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An MCMC method for the evaluation of the Fisher information matrix for non-linear mixed effect models.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials.
- Published in:
- 2016
- By:
- Publication type:
- journal article
High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy.
- Published in:
- 2005
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- Publication type:
- journal article
Cardiovascular remodelling and extracellular fluid excess in early stages of chronic kidney disease.
- Published in:
- Nephrology Dialysis Transplantation, 2008, v. 23, n. 1, p. 239
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- Publication type:
- Article
Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593–606, Sep/Oct 2018, DOI: 10.1002/pst.1873.
- Published in:
- Pharmaceutical Statistics, 2019, v. 18, n. 3, p. 278, doi. 10.1002/pst.1940
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- Publication type:
- Article
A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.
- Published in:
- Pharmaceutical Statistics, 2013, v. 12, n. 3, p. 129, doi. 10.1002/pst.1561
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- Publication type:
- Article
Lessons learned from IDeAl - 33 recommendations from the IDeAl-net about design and analysis of small population clinical trials.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Population pharmacodynamic analysis of octreotide in acromegalic patients<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 1, p. 95, doi. 10.1067/mcp.2003.6
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- Publication type:
- Article
Pharmacokinetic and pharmacodynamic modeling of mizolastine in healthy volunteers with an indirect response model.
- Published in:
- Clinical Pharmacology & Therapeutics, 2000, v. 68, n. 6, p. 647, doi. 10.1067/mcp.2000.112341
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- Publication type:
- Article
Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1998, v. 63, n. 1, p. 64, doi. 10.1016/S0009-9236(98)90122-9
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- Publication type:
- Article
Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach.
- Published in:
- BMC Medical Research Methodology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2288-13-60
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- Publication type:
- Article
Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach.
- Published in:
- 2013
- By:
- Publication type:
- journal article
Endpoints for randomized controlled clinical trials for COVID-19 treatments.
- Published in:
- Clinical Trials, 2020, v. 17, n. 5, p. 472, doi. 10.1177/1740774520939938
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- Publication type:
- Article
Model‐based bioequivalence approach for sparse pharmacokinetic bioequivalence studies: Model selection or model averaging?
- Published in:
- Statistics in Medicine, 2024, v. 43, n. 18, p. 3403, doi. 10.1002/sim.10088
- By:
- Publication type:
- Article
cLRT-Mod: An efficient methodology for pharmacometric model-based analysis of longitudinal phase II dose finding studies under model uncertainty.
- Published in:
- 2021
- By:
- Publication type:
- journal article
Interrupter resistance to measure dose‐response to salbutamol in wheezy preschool children.
- Published in:
- Pediatric Pulmonology, 2018, v. 53, n. 9, p. 1252, doi. 10.1002/ppul.24116
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- Publication type:
- Article
Efficient model-based bioequivalence testing.
- Published in:
- 2022
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- Publication type:
- journal article
Optimal design in random-effects regression models.
- Published in:
- Biometrika, 1997, v. 84, n. 2, p. 429, doi. 10.1093/biomet/84.2.429
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- Publication type:
- Article
Screening for risk factors of relational withdrawal behaviour in infants aged 14–18months
- Published in:
- European Psychiatry, 2008, v. 23, n. 2, p. 150, doi. 10.1016/j.eurpsy.2007.07.008
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- Publication type:
- Article
The safety profile of favipiravir should not be the first argument to suspend its evaluation in viral hemorrhagic fevers.
- Published in:
- PLoS Neglected Tropical Diseases, 2020, v. 14, n. 6, p. 1, doi. 10.1371/journal.pntd.0008259
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- Publication type:
- Article
Individual Bayesian Information Matrix for Predicting Estimation Error and Shrinkage of Individual Parameters Accounting for Data Below the Limit of Quantification.
- Published in:
- Pharmaceutical Research, 2017, v. 34, n. 10, p. 2119, doi. 10.1007/s11095-017-2217-0
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- Publication type:
- Article
Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak.
- Published in:
- 2021
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- Publication type:
- journal article
eOSCE stations live versus remote evaluation and scores variability.
- Published in:
- BMC Medical Education, 2022, v. 22, n. 1, p. 1, doi. 10.1186/s12909-022-03919-1
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- Publication type:
- Article
Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART.
- Published in:
- European Journal of Clinical Pharmacology, 2009, v. 65, n. 7, p. 667, doi. 10.1007/s00228-009-0660-5
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- Publication type:
- Article
Population pharmacokinetic analysisof lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART.
- Published in:
- European Journal of Clinical Pharmacology, 2007, v. 63, n. 11, p. 1019, doi. 10.1007/s00228-007-0337-x
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- Publication type:
- Article
Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters.
- Published in:
- European Journal of Clinical Pharmacology, 2007, v. 63, n. 5, p. 437, doi. 10.1007/s00228-007-0269-5
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- Publication type:
- Article
A Colon‐Targeted Adsorbent (DAV132) Does Not Affect the Pharmacokinetics of Warfarin or Clonazepam in Healthy Subjects.
