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PPARα/β Activation Alleviates Age-Associated Renal Fibrosis in Sprague Dawley Rats.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Effects of MHY908, a New Synthetic PPARα/γ Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Hyaluronic Acid-Conjugated PLGA Nanoparticles Alleviate Ulcerative Colitis via CD44-Mediated Dual Targeting to Inflamed Colitis Tissue and Macrophages.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/pharmaceutics14102118
- By:
- Publication type:
- Article
Highly Concise Synthesis of 3'-"Up"-ethynyl-5'-methylbicyclo- [3.1.0]hexyl Purine and Pyrimidine Nucleoside Derivatives Using Rhodium(II) Carbenoid Cycloaddition and Highly Diastereoselective Grignard Reaction.
- Published in:
- Chinese Journal of Chemistry, 2009, v. 27, n. 12, p. 2405, doi. 10.1002/cjoc.201090016
- By:
- Publication type:
- Article
PPAR Pan Agonist MHY2013 Alleviates Renal Fibrosis in a Mouse Model by Reducing Fibroblast Activation and Epithelial Inflammation.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4882, doi. 10.3390/ijms24054882
- By:
- Publication type:
- Article
MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1590, doi. 10.3390/ijms23031590
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- Publication type:
- Article
Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5616, doi. 10.3390/ijms22115616
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- Publication type:
- Article
A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation.
- Published in:
- International Journal of Molecular Sciences, 2018, v. 19, n. 9, p. 2743, doi. 10.3390/ijms19092743
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- Publication type:
- Article
Compounds That Have an Anti-Biofilm Effect against Common Bacteria at Very Low Concentrations and Their Antibiotic Combination Effect.
- Published in:
- Antibiotics (2079-6382), 2023, v. 12, n. 5, p. 853, doi. 10.3390/antibiotics12050853
- By:
- Publication type:
- Article
(Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice.
- Published in:
- Oxidative Medicine & Cellular Longevity, 2016, p. 1, doi. 10.1155/2016/2761463
- By:
- Publication type:
- Article
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair.
- Published in:
- Experimental & Molecular Medicine EMM, 2021, v. 53, n. 9, p. 1423, doi. 10.1038/s12276-021-00676-x
- By:
- Publication type:
- Article
In vitro and in vivo evidence of tyrosinase inhibitory activity of a synthesized (Z)‐5‐(3‐hydroxy‐4‐methoxybenzylidene)‐2‐thioxothiazolidin‐4‐one (5‐HMT).
- Published in:
- Experimental Dermatology, 2019, v. 28, n. 6, p. 734, doi. 10.1111/exd.13863
- By:
- Publication type:
- Article
Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signalling.
- Published in:
- Experimental Dermatology, 2016, v. 25, n. 8, p. 652, doi. 10.1111/exd.12953
- By:
- Publication type:
- Article
Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells.
- Published in:
- Oxidative Medicine & Cellular Longevity, 2018, p. 1, doi. 10.1155/2018/4528184
- By:
- Publication type:
- Article
Potent Anti-Diabetic Effects of MHY908, a Newly Synthesized PPAR α/γ Dual Agonist in db/db Mice.
- Published in:
- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0078815
- By:
- Publication type:
- Article
The Novel PPAR α/γ Dual Agonist MHY 966 Modulates UVB–Induced Skin Inflammation by Inhibiting NF-κB Activity.
- Published in:
- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076820
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- Publication type:
- Article
Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043418
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- Publication type:
- Article
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis.
- Published in:
- Archives of Pharmacal Research, 2023, v. 46, n. 7, p. 646, doi. 10.1007/s12272-023-01456-z
- By:
- Publication type:
- Article
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process.
- Published in:
- Archives of Pharmacal Research, 2022, v. 45, n. 3, p. 159, doi. 10.1007/s12272-022-01375-5
- By:
- Publication type:
- Article
Colon-targeted delivery of cyclosporine A using dual-functional Eudragit<sup>®</sup> FS30D/PLGA nanoparticles ameliorates murine experimental colitis.
