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Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H<sub>3</sub>R-Antagonismus bei neurodegenerativen Erkrankungen.
- Published in:
- Angewandte Chemie, 2017, v. 129, n. 41, p. 12939, doi. 10.1002/ange.201706072
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- Article
In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system.
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- Journal of Pharmacy & Pharmacology, 2017, v. 69, n. 3, p. 314, doi. 10.1111/jphp.12697
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- Article
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.
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- Pharmaceutics, 2024, v. 16, n. 1, p. 121, doi. 10.3390/pharmaceutics16010121
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- Article
Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 11, p. 1363, doi. 10.3390/ph15111363
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- Article
Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 9, p. 861, doi. 10.3390/ph14090861
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- Article
In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234.
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- 2018
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- Letter to the Editor
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H<sub>3</sub>R Antagonism for Neurodegenerative Diseases.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 41, p. 12765, doi. 10.1002/anie.201706072
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- Article
Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9742, doi. 10.3390/ijms24119742
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- Article
Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 13, p. 7449, doi. 10.3390/ijms23137449
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- Article
Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia–Reperfusion.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 6, p. 3411, doi. 10.3390/ijms23063411
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- Article
Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 7949, doi. 10.3390/ijms21217949
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- Article
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7652, doi. 10.3390/ijms21207652
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- Article
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 3913, doi. 10.3390/ijms21113913
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- Article
Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5‐a]pyridine Derivatives.
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- ChemistrySelect, 2021, v. 6, n. 5, p. 945, doi. 10.1002/slct.202004577
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- Article
Automated Synthesis of New Quinoxalinetacrines.
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- ChemistrySelect, 2020, v. 5, n. 21, p. 6491, doi. 10.1002/slct.202001593
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- Article
Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles
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- ChemistrySelect, 2019, v. 4, n. 44, p. 12902, doi. 10.1002/slct.201903982
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- Article
Synthesis, Monoamine Oxidase Inhibition and Computational Analysis of Diversely Substituted N‐Propargylated‐1,3,5‐triazines.
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- ChemistrySelect, 2019, v. 4, n. 28, p. 8334, doi. 10.1002/slct.201901271
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- Publication type:
- Article
Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models.
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- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-29929-7
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- Publication type:
- Article
Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy.
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- CNS Neuroscience & Therapeutics, 2016, v. 22, n. 9, p. 799, doi. 10.1111/cns.12590
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- Publication type:
- Article
Neuroprotective Effects of the MAO- B Inhibitor, PF9601 N, in an In Vivo Model of Excitotoxicity.
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- CNS Neuroscience & Therapeutics, 2014, v. 20, n. 7, p. 641, doi. 10.1111/cns.12271
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- Publication type:
- Article
N-(furan-2-ylmethyl)- N-methylprop-2-yn-1-amine (F2 MPA): A Potential Cognitive Enhancer with MAO Inhibitor Properties.
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- CNS Neuroscience & Therapeutics, 2014, v. 20, n. 7, p. 633, doi. 10.1111/cns.12284
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- Publication type:
- Article
Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS234.
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- CNS Neuroscience & Therapeutics, 2014, v. 20, n. 6, p. 568, doi. 10.1111/cns.12269
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- Article
Enantioselective Neuroprotective Effects of Tacripyrine ITH122 Against Oxygen and Glucose Deprivation in Rat Hippocampal Slices.
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- CNS Neuroscience & Therapeutics, 2013, v. 19, n. 4, p. 285, doi. 10.1111/cns.12073
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- Article
Synthesis of 5-Amino-3,3-dimethyl-7-phenyl-3 H-[1,2]oxathiolo[4,3- b]pyridine-6-carbonitrile 1,1-Dioxides.
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- Journal of Heterocyclic Chemistry, 2014, v. 51, n. 5, p. 1452, doi. 10.1002/jhet.1678
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- Article
Synthesis of 7-azabicyclo[2.2.1]heptane derivatives by transformation of tropinone.
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- Journal of Heterocyclic Chemistry, 2006, v. 43, n. 6, p. 1455, doi. 10.1002/jhet.5570430607
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- Article
Efficient Two-Step Synthesis of Novel Pyrimido[4,5- d ] Pyrimidines with Potent Neuroprotective, Antioxidant, and A β Anti-Aggregation Properties.
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- Chemistry (2624-8549), 2024, v. 6, n. 4, p. 695, doi. 10.3390/chemistry6040041
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- Article
Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.
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- Frontiers in Aging Neuroscience, 2016, v. 8, p. 1, doi. 10.3389/fnagi.2016.00281
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- Article
Updating the CSIC Reaction (2003–2020).
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- European Journal of Organic Chemistry, 2021, v. 2021, n. 8, p. 1229, doi. 10.1002/ejoc.202001330
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- Article
Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases.
