Found: 18
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Cerebrospinal Fluid β-Amyloid Turnover in the Mouse, Dog, Monkey and Human Evaluated by Systematic Quantitative Analyses.
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- Neurodegenerative Diseases, 2013, v. 12, n. 1, p. 36, doi. 10.1159/000341217
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- Article
An updated Aβ systems kinetic model for mouse, monkey and human
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- 2012
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- Abstract
Beta-amyloid aggregation human systems pharmacology modeling: Development and application to pharmacological targets in Alzheimer's disease
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- 2012
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Gamma-secretase modulators demonstrate similar exposure-response relationship in the rat and guinea pig
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- 2012
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Existing data support wild-type mouse is a suitable preclinical model for predicting human CSF abeta efficacy of gamma secreatase inhibitors
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- 2011
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Significant reduction of brain and CSF amyloid-β in mice following acute administration of a brain-penetrant BACE1 inhibitor
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- 2010
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- Abstract
Pharmacokinetic/pharmacodynamic analysis of β-amyloid response following modulation of the gamma secretase enzyme
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- 2010
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Using single-point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β-site APP cleaving enzyme 1 (BACE1)
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- 2010
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β-secretase inhibitors for treatment of Alzheimer's disease
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- 2010
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- Abstract
Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics.
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- Archives of Toxicology, 2008, v. 82, n. 2, p. 103, doi. 10.1007/s00204-007-0238-x
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- Article
Population Pharmacokinetics of Patritumab Deruxtecan in Patients With Solid Tumors.
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- Journal of Clinical Pharmacology, 2023, v. 63, n. 1, p. 77, doi. 10.1002/jcph.2137
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- Article
Ribociclib Population Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Analysis of Neutrophils in Cancer Patients.
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- Journal of Clinical Pharmacology, 2021, v. 61, n. 8, p. 1054, doi. 10.1002/jcph.1856
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- Article
A Possible Role of Multidrug Resistance-Associated Protein 2 (Mrp2) in Hepatic Excretion of PCB126, an Environmental Contaminant: PBPK/PD Modeling.
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- Toxicological Sciences, 2008, v. 104, n. 1, p. 27, doi. 10.1093/toxsci/kfn026
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- Article
An Updated Physiologically Based Pharmacokinetic Model for Hexachlorobenzene: Incorporation of Pathophysiological States following Partial Hepatectomy and Hexachlorobenzene Treatment.
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- Toxicological Sciences, 2006, v. 91, n. 1, p. 29, doi. 10.1093/toxsci/kfj133
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- Article
Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 517, doi. 10.1002/cpt.2023
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- Article
Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 2, p. 374, doi. 10.1002/cpt.940
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Application of the model‐informed drug development paradigm to datopotamab deruxtecan dose selection for late‐stage development.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 1, p. 23, doi. 10.1002/psp4.13058
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Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans.
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- Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00274
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- Article