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No relation between docetaxel administration route and high‐grade diarrhea incidence.
Published in:
Pharmacology Research & Perspectives, 2020, v. 8, n. 4, p. 1, doi. 10.1002/prp2.633
By:
- Hendrikx, Jeroen J. M. A.;
- Stuurman, Frederik E.;
- Song, Ji‐Ying;
- de Weger, Vincent A.;
- Lagas, Jurjen S.;
- Rosing, Hilde;
- Beijnen, Jos H.;
- Schinkel, Alfred H.;
- Schellens, Jan H. M.;
- Marchetti, Serena
Publication type:
Article
A Phase 1 Dose‐Escalation Study of Low‐Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors.
Published in:
Clinical Pharmacology in Drug Development, 2021, v. 10, n. 6, p. 607, doi. 10.1002/cpdd.880
By:
- Weger, Vincent A.;
- Vermunt, Marit A.C.;
- Stuurman, Frederik E.;
- Burylo, Artur M.;
- Damoiseaux, David;
- Hendrikx, Jeroen J.M.A.;
- Sawicki, Emilia;
- Moes, Johannes J.;
- Huitema, Alwin D.R.;
- Nuijen, Bastiaan;
- Rosing, Hilde;
- Mergui‐Roelvink, Marja;
- Beijnen, Jos H.;
- Marchetti, Serena
Publication type:
Article
Effect of Food on the Pharmacokinetics of the Oral Docetaxel Tablet Formulation ModraDoc006 Combined with Ritonavir (ModraDoc006/r) in Patients with Advanced Solid Tumours.
Published in:
Drugs in R&D, 2021, v. 21, n. 1, p. 103, doi. 10.1007/s40268-020-00336-x
By:
- Vermunt, Marit A. C.;
- de Weger, Vincent A.;
- Janssen, Julie M.;
- Lopez-Yurda, Marta I.;
- Keessen, Marianne;
- Thijssen, Bas;
- Rosing, Hilde;
- Huitema, Alwin D. R.;
- Beijnen, Jos H.;
- Marchetti, Serena
Publication type:
Article
Phase I pharmacological study of continuous chronomodulated capecitabine treatment.
Published in:
Pharmaceutical Research, 2020, v. 37, n. 5, p. 1, doi. 10.1007/s11095-020-02828-6
By:
- Roosendaal, Jeroen;
- Jacobs, Bart A. W.;
- Pluim, Dick;
- Rosing, Hilde;
- de Vries, Niels;
- van Werkhoven, Erik;
- Nuijen, Bastiaan;
- Beijnen, Jos H.;
- Huitema, Alwin D. R.;
- Schellens, Jan H. M.;
- Marchetti, Serena
Publication type:
Article
Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir.
Published in:
Investigational New Drugs, 2020, v. 38, n. 5, p. 1526, doi. 10.1007/s10637-020-00935-0
By:
- Yu, Huixin;
- Janssen, Julie M.;
- de Weger, Vincent A.;
- Nuijen, Bastiaan;
- Stuurman, Rik E.;
- Marchetti, Serena;
- Schellens, Jan H. M.;
- Beijnen, Jos H.;
- Dorlo, Thomas P. C.;
- Huitema, Alwin D. R.
Publication type:
Article
Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1).
Published in:
Investigational New Drugs, 2020, v. 38, n. 4, p. 1117, doi. 10.1007/s10637-019-00856-7
By:
- van der Noll, Ruud;
- Jager, Agnes;
- Ang, Joo Ern;
- Marchetti, Serena;
- Mergui-Roelvink, Marja W. J.;
- Lolkema, Martijn P.;
- de Jonge, Maja J. A.;
- van der Biessen, Diane A.;
- Brunetto, Andre T.;
- Arkenau, Hendrik-Tobias;
- Tchakov, Ilian;
- Beijnen, Jos H.;
- de Bono, Johann S.;
- Schellens, Jan H. M.
Publication type:
Article
Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2).
Published in:
Investigational New Drugs, 2020, v. 38, n. 4, p. 1096, doi. 10.1007/s10637-019-00857-6
By:
- van der Noll, Ruud;
- Jager, Agnes;
- Ang, Joo Ern;
- Marchetti, Serena;
- Mergui-Roelvink, Marja W. J.;
- de Bono, Johann S.;
- Lolkema, Martijn P.;
- de Jonge, Maja J. A.;
- van der Biessen, Diane A.;
- Brunetto, Andre T.;
- Arkenau, Hendrik-Tobias;
- Tchakov, Ilian;
- Beijnen, Jos H.;
- De Grève, Jacques;
- Schellens, Jan H. M.
Publication type:
Article
'Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183'.