- Published in:
- Clinical Pharmacology in Drug Development, 2021, v. 10, n. 8, p. 908, doi. 10.1002/cpdd.901
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- Publication type:
- Article
Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06215-z
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- Publication type:
- Article
Influence of the Size of Cohorts in Adaptive Design for Nonlinear Mixed Effects Models: An Evaluation by Simulation for a Pharmacokinetic and Pharmacodynamic Model for a Biomarker in Oncology.
- Published in:
- Pharmaceutical Research, 2015, v. 32, n. 10, p. 3159, doi. 10.1007/s11095-015-1693-3
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- Publication type:
- Article
Prediction of Shrinkage of Individual Parameters Using the Bayesian Information Matrix in Non-Linear Mixed Effect Models with Evaluation in Pharmacokinetics.
- Published in:
- Pharmaceutical Research, 2013, v. 30, n. 9, p. 2355, doi. 10.1007/s11095-013-1079-3
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- Publication type:
- Article
MOSAIC: a European cohort study of human Mpox – the challenges of clinical research in outbreaks.
- Published in:
- Virologie, 2023, v. 27, n. 1, p. 12, doi. 10.1684/vir.2023.986
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- Publication type:
- Article
Mathematical Modeling of Bacterial Kinetics to Predict the Impact of Antibiotic Colonic Exposure and Treatment Duration on the Amount of Resistant Enterobacteria Excreted.
- Published in:
- PLoS Computational Biology, 2014, v. 10, n. 9, p. 1, doi. 10.1371/journal.pcbi.1003840
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- Publication type:
- Article
Persistent low-level HIV-1 RNA between 20 and 50 copies/mL in antiretroviral-treated patients: associated factors and virological outcome.
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- Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 9, p. 2231, doi. 10.1093/jac/dks191
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- Publication type:
- Article
Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22269-y
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- Publication type:
- Article
Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder.
- Published in:
- Drug Design, Development & Therapy, 2014, v. 8, p. 2321, doi. 10.2147/DDDT.S65495
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- Publication type:
- Article
Different Factors Associated with CTX-M-Producing ST131 and Non-ST131 <i>Escherichia coli</i> Clinical Isolates.
- Published in:
- PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0072191
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- Publication type:
- Article
Electronic Sensors for Assessing Interactions between Healthcare Workers and Patients under Airborne Precautions.
- Published in:
- PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037893
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- Publication type:
- Article
Patient's Origin and Lifestyle Associated with CTX-MProducing Escherichia coli : A Case-Control-Control Study.
- Published in:
- PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0030498
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- Publication type:
- Article
Association between Nasal Carriage of Staphylococcus Aureus and Infection in Liver Transplant Recipients.
- Published in:
- Clinical Infectious Diseases, 2000, v. 31, n. 5, p. 1295, doi. 10.1086/317469
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- Publication type:
- Article
Using the SAEM algorithm for mechanistic joint models characterizing the relationship between nonlinear PSA kinetics and survival in prostate cancer patients.
- Published in:
- Biometrics, 2017, v. 73, n. 1, p. 305, doi. 10.1111/biom.12537
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- Publication type:
- Article
Some Alternatives to Asymptotic Tests for the Analysis of Pharmacogenetic Data Using Nonlinear Mixed Effects Models.
- Published in:
- Biometrics, 2012, v. 68, n. 1, p. 146, doi. 10.1111/j.1541-0420.2011.01665.x
- By:
- Publication type:
- Article
Maximum Likelihood Estimation of Long-Term HIV Dynamic Models and Antiviral Response.
- Published in:
- Biometrics, 2011, v. 67, n. 1, p. 250, doi. 10.1111/j.1541-0420.2010.01422.x
- By:
- Publication type:
- Article
Heparin Bridging Therapy and Bleeding Events in Octogenarian Inpatients with Atrial Fibrillation Starting Anticoagulation: Results of an Ancillary Study.
- Published in:
- 2011
- By:
- Publication type:
- Letter
Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study.
- Published in:
- Malaria Journal, 2016, v. 13, p. 1, doi. 10.1186/s12936-016-1364-9
- By:
- Publication type:
- Article
Efficacy of Oseltamivir-Zanamivir Combination Compared to Each Monotherapy for Seasonal Influenza: A Randomized Placebo-Controlled Trial.
- Published in:
- PLoS Medicine, 2010, v. 7, n. 11, p. 1, doi. 10.1371/journal.pmed.1000362
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- Publication type:
- Article
Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice.
- Published in:
- British Journal of Pharmacology, 2004, v. 141, n. 7, p. 1214, doi. 10.1038/sj.bjp.0705721
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- Publication type:
- Article
Modeling changes in biomarkers in Gaucher disease patients receiving enzyme replacement therapy using a pathophysiological model.
- Published in:
- Orphanet Journal of Rare Diseases, 2014, v. 9, n. 1, p. 1, doi. 10.1186/1750-1172-9-95
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- Publication type:
- Article
Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models.
- Published in:
- Statistics in Medicine, 2012, v. 31, n. 11/12, p. 1043, doi. 10.1002/sim.4390
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- Publication type:
- Article
Model-based analyses of bioequivalence crossover trials using the stochastic approximation expectation maximisation algorithm.
- Published in:
- Statistics in Medicine, 2011, v. 30, n. 21, p. 2582, doi. 10.1002/sim.4286
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- Publication type:
- Article