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Tocilizumab therapy in individuals with COVID‐19 infection and hyperinflammatory state.
Published in:
Respirology, 2020, v. 25, n. 10, p. 1090, doi. 10.1111/resp.13912
By:
- McCarthy, Cormac;
- Savinelli, Stefano;
- Feeney, Eoin R.;
- Butler, Marcus W.;
- O'Broin, Cathal;
- Ryan, Silke;
- O'Neill, Lorraine;
- Murphy, David J.;
- Gallagher, Charles G.;
- McKone, Edward F.;
- Waqas, Sarmad;
- Cotter, Aoife;
- Doran, Peter;
- Keane, Michael P.;
- Mallon, Patrick W.
Publication type:
Article
Acute Pulmonary Exacerbation Phenotypes in Patients with Cystic Fibrosis.
Published in:
Annals of the American Thoracic Society, 2022, v. 19, n. 11, p. 1818, doi. 10.1513/AnnalsATS.202111-1266OC
By:
- Carter, Suzanne C.;
- Franciosi, Alessandro N.;
- O’Shea, Kate M.;
- O’Carroll, Orla M.;
- Sharma, Ashutosh;
- Bell, Aoife;
- Keogan, Brian;
- O’Reilly, Paul;
- Coughlan, Suzie;
- Law, Sheonagh M.;
- Gray, Robert D.;
- Hisert, Katherine B.;
- Singh, Pradeep K.;
- Cooke, Gordon;
- Grogan, Brenda;
- De Gascun, Cillian F.;
- Gallagher, Charles G.;
- Nicholson, Trevor T.;
- Quon, Bradley S.;
- McKone, Edward F.
Publication type:
Article
Correlation between Ivacaftor-induced CFTR Activation in Airway Epithelial Cells and Improved Lung Function: A Proof-of-Concept Study.
Published in:
2020
By:
- Debley, Jason S.;
- Barrow, Kaitlyn A.;
- Rich, Lucille M.;
- Singh, Pradeep;
- McKone, Edward F.;
- Nichols, David P.
Publication type:
Letter
Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in a patient with cystic fibrosis.
Published in:
Pediatric Pulmonology, 2002, v. 34, n. 5, p. 381, doi. 10.1002/ppul.10184
By:
- McKone, Edward F.;
- Tonelli, Mark R.;
- Aitken, Moira L.
Publication type:
Article
A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One Allele.
Published in:
2021
By:
- Zemanick, Edith T.;
- Taylor-Cousar, Jennifer L.;
- Davies, Jane;
- Gibson, Ronald L.;
- Mall, Marcus A.;
- McKone, Edward F.;
- McNally, Paul;
- Ramsey, Bonnie W.;
- Rayment, Jonathan H.;
- Rowe, Steven M.;
- Tullis, Elizabeth;
- Ahluwalia, Neil;
- Chenghao Chu;
- Thang Ho;
- Moskowitz, Samuel M.;
- Noel, Sabrina;
- Tian, Simon;
- Waltz, David;
- Weinstock, Tanya G.;
- Fengjuan Xuan
Publication type:
journal article
Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor for 24 Weeks or Longer in People with Cystic Fibrosis and One or More Alleles: Interim Results of an Open-Label Phase 3 Clinical Trial.
Published in:
2021
By:
- Griese, Matthias;
- Costa, Stefano;
- Linnemann, Rachel W.;
- Mall, Marcus A.;
- McKone, Edward F.;
- Polineni, Deepika;
- Quon9., Bradley S.;
- Ringshausen, Felix C.;
- Taylor-Cousar, Jennifer L.;
- Withers, Nicholas J.;
- Moskowitz, Samuel M.;
- Daines, Cori L.;
- Quon, Bradley S
Publication type:
clinical trial
Patients with Cystic Fibrosis and a G551D or Homozygous F508del Mutation: Similar Lung Function Decline.
Published in:
2017
By:
- Sawicki, Gregory S.;
- McKone, Edward F.;
- Millar, Stefanie J.;
- Pasta, David J.;
- Konstan, Michael W.;
- Lubarsky, Barry;
- Wagener, Jeffrey S.
Publication type:
Letter
Sustained Benefit from ivacaftor demonstrated by combining clinical trial and cystic fibrosis patient registry data.
Published in:
2015
By:
- Sawicki, Gregory S.;
- McKone, Edward F.;
- Pasta, David J.;
- Millar, Stefanie J.;
- Wagener, Jeffrey S.;
- Johnson, Charles A.;
- Konstan, Michael W.
Publication type:
journal article
CFTR Modulator Therapy Enhances Peripheral Blood Monocyte Contributions to Immune Responses in People With Cystic Fibrosis.
Published in:
Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.01219
By:
- Hisert, Katherine B.;
- Birkland, Timothy P.;
- Schoenfelt, Kelly Q.;
- Long, Matthew E.;
- Grogan, Brenda;
- Carter, Suzanne;
- Liles, W. Conrad;
- McKone, Edward F.;
- Becker, Lev;
- Manicone, Anne M.;
- Gharib, Sina A.
Publication type:
Article
Ivacaftor-induced proteomic changes suggest monocyte defects may contribute to the pathogenesis of cystic fibrosis.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2016, v. 54, n. 4, p. E1, doi. 10.1165/rcmb.2015-0322le
By:
- Hisert, Katherine B.;
- Schoenfelt, Kelly Q.;
- Cooke, Gordon;
- Grogan, Brenda;
- Launspach, Jan L.;
- Gallagher, Charles G.;
- Donnelly, Seamas C.;
- Welsh, Michael J.;
- Singh, Pradeep K.;
- McKone, Edward F.;
- Becker, Lev
Publication type:
Article
Pulmonary blastoma: a case report and review of the literature.