Published in:
Investigational New Drugs, 2014, v. 32, n. 6, p. 1083, doi. 10.1007/s10637-014-0143-0
By:
- Marchetti, Serena;
- Pluim, Dick;
- Beijnen, Jos;
- Mazzanti, Roberto;
- Tellingen, Olaf;
- Schellens, Jan
Publication type:
Article
Population Pharmacokinetics of Intracellular 5-Fluorouridine 5′-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine.
Published in:
AAPS Journal, 2021, v. 23, n. 1, p. 1, doi. 10.1208/s12248-020-00533-1
By:
- Janssen, Julie M.;
- Jacobs, Bart A. W.;
- Roosendaal, Jeroen;
- Derissen, Ellen J. B.;
- Marchetti, Serena;
- Beijnen, Jos H.;
- Huitema, Alwin D. R.;
- Dorlo, Thomas P. C.
Publication type:
Article
The effect of Echinacea purpurea on the pharmacokinetics of docetaxel.
Published in:
British Journal of Clinical Pharmacology, 2013, v. 76, n. 3, p. 467, doi. 10.1111/bcp.12159
By:
- Goey, Andrew K. L.;
- Meijerman, Irma;
- Rosing, Hilde;
- Burgers, Jacobus A.;
- Mergui‐Roelvink, Marja;
- Keessen, Marianne;
- Marchetti, Serena;
- Beijnen, Jos H.;
- Schellens, Jan H. M.
Publication type:
Article
Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin.
Published in:
British Journal of Clinical Pharmacology, 2013, v. 75, n. 2, p. 507, doi. 10.1111/j.1365-2125.2012.04381.x
By:
- Devriese, Lot A.;
- Witteveen, Petronella (Els) O.;
- Wanders, Jantien;
- Law, Kenneth;
- Edwards, Geoff;
- Reyderman, Larisa;
- Copalu, William;
- Peng, Fuping;
- Marchetti, Serena;
- Beijnen, Jos H.;
- Huitema, Alwin D. R.;
- Voest, Emile E.;
- Schellens, Jan H. M.
Publication type:
Article
Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.
Published in:
Investigational New Drugs, 2013, v. 31, n. 5, p. 1125, doi. 10.1007/s10637-013-9923-1
By:
- Marchetti, Serena;
- Pluim, Dick;
- Eijndhoven, Monique;
- Tellingen, Olaf;
- Mazzanti, Roberto;
- Beijnen, Jos;
- Schellens, Jan
Publication type:
Article
Erratum to: Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.
Published in:
2013
By:
- Marchetti, Serena;
- Pluim, Dick;
- Eijndhoven, Monique;
- Tellingen, Olaf;
- Mazzanti, Roberto;
- Beijnen, Jos;
- Schellens, Jan
Publication type:
Correction Notice
Pharmacokinetics and Toxicities of Oral Docetaxel Formulations Co-Administered with Ritonavir in Phase I Trials.
Published in:
Clinical Pharmacology, 2021, v. 13, p. 21, doi. 10.2147/CPAA.S292746
By:
- Vermunt, Marit;
- Marchetti, Serena;
- Beijnen, Jos
Publication type:
Article
Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane.
Published in:
Journal of Cellular & Molecular Medicine, 2015, v. 19, n. 6, p. 1410, doi. 10.1111/jcmm.12528
By:
- Fantappiè, Ornella;
- Sassoli, Chiara;
- Tani, Alessia;
- Nosi, Daniele;
- Marchetti, Serena;
- Formigli, Lucia;
- Mazzanti, Roberto
Publication type:
Article
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.
Published in:
2020
By:
- van Geel, Robin M. J. M.;
- van Brummelen, Emilie M. J.;
- Eskens, Ferry A. L. M.;
- Huijberts, Sanne C. F. A.;
- de Vos, Filip Y. F. L.;
- Lolkema, Martijn P. J. K.;
- Devriese, Lot A.;
- Opdam, Frans L.;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Monkhorst, Kim;
- Thijssen, Bas;
- Rosing, Hilde;
- Huitema, Alwin D. R.;
- Beijnen, Jos H.;
- Bernards, René;
- Schellens, Jan H. M.
Publication type:
journal article
Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.
Published in:
British Journal of Cancer, 2015, v. 113, n. 3, p. 396, doi. 10.1038/bjc.2015.256
By:
- van der Noll, Ruud;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Beijnen, Jos H;
- Mergui-Roelvink, Marja W J;
- Harms, Emmy;
- Rehorst, Harriet;
- Sonke, Gabe S;
- Schellens, Jan H M
Publication type:
Article
Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.
