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Quantifying DNA?protein interactions by double-stranded DNA arrays.
Published in:
Nature Biotechnology, 1999, v. 17, n. 6, p. 573, doi. 10.1038/9878
By:
- Bulyk, Martha L.;
- Gentalen, Erik;
- Lockhart, David J.;
- Church, George M.
Publication type:
Article
Safety and pharmacodynamic effects of a pharmacological chaperone on α-galactosidase A activity and globotriaosylceramide clearance in Fabry disease: report from two phase 2 clinical studies.
Published in:
2012
By:
- Germain, Dominique P;
- Giugliani, Roberto;
- Hughes, Derralynn A;
- Mehta, Atul;
- Nicholls, Kathy;
- Barisoni, Laura;
- Jennette, Charles J;
- Bragat, Alexander;
- Castelli, Jeff;
- Sitaraman, Sheela;
- Lockhart, David J;
- Boudes, Pol F
Publication type:
journal article
Safety and pharmacodynamic effects of a pharmacological chaperone on α-galactosidase A activity and globotriaosylceramide clearance in Fabry disease: report from two phase 2c linical studies.
Published in:
Orphanet Journal of Rare Diseases, 2012, v. 7, n. 1, p. 91, doi. 10.1186/1750-1172-7-91
By:
- Germain, Dominique P.;
- Giugliani, Roberto;
- Hughes, Derralynn A.;
- Mehta, Atul;
- Nicholls, Kathy;
- Barisoni, Laura;
- Jennette, Charles J.;
- Bragat, Alexander;
- Castelli, Jeff;
- Sitaraman, Sheela;
- Lockhart, David J.;
- Boudes, Pol F.
Publication type:
Article
Mutant yeast on drugs.
Published in:
Nature Medicine, 1998, v. 4, n. 11, p. 1235, doi. 10.1038/3212
By:
- Lockhart, David J.
Publication type:
Article
OPINION: Expressing what's on your mind: DNA arrays and the brain.
Published in:
Nature Reviews Neuroscience, 2001, v. 2, n. 1, p. 63, doi. 10.1038/35049070
By:
- Lockhart, David J.;
- Barlow, Carrolee
Publication type:
Article
Response to Molecule–kinase interaction map.
Published in:
2005
By:
- Fabian, Miles A.;
- Biggs, William H.;
- Treiber, Daniel K.;
- Zarrinkar, Patrick P.;
- Lockhart, David J.
Publication type:
Letter
Reply to BIRB-796 is not an effective ABL(T315I) inhibitor.
Published in:
2005
By:
- Fabian, Miles A.;
- Biggs, III, William H.;
- Treiber, Daniel K.;
- Zarrinkar, Patrick P.;
- Lockhart, David J.
Publication type:
Letter
Multiplex metallica.
Published in:
Nature Biotechnology, 2001, v. 19, n. 12, p. 1122, doi. 10.1038/nbt1201-1122
By:
- Lockhart, David J.;
- Trulson, Mark O.
Publication type:
Article
RNA expression analysis using a 30 base pair resolution Escherichia coli genome array.
Published in:
Nature Biotechnology, 2000, v. 18, n. 12, p. 1262, doi. 10.1038/82367
By:
- Selinger, Douglas W.;
- Cheung, Kevin J.;
- Mei, Rui;
- Johansson, Erik M.;
- Richmond, Craig S.;
- Blattner, Frederick R.;
- Lockhart, David J.;
- Church, George M.
Publication type:
Article
Myoseverin, a microtubule-binding molecule with novel cellular effects.
Published in:
Nature Biotechnology, 2000, v. 18, n. 3, p. 304, doi. 10.1038/73753
By:
- Rosania, Gustavo R.;
- Chang, Young-Tae;
- Perez, Omar;
- Sutherlin, Daniel;
- Dong, Helin;
- Lockhart, David J.;
- Schultz, Peter G.
