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Consequences of HLA‐associated mutations in HIV‐1 subtype C Nef on HLA‐I downregulation ability.
Published in:
Journal of Medical Virology, 2020, v. 92, n. 8, p. 1182, doi. 10.1002/jmv.25676
By:
- Mann, Jaclyn K.;
- Rajkoomar, Erasha;
- Jin, Steven W.;
- Mkhize, Qiniso;
- Baiyegunhi, Omolara;
- Mbona, Pholisiwe;
- Brockman, Mark A.;
- Ndung'u, Thumbi
Publication type:
Article
Modelling and in vitro testing of the HIV-1 Nef fitness landscape.
Published in:
Virus Evolution, 2019, v. 5, n. 2, p. N.PAG, doi. 10.1093/ve/vez029
By:
- Barton, John P;
- Rajkoomar, Erasha;
- Mann, Jaclyn K;
- Murakowski, Dariusz K;
- Toyoda, Mako;
- Mahiti, Macdonald;
- Mwimanzi, Phillip;
- Ueno, Takamasa;
- Chakraborty, Arup K;
- Ndung'u, Thumbi
Publication type:
Article
Differing natural killer cell, T cell and antibody profiles in antiretroviral-naive HIV-1 viraemic controllers with and without protective HLA alleles.
Published in:
PLoS ONE, 2023, v. 17, n. 6, p. 1, doi. 10.1371/journal.pone.0286507
By:
- Moyano, Ana;
- Ndlovu, Bongiwe;
- Mbele, Msizi;
- Naidoo, Kewreshini;
- Khan, Nasreen;
- Mann, Jaclyn K.;
- Ndung'u, Thumbi
Publication type:
Article
Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection.
Published in:
2020
By:
- Muema, Daniel M.;
- Akilimali, Ngomu A.;
- Ndumnego, Okechukwu C.;
- Rasehlo, Sipho S.;
- Durgiah, Raveshni;
- Ojwach, Doty B.A.;
- Ismail, Nasreen;
- Dong, Mary;
- Moodley, Amber;
- Dong, Krista L.;
- Ndhlovu, Zaza M.;
- Mabuka, Jenniffer M.;
- Walker, Bruce D.;
- Mann, Jaclyn K.;
- Ndung'u, Thumbi
Publication type:
journal article
High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119886
By:
- Gounder, Kamini;
- Padayachi, Nagavelli;
- Mann, Jaclyn K.;
- Radebe, Mopo;
- Mokgoro, Mammekwa;
- van der Stok, Mary;
- Mkhize, Lungile;
- Mncube, Zenele;
- Jaggernath, Manjeetha;
- Reddy, Tarylee;
- Walker, Bruce D.;
- Ndung’u, Thumbi
Publication type:
Article
No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial.
Published in:
PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071758
By:
- Chopera, Denis R.;
- Mann, Jaclyn K.;
- Mwimanzi, Philip;
- Omarjee, Saleha;
- Kuang, Xiaomei T.;
- Ndabambi, Nonkululeko;
- Goodier, Sarah;
- Martin, Eric;
- Naranbhai, Vivek;
- Karim, Salim Abdool;
- Karim, Quarraisha Abdool;
- Brumme, Zabrina L.;
- Ndung'u, Thumbi;
- Williamson, Carolyn;
- Brockman, Mark A.
Publication type:
Article
Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C.
Published in:
Virology Journal, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12985-015-0429-7
By:
- Mann, Jaclyn K.;
- Omarjee, Saleha;
- Khumalo, Phumzile;
- Ndung'u, Thumbi
Publication type:
Article
Editorial: Characterization of HIV-1 variants: implications for HIV-1 prevention, treatment and cure.
Published in:
Frontiers in Virology, 2024, p. 01, doi. 10.3389/fviro.2024.1465702
By:
- Mann, Jaclyn K.;
- Tongo, Marcel;
- Takamasa Ueno
Publication type:
Article
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity.
Published in:
Retrovirology, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12977-023-00618-7
By:
- Naicker, Delon;
- Sonela, Nelson;
- Jin, Steven W.;
- Mulaudzi, Takalani;
- Ojwach, Doty;
- Reddy, Tarylee;
- Brockman, Mark A.;
- Brumme, Zabrina L.;
- Ndung'u, Thumbi;
- Mann, Jaclyn K.
Publication type:
Article
Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa.
Published in:
Retrovirology, 2021, v. 18, n. 1, p. 1, doi. 10.1186/s12977-021-00554-4
By:
- Farinre, Omotayo;
- Gounder, Kamini;
- Reddy, Tarylee;
- Tongo, Marcel;
- Hare, Jonathan;
- Chaplin, Beth;
- Gilmour, Jill;
- Kanki, Phyllis;
- Mann, Jaclyn K.;
- Ndung'u, Thumbi
Publication type:
Article
The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by <i>In Vitro</i> Testing.
