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Ein Instrumentarium von αv‐RGD‐Integrin‐Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten.
Published in:
Angewandte Chemie, 2018, v. 130, n. 13, p. 3354, doi. 10.1002/ange.201707948
By:
- Hatley, Richard J. D.;
- Macdonald, Simon J. F.;
- Slack, Robert J.;
- Le, Joelle;
- Ludbrook, Steven B.;
- Lukey, Pauline T.
Publication type:
Article
An αv‐RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.
Published in:
Angewandte Chemie International Edition, 2018, v. 57, n. 13, p. 3298, doi. 10.1002/anie.201707948
By:
- Hatley, Richard J. D.;
- Macdonald, Simon J. F.;
- Slack, Robert J.;
- Le, Joelle;
- Ludbrook, Steven B.;
- Lukey, Pauline T.
Publication type:
Article
HLA-B*35-Restricted CD8 T Cell Epitopes in the Antigen 85 Complex of Mycobacterium tuberculosis.
Published in:
Journal of Infectious Diseases, 2001, v. 183, n. 6, p. 928, doi. 10.1086/319267
By:
- Klein, Michel R.;
- Smith, Steven M.;
- Hammond, Abdulrahman S.;
- Ogg, Graham S.;
- King, Abigail S.;
- Vekemans, Johan;
- Jaye, Assan;
- Lukey, Pauline T.;
- McAdam, Keith P. W. J.
Publication type:
Article
A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6.
Published in:
2018
By:
- Keat, Nicholas;
- Kenny, Julia;
- Keguan Chen;
- Onega, Mayca;
- Garman, Nadia;
- Slack, Robert J.;
- Parker, Christine A.;
- Lumbers, R. Thomas;
- Hallett, Will;
- Saleem, Azeem;
- Passchier, Jan;
- Lukey, Pauline T.;
- Chen, Keguan
Publication type:
journal article
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.
Published in:
Molecular Microbiology, 2002, v. 43, n. 3, p. 717, doi. 10.1046/j.1365-2958.2002.02779.x
By:
- Betts, Joanna C;
- Lukey, Pauline T;
- Robb, Linda C;
- McAdam, Ruth A;
- Duncan, Ken
Publication type:
Article
Distinct Phases of Blood Gene Expression Pattern Through Tuberculosis Treatment Reflect Modulation of the Humoral Immune Response.
Published in:
Journal of Infectious Diseases, 2013, v. 207, n. 1, p. 18, doi. 10.1093/infdis/jis499
By:
- Cliff, Jacqueline M.;
- Lee, Ji-Sook;
- Constantinou, Nicholas;
- Cho, Jang-Eun;
- Clark, Taane G.;
- Ronacher, Katharina;
- King, Elizabeth C.;
- Lukey, Pauline T.;
- Duncan, Ken;
- Van Helden, Paul D.;
- Walzl, Gerhard;
- Dockrell, Hazel M.
Publication type:
Article
Gene-Expression Patterns in Whole Blood Identify Subjects at Risk for Recurrent Tuberculosis.
Published in:
Journal of Infectious Diseases, 2007, v. 195, n. 3, p. 357, doi. 10.1086/510397
By:
- Rohit Mistry;
- Cliff, Jacqueline M.;
- Clayton, Christopher L.;
- Beyers, Nulda;
- Mohamed, Yasmin S.;
- Wilson, Paul A.;
- Dockrell, Hazel M.;
- Wallace, Don M.;
- Van Helden, Paul D.;
- Duncan, Ken;
- Lukey, Pauline T.
Publication type:
Article
Associations between Toll-Like Receptors and Interleukin-4 in the Lungs of Patients with Tuberculosis.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2003, v. 29, n. 1, p. 28, doi. 10.1165/rcmb.2002-0163OC
By:
- Fenhalls, Gael;
- Squires, Ginette R.;
- Stevens-Muller, Liesel;
- Bezuidenhout, Juanita;
- Amphlett, Gillian;
- Duncan, Ken;
- Lukey, Pauline T.
Publication type:
Article
Daily Home Spirometry: An Effective Tool for Detecting Progression in Idiopathic Pulmonary Fibrosis.
Published in:
2016
By:
- Russell, Anne-Marie;
- Adamali, Huzaifa;
- Molyneaux, Philip L.;
- Lukey, Pauline T.;
- Marshall, Richard P.;
- Renzoni, Elisabetta A.;
- Wells, Athol U.;
- Maher, Toby M.
Publication type:
journal article
The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis.
Published in:
2018
By:
- Usmani, Omar S.;
- Biddiscombe, Martyn F.;
- Yang, Shuying;
- Meah, Sally;
- Oballa, Eunice;
- Simpson, Juliet K.;
- Fahy, William A.;
- Marshall, Richard P.;
- Lukey, Pauline T.;
- Maher, Toby M.
Publication type:
journal article
Distribution of IFN-γ, IL-4 and TNF-α protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas.
Published in:
Immunology, 2002, v. 105, n. 3, p. 325, doi. 10.1046/j.1365-2567.2002.01378.x
By:
- Fenhalls, Gael;
- Stevens, Liesel;
- Bezuidenhout, Juanita;
- Amphlett, Gillian E;
- Duncan, Ken;
- Bardin, Philip;
- Lukey, Pauline T
