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Are sirtuins viable targets for improving healthspan and lifespan?
Published in:
Nature Reviews Drug Discovery, 2012, v. 11, n. 6, p. 443, doi. 10.1038/nrd3738
By:
- Baur, Joseph A.;
- Ungvari, Zoltan;
- Minor, Robin K.;
- Le Couteur, David G.;
- de Cabo, Rafael
Publication type:
Article
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.
Published in:
2020
By:
- Palliyaguru, Dushani L;
- Minor, Robin K;
- Mitchell, Sarah J;
- Palacios, Hector H;
- Licata, Jordan J;
- Ward, Theresa M;
- Abulwerdi, Gelareh;
- Elliott, Peter;
- Westphal, Christoph;
- Ellis, James L;
- Sinclair, David A;
- Price, Nathan L;
- Bernier, Michel;
- Cabo, Rafael de;
- Palacio, Hector H;
- de Cabo, Rafael
Publication type:
journal article
Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2010, v. 65A, n. 7, p. 695, doi. 10.1093/gerona/glq042
By:
- Minor, Robin K.;
- Allard, Joanne S.;
- Younts, Caitlin M.;
- Ward, Theresa M.;
- de Cabo, Rafael
Publication type:
Article
Metformin improves healthspan and lifespan in mice.
Published in:
Nature Communications, 2013, v. 4, n. 7, p. 2192, doi. 10.1038/ncomms3192
By:
- Martin-Montalvo, Alejandro;
- Mercken, Evi M.;
- Mitchell, Sarah J.;
- Palacios, Hector H.;
- Mote, Patricia L.;
- Scheibye-Knudsen, Morten;
- Gomes, Ana P.;
- Ward, Theresa M.;
- Minor, Robin K.;
- Blouin, Marie-José;
- Schwab, Matthias;
- Pollak, Michael;
- Zhang, Yongqing;
- Yu, Yinbing;
- Becker, Kevin G.;
- Bohr, Vilhelm A.;
- Ingram, Donald K.;
- Sinclair, David A.;
- Wolf, Norman S.;
- Spindler, Stephen R.
Publication type:
Article
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Published in:
Aging Cell, 2014, v. 13, n. 5, p. 787, doi. 10.1111/acel.12220
By:
- Mercken, Evi M.;
- Mitchell, Sarah J.;
- Martin‐Montalvo, Alejandro;
- Minor, Robin K.;
- Almeida, Maria;
- Gomes, Ana P.;
- Scheibye‐Knudsen, Morten;
- Palacios, Hector H.;
- Licata, Jordan J.;
- Zhang, Yongqing;
- Becker, Kevin G.;
- Khraiwesh, Husam;
- González‐Reyes, José A.;
- Villalba, José M.;
- Baur, Joseph A.;
- Elliott, Peter;
- Westphal, Christoph;
- Vlasuk, George P.;
- Ellis, James L.;
- Sinclair, David A.
Publication type:
Article
The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.
Published in:
Aging Cell, 2011, v. 10, n. 3, p. 483, doi. 10.1111/j.1474-9726.2011.00693.x
By:
- Minor, Robin K.;
- López, Miguel;
- Younts, Caitlin M.;
- Jones, Bruce;
- Pearson, Kevin J.;
- Michael Anson, Robert;
- Diéguez, Carlos;
- de Cabo, Rafael
Publication type:
Article
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.
Published in:
Aging Cell, 2009, v. 8, n. 2, p. 140, doi. 10.1111/j.1474-9726.2009.00461.x
By:
- Jiménez-Hidalgo, María;
- Santos-Ocaña, Carlos;
- Padilla, Sergio;
- Villalba, José M.;
- López-Lluch, Guillermo;
- Martín-Montalvo, Alejandro;
- Minor, Robin K.;
- Sinclair, David A.;
- de Cabo, Rafael;
- Navas, Plácido
Publication type:
Article

Found: 7

Are sirtuins viable targets for improving healthspan and lifespan?

Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction.

Metformin improves healthspan and lifespan in mice.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.

The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.