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Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues.
Published in:
Angewandte Chemie, 2020, v. 132, n. 41, p. 18351, doi. 10.1002/ange.202006881
By:
- Newell, Clare L.;
- Vorng, Jean‐Luc;
- MacRae, James I.;
- Gilmore, Ian S.;
- Gould, Alex P.
Publication type:
Article
Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.
Published in:
Cellular Microbiology, 2017, v. 19, n. 1, p. n/a, doi. 10.1111/cmi.12633
By:
- Shears, Melanie J.;
- MacRae, James I.;
- Mollard, Vanessa;
- Goodman, Christopher D.;
- Sturm, Angelika;
- Orchard, Lindsey M.;
- Llinás, Manuel;
- McConville, Malcolm J.;
- Botté, Cyrille Y.;
- McFadden, Geoffrey I.
Publication type:
Article
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24624-5
By:
- Lattke, Michael;
- Goldstone, Robert;
- Ellis, James K.;
- Boeing, Stefan;
- Jurado-Arjona, Jerónimo;
- Marichal, Nicolás;
- MacRae, James I.;
- Berninger, Benedikt;
- Guillemot, Francois
Publication type:
Article
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia.
Published in:
EMBO Journal, 2024, v. 43, n. 8, p. 1545, doi. 10.1038/s44318-024-00065-w
By:
- Grimm, Fiona;
- Asuaje, Agustín;
- Jain, Aakriti;
- Silva dos Santos, Mariana;
- Kleinjung, Jens;
- Nunes, Patrícia M;
- Gehrig, Stefanie;
- Fets, Louise;
- Darici, Salihanur;
- MacRae, James I;
- Anastasiou, Dimitrios
Publication type:
Article
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42544-4
By:
- Rzechorzek, Neil J.;
- Kunzelmann, Simone;
- Purkiss, Andrew G.;
- Silva Dos Santos, Mariana;
- MacRae, James I.;
- Taylor, Ian A.;
- Fugger, Kasper;
- West, Stephen C.
Publication type:
Article
Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium‐dependent protein kinase 3.
Published in:
Molecular Microbiology, 2019, v. 111, n. 5, p. 1167, doi. 10.1111/mmi.14156
By:
- Wallbank, Bethan A.;
- Dominicus, Caia S.;
- Broncel, Malgorzata;
- Legrave, Nathalie;
- Kelly, Gavin;
- MacRae, James I.;
- Staines, Henry M.;
- Treeck, Moritz
Publication type:
Article
The intracellular parasite T oxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.
Published in:
Molecular Microbiology, 2015, v. 97, n. 1, p. 64, doi. 10.1111/mmi.13010
By:
- Ramakrishnan, Srinivasan;
- Docampo, Melissa D.;
- MacRae, James I.;
- Ralton, Julie E.;
- Rupasinghe, Thusitha;
- McConville, Malcolm J.;
- Striepen, Boris
Publication type:
Article
P lasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity.
Published in:
Molecular Microbiology, 2014, v. 91, n. 4, p. 762, doi. 10.1111/mmi.12496
By:
- MacRae, James I.;
- Lopaticki, Sash;
- Maier, Alexander G.;
- Rupasinghe, Thusitha;
- Nahid, Amsha;
- Cowman, Alan F.;
- McConville, Malcolm J.
Publication type:
Article
Use cases, best practice and reporting standards for metabolomics in regulatory toxicology.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10900-y
By:
- Viant, Mark R.;
- Ebbels, Timothy M. D.;
- Beger, Richard D.;
- Ekman, Drew R.;
- Epps, David J. T.;
- Kamp, Hennicke;
- Leonards, Pim E. G.;
- Loizou, George D.;
- MacRae, James I.;
- van Ravenzwaay, Bennard;
- Rocca-Serra, Philippe;
- Salek, Reza M.;
- Walk, Tilmann;
- Weber, Ralf J. M.
Publication type:
Article
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10189-x
By:
- Haythorne, Elizabeth;
- Rohm, Maria;
- van de Bunt, Martijn;
- Brereton, Melissa F.;
- Tarasov, Andrei I.;
- Blacker, Thomas S.;
- Sachse, Gregor;
- Silva dos Santos, Mariana;
- Terron Exposito, Raul;
- Davis, Simon;
- Baba, Otto;
- Fischer, Roman;
- Duchen, Michael R.;
- Rorsman, Patrik;
- MacRae, James I.;
- Ashcroft, Frances M.
Publication type:
Article
Alveolate Mitochondrial Metabolic Evolution: Dinoflagellates Force Reassessment of the Role of Parasitism as a Driver of Change in Apicomplexans.
Published in:
Molecular Biology & Evolution, 2013, v. 30, n. 1, p. 123, doi. 10.1093/molbev/mss205
By:
- Danne, Jillian C.;
- Gornik, Sebastian G.;
- MacRae, James I.;
- McConville, Malcolm J.;
- Waller, Ross F.
