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Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment.
Published in:
Molecular Cancer, 2024, p. 1, doi. 10.1186/s12943-024-02114-8
By:
- Sternberg, Christina;
- Raigel, Martin;
- Limberger, Tanja;
- Trachtová, Karolína;
- Schlederer, Michaela;
- Lindner, Desiree;
- Kodajova, Petra;
- Yang, Jiaye;
- Ziegler, Roman;
- Kalla, Jessica;
- Stoiber, Stefan;
- Dey, Saptaswa;
- Zwolanek, Daniela;
- Neubauer, Heidi A.;
- Oberhuber, Monika;
- Redmer, Torben;
- Hejret, Václav;
- Tichy, Boris;
- Tomberger, Martina;
- Harbusch, Nora S.
Publication type:
Article
High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.
Published in:
Pharmaceuticals (14248247), 2022, v. 15, n. 11, p. 1321, doi. 10.3390/ph15111321
By:
- Garcha, Harsimran Kaur;
- Nawar, Nabanita;
- Sorger, Helena;
- Erdogan, Fettah;
- Aung, Myint Myat Khine;
- Sedighi, Abootaleb;
- Manaswiyoungkul, Pimyupa;
- Seo, Hyuk-Soo;
- Schönefeldt, Susann;
- Pölöske, Daniel;
- Dhe-Paganon, Sirano;
- Neubauer, Heidi A.;
- Mustjoki, Satu M.;
- Herling, Marco;
- de Araujo, Elvin D.;
- Moriggl, Richard;
- Gunning, Patrick T.
Publication type:
Article
Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 5, p. 1028, doi. 10.3390/ijms20051028
By:
- Rauth, Manuel;
- Freund, Patricia;
- Orlova, Anna;
- Grünert, Stefan;
- Tasic, Nikola;
- Han, Xiaonan;
- Ruan, Hai-Bin;
- Neubauer, Heidi A.;
- Moriggl, Richard
Publication type:
Article
Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.
Published in:
Biochemical Journal, 2019, v. 476, n. 21, p. 3211, doi. 10.1042/BCJ20190245
By:
- Powell, Jason A.;
- Pitman, Melissa R.;
- Zebol, Julia R.;
- Moretti, Paul A. B.;
- Neubauer, Heidi A.;
- Davies, Lorena T.;
- Lewis, Alexander C.;
- Dagley, Laura F.;
- Webb, Andrew I.;
- Costabile, Maurizio;
- Pitson, Stuart M.
Publication type:
Article
ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41229-2
By:
- Ebner, Jessica;
- Schmoellerl, Johannes;
- Piontek, Martin;
- Manhart, Gabriele;
- Troester, Selina;
- Carter, Bing Z.;
- Neubauer, Heidi;
- Moriggl, Richard;
- Szakács, Gergely;
- Zuber, Johannes;
- Köcher, Thomas;
- Andreeff, Michael;
- Sperr, Wolfgang R.;
- Valent, Peter;
- Grebien, Florian
Publication type:
Article
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.
Published in:
Molecular Cancer, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12943-023-01825-8
By:
- Pencik, Jan;
- Philippe, Cecile;
- Schlederer, Michaela;
- Atas, Emine;
- Pecoraro, Matteo;
- Grund-Gröschke, Sandra;
- Li, Wen;
- Tracz, Amanda;
- Heidegger, Isabel;
- Lagger, Sabine;
- Trachtová, Karolína;
- Oberhuber, Monika;
- Heitzer, Ellen;
- Aksoy, Osman;
- Neubauer, Heidi A.;
- Wingelhofer, Bettina;
- Orlova, Anna;
- Witzeneder, Nadine;
- Dillinger, Thomas;
- Redl, Elisa
Publication type:
Article
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
Published in:
Molecular Cancer, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12943-022-01542-8
By:
- Limberger, Tanja;
- Schlederer, Michaela;
- Trachtová, Karolina;
- Garces de los Fayos Alonso, Ines;
- Yang, Jiaye;
- Högler, Sandra;
- Sternberg, Christina;
- Bystry, Vojtech;
- Oppelt, Jan;
- Tichý, Boris;
- Schmeidl, Margit;
- Kodajova, Petra;
- Jäger, Anton;
- Neubauer, Heidi A.;
- Oberhuber, Monika;
- Schmalzbauer, Belinda S.;
- Pospisilova, Sarka;
- Dolznig, Helmut;
- Wadsak, Wolfgang;
- Culig, Zoran
Publication type:
Article
Structural and functional consequences of the STAT5B<sup>N642H</sup> driver mutation.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10422-7
By:
- de Araujo, Elvin D.;
- Erdogan, Fettah;
- Neubauer, Heidi A.;
- Meneksedag-Erol, Deniz;
- Manaswiyoungkul, Pimyupa;
- Eram, Mohammad S.;
- Seo, Hyuk-Soo;
- Qadree, Abdul K.;
- Israelian, Johan;
- Orlova, Anna;
- Suske, Tobias;
- Pham, Ha T. T.;
- Boersma, Auke;
- Tangermann, Simone;
- Kenner, Lukas;
- Rülicke, Thomas;
- Dong, Aiping;
- Ravichandran, Manimekalai;
- Brown, Peter J.;
- Audette, Gerald F.
