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A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.
Published in:
Journal of Pathology, 2020, v. 252, n. 2, p. 125, doi. 10.1002/path.5504
By:
- Bowman, Brittany M;
- Montgomery, Stephanie A;
- Schrank, Travis P;
- Simon, Jeremy M;
- Ptacek, Travis S;
- Tamir, Tigist Y;
- Mulvaney, Kathleen M;
- Weir, Seth J;
- Nguyen, Tuong T;
- Murphy, Ryan M;
- Makowski, Liza;
- Hayes, D Neil;
- Chen, Xiaoxin L;
- Randell, Scott H;
- Weissman, Bernard E;
- Major, Michael B
Publication type:
Article
The mucolipidosis IV Ca<sup>2+</sup> channel TRPML1 (MCOLN1) is regulated by the TOR kinase.
Published in:
Biochemical Journal, 2015, v. 470, n. 3, p. 331, doi. 10.1042/BJ20150219
By:
- Onyenwoke, Rob U.;
- Sexton, Jonathan Z.;
- Feng Yan;
- Huertas Díaz, María Cristina;
- Forsberg, Lawrence J.;
- Major, Michael B.;
- Brenman, Jay E.
Publication type:
Article
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.17101
By:
- Harrison, Joseph S.;
- Cornett, Evan M.;
- Goldfarb, Dennis;
- DaRosa, Paul A.;
- Li, Zimeng M.;
- Feng Yan;
- Dickson, Bradley M.;
- Guo, Angela H.;
- Cantu, Daniel V.;
- Kaustov, Lilia;
- Brown, Peter J.;
- Arrowsmith, Cheryl H.;
- Erie, Dorothy A.;
- Major, Michael B.;
- Klevit, Rachel E.;
- Krajewski, Krzysztof;
- Kuhlman, Brian;
- Strahl, Brian D.;
- Rothbart, Scott B.
Publication type:
Article
The MyMOMA domain of MYO19 encodes for distinct Miro‐dependent and Miro‐independent mechanisms of interaction with mitochondrial membranes.
Published in:
Cytoskeleton, 2020, v. 77, n. 3/4, p. 149, doi. 10.1002/cm.21560
By:
- Bocanegra, Jennifer L.;
- Fujita, Barbara M.;
- Melton, Natalie R.;
- Cowan, James M.;
- Schinski, Elizabeth L.;
- Tamir, Tigist Y.;
- Major, Michael B.;
- Quintero, Omar A.
Publication type:
Article
FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.
Published in:
Science Signaling, 2015, v. 8, n. 362, p. 1, doi. 10.1126/scisignal.2005654
By:
- Walker, Matthew P.;
- Rabinowitz, Alex D.;
- Graham, David M.;
- Feng Yan;
- Major, Michael B.;
- Stopford, Charles M.;
- Damania, Blossom;
- Cederlund, Maria;
- Jahn, Christopher;
- Weidinger, Gilbert;
- Fang Fang;
- Davis, Ian J.;
- Goldfarb, Dennis;
- Deal, Allison M.;
- Fedoriw, Yuri;
- Richards, Kristy L.
Publication type:
Article
ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas.
Published in:
PLoS ONE, 2024, v. 19, n. 2, p. 1, doi. 10.1371/journal.pone.0297741
By:
- Nguyen, Vinh;
- Schrank, Travis P.;
- Major, Michael B.;
- Weissman, Bernard E.
Publication type:
Article
WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling.
Published in:
PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0050457
By:
- James, Richard G.;
- Davidson, Kathryn C.;
- Bosch, Katherine A.;
- Biechele, Travis L.;
- Robin, Nicholas C.;
- Taylor, Russell J.;
- Major, Michael B.;
- Camp, Nathan D.;
- Fowler, Kerry;
- Martins, Timothy J.;
- Moon, Randall T.
Publication type:
Article
Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.
Published in:
EMBO Journal, 2017, v. 36, n. 15, p. 2233, doi. 10.15252/embj.201696113
By:
- Chen, Po‐Han;
- Smith, Timothy J;
- Wu, Jianli;
- Siesser, Priscila F;
- Bisnett, Brittany J;
- Khan, Farhan;
- Hogue, Maxwell;
- Soderblom, Erik;
- Tang, Flora;
- Marks, Jeffrey R;
- Major, Michael B;
- Swarts, Benjamin M;
- Boyce, Michael;
- Chi, Jen‐Tsan
Publication type:
Article
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.