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- Biomolecules (2218-273X), 2024, v. 14, n. 5, p. 588, doi. 10.3390/biom14050588
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- Article
Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors.
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- Biomolecules (2218-273X), 2019, v. 9, n. 8, p. 379, doi. 10.3390/biom9080379
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- Article
Transition Metal-Assisted Transformations of Diversely Functionalized Dienynes.
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- European Journal of Organic Chemistry, 2003, v. 2003, n. 9, p. 1759, doi. 10.1002/ejoc.200310007
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- Article
New Agents with Antimycobacterial ActivityThis paper is dedicated with respect to the memory of Professor Dr. Eldiberto Fernández Alvarez, deceased in Madrid (Spain) in 1996, who designed and conceived the synthesis and biological evaluation of all the compounds shown here, for his pioneering contribution to the development of the bioorganic chemistry in Spain.
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- Archiv der Pharmazie, 2005, v. 338, n. 11, p. 562, doi. 10.1002/ardp.200500133
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- Article
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.
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- Molecules, 2023, v. 28, n. 1, p. 71, doi. 10.3390/molecules28010071
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- Article
Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties.
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- Molecules, 2022, v. 27, n. 22, p. 7878, doi. 10.3390/molecules27227878
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- Publication type:
- Article
N -Hydroxy- N -Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.
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- Molecules, 2022, v. 27, n. 21, p. 7437, doi. 10.3390/molecules27217437
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- Publication type:
- Article
ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.
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- Frontiers in Neuroscience, 2016, p. 1, doi. 10.3389/fnins.2016.00294
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- Article
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.
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- Frontiers in Neuroscience, 2016, p. 1, doi. 10.3389/fnins.2016.00205
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- Publication type:
- Article
Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.
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- Medicinal Research Reviews, 2013, v. 33, n. 1, p. 139, doi. 10.1002/med.20248
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- Publication type:
- Article
Metal-Catalyzed Cyclization of β- and γ-Allenols Derived from D-Glyceraldehyde-Synthesis of Enantiopure Dihydropyrans and Tetrahydrooxepines: An Experimental and Theoretical Study.
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- Chemistry - A European Journal, 2009, v. 15, n. 36, p. 9127, doi. 10.1002/chem.200901180
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- Publication type:
- Article
Regioselectivity Control in the Metal-Catalyzed Functionalization of γ-Allenols, Part 2: Theoretical Study.
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- Chemistry - A European Journal, 2009, v. 15, n. 8, p. 1909, doi. 10.1002/chem.200802035
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- Publication type:
- Article
Regioselectivity Control in the Metal-Catalyzed OC Functionalization of γ-Allenols, Part 1: Experimental Study.
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- Chemistry - A European Journal, 2009, v. 15, n. 8, p. 1901, doi. 10.1002/chem.200802034
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- Publication type:
- Article
New Insights on the Mechanism of the Transition-Metal Stereoselective Olefin Cyclopropanation.
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- Chemistry - A European Journal, 2008, v. 14, n. 22, p. 6771, doi. 10.1002/chem.200800305
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- Publication type:
- Article
Recent Developments in the Metal-Catalyzed Reactions of Metallocarbenoids from Propargylic Esters.
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- Chemistry - A European Journal, 2007, v. 13, n. 5, p. 1350, doi. 10.1002/chem.200601522
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- Article
A DFT-Based Theoretical Investigation of the Mechanism of the PtCl2-Mediated Cycloisomerization of Allenynes.
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- Chemistry - A European Journal, 2005, v. 11, n. 2, p. 521, doi. 10.1002/chem.200400618
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- Article
β-Lactam-Synthese durch die Kinugasa-Reaktion.
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- Angewandte Chemie, 2004, v. 116, n. 17, p. 2248, doi. 10.1002/ange.200301730
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- Publication type:
- Article
Predicting targets of compounds against neurological diseases using cheminformatic methodology.
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- Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 2, p. 183, doi. 10.1007/s10822-014-9816-1
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- Publication type:
- Article
In Vitro Modulation of Autophagy by New Antioxidant Nitrones as a Potential Therapeutic Approach for the Treatment of Ischemic Stroke.
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- Antioxidants, 2024, v. 13, n. 8, p. 946, doi. 10.3390/antiox13080946
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- Publication type:
- Article
α-Phenyl- N-tert -Butylnitrone and Analogous α-Aryl- N -alkylnitrones as Neuroprotective Antioxidant Agents for Stroke.
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- Antioxidants, 2024, v. 13, n. 4, p. 440, doi. 10.3390/antiox13040440
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- Publication type:
- Article
Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death.
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- Antioxidants, 2023, v. 12, n. 7, p. 1364, doi. 10.3390/antiox12071364
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- Article
Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones.
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- Antioxidants, 2023, v. 12, n. 1, p. 36, doi. 10.3390/antiox12010036
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- Publication type:
- Article