Publication type:
Article
Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes.
Published in:
Molecular Systems Biology, 2018, v. 14, n. 8, p. 1, doi. 10.15252/msb.20188376
By:
- Rey, Guillaume;
- Milev, Nikolay B;
- Valekunja, Utham K;
- Ch, Ratnasekhar;
- Ray, Sandipan;
- Silva Dos Santos, Mariana;
- Nagy, Andras D;
- Antrobus, Robin;
- MacRae, James I;
- Reddy, Akhilesh B
Publication type:
Article
An engineered photoswitchable mammalian pyruvate kinase.
Published in:
2017
By:
- Gehrig, Stefanie;
- Macpherson, Jamie A.;
- Driscoll, Paul C.;
- Symon, Alastair;
- Martin, Stephen R.;
- MacRae, James I.;
- Kleinjung, Jens;
- Fraternali, Franca;
- Anastasiou, Dimitrios
Publication type:
Editorial
Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target.
Published in:
FEBS Journal, 2015, v. 282, n. 19, p. 3808, doi. 10.1111/febs.13380
By:
- Allen, Stacey M.;
- Lim, Erin E.;
- Jortzik, Esther;
- Preuss, Janina;
- Chua, Hwa Huat;
- MacRae, James I.;
- Rahlfs, Stefan;
- Haeussler, Kristina;
- Downton, Matthew T.;
- McConville, Malcolm J.;
- Becker, Katja;
- Ralph, Stuart A.
Publication type:
Article
Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis.
Published in:
PLoS Biology, 2021, v. 19, n. 1, p. 1, doi. 10.1371/journal.pbio.3000796
By:
- Sterkel, Marcos;
- Haines, Lee R.;
- Casas-Sánchez, Aitor;
- Owino Adung'a, Vincent;
- Vionette-Amaral, Raquel J.;
- Quek, Shannon;
- Rose, Clair;
- Silva dos Santos, Mariana;
- García Escude, Natalia;
- Ismail, Hanafy M.;
- Paine, Mark I.;
- Barribeau, Seth M.;
- Wagstaff, Simon;
- MacRae, James I.;
- Masiga, Daniel;
- Yakob, Laith;
- Oliveira, Pedro L.;
- Acosta-Serrano, Álvaro
Publication type:
Article
Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei.
Published in:
Frontiers in Cellular & Infection Microbiology, 2017, v. 7, p. 1, doi. 10.3389/fcimb.2017.00368
By:
- Pasricha, Shivani;
- MacRae, James I.;
- Chua, Hwa H.;
- Chambers, Jenny;
- Boyce, Kylie J.;
- McConville, Malcolm J.;
- Andrianopoulos, Alex
Publication type:
Article
Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues.
Published in:
Angewandte Chemie International Edition, 2020, v. 59, n. 41, p. 18194, doi. 10.1002/anie.202006881
By:
- Newell, Clare L.;
- Vorng, Jean‐Luc;
- MacRae, James I.;
- Gilmore, Ian S.;
- Gould, Alex P.
Publication type:
Article
Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.
Published in:
2019
By:
- Sellers, Katherine;
- Allen, Thaddeus D.;
- Bousamra II, Michael;
- Tan, JinLian;
- Méndez-Lucas, Andrés;
- Lin, Wei;
- Bah, Nourdine;
- Chernyavskaya, Yelena;
- MacRae, James I.;
- Higashi, Richard M.;
- Lane, Andrew N.;
- Fan, Teresa W.-M.;
- Yuneva, Mariia O.;
- Bousamra, Michael 2nd
Publication type:
journal article
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum.
Published in:
BMC Biology, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7007-11-67
By:
- MacRae, James I.;
- Dixon, Matthew W. A.;
- Dearnley, Megan K.;
- Chua, Hwa H.;
- Chambers, Jennifer M.;
- Kenny, Shannon;
- Bottova, Iveta;
- Tilley, Leann;
- McConville, Malcolm J.
Publication type:
Article
Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.
Published in:
PLoS Pathogens, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.ppat.1005765
By:
- Amiar, Souad;
- MacRae, James I.;
- Callahan, Damien L.;
- Dubois, David;
- van Dooren, Giel G.;
- Shears, Melanie J.;
- Cesbron-Delauw, Marie-France;
- Maréchal, Eric;
- McConville, Malcolm J.;
- McFadden, Geoffrey I.;
- Yamaryo-Botté, Yoshiki;
- Botté, Cyrille Y.
Publication type:
Article
BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of <i>Toxoplasma gondii</i> and <i>Plasmodium berghei</i>.
