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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27032-x
By:
- Meng, Yanxiang;
- Davies, Katherine A.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Garnish, Sarah E.;
- Horne, Christopher R.;
- Luo, Cindy;
- Garnier, Jean-Marc;
- Liang, Lung-Yu;
- Cowan, Angus D.;
- Samson, Andre L.;
- Lessene, Guillaume;
- Sandow, Jarrod J.;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23474-5
By:
- Garcia, Laura Ramos;
- Tenev, Tencho;
- Newman, Richard;
- Haich, Rachel O.;
- Liccardi, Gianmaria;
- John, Sidonie Wicky;
- Annibaldi, Alessandro;
- Yu, Lu;
- Pardo, Mercedes;
- Young, Samuel N.;
- Fitzgibbon, Cheree;
- Fernando, Winnie;
- Guppy, Naomi;
- Kim, Hyojin;
- Liang, Lung-Yu;
- Lucet, Isabelle S.;
- Kueh, Andrew;
- Roxanis, Ioannis;
- Gazinska, Patrycja;
- Sims, Martin
Publication type:
Article
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38869-9
By:
- Roy, Michael J.;
- Surudoi, Minglyanna G.;
- Kropp, Ashleigh;
- Hou, Jianmei;
- Dai, Weiwen;
- Hardy, Joshua M.;
- Liang, Lung-Yu;
- Cotton, Thomas R.;
- Lechtenberg, Bernhard C.;
- Dite, Toby A.;
- Ma, Xiuquan;
- Daly, Roger J.;
- Patel, Onisha;
- Lucet, Isabelle S.
Publication type:
Article
The Roc‐COR tandem domain of leucine‐rich repeat kinase 2 forms dimers and exhibits conventional Ras‐like GTPase properties.
Published in:
Journal of Neurochemistry, 2018, v. 147, n. 3, p. 409, doi. 10.1111/jnc.14566
By:
- Mills, Ryan D.;
- Liang, Lung‐Yu;
- Lio, Daisy Sio‐Seng;
- Mok, Yee‐Foong;
- Mulhern, Terrence D.;
- Cao, George;
- Griffin, Michael;
- Kenche, Vijaya B.;
- Culvenor, Janetta G.;
- Cheng, Heung‐Chin
Publication type:
Article
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7
By:
- Petrie, Emma J.;
- Sandow, Jarrod J.;
- Jacobsen, Annette V.;
- Smith, Brian J.;
- Griffin, Michael D. W.;
- Lucet, Isabelle S.;
- Weiwen Dai;
- Young, Samuel N.;
- Tanzer, Maria C.;
- Wardak, Ahmad;
- Lung-Yu Liang;
- Cowan, Angus D.;
- Hildebrand, Joanne M.;
- Kersten, Wilhelmus J. A.;
- Lessene, Guillaume;
- Silke, John;
- Czabotar, Peter E.;
- Webb, Andrew I.;
- Murphy, James M.
Publication type:
Article
Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1.
Published in:
Plant Physiology, 2024, v. 196, n. 1, p. 651, doi. 10.1093/plphys/kiae268
By:
- Diplock, Nathan;
- Baudin, Maël;
- Xiang, Xincheng;
- Liang, Lung-Yu;
- Dai, Weiwen;
- Murphy, James M;
- Lucet, Isabelle S;
- Hassan, Jana A;
- Lewis, Jennifer D
Publication type:
Article
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion.
Published in:
Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06118-4
By:
- Liang, Lung-Yu;
- Geoghegan, Niall D.;
- Mlodzianoski, Michael;
- Leis, Andrew;
- Whitehead, Lachlan W.;
- Surudoi, Minglyanna G.;
- Young, Samuel N.;
- Janes, Peter;
- Shepherd, Doulin;
- Ghosal, Debnath;
- Rogers, Kelly L.;
- Murphy, James M.;
- Lucet, Isabelle S.
Publication type:
Article
Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21191-7
By:
- Oliver, Michael R.;
- Horne, Christopher R.;
- Shrestha, Safal;
- Keown, Jeremy R.;
- Liang, Lung-Yu;
- Young, Samuel N.;
- Sandow, Jarrod J.;
- Webb, Andrew I.;
- Goldstone, David C.;
- Lucet, Isabelle S.;
- Kannan, Natarajan;
- Metcalf, Peter;
- Murphy, James M.
Publication type:
Article
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16823-3
By:
- Davies, Katherine A.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Garnish, Sarah E.;
- Yeung, Wayland;
- Coursier, Diane;
- Birkinshaw, Richard W.;
- Sandow, Jarrod J.;
- Lehmann, Wil I. L.;
- Liang, Lung-Yu;
- Lucet, Isabelle S.;
- Chalmers, James D.;
- Patrick, Wayne M.;
- Kannan, Natarajan;
- Petrie, Emma J.;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article

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