Publication type:
Article
A cell-based model for presenilin 1 early-onset familial Alzheimer's disease (EOFAD): Dominant negative effects and relative stabilities of presenilin 1 with EOFAD mutations
Published in:
2012
By:
- Stevens, Anthony;
- Collins, Carolyn;
- Katz, Evan;
- Lee, Gary;
- Alford, Vernon;
- Williams, Hadis;
- Guillen, Darlene;
- Wu, Xiaoyang;
- Flanagan, John;
- Sjoberg, Eric;
- Gandy, Sam;
- Lockhart, David J.;
- Wustman, Brandon;
- Dungan, LB
Publication type:
Abstract
Pharmacological chaperones increase wild type presenilin 1 levels and promote the normalization of gamma-secretase function in presenilin 1 early-onset familial Alzheimer's disease models
Published in:
2012
By:
- Stevens, Anthony;
- Williams, Hadis;
- Collins, Carolyn;
- Mughal, Mohammed;
- Garcia, Anadina;
- Dungan, LB;
- Katz, Evan;
- Fascella, Michelle;
- Lee, Gary;
- Alford, Vernon;
- Zhu, Julia;
- Wu, Xiaoyang;
- Brignol, Nastry;
- Khanna, Richie;
- Sjoberg, Eric;
- Sam Gandy;
- Mattson, Mark;
- Lockhart, David J.;
- Wustman, Brandon
Publication type:
Abstract
Transcriptional regulation and function during the human cell cycle.
Published in:
Nature Genetics, 2001, v. 27, n. 1, p. 48, doi. 10.1038/83751
By:
- Cho, Raymond J.;
- Huang, Mingxia;
- Campbell, Michael J.;
- Dong, Helin;
- Steinmetz, Lars;
- Sapinoso, Lisa;
- Hampton, Garret;
- Elledge, Stephen J.;
- Davis, Ronald W.;
- Lockhart, David J.
Publication type:
Article
Genomics, genes, tags, SNPs, drugs and chips.
Published in:
1999
By:
- Lockhart, David J.
Publication type:
Abstract
Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase.
Published in:
PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0134341
By:
- Warnock, David G.;
- Bichet, Daniel G.;
- Holida, Myrl;
- Goker-Alpan, Ozlem;
- Nicholls, Kathy;
- Thomas, Mark;
- Eyskens, Francois;
- Shankar, Suma;
- Adera, Mathews;
- Sitaraman, Sheela;
- Khanna, Richie;
- Flanagan, John J.;
- Wustman, Brandon A.;
- Barth, Jay;
- Barlow, Carrolee;
- Valenzano, Kenneth J.;
- Lockhart, David J.;
- Boudes, Pol;
- Johnson, Franklin K.
Publication type:
Article
The Pharmacological Chaperone AT2220 Increases the Specific Activity and Lysosomal Delivery of Mutant Acid Alpha-Glucosidase, and Promotes Glycogen Reduction in a Transgenic Mouse Model of Pompe Disease.
Published in:
PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0102092
By:
- Khanna, Richie;
- Powe Jr, Allan C.;
- Lun, Yi;
- Soska, Rebecca;
- Feng, Jessie;
- Dhulipala, Rohini;
- Frascella, Michelle;
- Garcia, Anadina;
- Pellegrino, Lee J.;
- Xu, Su;
- Brignol, Nastry;
- Toth, Matthew J.;
- Do, Hung V.;
- Lockhart, David J.;
- Wustman, Brandon A.;
- Valenzano, Kenneth J.
Publication type:
Article
Migalastat HCl Reduces Globotriaosylsphingosine (Lyso-Gb<sub>3</sub>) in Fabry Transgenic Mice and in the Plasma of Fabry Patients.
