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Insulin's direct effects on the liver dominate the control of hepatic glucose production.
Published in:
2006
By:
- Edgerton, Dale S.;
- Lautz, Margaret;
- Scott, Melanie;
- Everett, Carrie A.;
- Stettler, Kathryn M.;
- Neal, Doss W.;
- Chu, Chang A.;
- Cherrington, Alan D.
Publication type:
journal article
Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs.
Published in:
Diabetes, Obesity & Metabolism, 2019, v. 21, n. 10, p. 2294, doi. 10.1111/dom.13808
By:
- Gregory, Justin M.;
- Kraft, Guillaume;
- Scott, Melanie F.;
- Neal, Doss W.;
- Farmer, Ben;
- Smith, Marta S.;
- Hastings, Jon R.;
- Madsen, Peter;
- Kjeldsen, Thomas B.;
- Hostrup, Susanne;
- Brand, Christian L.;
- Fledelius, Christian;
- Nishimura, Erica;
- Cherrington, Alan D.
Publication type:
Article
Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog.
Published in:
Diabetes, 2009, v. 58, n. 1, p. 243, doi. 10.2337/db08-0515
By:
- Edgerton, Dale S.;
- Johnson, Kathryn M. S.;
- Neal, Doss W.;
- Scott, Melanie;
- Hobbs, Charles H.;
- Zhang, Xia;
- Duttaroy, Alokesh;
- Cherrington, Alan D.
Publication type:
Article
Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo.
Published in:
Diabetes, 2006, v. 55, n. 12, p. 3604, doi. 10.2337/db06-0718
By:
- Edgerton, Dale S.;
- Cherrington, Alan D.;
- Williams, Phillip;
- Neal, Doss W.;
- Scott, Melanie;
- Bowen, Larry;
- Wilson, Warren;
- Hobbs, Charles H.;
- Leach, Chet;
- Mei-chang Kuo;
- Strack, Thomas R.
Publication type:
Article
Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs.
Published in:
2005
By:
- Edgerton, Dale S.;
- Neal, Doss W.;
- Scott, Melanie;
- Bowen, Larry;
- Wilson, Warren;
- Hobbs, Charles H.;
- Leach, Chet;
- Sivakumaran, Shantha;
- Strack, Thomas R.;
- Cherrington, Alan D.
Publication type:
journal article
Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection.
Published in:
2004
By:
- Cherrington, Alan D;
- Neal, Doss W;
- Edgerton, Dale S;
- Glass, Dana;
- Bowen, Larry;
- Hobbs, Charles H;
- Leach, Chet;
- Rosskamp, Ralf;
- Strack, Thomas R
Publication type:
journal article
Inhalation of Insulin in Dogs.
Published in:
Diabetes, 2004, v. 53, n. 4, p. 877, doi. 10.2337/diabetes.53.4.877
By:
- Cherrington, Alan D.;
- Neal, Doss W.;
- Edgerton, Dale S.;
- Glass, Dana;
- Bowen, Larry;
- Hobbs, Charles H.;
- Leach, Chet;
- Rosskamp, Ralf;
- Strack, Thomas R.
Publication type:
Article
Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog.
Published in:
2004
By:
- Moore, Mary Courtney;
- Satake, Shosuke;
- Lautz, Margaret;
- Neal, Doss W.;
- Smith, Marta;
- Cherrington, Alan D.;
- Soleimanpour, Scott A.
Publication type:
journal article
Portal serotonin infusion and glucose disposal in conscious dogs.
Published in:
2004
By:
- Moore, Mary Courtney;
- Geho, W. Blair;
- Lautz, Margaret;
- Farmer, Ben;
- Neal, Doss W.;
- Cherrington, Alan D.
Publication type:
journal article
Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog.
Published in:
2002
By:
- Igawa, Kayano;
- Mugavero, Mike;
- Shiota, Masakazu;
- Neal, Doss W.;
- Cherrington, Alan D.
Publication type:
journal article
Direct and indirect effects of insulin on glucose uptake and storage by the liver.