Published in:
PLoS Computational Biology, 2014, v. 10, n. 8, p. 1, doi. 10.1371/journal.pcbi.1003776
By:
- Mann, Jaclyn K.;
- Barton, John P.;
- Ferguson, Andrew L.;
- Omarjee, Saleha;
- Walker, Bruce D.;
- Chakraborty, Arup;
- Ndung'u, Thumbi
Publication type:
Article
Determinants of natural HIV-1 control.
Published in:
AIDS Reviews, 2022, v. 24, n. 2, p. 51, doi. 10.24875/AIDSRev.21000048
By:
- Moyano, Ana;
- Mann, Jaclyn K.;
- Ndung'u, Thumbi
Publication type:
Article
Limited Sequence Variation and Similar Phenotypic Characteristics of HIV-1 Subtype C Gag Variants Derived From the Reservoir and Pre-Therapy Plasma.
Published in:
Frontiers in Virology, 2022, p. 1, doi. 10.3389/fviro.2022.916095
By:
- Ojwach, Doty;
- Gounder, Kamini;
- Mulaudzi, Takalani;
- Gumede, Nombali;
- Baiyegunhi, Omolara O.;
- Reddy, Kavidha;
- Giandhari, Jennifer;
- Dong, Krista L.;
- Ndhlovu, Zaza;
- Ndung'u, Thumbi;
- Mann, Jaclyn K.
Publication type:
Article
Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors.
Published in:
Frontiers in Virology, 2022, p. 1, doi. 10.3389/fviro.2022.917902
By:
- Umviligihozo, Gisele;
- Mann, Jaclyn K.;
- Jin, Steven W.;
- Mwimanzi, Francis M.;
- Hua-Shiuan A. Hsieh;
- Hanwei Sudderuddin;
- Lee, Guinevere Q.;
- Byakwaga, Helen;
- Muzoora, Conrad;
- Hunt, Peter W.;
- Martin, Jeff N.;
- Haberer, Jessica E.;
- Karita, Etienne;
- Allen, Susan;
- Hunter, Eric;
- Brumme, Zabrina L.;
- Brockman, Mark A.
Publication type:
Article
HIV-1 vaccine immunogen design strategies.
Published in:
Virology Journal, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12985-014-0221-0
By:
- Mann, Jaclyn K.;
- Ndung'u, Thumbi
Publication type:
Article
HIV-1 vaccine immunogen design strategies.
Published in:
Virology Journal, 2015, v. 12, n. 1, p. 27, doi. 10.1186/s12985-014-0221-0
By:
- Mann, Jaclyn K;
- Ndung'u, Thumbi
Publication type:
Article
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5.
Published in:
PLoS Pathogens, 2020, v. 16, n. 9, p. 1, doi. 10.1371/journal.ppat.1008813
By:
- Jin, Steven W.;
- Mwimanzi, Francis M.;
- Mann, Jaclyn K.;
- Bwana, Mwebesa Bosco;
- Lee, Guinevere Q.;
- Brumme, Chanson J.;
- Hunt, Peter W.;
- Martin, Jeff N.;
- Bangsberg, David R.;
- Ndung'u, Thumbi;
- Brumme, Zabrina L.;
- Brockman, Mark A.
Publication type:
Article
Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Published in:
2015
By:
- Hölzemer, Angelique;
- Thobakgale, Christina F.;
- Cruz, Camilo A. Jimenez;
- Garcia-Beltran, Wilfredo F.;
- Carlson, Jonathan M.;
- van Teijlingen, Nienke H.;
- Mann, Jaclyn K.;
- Jaggernath, Manjeetha;
- Seung-gu Kang;
- Körner, Christian;
- Chung, Amy W.;
- Schafer, Jamie L.;
- Evans, David T.;
- Alter, Galit;
- Walker, Bruce D.;
- Goulder, Philip J.;
- Carrington, Mary;
- Hartmann, Pia;
- Pertel, Thomas;
- Ruhong Zhou
Publication type:
journal article
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.
Published in:
Retrovirology, 2013, v. 10, n. 1, p. 1, doi. 10.1186/1742-4690-10-100
By:
- Mann, Jaclyn K.;
- Byakwaga, Helen;
- Xiaomei T. Kuang;
- Anh Q. Le;
- Brumme, Chanson J.;
- Mwimanzi, Philip;
- Omarjee, Saleha;
- Martin, Eric;
- Lee, Guinevere Q.;
- Baraki, Bemuluyigza;
- Danroth, Ryan;
- McCloskey, Rosemary;
- Muzoora, Conrad;
- Bangsberg, David R.;
- Hunt, Peter W.;
- Goulder, Philip J. R.;
- Walker, Bruce D.;
- Richard Harrigan, P.;
- Martin, Jeff N.;
- Thumbi Ndung'u
Publication type:
Article

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