Published in:
PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0057631
By:
- Young-Gqamana, Brandy;
- Brignol, Nastry;
- Chang, Hui-Hwa;
- Khanna, Richie;
- Soska, Rebecca;
- Fuller, Maria;
- Sitaraman, Sheela A.;
- Germain, Dominique P.;
- Giugliani, Roberto;
- Hughes, Derralynn A.;
- Mehta, Atul;
- Nicholls, Kathy;
- Boudes, Pol;
- Lockhart, David J.;
- Valenzano, Kenneth J.;
- Benjamin, Elfrida R.
Publication type:
Article
The Pharmacological Chaperone AT2220 Increases Recombinant Human Acid α-Glucosidase Uptake and Glycogen Reduction in a Mouse Model of Pompe Disease.
Published in:
PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040776
By:
- Khanna, Richie;
- Flanagan, John J.;
- Feng, Jessie;
- Soska, Rebecca;
- Frascella, Michelle;
- Pellegrino, Lee J.;
- Yi Lun;
- Guillen, Darlene;
- Lockhart, David J.;
- Valenzano, Kenneth J.
Publication type:
Article
Expressing what's on your mind: DNA arrays and the brain.
Published in:
Nature Reviews Genetics, 2004, v. 5, p. 41
By:
- Lockhart, David J.;
- Barlow, Carrolee
Publication type:
Article
The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of β-glucosidase.
Published in:
FEBS Journal, 2010, v. 277, n. 7, p. 1618, doi. 10.1111/j.1742-4658.2010.07588.x
By:
- Khanna, Richie;
- Benjamin, Elfrida R.;
- Pellegrino, Lee;
- Schilling, Adriane;
- Rigat, Brigitte A.;
- Soska, Rebecca;
- Nafar, Hadis;
- Ranes, Brian E.;
- Feng, Jessie;
- Lun, Yi;
- Powe, Allan C.;
- Palling, David J.;
- Wustman, Brandon A.;
- Schiffmann, Raphael;
- Mahuran, Don J.;
- Lockhart, David J.;
- Valenzano, Kenneth J.
Publication type:
Article
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.
Published in:
Nature, 2005, v. 438, n. 7068, p. 662, doi. 10.1038/nature04250
By:
- Hovatta, Iiris;
- Tennant, Richard S.;
- Helton, Robert;
- Marr, Robert A.;
- Singer, Oded;
- Redwine, Jeffrey M.;
- Ellison, Julie A.;
- Schadt, Eric E.;
- Verma, Inder M.;
- Lockhart, David J.;
- Barlow, Carrolee
Publication type:
Article
Risk of Death in Heart Disease is Associated With Elevated Urinary Globotriaosylceramide.
Published in:
Journal of the American Heart Association, 2014, v. 3, n. 1, p. 1, doi. 10.1161/JAHA.113.000394
By:
- Schiffmann, Raphael;
- Forni, Sabrina;
- Swift, Caren;
- Brignol, Nastry;
- Wu, Xiaoyang;
- Lockhart, David J.;
- Blankenship, Derek;
- Wang, Xuan;
- Grayburn, Paul A.;
- Taylor, Matthew R. G.;
- Lowes, Brian D.;
- Fuller, Maria;
- Benjamin, Elfrida R.;
- Sweetman, Lawrence
Publication type:
Article
Co-administration With the Pharmacological Chaperone AT1001 Increases Recombinant Human α-Galactosidase A Tissue Uptake and Improves Substrate Reduction in Fabry Mice.
Published in:
Molecular Therapy, 2012, v. 20, n. 4, p. 717, doi. 10.1038/mt.2011.271
By:
- Benjamin, Elfrida R;
- Khanna, Richie;
- Schilling, Adriane;
- Flanagan, John J;
- Pellegrino, Lee J;
- Brignol, Nastry;
- Lun, Yi;
- Guillen, Darlene;
- Ranes, Brian E;
- Frascella, Michelle;
- Soska, Rebecca;
- Feng, Jessie;
- Dungan, Leo;
- Young, Brandy;
- Lockhart, David J;
- Valenzano, Kenneth J
Publication type:
Article
The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease.