Published in:
2002
By:
- Satake, Shosuke;
- Moore, Mary Courtney;
- Igawa, Kayano;
- Converse, Margaret;
- Farmer, Benjamin;
- Neal, Doss W.;
- Cherrington, Alan D.
Publication type:
journal article
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
Published in:
2002
By:
- Shiota, Masakazu;
- Moore, Mary Courtney;
- Galassetti, Pietro;
- Monohan, Michael;
- Neal, Doss W.;
- Shulman, Gerald I.;
- Cherrington, Alan D.
Publication type:
journal article
Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input.
Published in:
2001
By:
- Sherck, Stephanie M.;
- Shiota, Masakazu;
- Saccomando, James;
- Cardin, Sylvain;
- Allen, Eric J.;
- Hastings, Jon R.;
- Neal, Doss W.;
- Williams, Phil E.;
- Cherrington, Alan D.;
- Sherck, S M;
- Shiota, M;
- Saccomando, J;
- Cardin, S;
- Allen, E J;
- Hastings, J R;
- Neal, D W;
- Williams, P E;
- Cherrington, A D
Publication type:
journal article
α- and β-Cell Responses to Small Changes in Plasma Glucose in the Conscious Dog.
Published in:
Diabetes, 2001, v. 50, n. 2, p. 367, doi. 10.2337/diabetes.50.2.367
By:
- Flattem, Nancy;
- Igawa, Kayano;
- Shiota, Masakazu;
- Emshwiller, Maya G.;
- Neal, Doss W.;
- Cherrington, Alan D.
Publication type:
Article
Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog.
Published in:
1998
By:
- Shiota, Masakazu;
- Galasetti, Pietro;
- Monohan, Michael;
- Neal, Doss W.;
- Cherrington, Alan D.;
- Shiota, M;
- Galassetti, P;
- Monohan, M;
- Neal, D W;
- Cherrington, A D
Publication type:
journal article
Basal hepatic glucose production is regulated by the portal vein insulin concentration.
Published in:
1998
By:
- Sindelar, Dana K.;
- Chu, Chang A.;
- Venson, Pam;
- Donahue, E. Patrick;
- Neal, Doss W.;
- Cherrington, Alan D.;
- Sindelar, D K;
- Chu, C A;
- Venson, P;
- Donahue, E P;
- Neal, D W;
- Cherrington, A D
Publication type:
journal article
The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog.
Published in:
1997
By:
- Sindelar, Dana K.;
- Chu, Chang A.;
- Rohlie, Michelle;
- Neal, Doss W.;
- Swift, Larry L.;
- Cherrington, Alan D.;
- Sindelar, D K;
- Chu, C A;
- Rohlie, M;
- Neal, D W;
- Swift, L L;
- Cherrington, A D
Publication type:
journal article
In the Absence of Counterregulatory Hormones, the Increase in Hepatic Glucose Production During Insulin-Induced Hypoglycemia in the Dog Is Initiated in the Liver Rather Than the Brain.
Published in:
Diabetes, 1996, v. 45, n. 12, p. 1805, doi. 10.2337/diab.45.12.1805
By:
- Connolly, Cynthia C.;
- Myers, Sharon R.;
- Neal, Doss W.;
- Hastings, Jon R.;
- Cherrington, Alan D.
Publication type:
Article
A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog.
Published in:
1996
By:
- Sindelar, Dana K.;
- Balcom, James H.;
- Chu, Chang A.;
- Neal, Doss W.;
- Cherrington, Alan D.;
- Sindelar, D K;
- Balcom, J H;
- Chu, C A;
- Neal, D W;
- Cherrington, A D
Publication type:
journal article
Counterregulation during hypoglycemia is directed by widespread brain regions.
Published in:
1993
By:
- Frizzell, R. Tyler;
- Jones, Elizabeth M.;
- Davis, Stephen N.;
- Biggers, David W.;
- Myers, Sharon R.;
- Connolly, Cynthia C.;
- Neal, Doss W.;
- Jaspan, Jonathan B.;
- Cherrington, Alan D.;
- Frizzell, R T;
- Jones, E M;
- Davis, S N;
- Biggers, D W;
- Myers, S R;
- Connolly, C C;
- Neal, D W;
- Jaspan, J B;
- Cherrington, A D
Publication type:
journal article
Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog.
