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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
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- Pharmaceutics, 2024, v. 16, n. 2, p. 158, doi. 10.3390/pharmaceutics16020158
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- Article
Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers.
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- Pharmaceutics, 2023, v. 15, n. 12, p. 2680, doi. 10.3390/pharmaceutics15122680
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- Publication type:
- Article
The Trimeric Artesunate Analog TF27, a Broadly Acting Anti-Infective Model Drug, Exerts Pronounced Anti-SARS-CoV-2 Activity Spanning Variants and Host Cell Types.
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- Pharmaceutics, 2023, v. 15, n. 1, p. 115, doi. 10.3390/pharmaceutics15010115
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- Article
A Peptide Inhibitor of the Human Cytomegalovirus Core Nuclear Egress Complex.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 9, p. N.PAG, doi. 10.3390/ph15091040
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- Article
The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids.
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- Reviews in Medical Virology, 2017, v. 27, n. 4, p. n/a, doi. 10.1002/rmv.1934
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- Article
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11814, doi. 10.3390/ijms231911814
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- Publication type:
- Article
Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 5, p. 2493, doi. 10.3390/ijms23052493
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- Article
Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 23, p. 12858, doi. 10.3390/ijms222312858
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- Article
Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs).
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- International Journal of Molecular Sciences, 2021, v. 22, n. 2, p. 575, doi. 10.3390/ijms22020575
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- Article
The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 15, p. 5578, doi. 10.3390/ijms21155578
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- Publication type:
- Article
Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti‐SARS‐CoV‐2 Activity.
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- ChemMedChem, 2024, v. 19, n. 19, p. 1, doi. 10.1002/cmdc.202400292
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- Article
Human Cytomegalovirus Replication Is Strictly Inhibited by siRNAs Targeting UL54, UL97 or UL122/123 Gene Transcripts.
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- PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0097231
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- Article
Front Cover: Light‐Driven Catalyst‐Free Access to Phthalazines: Entry to Antiviral Model Drugs by Merging Domino Reactions (Eur. J. Org. Chem. 5/2023).
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- European Journal of Organic Chemistry, 2023, v. 26, n. 5, p. 1, doi. 10.1002/ejoc.202300057
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- Publication type:
- Article
Light‐Driven Catalyst‐Free Access to Phthalazines: Entry to Antiviral Model Drugs by Merging Domino Reactions**.
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- European Journal of Organic Chemistry, 2023, v. 26, n. 5, p. 1, doi. 10.1002/ejoc.202200994
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- Publication type:
- Article
Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses.
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- Journal of Molecular Medicine, 2002, v. 80, n. 4, p. 233, doi. 10.1007/s00109-001-0300-8
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- Publication type:
- Article
Back Cover: Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products (ChemistryOpen 3/2017).
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- ChemistryOpen, 2017, v. 6, n. 3, p. 452, doi. 10.1002/open.201700092
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- Publication type:
- Article
Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products.
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- ChemistryOpen, 2017, v. 6, n. 3, p. 364, doi. 10.1002/open.201700005
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- Publication type:
- Article
Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus.
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- Microorganisms, 2020, v. 8, n. 6, p. 820, doi. 10.3390/microorganisms8060820
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- Article
The Cytomegalovirus Protein Kinase pUL97: Host Interactions, Regulatory Mechanisms and Antiviral Drug Targeting.
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- Microorganisms, 2020, v. 8, n. 4, p. 515, doi. 10.3390/microorganisms8040515
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- Article
Visible‐Light‐Driven C−H Oxidation of Cyclic Tertiary Amines: Access to Synthetic Strychnos Alkaloids with Antiviral Activity.
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- Chemistry - A European Journal, 2019, v. 25, n. 16, p. 4062, doi. 10.1002/chem.201900078
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- Article
Frontispiece: Synthesis of Artemisinin‐Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action.
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- 2018
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- Cover Art
Synthesis of Artemisinin‐Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action.
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- Chemistry - A European Journal, 2018, v. 24, n. 32, p. 8103, doi. 10.1002/chem.201800729
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- Publication type:
- Article
Establishment of a Luciferase-Based Reporter System to Study Aspects of Human Cytomegalovirus Infection, Replication Characteristics, and Antiviral Drug Efficacy.
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- Pathogens, 2024, v. 13, n. 8, p. 645, doi. 10.3390/pathogens13080645
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- Publication type:
- Article
Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2.
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- Pathogens, 2021, v. 10, n. 9, p. 1076, doi. 10.3390/pathogens10091076
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- Article
Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions.
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- Nature Communications, 2017, v. 8, n. 5, p. 15071, doi. 10.1038/ncomms15071
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- Publication type:
- Article
Human Cytomegalovirus Dysregulates Cellular Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases and Sonic Hedgehog Pathway Proteins in Neural Astrocyte and Placental Models.