Published in:
2014
By:
- Smyth, Robert J.;
- Fabre, Aurelie;
- Dodd, Johnathan D.;
- Bartosik, Waldemar;
- Gallagher, Charles G.;
- McKone, Edward F.
Publication type:
Case Study
Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis.
Published in:
FASEB Journal, 2017, v. 31, n. 11, p. 5102, doi. 10.1096/fj.201700463R
By:
- Tynan, Aisling;
- Mawhinney, Leona;
- Armstrong, Michelle E.;
- O'Reilly, Ciaran;
- Kennedy, Sarah;
- Caraher, Emma;
- Jülicher, Karen;
- O'Dwyer, David;
- Maher, Lewena;
- Schaffer, Kirsten;
- Fabre, Aurélie;
- McKone, Edward F.;
- Lin Leng;
- Bucala, Richard;
- Bernhagen, Jürgen;
- Cooke, Gordon;
- Donnelly, Seamas C.
Publication type:
Article
Inflammatory cytokines TNF-α and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.
Published in:
2021
By:
- Rehman, Tayyab;
- Karp, Philip H.;
- Ping Tan;
- Goodell, Brian J.;
- Pezzulo, Alejandro A.;
- Thurman, Andrew L.;
- Thornell, Ian M.;
- Durfey, Samantha L.;
- Duffey, Michael E.;
- Stoltz, David A.;
- McKone, Edward F.;
- Singh, Pradeep K.;
- Welsh, Michael J.;
- Tan, Ping
Publication type:
journal article
Ivacaftor imaging response in cystic fibrosis.
Published in:
2014
By:
- Hoare, Siobhan;
- McEvoy, Sinead;
- McCarthy, Colin J;
- Kilcoyne, Aoife;
- Brady, Darragh;
- Gibney, Brian;
- Gallagher, Charles G;
- McKone, Edward F;
- Dodd, Jonathan D
Publication type:
journal article
Ivacaftor Imaging Response in Cystic Fibrosis.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 4, p. 484, doi. 10.1164/rccm.201308-1433im
By:
- Hoare, Siobhan;
- McEvoy, Sinead;
- McCarthy, Cohn J.;
- Kilcoyne, Aoife;
- Brady, Darragh;
- Gibney, Brian;
- Gallagher, Charles G.;
- McKone, Edward F.;
- Dodd, Jonathan D.
Publication type:
Article
Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease.
Published in:
2006
By:
- McKone EF;
- Shao J;
- Frangolias DD;
- Keener CL;
- Shephard CA;
- Farin FM;
- Tonelli MR;
- Pare PD;
- Sandford AJ;
- Aitken ML;
- Kavanagh TJ;
- McKone, Edward F;
- Shao, Jing;
- Frangolias, Daisy D;
- Keener, Cassie L;
- Shephard, Cynthia A;
- Farin, Federico M;
- Tonelli, Mark R;
- Pare, Peter D;
- Sandford, Andrew J
Publication type:
journal article
Variants in the Glutamate-Cysteine-Ligase Gene Are Associated with Cystic Fibrosis Lung Disease.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2006, v. 174, n. 4, p. 415, doi. 10.1164/rccm.200508-1281OC
By:
- McKone, Edward F.;
- Jing Shao;
- Frangolias, Daisy D.;
- Keener, Cassie L.;
- Shephard, Cynthia A.;
- Farin, Federico M.;
- Tonelli, Mark R.;
- Pare, Peter D.;
- Sandford, Andrew J.;
- Aitken, Moira L.;
- Kavanagh, Terrance J.
Publication type:
Article
Cystic Fibrosis, 3rd edition.
Published in:
2008
By:
- McKone, Edward F.
Publication type:
Book Review
Relationship between pulmonary hyperinflation and dyspnoea severity during acute exacerbations of cystic fibrosis.
Published in:
Respirology, 2017, v. 22, n. 1, p. 141, doi. 10.1111/resp.12885
By:
- Nicholson, Trevor T.;
- Barry, Peter J.;
- Waterhouse, Deirdre F.;
- Nolan, Geraldine M.;
- McKone, Edward F.;
- Gallagher, Charles G.
Publication type:
Article
Rate of Lung Function Decline in People with Cystic Fibrosis Having a Residual Function Gene Mutation.
Published in:
Pulmonary Therapy, 2022, v. 8, n. 4, p. 385, doi. 10.1007/s41030-022-00202-y
By:
- Sawicki, Gregory S.;
- Konstan, Michael W.;
- McKone, Edward F.;
- Moss, Richard B.;
- Lubarsky, Barry;
- Suthoff, Ellison;
- Millar, Stefanie J.;
- Pasta, David J.;
- Mayer-Hamblett, Nicole;
- Goss, Christopher H.;
- Morgan, Wayne J.;
- Duncan, Margaret E.;
- Yang, Yoojung
Publication type:
Article
Longitudinal Trends in Real-World Outcomes after Initiation of Ivacaftor. A Cohort Study from the Cystic Fibrosis Registry of Ireland.
Published in:
2019
By:
- Kirwan, Laura;
- Fletcher, Godfrey;
- Harrington, Mary;
- Jeleniewska, Paulina;
- Zhou, Shijun;
- Casserly, Brian;
- Gallagher, Charles G;
- Greally, Peter;
- Gunaratnam, Cedric;
- Herzig, Mary;
- Linnane, Barry;
- McElvaney, Noel Gerard;
- McKone, Edward F;
- McNally, Paul;
- Mullane, David;
- Ní Chróinín, Muireann;
- O'Mahony, Michael;
- Plant, Barry J;
- Jackson, Abaigeal D
Publication type:
journal article

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