Publication type:
Article
The Diverse Roles of γδ T Cells in Cancer: From Rapid Immunity to Aggressive Lymphoma.
Published in:
Cancers, 2021, v. 13, n. 24, p. 6212, doi. 10.3390/cancers13246212
By:
- Schönefeldt, Susann;
- Wais, Tamara;
- Herling, Marco;
- Mustjoki, Satu;
- Bekiaris, Vasileios;
- Moriggl, Richard;
- Neubauer, Heidi A.
Publication type:
Article
Proteomic Analysis Identifies NDUFS1 and ATP5O as Novel Markers for Survival Outcome in Prostate Cancer.
Published in:
Cancers, 2021, v. 13, n. 23, p. 6036, doi. 10.3390/cancers13236036
By:
- Wiebringhaus, Robert;
- Pecoraro, Matteo;
- Neubauer, Heidi A.;
- Trachtová, Karolína;
- Trimmel, Bettina;
- Wieselberg, Maritta;
- Pencik, Jan;
- Egger, Gerda;
- Krall, Christoph;
- Moriggl, Richard;
- Mann, Matthias;
- Hantusch, Brigitte;
- Kenner, Lukas
Publication type:
Article
A Recurrent STAT5B N642H Driver Mutation in Feline Alimentary T Cell Lymphoma.
Published in:
Cancers, 2021, v. 13, n. 20, p. 5238, doi. 10.3390/cancers13205238
By:
- Kieslinger, Matthias;
- Swoboda, Alexander;
- Kramer, Nina;
- Freund, Patricia;
- Pratscher, Barbara;
- Neubauer, Heidi A.;
- Steinborn, Ralf;
- Wolfesberger, Birgitt;
- Fuchs-Baumgartinger, Andrea;
- Moriggl, Richard;
- Burgener, Iwan A.
Publication type:
Article
STAT5 is Expressed in CD34+/CD38− Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms.
Published in:
Cancers, 2020, v. 12, n. 4, p. 1021, doi. 10.3390/cancers12041021
By:
- Hadzijusufovic, Emir;
- Keller, Alexandra;
- Berger, Daniela;
- Greiner, Georg;
- Wingelhofer, Bettina;
- Witzeneder, Nadine;
- Ivanov, Daniel;
- Pecnard, Emmanuel;
- Nivarthi, Harini;
- Schur, Florian K. M.;
- Filik, Yüksel;
- Kornauth, Christoph;
- Neubauer, Heidi A.;
- Müllauer, Leonhard;
- Tin, Gary;
- Park, Jisung;
- de Araujo, Elvin D.;
- Gunning, Patrick T.;
- Hoermann, Gregor;
- Gouilleux, Fabrice
Publication type:
Article
Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers.
Published in:
Cancers, 2020, v. 12, n. 1, p. 240, doi. 10.3390/cancers12010240
By:
- Brachet-Botineau, Marie;
- Polomski, Marion;
- Neubauer, Heidi A.;
- Juen, Ludovic;
- Hédou, Damien;
- Viaud-Massuard, Marie-Claude;
- Prié, Gildas;
- Gouilleux, Fabrice
Publication type:
Article
Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.
Published in:
Cancers, 2019, v. 11, n. 11, p. 1757, doi. 10.3390/cancers11111757
By:
- de Araujo, Elvin D.;
- Orlova, Anna;
- Neubauer, Heidi A.;
- Bajusz, Dávid;
- Seo, Hyuk-Soo;
- Dhe-Paganon, Sirano;
- Keserű, György M.;
- Moriggl, Richard;
- Gunning, Patrick T.
Publication type:
Article
STAT3 and STAT5 Activation in Solid Cancers.
Published in:
Cancers, 2019, v. 11, n. 10, p. 1428, doi. 10.3390/cancers11101428
By:
- Igelmann, Sebastian;
- Neubauer, Heidi A.;
- Ferbeyre, Gerardo
Publication type:
Article
Roles, regulation and inhibitors of sphingosine kinase 2.
Published in:
FEBS Journal, 2013, v. 280, n. 21, p. 5317, doi. 10.1111/febs.12314
By:
- Neubauer, Heidi A.;
- Pitson, Stuart M.
Publication type:
Article
The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.
Published in:
2020
By:
- Kadekar, Darshana;
- Agerholm, Rasmus;
- Rizk, John;
- Neubauer, Heidi A.;
- Suske, Tobias;
- Maurer, Barbara;
- Viñals, Monica Torrellas;
- Comelli, Elena M.;
- Taibi, Amel;
- Moriggl, Richard;
- Bekiaris, Vasileios
Publication type:
journal article
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression.
Published in:
Molecular Cancer, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12943-024-02022-x
By:
- Redmer, Torben;
- Raigel, Martin;
- Sternberg, Christina;
- Ziegler, Roman;
- Probst, Clara;
- Lindner, Desiree;
- Aufinger, Astrid;
- Limberger, Tanja;
- Trachtova, Karolina;
- Kodajova, Petra;
- Högler, Sandra;
- Schlederer, Michaela;
- Stoiber, Stefan;
- Oberhuber, Monika;
- Bolis, Marco;
- Neubauer, Heidi A.;
- Miranda, Sara;
- Tomberger, Martina;
- Harbusch, Nora S.;
- Garces de los Fayos Alonso, Ines
Publication type:
Article

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