Published in:
Advanced Science, 2023, v. 10, n. 3, p. 1, doi. 10.1002/advs.202203718
By:
- Zhu, Zhichuan;
- Zhou, Xin;
- Du, Hongwei;
- Cloer, Erica W.;
- Zhang, Jiaming;
- Mei, Liu;
- Wang, Ying;
- Tan, Xianming;
- Hepperla, Austin J.;
- Simon, Jeremy M.;
- Cook, Jeanette Gowen;
- Major, Michael B.;
- Dotti, Gianpietro;
- Liu, Pengda
Publication type:
Article
A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.
Published in:
Nature Communications, 2016, v. 7, n. 7, p. 12105, doi. 10.1038/ncomms12105
By:
- Gao, Yanzhe;
- Mutter-Rottmayer, Elizabeth;
- Greenwalt, Alicia M.;
- Goldfarb, Dennis;
- Yan, Feng;
- Yang, Yang;
- Martinez-Chacin, Raquel C.;
- Pearce, Kenneth H.;
- Tateishi, Satoshi;
- Major, Michael B.;
- Vaziri, Cyrus
Publication type:
Article
A 1,536-Well Ultra-High-Throughput siRNA Screen to Identify Regulators of the Wnt/β-Catenin Pathway.
Published in:
Assay & Drug Development Technologies, 2010, v. 8, n. 3, p. 286, doi. 10.1089/adt.2009.0262
By:
- Namjin Chung;
- Shane Marine;
- Emily A. Smith;
- Robert Liehr;
- S. Todd Smith;
- Louis Locco;
- Edward Hudak;
- Anthony Kreamer;
- Alison Rush;
- Brian Roberts;
- Michael B. Major;
- Randall T. Moon;
- William Arthur;
- Michele Cleary;
- Berta Strulovici;
- Marc Ferrer
Publication type:
Article
Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency.
Published in:
Nucleic Acids Research, 2024, v. 52, n. 19, p. 11536, doi. 10.1093/nar/gkae761
By:
- Chen, Jianfeng;
- Su, Siyuan;
- Pickar-Oliver, Adrian;
- Chiarella, Anna M;
- Hahn, Quentin;
- Goldfarb, Dennis;
- Cloer, Erica W;
- Small, George W;
- Sivashankar, Smaran;
- Ramsden, Dale A;
- Major, Michael B;
- Hathaway, Nathaniel A;
- Gersbach, Charles A;
- Liu, Pengda
Publication type:
Article
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 17, p. 9415, doi. 10.1093/nar/gkaa544
By:
- Skrajna, Aleksandra;
- Goldfarb, Dennis;
- Kedziora, Katarzyna M;
- Cousins, Emily M;
- Grant, Gavin D;
- Spangler, Cathy J;
- Barbour, Emily H;
- Yan, Xiaokang;
- Hathaway, Nathaniel A;
- Brown, Nicholas G;
- Cook, Jeanette G;
- Major, Michael B;
- McGinty, Robert K
Publication type:
Article
Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.
Published in:
Integrative Biology, 2014, v. 6, n. 7, p. 673, doi. 10.1039/c4ib00050a
By:
- Shah, Pavak K.;
- Walker, Matthew P.;
- Sims, Christopher E.;
- Major, Michael B.;
- Allbritton, Nancy L.
Publication type:
Article
Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53.
Published in:
PLoS Genetics, 2012, v. 8, n. 8, p. 1, doi. 10.1371/journal.pgen.1002922
By:
- Sorrells, Shelly;
- Carbonneau, Seth;
- Harrington, Erik;
- Chen, Aye T.;
- Hast, Bridgid;
- Milash, Brett;
- Pyati, Ujwal;
- Major, Michael B.;
- Yi Zhou;
- Zon, Leonard I.;
- Stewart, Rodney A.;
- Look, A. Thomas;
- Jette, Cicely
Publication type:
Article
The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33601-w
By:
- Gao, Yanzhe;
- Kardos, Jordan;
- Yang, Yang;
- Tamir, Tigist Y.;
- Mutter-Rottmayer, Elizabeth;
- Weissman, Bernard;
- Major, Michael B.;
- Kim, William Y.;
- Vaziri, Cyrus
Publication type:
Article
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52803-7
By:
- Puray-Chavez, Maritza;
- Eschbach, Jenna E.;
- Xia, Ming;
- LaPak, Kyle M.;
- Zhou, Qianzi;
- Jasuja, Ria;
- Pan, Jiehong;
- Xu, Jian;
- Zhou, Zixiang;
- Mohammed, Shawn;
- Wang, Qibo;
- Lawson, Dana Q.;
- Djokic, Sanja;
- Hou, Gaopeng;
- Ding, Siyuan;
- Brody, Steven L.;
- Major, Michael B.;
- Goldfarb, Dennis;
- Kutluay, Sebla B.
