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Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open‐label, long‐term extension study with up to 7.0 years of treatment.
Published in:
Alimentary Pharmacology & Therapeutics, 2022, v. 55, n. 4, p. 464, doi. 10.1111/apt.16712
By:
- Sandborn, William J.;
- Lawendy, Nervin;
- Danese, Silvio;
- Su, Chinyu;
- Loftus, Edward V.;
- Hart, Ailsa;
- Dotan, Iris;
- Damião, Adérson O. M. C.;
- Judd, Donna T.;
- Guo, Xiang;
- Modesto, Irene;
- Wang, Wenjin;
- Panés, Julian
Publication type:
Article
Worldwide post‐marketing safety surveillance experience with tofacitinib in ulcerative colitis.
Published in:
Alimentary Pharmacology & Therapeutics, 2022, v. 55, n. 3, p. 302, doi. 10.1111/apt.16619
By:
- Rubin, David T.;
- Modesto, Irene;
- Vermeire, Séverine;
- Danese, Silvio;
- Ng, Siew C.;
- Kwok, Kenneth K.;
- Koram, Nana;
- Jones, Thomas V.
Publication type:
Article
Living with Ulcerative Colitis in Japan: Biologic Persistence and Health-Care Resource Use.
Published in:
Inflammatory Intestinal Diseases, 2021, v. 6, n. 4, p. 186, doi. 10.1159/000519123
By:
- Bargo, Danielle;
- Tritton, Theo;
- Cappelleri, Joseph C.;
- DiBonaventura, Marco;
- Smith, Timothy W.;
- Tsuchiya, Takanori;
- Gardiner, Sean;
- Modesto, Irene;
- Holbrook, Tim;
- Bluff, Daniel;
- Kobayashi, Taku
Publication type:
Article
Prevalence of Hepatitis B Virus Markers in Patients with Autoimmune Inflammatory Rheumatic Diseases in Italy.
Published in:
Microorganisms, 2020, v. 8, n. 11, p. 1792, doi. 10.3390/microorganisms8111792
By:
- Canzoni, Marco;
- Marignani, Massimo;
- Sorgi, Maria Laura;
- Begini, Paola;
- Biondo, Michela Ileen;
- Caporuscio, Sara;
- Colonna, Vincenzo;
- Casa, Francesca Della;
- Conigliaro, Paola;
- Marrese, Cinzia;
- Celletti, Eleonora;
- Modesto, Irene;
- Peragallo, Mario Stefano;
- Laganà, Bruno;
- Picchianti-Diamanti, Andrea;
- Rosa, Roberta Di;
- Ferlito, Claudia;
- Salemi, Simonetta;
- D'Amelio, Raffaele;
- Stroffolini, Tommaso
Publication type:
Article
The Role of Portal Vein Thrombosis in the Clinical Course of Inflammatory Bowel Diseases: Report on Three Cases and Review of the Literature.
Published in:
Gastroenterology Research & Practice, 2012, p. 1, doi. 10.1155/2012/916428
By:
- Sinagra, Emanuele;
- Aragona, Emma;
- Romano, Claudia;
- Maisano, Simonetta;
- Orlando, Ambrogio;
- Virdone, Roberto;
- Tesè, Lorenzo;
- Modesto, Irene;
- Criscuoli, Valeria;
- Cottone, Mario
Publication type:
Article
Impact of Concomitant Corticosteroids on Tofacitinib Induction Efficacy and Infection Rates in Ulcerative Colitis.
Published in:
Digestive Diseases & Sciences, 2023, v. 68, n. 6, p. 2624, doi. 10.1007/s10620-022-07794-0
By:
- Lichtenstein, Gary R.;
- Cohen, Benjamin L.;
- Salese, Leonardo;
- Modesto, Irene;
- Wang, Wenjin;
- Chan, Gary;
- Ahmed, Haytham Mohamed;
- Su, Chinyu;
- Peyrin-Biroulet, Laurent
Publication type:
Article
Exposure‐Response Characterization of Tofacitinib Efficacy in Moderate to Severe Ulcerative Colitis: Results From Phase II and Phase III Induction and Maintenance Studies.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 1, p. 90, doi. 10.1002/cpt.2601
By:
- Mukherjee, Arnab;
- Tsuchiwata, Shinichi;
- Nicholas, Timothy;
- Cook, Jack A.;
- Modesto, Irene;
- Su, Chinyu;
- D'Haens, Geert R.;
- Sandborn, William J.