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS‐CoV2 Infection and Comparison to Fibrotic Lungs: 1.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 12, p. 1, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS‐CoV2 Infection and Comparison to Fibrotic Lungs.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 11, p. 1, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS‐CoV2 Infection and Comparison to Fibrotic Lungs.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 10, p. 1, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 8, p. 1, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 7, p. 1, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 6, p. 33, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.
Published in:
Journal of Nuclear Medicine, 2021, v. 62, n. 5, p. 1, doi. 10.2967/jnumed.121.262342
By:
- Lukey, Pauline T.;
- Wilson, Frederick J.
Publication type:
Article
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants.
Published in:
European Journal of Clinical Pharmacology, 2018, v. 74, n. 6, p. 701, doi. 10.1007/s00228-018-2435-3
By:
- Maden, Charlotte H.;
- Fairman, David;
- Chalker, Michelle;
- Costa, Maria J.;
- Fahy, William A.;
- Garman, Nadia;
- Lukey, Pauline T.;
- Mant, Tim;
- Parry, Simon;
- Simpson, Juliet K.;
- Slack, Robert J.;
- Kendrick, Stuart;
- Marshall, Richard P.
Publication type:
Article
Basic fibroblast growth factor modulates the expression of glycophorin A and c-kit and inhibits erythroid differentiation in K562 cells.
Published in:
Journal of Cellular Physiology, 2002, v. 190, n. 1, p. 83, doi. 10.1002/jcp.10038
By:
- Burger, Patricia E.;
- Lukey, Pauline T.;
- Coetzee, Sandra;
- Wilson, E. Lynette
Publication type:
Article
A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.
Published in:
2020
By:
- Maher, Toby M.;
- Simpson, Juliet K.;
- Porter, Joanna C.;
- Wilson, Frederick J.;
- Chan, Robert;
- Eames, Rhena;
- Cui, Yi;
- Siederer, Sarah;
- Parry, Simon;
- Kenny, Julia;
- Slack, Robert J.;
- Sahota, Jagdeep;
- Paul, Lyn;
- Saunders, Peter;
- Molyneaux, Philip L.;
- Lukey, Pauline T.;
- Rizzo, Gaia;
- Searle, Graham E.;
- Marshall, Richard P.;
- Saleem, Azeem
Publication type:
journal article
HR‐pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta‐Analysis.
Published in:
Journal of Bone & Mineral Research, 2020, v. 35, n. 3, p. 446, doi. 10.1002/jbmr.3901
By:
- Mikolajewicz, Nicholas;
- Bishop, Nick;
- Burghardt, Andrew J;
- Folkestad, Lars;
- Hall, Anthony;
- Kozloff, Kenneth M;
- Lukey, Pauline T;
- Molloy‐Bland, Michael;
- Morin, Suzanne N;
- Offiah, Amaka C;
- Shapiro, Jay;
- Rietbergen, Bert;
- Wager, Kim;
- Willie, Bettina M;
- Komarova, Svetlana V;
- Glorieux, Francis H
Publication type:
Article
Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung.
Published in:
European Journal of Nuclear Medicine & Molecular Imaging, 2020, v. 47, n. 4, p. 958, doi. 10.1007/s00259-019-04653-5
By:
- Onega, Mayca;
- Parker, Christine A.;
- Coello, Christopher;
- Rizzo, Gaia;
- Keat, Nicholas;
- Ramada-Magalhaes, Joaquim;
- Moz, Sara;
- Tang, Sac-Pham;
- Plisson, Christophe;
- Wells, Lisa;
- Ashworth, Sharon;
- Slack, Robert J.;
- Vitulli, Giovanni;
- Wilson, Frederick J.;
- Gunn, Roger;
- Lukey, Pauline T.;
- Passchier, Jan
Publication type:
Article
Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study).
Published in:
European Journal of Nuclear Medicine & Molecular Imaging, 2020, v. 47, n. 4, p. 967, doi. 10.1007/s00259-019-04586-z
By:
- Lukey, Pauline T.;
- Coello, Christopher;
- Gunn, Roger;
- Parker, Christine;
- Wilson, Frederick J.;
- Saleem, Azeem;
- Garman, Nadia;
- Costa, Maria;
- Kendrick, Stuart;
- Onega, Mayca;
- Kang'ombe, Arthur R.;
- Listanco, Allan;
- Davies, James;
- Ramada-Magalhaes, Joaquim;
- Moz, Sara;
- Fahy, William A.;
- Maher, Toby M.;
- Jenkins, Gisli;
- Passchier, Jan;
- Marshall, Richard P.
Publication type:
Article
Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF).
Published in:
European Journal of Nuclear Medicine & Molecular Imaging, 2018, v. 45, n. 5, p. 806, doi. 10.1007/s00259-017-3917-8
By:
- Win, Thida;
- Screaton, Nicholas J.;
- Porter, Joanna C.;
- Ganeshan, Balaji;
- Maher, Toby M.;
- Fraioli, Francesco;
- Endozo, Raymondo;
- Shortman, Robert I.;
- Hurrell, Lynn;
- Holman, Beverley F.;
- Thielemans, Kris;
- Rashidnasab, Alaleh;
- Hutton, Brian F.;
- Lukey, Pauline T.;
- Flynn, Aiden;
- Ell, Peter J.;
- Groves, Ashley M.
Publication type:
Article

