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Synthesis of exo‐3‐Amino‐7‐azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets.
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- European Journal of Organic Chemistry, 2009, v. 2009, n. 11, p. 1707, doi. 10.1002/ejoc.200801184
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Potent Inhibitors of Malarial Aspartic Proteases, the Plasmepsins, by Hydroformylation of Substituted 7-Azanorbornenes.
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- Chemistry - A European Journal, 2013, v. 19, n. 1, p. 155, doi. 10.1002/chem.201202941
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Aushungern des Malaria-Erregers: Hemmer der Aspartylproteasen Plasmepsin I, II und IVF.H. dankt der “Novartis Foundation” und dem “Human Frontier Science Program” für finanzielle Unterstützung. Diese Arbeit...
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- Angewandte Chemie, 2006, v. 118, n. 13, p. 2193, doi. 10.1002/ange.200504119
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- Article
Exploring the Flap Pocket of the Antimalarial Target Plasmepsin II: The '55 % Rule' Applied to Enzymes.
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- ChemMedChem, 2008, v. 3, n. 2, p. 237, doi. 10.1002/cmdc.200700236
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Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV.
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- ChemMedChem, 2006, v. 1, n. 12, p. 1341, doi. 10.1002/cmdc.200600223
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Replacement of Isobutyl by Trifluoromethyl in Pepstatin A Selectively Affects Inhibition of Aspartic Proteinases.
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- ChemBioChem, 2006, v. 7, n. 1, p. 181, doi. 10.1002/cbic.200500180
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Fragment‐based screening targeting an open form of the SARS‐CoV‐2 main protease binding pocket.
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- Acta Crystallographica: Section D, Structural Biology, 2024, v. 80, n. 2, p. 123, doi. 10.1107/S2059798324000329
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Starving the Malaria Parasite: Inhibitors Active against the Aspartic Proteases Plasmepsins I, II, and IVF.H. thanks the Novartis Foundation and the Human Frontier Science Program for financial support. This research was supported by the ETH Research Council. We thank Anna Oksman for technical assistance.
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- Angewandte Chemie International Edition, 2006, v. 45, n. 13, p. 2138, doi. 10.1002/anie.200504119
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Identification of a New Chemical Class of Antimalarials.
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- Journal of Infectious Diseases, 2012, v. 206, n. 5, p. 735, doi. 10.1093/infdis/jis418
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- Article