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Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 12, p. 3080, doi. 10.3390/ijms20123080
By:
- Wu, Fan;
- McCuaig, Robert D.;
- Sutton, Christopher R.;
- Tan, Abel H. Y.;
- Jeelall, Yoshni;
- Bean, Elaine G.;
- Dai, Jin;
- Prasanna, Thiru;
- Batham, Jacob;
- Malik, Laeeq;
- Yip, Desmond;
- Dahlstrom, Jane E.;
- Rao, Sudha
Publication type:
Article
In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39341-4
By:
- Tu, Wen Juan;
- Melino, Michelle;
- Dunn, Jenny;
- McCuaig, Robert D.;
- Bielefeldt-Ohmann, Helle;
- Tsimbalyuk, Sofiya;
- Forwood, Jade K.;
- Ahuja, Taniya;
- Vandermeide, John;
- Tan, Xiao;
- Tran, Minh;
- Nguyen, Quan;
- Zhang, Liang;
- Nam, Andy;
- Pan, Liuliu;
- Liang, Yan;
- Smith, Corey;
- Lineburg, Katie;
- Nguyen, Tam H.;
- Sng, Julian D. J.
Publication type:
Article
Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Published in:
Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.01228
By:
- Tu, Wen Juan;
- McCuaig, Robert D.;
- Tan, Abel H. Y.;
- Hardy, Kristine;
- Seddiki, Nabila;
- Ali, Sayed;
- Dahlstrom, Jane E.;
- Bean, Elaine G.;
- Dunn, Jenny;
- Forwood, Jade;
- Tsimbalyuk, Sofia;
- Smith, Kate;
- Yip, Desmond;
- Malik, Laeeq;
- Prasanna, Thiru;
- Milburn, Peter;
- Rao, Sudha
Publication type:
Article
Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8 + T Cells in Immunotherapy-Resistant and Metastatic Cancers.
Published in:
Cancers, 2022, v. 14, n. 6, p. 1596, doi. 10.3390/cancers14061596
By:
- Dunn, Jenny;
- McCuaig, Robert D.;
- Tan, Abel H. Y.;
- Tu, Wen Juan;
- Wu, Fan;
- Wagstaff, Kylie M.;
- Zafar, Anjum;
- Ali, Sayed;
- Diwakar, Himanshu;
- Dahlstrom, Jane E.;
- Bean, Elaine G.;
- Forwood, Jade K.;
- Tsimbalyuk, Sofiya;
- Cross, Emily M.;
- Hardy, Kristine;
- Bain, Amanda L.;
- Ahern, Elizabeth;
- Dolcetti, Riccardo;
- Mazzieri, Roberta;
- Yip, Desmond
Publication type:
Article
A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED).
Published in:
Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.862427
By:
- Prasanna, Thiru;
- Malik, Laeeq;
- McCuaig, Robert D.;
- Tu, Wen Juan;
- Wu, Fan;
- Lim, Pek Siew;
- Tan, Abel H. Y.;
- Dahlstrom, Jane E.;
- Clingan, Philip;
- Moylan, Eugene;
- Chrisp, Jeremy;
- Fuller, David;
- Rao, Sudha;
- Yip, Desmond
Publication type:
Article
Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Published in:
Cell Discovery, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41421-021-00279-w
By:
- Tu, Wen Juan;
- McCuaig, Robert D.;
- Melino, Michelle;
- Rawle, Daniel J.;
- Le, Thuy T.;
- Yan, Kexin;
- Suhrbier, Andreas;
- Johnston, Rebecca L.;
- Koufariotis, Lambros T.;
- Waddell, Nicola;
- Cross, Emily M.;
- Tsimbalyuk, Sofiya;
- Bain, Amanda;
- Ahern, Elizabeth;
- Collinson, Natasha;
- Phipps, Simon;
- Forwood, Jade K.;
- Seddiki, Nabila;
- Rao, Sudha
Publication type:
Article

Found: 6

Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer.

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting.

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.

Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8 + T Cells in Immunotherapy-Resistant and Metastatic Cancers.

A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED).

Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.