Publication type:
Article
Weight loss reduces basal-like breast cancer through kinome reprogramming.
Published in:
Cancer Cell International, 2016, v. 16, p. 1, doi. 10.1186/s12935-016-0300-y
By:
- Yuanyuan Qin;
- Sundaram, Sneha;
- Essaid, Luma;
- Xin Chen;
- Miller, Samantha M.;
- Feng Yan;
- Darr, David B.;
- Galanko, Joseph A.;
- Montgomery, Stephanie A.;
- Major, Michael B.;
- Johnson, Gary L.;
- Troester, Melissa A.;
- Makowski, Liza
Publication type:
Article
MSAcquisitionSimulator: data-dependent acquisition simulator for LC-MS shotgun proteomics.
Published in:
Bioinformatics, 2016, v. 32, n. 8, p. 1269, doi. 10.1093/bioinformatics/btv745
By:
- Goldfarb, Dennis;
- Wei Wang;
- Major, Michael B.
Publication type:
Article
FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility.
Published in:
Science Signaling, 2012, v. 5, n. 240, p. 1, doi. 10.1126/scisignal.2002871
By:
- Siesser, Priscila F.;
- Motolese, Marta;
- Walker, Matthew P.;
- Goldfarb, Dennis;
- Gewain, Kelly;
- Yan, Feng;
- Kulikauskas, Rima M.;
- Chien, Andy J.;
- Wordeman, Linda;
- Major, Michael B.
Publication type:
Article
Bruton's Tyrosine Kinase Revealed as a Negative Regulator of Wnt-β-Catenin Signaling.
Published in:
Science Signaling, 2009, v. 2, n. 72, p. 1, doi. 10.1126/scisignal.2000230
By:
- James, Richard G.;
- Biechele, Travis L.;
- Conrad, William H.;
- Camp, Nathan D.;
- Fass, Daniel M.;
- Major, Michael B.;
- Sommer, Karen;
- Yi, XianHua;
- Roberts, Brian S.;
- Cleary, Michele A.;
- Arthur, William T.;
- MacCoss, Michael;
- Rawlings, David J.;
- Haggarty, Stephen J.;
- Moon, Randall T.
Publication type:
Article
"Omic" Risk Assessment.
Published in:
Science Signaling, 2009, v. 2, n. 72, p. 1, doi. 10.1126/scisignal.272eg7
By:
- Major, Michael B.;
- Moon, Randall T.
Publication type:
Article
Integrative Analysis of Genome-Wide RNA Interference Screens.
Published in:
Science Signaling, 2009, v. 2, n. 70, p. 1, doi. 10.1126/scisignal.270pt4
By:
- Berndt, Jason D.;
- Biechele, Travis L.;
- Moon, Randall T.;
- Major, Michael B.
Publication type:
Article
New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening.
Published in:
Science Signaling, 2008, v. 1, n. 45, p. 1, doi. 10.1126/scisignal.2000037
By:
- Major, Michael B.;
- Roberts, Brian S.;
- Berndt, Jason D.;
- Marine, Shane;
- Anastas, Jamie;
- Chung, Namjin;
- Ferrer, Marc;
- XianHua Yi;
- Stoick-Cooper, Cristi L.;
- Haller, Priska D. von;
- Kategaya, Lorna;
- Chien, Andy;
- Angers, Stephane;
- MacCoss, Michael;
- Cleary, Michele A.;
- Arthur, William T.;
- Moon, Randall T.
Publication type:
Article
Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.
Published in:
PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0174863
By:
- Stratford, Jeran K.;
- Graves, Lee M.;
- Der, Channing J.;
- Yeh, Jen Jen;
- Hill, Rebecca A.;
- Major, Michael B.;
- Yan, Feng
Publication type:
Article
Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display.
Published in:
PEDS: Protein Engineering, Design & Selection, 2016, v. 29, n. 1, p. 1, doi. 10.1093/protein/gzv055
By:
- Guntas, Gurkan;
- Lewis, Steven M.;
- Mulvaney, Kathleen M.;
- Cloer, Erica W.;
- Tripathy, Ashutosh;
- Lane, Thomas R.;
- Major, Michael B.;
- Kuhlman, Brian
Publication type:
Article

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