Published in:
1992
By:
- Connolly, Cynthia C.;
- Adkins-Marshall, Bess A.;
- Neal, Doss W.;
- Pugh, William;
- Jaspan, Jonathan B.;
- Cherrington, Alan D.;
- Connolly, C C;
- Adkins-Marshall, B A;
- Neal, D W;
- Pugh, W;
- Jaspan, J B;
- Cherrington, A D
Publication type:
journal article
Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog.
Published in:
1992
By:
- Pagliassotti, Michael J.;
- Moore, Mary C.;
- Neal, Doss W.;
- Cherrington, Alan D.;
- Pagliassotti, M J;
- Moore, M C;
- Neal, D W;
- Cherrington, A D
Publication type:
journal article
Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs.
Published in:
1991
By:
- Pagliassotti, Michael J.;
- Myers, Sharon R.;
- Moore, Mary C.;
- Neal, Doss W.;
- Cherrington, Alan D.;
- Pagliassotti, M J;
- Myers, S R;
- Moore, M C;
- Neal, D W;
- Cherrington, A D
Publication type:
journal article
Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes.
Published in:
2015
By:
- Gregory, Justin M.;
- Kraft, Guillaume;
- Scott, Melanie F.;
- Neal, Doss W.;
- Farmer, Ben;
- Smith, Marta S.;
- Hastings, Jon R.;
- Allen, Eric J.;
- Donahue, E. Patrick;
- Rivera, Noelia;
- Winnick, Jason J.;
- Edgerton, Dale S.;
- Nishimura, Erica;
- Fledelius, Christian;
- Brand, Christian L.;
- Cherrington, Alan D.
Publication type:
journal article
Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs.
Published in:
2013
By:
- Coate KC;
- Kraft G;
- Irimia JM;
- Smith MS;
- Farmer B;
- Neal DW;
- Roach PJ;
- Shiota M;
- Cherrington AD;
- Coate, Katie C;
- Kraft, Guillaume;
- Irimia, Jose M;
- Smith, Marta S;
- Farmer, Ben;
- Neal, Doss W;
- Roach, Peter J;
- Shiota, Masakazu;
- Cherrington, Alan D
Publication type:
journal article
Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat /High-Fructose--Fed Dogs.
Published in:
Diabetes, 2013, v. 62, n. 2, p. 392, doi. 10.2337/db12-0417
By:
- Coate, Katie C.;
- Kraft, Guillaume;
- Irimia, Jose M.;
- Smith, Marta S.;
- Farmer, Ben;
- Neal, Doss W.;
- Roach, Peter J.;
- Shiota, Masakazu;
- Cherrington, Alan D.
Publication type:
Article
Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver.
Published in:
Diabetes, 2011, v. 60, n. 2, p. 398, doi. 10.2337/db10-0592
By:
- Winnick, Jason J.;
- An, Zhibo;
- Ramnanan, Christopher J.;
- Smith, Marta;
- Irimia, Jose M.;
- Neal, Doss W.;
- Moore, Mary Courtney;
- Roach, Peter J.;
- Cherrington, Alan D.
Publication type:
Article
Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo.
Published in:
Diabetes, 2010, v. 59, n. 6, p. 1302, doi. 10.2337/db09-1625
By:
- Ramnanan, Christopher J.;
- Edgerton, Dale S.;
- Rivera, Noelia;
- Irimia-Dominguez, Jose;
- Farmer, Ben;
- Neal, Doss W.;
- Lautz, Margaret;
- Donahue, E. Patrick;
- Meyer, Catalina M.;
- Roach, Peter J.;
- Cherrington, Alan D.
Publication type:
Article
Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo.
Published in:
Diabetes, 2009, v. 58, n. 12, p. 2766, doi. 10.2337/db09-0328
By:
- Edgerton, Dale S.;
- Ramnanan, Christopher J.;
- Grueter, Carrie A.;
- Johnson, Kathryn M. S.;
- Lautz, Margaret;
- Neal, Doss W.;
- Williams, Phillip E.;
- Cherrington, Alan D.
Publication type:
Article

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