Published in:
Molecular Therapy, 2010, v. 18, n. 1, p. 23, doi. 10.1038/mt.2009.220
By:
- Khanna, Richie;
- Soska, Rebecca;
- Yi Lun;
- Feng, Jessie;
- Frascella, Michelle;
- Young, Brandy;
- Brignol, Nastry;
- Pellegrino, Lee;
- Sitaraman, Sheela A.;
- Desnick, Robert J.;
- Benjamin, Elfrida R.;
- Lockhart, David J.;
- Valenzano, Kenneth J.
Publication type:
Article
A pharmacogenetic approach to identify mutant forms of α-galactosidase a that respond to a pharmacological chaperone for Fabry disease.
Published in:
Human Mutation, 2011, v. 32, n. 8, p. 965, doi. 10.1002/humu.21530
By:
- Wu, Xiaoyang;
- Katz, Evan;
- Valle, Maria Cecilia Della;
- Mascioli, Kirsten;
- Flanagan, John J.;
- Castelli, Jeffrey P.;
- Schiffmann, Raphael;
- Boudes, Pol;
- Lockhart, David J.;
- Valenzano, Kenneth J.;
- Benjamin, Elfrida R.
Publication type:
Article
The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase.
Published in:
Human Mutation, 2009, v. 30, n. 12, p. 1683, doi. 10.1002/humu.21121
By:
- Flanagan, John J.;
- Rossi, Barbara;
- Tang, Katherine;
- Wu, Xiaoyang;
- Mascioli, Kirsten;
- Donaudy, Francesca;
- Tuzzi, Maria Rosaria;
- Fontana, Federica;
- Cubellis, Maria Vittoria;
- Porto, Caterina;
- Benjamin, Elfrida;
- Lockhart, David J.;
- Valenzano, Kenneth J.;
- Andria, Generoso;
- Parenti, Giancarlo;
- Do, Hung V.
Publication type:
Article
Aberrant recombination involving the granzyme locus occurs in Atm<sup>−/−</sup> T-cell lymphomas.
Published in:
Human Molecular Genetics, 2005, v. 14, n. 18, p. 2671, doi. 10.1093/hmg/ddi301
By:
- Winrow, Christopher J.;
- Pankratz, Daniel G.;
- Vibat, Cecile Rose T.;
- Bowen, T.J.;
- Callahan, Marie A.;
- Warren, Amy J.;
- Hilbush, Brian S.;
- Wynshaw-Boris, Anthony;
- Hasel, Karl W.;
- Weaver, Zoë;
- Lockhart, David J.;
- Barlow, Carrolee
Publication type:
Article
High density synthetic oligonucleotide arrays.
Published in:
Nature Genetics, 1999, v. 21, p. 20, doi. 10.1038/4447
By:
- Lipshutz, Robert J.;
- Fodor, Stephen P.A.;
- Gingeras, Thomas R.;
- Lockhart, David J.
Publication type:
Article
Genomics, gene expression and DNA arrays.
Published in:
Nature, 2000, v. 405, n. 6788, p. 827, doi. 10.1038/35015701
By:
- Lockhart, David J.;
- Winzeler, Elizabeth A.
Publication type:
Article
Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-ß Peptide.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 15, p. 5223, doi. 10.1523/JNEUROSCI.4860-11.2012
By:
- Keilani, Serene;
- Lun, Yi;
- Stevens, Anthony C.;
- Williams, Hadis N.;
- Sjoberg, Eric R.;
- Khanna, Richie;
- Valenzano, Kenneth J.;
- Checler, Frederic;
- Buxbaum, Joseph D.;
- Yanagisawa, Katsuhiko;
- Lockhart, David J.;
- Wustman, Brandon A.;
- Gandy, Sam
Publication type:
Article

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