Published in:
2020
By:
- Huijberts, Sanne C. F. A.;
- van Geel, Robin M. J. M.;
- van Brummelen, Emilie M. J.;
- Opdam, Frans L.;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Pulleman, Saskia;
- Thijssen, Bas;
- Rosing, Hilde;
- Monkhorst, Kim;
- Huitema, Alwin D. R.;
- Beijnen, Jos H.;
- Bernards, René;
- Schellens, Jan H. M.
Publication type:
journal article
A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine.
Published in:
2016
By:
- Jacobs, Bart;
- Meulenaar, Jelte;
- Rosing, Hilde;
- Pluim, Dick;
- Tibben, Matthijs;
- Vries, Niels;
- Nuijen, Bastiaan;
- Huitema, Alwin;
- Beijnen, Jos;
- Schellens, Jan;
- Marchetti, Serena;
- Jacobs, Bart A W;
- Tibben, Matthijs M;
- de Vries, Niels;
- Huitema, Alwin D R;
- Beijnen, Jos H;
- Schellens, Jan H M
Publication type:
journal article
Disposition and metabolism of C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors.
Published in:
Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 5, p. 653, doi. 10.1007/s00280-012-1947-2
By:
- Dubbelman, Anne-Charlotte;
- Upthagrove, Alana;
- Beijnen, Jos;
- Marchetti, Serena;
- Tan, Eugene;
- Krone, Kimberly;
- Anand, Suraj;
- Schellens, Jan
Publication type:
Article
The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate.
Published in:
Cancer Chemotherapy & Pharmacology, 2007, v. 59, n. 6, p. 855, doi. 10.1007/s00280-006-0334-2
By:
- Oostendorp, Roos L.;
- Marchetti, Serena;
- Beijnen, Jos H.;
- Mazzanti, R.;
- Schellens, Jan H. M.
Publication type:
Article
The Effect of St John's Wort on the Pharmacokinetics of Docetaxel.
Published in:
Clinical Pharmacokinetics, 2014, v. 53, n. 1, p. 103, doi. 10.1007/s40262-013-0102-5
By:
- Goey, Andrew;
- Meijerman, Irma;
- Rosing, Hilde;
- Marchetti, Serena;
- Mergui-Roelvink, Marja;
- Keessen, Marianne;
- Burgers, Jacobus;
- Beijnen, Jos;
- Schellens, Jan
Publication type:
Article
A Phase I dose‐escalation study of two cycles carboplatin‐olaparib followed by olaparib monotherapy in patients with advanced cancer.
Published in:
International Journal of Cancer, 2021, v. 148, n. 12, p. 3041, doi. 10.1002/ijc.33498
By:
- Geenen, Jill J. J.;
- Dackus, Gwen M. H. E.;
- Schouten, Philip C.;
- Pluim, Dick;
- Marchetti, Serena;
- Sonke, Gabe S.;
- Jóźwiak, Katarzyna;
- Huitema, Alwin D. R.;
- Beijnen, Jos H.;
- Schellens, Jan H. M.;
- Linn, Sabine C.
Publication type:
Article
The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients.
Published in:
Journal of Clinical Pharmacology, 2016, v. 56, n. 10, p. 1307, doi. 10.1002/jcph.728
By:
- Nijenhuis, Cynthia M.;
- Huitema, Alwin D.R.;
- Marchetti, Serena;
- Blank, Christian;
- Haanen, John B.A.G.;
- Thienen, Johannes V.;
- Rosing, Hilde;
- Schellens, Jan H.M.;
- Beijnen, Jos H.
Publication type:
Article
A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.
Published in:
2016
By:
- Schouten, Philip C.;
- Dackus, Gwen M. H. E.;
- Marchetti, Serena;
- van Tinteren, Harm;
- Sonke, Gabe S.;
- Schellens, Jan H. M.;
- Linn, Sabine C.
Publication type:
journal article
Phase I Study of Afatinib and Selumetinib in Patients with KRAS‐Mutated Colorectal, Non‐Small Cell Lung, and Pancreatic Cancer.
Published in:
Oncologist, 2021, v. 26, n. 4, p. 290, doi. 10.1002/onco.13631
By:
- Brummelen, Emilie M.J.;
- Huijberts, Sanne;
- Herpen, Carla;
- Desar, Ingrid;
- Opdam, Frans;
- Geel, Robin;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Monkhorst, Kim;
- Thijssen, Bas;
- Rosing, Hilde;
- Huitema, Alwin;
- Beijnen, Jos;
- Bernards, Rene;
- Schellens, Jan
Publication type:
Article
Concise Review: Clinical Relevance of Drug-Drug and Herb-Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein).
Published in:
Oncologist, 2007, v. 12, n. 8, p. 927, doi. 10.1634/theoncologist.12-8-927
By:
- Marchetti, Serena;
- Mazzanti, Roberto;
- Beijnen, Jos H.;
- Schellens, Jan H. M.
Publication type:
Article

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