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- Viruses (1999-4915), 2024, v. 16, n. 6, p. 918, doi. 10.3390/v16060918
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- Article
Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses.
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- Viruses (1999-4915), 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/v14102285
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- Article
The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors.
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- Viruses (1999-4915), 2022, v. 14, n. 5, p. 1021, doi. 10.3390/v14051021
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- Publication type:
- Article
Antiviral Strategies Using Natural Source-Derived Sulfated Polysaccharides in the Light of the COVID-19 Pandemic and Major Human Pathogenic Viruses.
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- Viruses (1999-4915), 2022, v. 14, n. 1, p. 35, doi. 10.3390/v14010035
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- Publication type:
- Article
Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97.
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- Viruses (1999-4915), 2021, v. 13, n. 7, p. 1248, doi. 10.3390/v13071248
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- Article
Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors.
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- Viruses (1999-4915), 2021, v. 13, n. 3, p. 471, doi. 10.3390/v13030471
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- Publication type:
- Article
Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule.
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- Viruses (1999-4915), 2021, v. 13, n. 3, p. 462, doi. 10.3390/v13030462
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- Publication type:
- Article
Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.
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- Viruses (1999-4915), 2021, v. 13, n. 2, p. 165, doi. 10.3390/v13020165
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- Publication type:
- Article
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.
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- Viruses (1999-4915), 2020, v. 12, n. 12, p. 1394, doi. 10.3390/v12121394
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- Article
Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties.
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- Viruses (1999-4915), 2020, v. 12, n. 6, p. 683, doi. 10.3390/v12060683
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- Publication type:
- Article
Patterns of Autologous and Nonautologous Interactions between Core Nuclear Egress Complex (NEC) Proteins of α-, β- and γ-Herpesviruses.
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- Viruses (1999-4915), 2020, v. 12, n. 3, p. 303, doi. 10.3390/v12030303
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- Publication type:
- Article
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97.
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- Viruses (1999-4915), 2018, v. 10, n. 1, p. 35, doi. 10.3390/v10010035
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- Publication type:
- Article
Begomoviral Movement Protein Effects in Human and Plant Cells: Towards New Potential Interaction Partners.
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- Viruses (1999-4915), 2017, v. 9, n. 11, p. 334, doi. 10.3390/v9110334
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- Publication type:
- Article
Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins.
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- Viruses (1999-4915), 2016, v. 8, n. 8, p. 219, doi. 10.3390/v8080219
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- Publication type:
- Article
Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope.
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- Viruses (1999-4915), 2016, v. 8, n. 3, p. 73, doi. 10.3390/v8030073
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- Article
The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.
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- Viruses (1999-4915), 2015, v. 7, n. 8, p. 4582, doi. 10.3390/v7082834
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- Article
The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins.
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- Viruses (1999-4915), 2013, v. 5, n. 12, p. 3213, doi. 10.3390/v5123213
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- Publication type:
- Article
Exploiting the Amazing Diversity of Natural Source-Derived Polysaccharides: Modern Procedures of Isolation, Engineering, and Optimization of Antiviral Activities.
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- Polymers (20734360), 2021, v. 13, n. 1, p. 136, doi. 10.3390/polym13010136
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- Publication type:
- Article
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress.
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- PLoS Pathogens, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.ppat.1005825
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- Article
Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target.
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- Cells (2073-4409), 2024, v. 13, n. 16, p. 1338, doi. 10.3390/cells13161338
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- Publication type:
- Article
Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target.
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- Cells (2073-4409), 2023, v. 12, n. 8, p. 1162, doi. 10.3390/cells12081162
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- Publication type:
- Article
'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis.
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- Cells (2073-4409), 2022, v. 11, n. 24, p. 4030, doi. 10.3390/cells11244030
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- Article
'Come together'—The Regulatory Interaction of Herpesviral Nuclear Egress Proteins Comprises Both Essential and Accessory Functions.
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- Cells (2073-4409), 2022, v. 11, n. 11, p. 1837, doi. 10.3390/cells11111837
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- Article
The Complex Regulatory Role of Cytomegalovirus Nuclear Egress Protein pUL50 in the Production of Infectious Virus.
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- Cells (2073-4409), 2021, v. 10, n. 11, p. 3119, doi. 10.3390/cells10113119
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- Publication type:
- Article
Autofluorescent Artemisinin‐Benzimidazole Hybrids via Organo‐Click Reaction: Study of Antiviral Properties and Mode of Action in Living Cells.
- Published in:
- Chemistry - A European Journal, 2023, v. 29, n. 48, p. 1, doi. 10.1002/chem.202301194
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- Publication type:
- Article