Publication type:
Article
Letter: thromboembolic and cardiovascular events with tofacitinib in ulcerative colitis—two cases in real world clinical practice. Authors' reply.
Published in:
Alimentary Pharmacology & Therapeutics, 2020, v. 51, n. 11, p. 1209, doi. 10.1111/apt.15735
By:
- Sandborn, William J.;
- Panés, Julian;
- Sands, Bruce E.;
- Reinisch, Walter;
- Su, Chinyu;
- Lawendy, Nervin;
- Koram, Nana;
- Fan, Haiyun;
- Jones, Thomas V.;
- Modesto, Irene;
- Quirk, Daniel;
- Danese, Silvio
Publication type:
Article
Venous thromboembolic events in the tofacitinib ulcerative colitis clinical development programme.
Published in:
Alimentary Pharmacology & Therapeutics, 2019, v. 50, n. 10, p. 1068, doi. 10.1111/apt.15514
By:
- Sandborn, William J.;
- Panés, Julian;
- Sands, Bruce E.;
- Reinisch, Walter;
- Su, Chinyu;
- Lawendy, Nervin;
- Koram, Nana;
- Fan, Haiyun;
- Jones, Thomas V.;
- Modesto, Irene;
- Quirk, Daniel;
- Danese, Silvio
Publication type:
Article
Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events from the ELEVATE UC Clinical Programme.
Published in:
Journal of Crohn's & Colitis, 2024, v. 18, n. 10, p. 1596, doi. 10.1093/ecco-jcc/jjae060
By:
- Regueiro, Miguel;
- Siegmund, Britta;
- Yarur, Andres J;
- Steinwurz, Flavio;
- Gecse, Krisztina B;
- Goetsch, Martina;
- Bhattacharjee, Abhishek;
- Wu, Joseph;
- Green, Jesse;
- McDonnell, Aoibhinn;
- Crosby, Catherine;
- Lazin, Krisztina;
- Branquinho, Diogo;
- Modesto, Irene;
- Abreu, Maria T
Publication type:
Article
Efficacy and Safety of Etrasimod in Patients with Moderately to Severely Active Isolated Proctitis: Results From the Phase 3 ELEVATE UC Clinical Programme.
Published in:
Journal of Crohn's & Colitis, 2024, v. 18, n. 8, p. 1270, doi. 10.1093/ecco-jcc/jjae038
By:
- Peyrin-Biroulet, Laurent;
- Dubinsky, Marla C;
- Sands, Bruce E;
- Panés, Julian;
- Schreiber, Stefan;
- Reinisch, Walter;
- Feagan, Brian G;
- Danese, Silvio;
- Yarur, Andres J;
- D'Haens, Geert R;
- Goetsch, Martina;
- Wosik, Karolina;
- Keating, Michael;
- Lazin, Krisztina;
- Wu, Joseph;
- Modesto, Irene;
- McDonnell, Aoibhinn;
- Bartolome, Lauren;
- Vermeire, Séverine
Publication type:
Article
Major Adverse Cardiovascular Events by Baseline Cardiovascular Risk in Patients with Ulcerative Colitis Treated with Tofacitinib: Data from the OCTAVE Clinical Programme.