- Published in:
- International Journal of Nanomedicine, 2018, v. 13, p. 1225, doi. 10.2147/IJN.S157566
- By:
- Publication type:
- Article
Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles.
- Published in:
- International Journal of Nanomedicine, 2015, v. 10, p. 4565, doi. 10.2147/IJN.S87816
- By:
- Publication type:
- Article
Exploration of Compounds with 2-Phenylbenzo[ d ]oxazole Scaffold as Potential Skin-Lightening Agents through Inhibition of Melanin Biosynthesis and Tyrosinase Activity.
- Published in:
- Molecules, 2024, v. 29, n. 17, p. 4162, doi. 10.3390/molecules29174162
- By:
- Publication type:
- Article
Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases.
- Published in:
- Molecules, 2024, v. 29, n. 12, p. 2887, doi. 10.3390/molecules29122887
- By:
- Publication type:
- Article
Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5 H)-one Derivatives: A Novel Class of Anti-Melanogenic Compounds.
- Published in:
- Molecules, 2023, v. 28, n. 8, p. 3293, doi. 10.3390/molecules28083293
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- Publication type:
- Article
Design and Synthesis of (Z)-2-(Benzylamino)-5-benzylidenethiazol-4(5 H)-one Derivatives as Tyrosinase Inhibitors and Their Anti-Melanogenic and Antioxidant Effects.
- Published in:
- Molecules, 2023, v. 28, n. 2, p. 848, doi. 10.3390/molecules28020848
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- Publication type:
- Article
Chinese Prescription Kangen-karyu and Salviae Miltiorrhizae Radix Improve Age-Related Oxidative Stress and Inflammatory Response through the PI3K/Akt or MAPK Pathways.
- Published in:
- American Journal of Chinese Medicine, 2014, v. 42, n. 4, p. 987, doi. 10.1142/S0192415X14500621
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- Publication type:
- Article
Tyrosinase Inhibitory Effects of Derivatives of (E)‐2‐(Substituted Benzylidene)‐3,4‐Dihydronaphthalen‐1(2H)‐One.
- Published in:
- Bulletin of the Korean Chemical Society, 2020, v. 41, n. 12, p. 1134, doi. 10.1002/bkcs.12122
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- Publication type:
- Article
Highly Efficient Synthesis of Conformationally Fixed Bicyclo[3.1.0]hexyl Nucleosides with an Ethenyl Group at C3'-Position as Potential Antiviral Agents.
- Published in:
- Bulletin of the Korean Chemical Society, 2014, v. 35, n. 9, p. 2649, doi. 10.5012/bkcs.2014.35.9.2649
- By:
- Publication type:
- Article
MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling.
- Published in:
- Oxidative Medicine & Cellular Longevity, 2019, p. 1, doi. 10.1155/2019/6492029
- By:
- Publication type:
- Article
A novel synthetic compound, (<italic>Z</italic>)-5-(3-hydroxy-4-methoxybenzylidene)-2-iminothiazolidin-4-one (MHY773) inhibits mushroom tyrosinase.
- Published in:
- Bioscience, Biotechnology & Biochemistry, 2018, v. 82, n. 5, p. 759, doi. 10.1080/09168451.2018.1445518
- By:
- Publication type:
- Article
A Novel Synthesized Tyrosinase Inhibitor: (E)-2-((2,4-Dihydroxyphenyl)diazenyl)phenyl 4-Methylbenzenesulfonate as an Azo-Resveratrol Analog.
- Published in:
- Bioscience, Biotechnology & Biochemistry, 2013, v. 77, n. 1, p. 65, doi. 10.1271/bbb.120547
- By:
- Publication type:
- Article
Design, Synthesis, and Anti-Melanogenic Activity of 2-Mercaptomethylbenzo[ d ]imidazole Derivatives Serving as Tyrosinase Inhibitors: An In Silico, In Vitro, and In Vivo Exploration.