Published in:
PLoS Pathogens, 2014, v. 10, n. 7, p. 1, doi. 10.1371/journal.ppat.1004263
By:
- Oppenheim, Rebecca D.;
- Creek, Darren J.;
- Macrae, James I.;
- Modrzynska, Katarzyna K.;
- Pino, Paco;
- Limenitakis, Julien;
- Polonais, Valerie;
- Seeber, Frank;
- Barrett, Michael P.;
- Billker, Oliver;
- McConville, Malcolm J.;
- Soldati-Favre, Dominique
Publication type:
Article
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 4, p. 693, doi. 10.1093/hmg/ddv507
By:
- Blassberg, Robert;
- Macrae, James I.;
- Briscoe, James;
- Jacob, John
Publication type:
Article
A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation.
Published in:
Nature Biotechnology, 2024, v. 42, n. 10, p. 1548, doi. 10.1038/s41587-023-02030-0
By:
- Ocasio, Cory A.;
- Baggelaar, Marc P.;
- Sipthorp, James;
- Losada de la Lastra, Ana;
- Tavares, Manuel;
- Volarić, Jana;
- Soudy, Christelle;
- Storck, Elisabeth M.;
- Houghton, Jack W.;
- Palma-Duran, Susana A.;
- MacRae, James I.;
- Tomić, Goran;
- Carr, Lotte;
- Downward, Julian;
- Eggert, Ulrike S.;
- Tate, Edward W.
Publication type:
Article
Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.
Published in:
PLoS Pathogens, 2016, v. 12, n. 12, p. 1, doi. 10.1371/journal.ppat.1006094
By:
- Srivastava, Anubhav;
- Philip, Nisha;
- Hughes, Katie R.;
- Georgiou, Konstantina;
- MacRae, James I.;
- Barrett, Michael P.;
- Creek, Darren J.;
- McConville, Malcolm J.;
- Waters, Andrew P.
Publication type:
Article
Developmental diet regulates Drosophila lifespan via lipid autotoxins.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01740-9
By:
- Stefana, M. Irina;
- Driscoll, Paul C.;
- Obata, Fumiaki;
- Pengelly, Ana Raquel;
- Newell, Clare L.;
- MacRae, James I.;
- Gould, Alex P.
Publication type:
Article
A robust and selective method for the quantification of glycosylphosphatidylinositols in biological samples.
Published in:
Glycobiology, 2005, v. 15, n. 2, p. 131
By:
- James I. MacRae;
- Michael A.J. Ferguson
Publication type:
Article
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03805-y
By:
- Fets, Louise;
- Bevan, Natalie;
- Nunes, Patrícia M.;
- Campos, Sebastien;
- dos Santos, Mariana Silva;
- Sherriff, Emma;
- MacRae, James I.;
- House, David;
- Anastasiou, Dimitrios
Publication type:
Article
Publisher Correction: MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03922-8
By:
- Fets, Louise;
- Bevan, Natalie;
- Nunes, Patrícia M.;
- Campos, Sebastien;
- dos Santos, Mariana Silva;
- Sherriff, Emma;
- MacRae, James I.;
- House, David;
- Anastasiou, Dimitrios
Publication type:
Article
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03805-y
By:
- Fets, Louise;
- Bevan, Natalie;
- Nunes, Patrícia M.;
- Campos, Sebastien;
- dos Santos, Mariana Silva;
- Sherriff, Emma;
- MacRae, James I.;
- House, David;
- Anastasiou, Dimitrios
Publication type:
Article
Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20479-4
By:
- Ch, Ratnasekhar;
- Rey, Guillaume;
- Ray, Sandipan;
- Jha, Pawan K.;
- Driscoll, Paul C.;
- Dos Santos, Mariana Silva;
- Malik, Dania M.;
- Lach, Radoslaw;
- Weljie, Aalim M.;
- MacRae, James I.;
- Valekunja, Utham K.;
- Reddy, Akhilesh B.
Publication type:
Article
Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.
Published in:
2018
By:
- Rohm, Maria;
- Savic, Dragana;
- Ball, Vicky;
- Curtis, M. Kate;
- Bonham, Sarah;
- Fischer, Roman;
- Legrave, Nathalie;
- MacRae, James I.;
- Tyler, Damian J.;
- Ashcroft, Frances M.
Publication type:
journal article
A malaria parasite phospholipase facilitates efficient asexual blood stage egress.
Published in:
PLoS Pathogens, 2023, v. 18, n. 6, p. 1, doi. 10.1371/journal.ppat.1011449
By:
- Ramaprasad, Abhinay;
- Burda, Paul-Christian;
- Koussis, Konstantinos;
- Thomas, James A.;
- Pietsch, Emma;
- Calvani, Enrica;
- Howell, Steven A.;
- MacRae, James I.;
- Snijders, Ambrosius P.;
- Gilberger, Tim-Wolf;
- Blackman, Michael J.
Publication type:
Article

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