Published in:
Journal of Crohn's & Colitis, 2023, v. 17, n. 11, p. 1761, doi. 10.1093/ecco-jcc/jjad104
By:
- Schreiber, Stefan;
- Rubin, David T;
- Ng, Siew C;
- Peyrin-Biroulet, Laurent;
- Danese, Silvio;
- Modesto, Irene;
- Guo, Xiang;
- Su, Chinyu;
- Kwok, Kenneth K;
- Jo, Hyejin;
- Chen, Yan;
- Yndestad, Arne;
- Reinisch, Walter;
- Dubinsky, Marla C
Publication type:
Article
Declining Enrolment and Other Challenges in IBD Clinical Trials: Causes and Potential Solutions.
Published in:
Journal of Crohn's & Colitis, 2023, v. 17, n. 7, p. 1066, doi. 10.1093/ecco-jcc/jjad020
By:
- Uzzan, Mathieu;
- Bouhnik, Yoram;
- Abreu, Maria;
- Ahmad, Harris A;
- Adsul, Shashi;
- Carlier, Hilde;
- Dubinsky, Marla;
- Germinaro, Matthew;
- Jairath, Vipul;
- Modesto, Irene;
- Mortensen, Eric;
- Narula, Neeraj;
- Neimark, Ezequiel;
- Oortwijn, Alessandra;
- Protic, Marijana;
- Rubin, David T;
- Oh, Young S;
- Wichary, Jolanta;
- Peyrin-Biroulet, Laurent;
- Reinisch, Walter
Publication type:
Article
Tofacitinib for the Treatment of Ulcerative Colitis: An Integrated Summary of up to 7.8 Years of Safety Data from the Global Clinical Programme.
Published in:
Journal of Crohn's & Colitis, 2023, v. 17, n. 3, p. 338, doi. 10.1093/ecco-jcc/jjac141
By:
- Sandborn, William J;
- D'Haens, Geert R;
- Sands, Bruce E;
- Panaccione, Remo;
- Ng, Siew C;
- Lawendy, Nervin;
- Kulisek, Nicole;
- Modesto, Irene;
- Guo, Xiang;
- Mundayat, Rajiv;
- Su, Chinyu;
- Vranic, Ivana;
- Panés, Julian
Publication type:
Article
Efficacy and Safety of Tofacitinib Re-treatment for Ulcerative Colitis After Treatment Interruption: Results from the OCTAVE Clinical Trials.
Published in:
Journal of Crohn's & Colitis, 2021, v. 15, n. 11, p. 1852, doi. 10.1093/ecco-jcc/jjab065
By:
- Panés, Julian;
- Vermeire, Séverine;
- Dubinsky, Marla C;
- Loftus, Edward V;
- Lawendy, Nervin;
- Wang, Wenjin;
- Salese, Leonardo;
- Su, Chinyu;
- Modesto, Irene;
- Guo, Xiang;
- Colombel, Jean-Frederic
Publication type:
Article
Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial.
Published in:
Journal of Crohn's & Colitis, 2021, v. 15, n. 7, p. 1130, doi. 10.1093/ecco-jcc/jjaa249
By:
- Vermeire, Séverine;
- Su, Chinyu;
- Lawendy, Nervin;
- Kobayashi, Taku;
- Sandborn, William J;
- Rubin, David T;
- Modesto, Irene;
- Gardiner, Sean;
- Kulisek, Nicole;
- Zhang, Haiying;
- Wang, Wenjin;
- Panés, Julian
Publication type:
Article
Modeling of Treatment Outcomes with Tofacitinib Maintenance Therapy in Patients with Ulcerative Colitis: A Post Hoc Analysis of Data from the OCTAVE Clinical Program.
Published in:
Advances in Therapy, 2023, v. 40, n. 10, p. 4440, doi. 10.1007/s12325-023-02603-0
By:
- Chiorean, Michael;
- Daperno, Marco;
- Lees, Charlie W.;
- Bonfanti, Gianluca;
- Soudis, Dimitrios;
- Modesto, Irene;
- Deuring, J. Jasper;
- Edwards, Roger A.
Publication type:
Article
Comment on: "Retrospective Claims Analysis Indirectly Comparing Medication Adherence and Persistence Between Intravenous Biologics and Oral Small-Molecule Therapies in Inflammatory Bowel Diseases".