Found: 25

Ein Instrumentarium von αv‐RGD‐Integrin‐Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten.

An αv‐RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.

HLA-B*35-Restricted CD8 T Cell Epitopes in the Antigen 85 Complex of Mycobacterium tuberculosis.

A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of <sup>18</sup>F-FB-A20FMDV2 for Imaging the Integrin α<sub>v</sub>β<sub>6</sub>.

Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.

Distinct Phases of Blood Gene Expression Pattern Through Tuberculosis Treatment Reflect Modulation of the Humoral Immune Response.

Gene-Expression Patterns in Whole Blood Identify Subjects at Risk for Recurrent Tuberculosis.

Associations between Toll-Like Receptors and Interleukin-4 in the Lungs of Patients with Tuberculosis.

Daily Home Spirometry: An Effective Tool for Detecting Progression in Idiopathic Pulmonary Fibrosis.

The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis.

Distribution of IFN-γ, IL-4 and TNF-α protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS‐CoV2 Infection and Comparison to Fibrotic Lungs: 1.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS‐CoV2 Infection and Comparison to Fibrotic Lungs.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS‐CoV2 Infection and Comparison to Fibrotic Lungs.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.

Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients after SARS-CoV2 Infection and Comparison to Fibrotic Lungs.

Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants.

Basic fibroblast growth factor modulates the expression of glycophorin A and c-kit and inhibits erythroid differentiation in K562 cells.

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.

HR‐pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta‐Analysis.

Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung.

Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study).

Pulmonary <sup>18</sup>F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF).