, v. 4, n. 11, p. 2773, doi. 10.1038/ncomms3773
By:
- Du, Lily M.;
- Nurden, Paquita;
- Nurden, Alan T.;
- Nichols, Timothy C.;
- Bellinger, Dwight A.;
- Jensen, Eric S.;
- Haberichter, Sandra L.;
- Merricks, Elizabeth;
- Raymer, Robin A.;
- Fang, Juan;
- Koukouritaki, Sevasti B.;
- Jacobi, Paula M.;
- Hawkins, Troy B.;
- Cornetta, Kenneth;
- Shi, Qizhen;
- Wilcox, David A.
Publication type:
Article
Evidence that rehydrated, lyophilized red blood cells are sufficiently deformable for normal microcirculation transit.
Published in:
Microscopy Research & Technique, 2004, v. 65, n. 1/2, p. 62, doi. 10.1002/jemt.20106
By:
- Fischer, Thomas H.;
- Robbins, Mary E.;
- Bode, Arthur P.;
- Nichols, Timothy C.;
- Bellinger, Dwight E.;
- Schoenfisch, Mark H.
Publication type:
Article
A Monoclonal Antibody Against αVβ3 Integrin Inhibits Development of Atherosclerotic Lesions in Diabetic Pigs.
Published in:
Science Translational Medicine, 2010, v. 2, n. 18, p. 1, doi. 10.1126/scitranslmed.3000476
By:
- Maile, Laura A.;
- Busby, Walker H.;
- Nichols, Timothy C.;
- Bellinger, Dwight A.;
- Merricks, Elizabeth P.;
- Rowland, Michael;
- Veluvolu, Umadevi;
- Clemmons, David R.
Publication type:
Article
Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors.
Published in:
Molecular Therapy, 2011, v. 19, n. 3, p. 442, doi. 10.1038/mt.2010.240
By:
- Sabatino, Denise E.;
- Lange, Amy M.;
- Altynova, Ekaterina S.;
- Sarkar, Rita;
- Shangzhen Zhou;
- Merricks, Elizabeth P.;
- Franck, Helen G.;
- Nichols, Timothy C.;
- Arruda, Valder R.;
- Kazazian Jr, Haig H.
Publication type:
Article
Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B.
Published in:
Molecular Therapy, 2010, v. 18, n. 11, p. 1896, doi. 10.1038/mt.2010.169
By:
- Hausl, Martin A.;
- Wenli Zhang;
- Müther, Nadine;
- Rauschhuber, Christina;
- Franck, Helen G.;
- Merricks, Elizabeth P.;
- Nichols, Timothy C.;
- Kay, Mark A.;
- Ehrhardt, Anja
Publication type:
Article
Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs.
Published in:
Molecular Therapy, 2010, v. 18, n. 7, p. 1318, doi. 10.1038/mt.2010.73
By:
- Haurigot, Virginia;
- Mingozzi, Federico;
- Buchlis, George;
- Hui, Daniel J.;
- Chen, Yifeng;
- Basner-Tschakarjan, Etiena;
- Arruda, Valder R.;
- Radu, Antoneta;
- Franck, Helen G.;
- Wright, J Fraser;
- Zhou, Shangzhen;
- Stedman, Hansell H;
- Bellinger, Dwight A.;
- Nichols, Timothy C;
- High, Katherine A.
Publication type:
Article
1086. T Cell Responses to Canine Factor IX and AAV Capsid Antigens in Hemophilia B Dogs after Intravascular Gene Delivery to Skeletal Muscle.
Published in:
Molecular Therapy, 2006, v. 13, p. S417, doi. 10.1016/j.ymthe.2006.08.1188
By:
- Hui, Daniel J.;
- Mingozzi, Federico;
- Dillow, Aaron;
- McCorquodale, Stephanie;
- Nichols, Timothy C.;
- Arruda, Valder R.;
- High, Katherine A.
Publication type:
Article
11. Transposition from a Gene-Deleted Adenoviral Vector Results in Phenotypic Correction in a Canine Model for Hemophilia B.
Published in:
Molecular Therapy, 2006, v. 13, p. S5, doi. 10.1016/j.ymthe.2006.08.022
By:
- Ehrhardt, Anja;
- Xu, Hui;
- Dillow, Aaron M.;
- Yant, Stephen R.;
- Nichols, Timothy C.;
- Kay, Mark A.
Publication type:
Article
1081. Sustained Correction of Disease in Naïve and AAV2-Pretreated Hemophilia B Dogs Using Pseudotyped AAV Vectors
Published in:
2005
By:
- Wang, Lili;
- Calcedo, Roberto;
- Nichols, Timothy C.;
- Verma, Inder M.;
- Wilson, James M.
Publication type:
Abstract
32. Tolerance after Neonatal Gene Transfer of a Human Factor IX-Expressing Retroviral Vector May Involve Clonal Deletion in C3H Mice and Is Effective in Hemophilia B Dogs
Published in:
2005
By:
- Xu, Lingfei;
- Haskins, Mark E.;
- Nichols, Timothy C.;
- Mei, Manxue;
- O'Donnell, Patty;
- Bellinger, Dwight A.;
- McCorquodale, Stephanie;
- Ponder, Katherine P.
Publication type:
Abstract
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin.
Published in:
British Journal of Haematology, 2011, v. 152, n. 1, p. 99, doi. 10.1111/j.1365-2141.2010.08432.x
By:
- Petersen, Lars C.;
- Karpf, Ditte M.;
- Agersø, Henrik;
- Hermit, Mette B.;
- Pelzer, Hermann;
- Persson, Egon;
- Nichols, Timothy C.;
- Ezban, Mirella
Publication type:
Article
Intracellular function in rehydrated lyophilized platelets.
Published in:
British Journal of Haematology, 2000, v. 111, n. 1, p. 167, doi. 10.1046/j.1365-2141.2000.02343.x
By:
- Fischer, Thomas H.;
- Merricks, Elizabeth P.;
- Russell, Karen E.;
- Raymer, Robin A.;
- White, Gilbert C.;
- Bode, Arthur P.;
- Nichols, Timothy C.;
- Read, Marjorie S.
Publication type:
Article
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Published in:
Science Translational Medicine, 2024, v. 16, n. 735, p. 1, doi. 10.1126/scitranslmed.adh0027
By:
- Strilchuk, Amy W.;
- Hur, Woosuk S.;
- Batty, Paul;
- Sang, Yaqiu;
- Abrahams, Sara R.;
- Yong, Alyssa S.M.;
- Leung, Jerry;
- Silva, Lakmali M.;
- Schroeder, Jocelyn A.;
- Nesbitt, Kate;
- de Laat, Bas;
- Moutsopoulos, Niki M.;
- Bugge, Thomas H.;
- Shi, Qizhen;
- Cullis, Pieter R.;
- Merricks, Elizabeth P.;
- Wolberg, Alisa S.;
- Flick, Matthew J.;
- Lillicrap, David;
- Nichols, Timothy C.
Publication type:
Article
γ-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.
Published in:
European Journal of Immunology, 1998, v. 28, n. 12, p. 4123, doi. 10.1002/(SICI)1521-4141(199812)28:12<4123::AID-IMMU4123>3.0.CO;2-G
By:
- Nichols, Timothy C.;
- Guthridge, Joel M.;
- Karp, David R.;
- Molina, Hector;
- Fletcher, Dana R.;
- Holers, V. Michael
Publication type:
Article
Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test – Demonstrated in vitro and ex vivo.
Published in:
PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0175030
By:
- Madsen, Daniel Elenius;
- Nichols, Timothy C.;
- Merricks, Elizabeth P.;
- Waters, Emily K.;
- Wiinberg, Bo
Publication type:
Article