- Published in:
- Antioxidants, 2024, v. 13, n. 10, p. 1248, doi. 10.3390/antiox13101248
- By:
- Publication type:
- Article
Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation.
- Published in:
- Antioxidants, 2023, v. 12, n. 11, p. 1947, doi. 10.3390/antiox12111947
- By:
- Publication type:
- Article
Anti-Browning Effect of 2-Mercaptobenzo[ d ]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity.
- Published in:
- Antioxidants, 2023, v. 12, n. 10, p. 1814, doi. 10.3390/antiox12101814
- By:
- Publication type:
- Article
Design and Synthesis of (Z)-5-(Substituted benzylidene)-3-cyclohexyl-2-thioxothiazolidin-4-one Analogues as Anti-Tyrosinase and Antioxidant Compounds: In Vitro and In Silico Insights.
- Published in:
- Antioxidants, 2022, v. 11, n. 10, p. N.PAG, doi. 10.3390/antiox11101918
- By:
- Publication type:
- Article
A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[ d ]thiazoles: In Vitro and In Silico Insights.
- Published in:
- Antioxidants, 2022, v. 11, n. 7, p. 1375, doi. 10.3390/antiox11071375
- By:
- Publication type:
- Article
Identification of a Novel Class of Anti-Melanogenic Compounds, (Z)-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities.
- Published in:
- Antioxidants, 2022, v. 11, n. 5, p. 948, doi. 10.3390/antiox11050948
- By:
- Publication type:
- Article
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson's Disease.
- Published in:
- Antioxidants, 2021, v. 10, n. 11, p. 1855, doi. 10.3390/antiox10111855
- By:
- Publication type:
- Article
New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities.
- Published in:
- Antioxidants, 2021, v. 10, n. 7, p. 1078, doi. 10.3390/antiox10071078
- By:
- Publication type:
- Article
MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells.
- Published in:
- International Journal of Oncology, 2015, v. 47, n. 2, p. 563, doi. 10.3892/ijo.2015.3031
- By:
- Publication type:
- Article
Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 9, p. 1, doi. 10.1038/s41419-018-0942-x
- By:
- Publication type:
- Article
Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives.
- Published in:
- Drug Design, Development & Therapy, 2017, v. 11, p. 827, doi. 10.2147/DDDT.S131538
- By:
- Publication type:
- Article
Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation.
- Published in:
- Drug Design, Development & Therapy, 2016, v. 10, p. 3947, doi. 10.2147/DDDT.S123759
- By:
- Publication type:
- Article
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
- Published in:
- Drug Design, Development & Therapy, 2015, v. 9, p. 4259, doi. 10.2147/DDDT.S89976
- By:
- Publication type:
- Article
Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process.
- Published in:
- Drug Design, Development & Therapy, 2015, v. 9, p. 4269, doi. 10.2147/DDDT.S90706
- By:
- Publication type:
- Article
Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target.
- Published in:
- Drug Design, Development & Therapy, 2015, v. 9, p. 4227, doi. 10.2147/DDDT.S88543
- By:
- Publication type:
- Article
Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy.
- Published in:
- Drug Design, Development & Therapy, 2015, v. 9, p. 3789, doi. 10.2147/DDDT.S88672
- By:
- Publication type:
- Article
Novel Anti-Melanogenic Compounds, (Z)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights.
- Published in:
- Molecules, 2021, v. 26, n. 16, p. 4963, doi. 10.3390/molecules26164963
- By:
- Publication type:
- Article
PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling.
- Published in:
- Molecules, 2021, v. 26, n. 11, p. 3197, doi. 10.3390/molecules26113197
- By:
- Publication type:
- Article
(E)-1-(Furan-2-yl)-(substituted phenyl)prop-2-en-1-one Derivatives as Tyrosinase Inhibitors and Melanogenesis Inhibition: An In Vitro and In Silico Study.
- Published in:
- Molecules, 2020, v. 25, n. 22, p. 5460, doi. 10.3390/molecules25225460
- By:
- Publication type:
- Article