Published in:
2020
By:
- Woolcott, John;
- Cappelleri, Joseph C.;
- Sharma, Puza;
- Modesto, Irene
Publication type:
Letter
Modified Mayo score versus Mayo score for evaluation of treatment efficacy in patients with ulcerative colitis: data from the tofacitinib OCTAVE program.
Published in:
Therapeutic Advances in Gastroenterology, 2022, p. 1, doi. 10.1177/17562848221136331
By:
- Sandborn, William J.;
- Sands, Bruce E.;
- Vermeire, Séverine;
- Leung, Yvette;
- Guo, Xiang;
- Modesto, Irene;
- Su, Chinyu;
- Wang, Wenjin;
- Panés, Julian
Publication type:
Article
Prediction of early clinical response in patients receiving tofacitinib in the OCTAVE Induction 1 and 2 studies.
Published in:
Therapeutic Advances in Gastroenterology, 2021, v. 14, p. 1, doi. 10.1177/17562848211054710
By:
- Lees, Charlie W.;
- Deuring, J. Jasper;
- Chiorean, Michael;
- Daperno, Marco;
- Bonfanti, Gianluca;
- Germino, Rebecca;
- Brown, Pritha Bhadra;
- Modesto, Irene;
- Edwards, Roger A.
Publication type:
Article
Extraintestinal manifestations at baseline, and the effect of tofacitinib, in patients with moderate to severe ulcerative colitis.
Published in:
Therapeutic Advances in Gastroenterology, 2021, v. 14, p. 1, doi. 10.1177/17562848211005708
By:
- Rubin, David T.;
- Reinisch, Walter;
- Greuter, Thomas;
- Kotze, Paulo G.;
- Pinheiro, Marcia;
- Mundayat, Rajiv;
- Maller, Eric;
- Fellmann, Marc;
- Lawendy, Nervin;
- Modesto, Irene;
- Vavricka, Stephan R.;
- Lichtenstein, Gary R.
Publication type:
Article
Prediction of early clinical response in patients receiving tofacitinib in the OCTAVE Induction 1 and 2 studies.
Published in:
Therapeutic Advances in Gastroenterology, 2021, v. 14, p. 1, doi. 10.1177/17562848211054710
By:
- Lees, Charlie W.;
- Deuring, J. Jasper;
- Chiorean, Michael;
- Daperno, Marco;
- Bonfanti, Gianluca;
- Germino, Rebecca;
- Brown, Pritha Bhadra;
- Modesto, Irene;
- Edwards, Roger A.
Publication type:
Article
Extraintestinal manifestations at baseline, and the effect of tofacitinib, in patients with moderate to severe ulcerative colitis.
Published in:
Therapeutic Advances in Gastroenterology, 2021, v. 14, p. 1, doi. 10.1177/17562848211005708
By:
- Rubin, David T.;
- Reinisch, Walter;
- Greuter, Thomas;
- Kotze, Paulo G.;
- Pinheiro, Marcia;
- Mundayat, Rajiv;
- Maller, Eric;
- Fellmann, Marc;
- Lawendy, Nervin;
- Modesto, Irene;
- Vavricka, Stephan R.;
- Lichtenstein, Gary R.
Publication type:
Article
The Role of CARD15 Mutations and Smoking in the Course of Crohn's Disease in a Mediterranean Area.
Published in:
American Journal of Gastroenterology (Springer Nature), 2008, v. 103, n. 3, p. 649, doi. 10.1111/j.1572-0241.2007.01589.x
By:
- Renda, Maria Concetta;
- Orlando, Ambrogio;
- Civitavecchia, Giuseppe;
- Criscuoli, Valeria;
- Maggio, Aurelio;
- Mocciaro, Filippo;
- Rossi, Francesca;
- Scimeca, Daniela;
- Modesto, Irene;
- Oliva, Lorenzo;
- Cottone, Mario
Publication type:
Article

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