Found: 31

Possible anaphylactic reaction to abciximab.

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector.

Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.

γ-Glutamyl transpeptidase is up-regulated on memory T lymphocytes.

Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies.

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.

Nuclear factor-kappaB activation in endothelium by Chlamydia pneumoniae without active infection.

Nuclear Factor--... B Activation in Endothelium by Chlamydia pneumoniae without Active Infection.

Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog.

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet.

Targeted Disruption of <i>LDLR</i> Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs.

Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.

Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4-driven transcriptional state.

The design and testing of a dual fiber textile matrix for accelerating surface hemostasis.

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models.

Cardiovascular disease, inflammation, and periodontal infection.

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.

Evidence that rehydrated, lyophilized red blood cells are sufficiently deformable for normal microcirculation transit.

A Monoclonal Antibody Against α<sub>V</sub>β<sub>3</sub> Integrin Inhibits Development of Atherosclerotic Lesions in Diabetic Pigs.

Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors.

Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B.

Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs.

1086. T Cell Responses to Canine Factor IX and AAV Capsid Antigens in Hemophilia B Dogs after Intravascular Gene Delivery to Skeletal Muscle.

11. Transposition from a Gene-Deleted Adenoviral Vector Results in Phenotypic Correction in a Canine Model for Hemophilia B.

1081. Sustained Correction of Disease in Naïve and AAV2-Pretreated Hemophilia B Dogs Using Pseudotyped AAV Vectors

32. Tolerance after Neonatal Gene Transfer of a Human Factor IX-Expressing Retroviral Vector May Involve Clonal Deletion in C3H Mice and Is Effective in Hemophilia B Dogs

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin.

Intracellular function in rehydrated lyophilized platelets.

Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.

γ-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.

Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test – Demonstrated in vitro and ex vivo.