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Dramatic activation of an antibody by a single amino acid change in framework.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01530-w
By:
- Liang, Wei-Ching;
- Yin, Jianping;
- Lupardus, Patrick;
- Zhang, Jianhuan;
- Loyet, Kelly M.;
- Sudhamsu, Jawahar;
- Wu, Yan
Publication type:
Article
A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK.
Published in:
AAPS Journal, 2024, v. 26, n. 1, p. 1, doi. 10.1208/s12248-023-00881-8
By:
- Li, Ran;
- Dere, Edward;
- Kwong, Mandy;
- Fei, Mingjian;
- Dave, Rutwij;
- Masih, Shabkhaiz;
- Wang, Joy;
- McNamara, Erin;
- Huang, Haochu;
- Liang, Wei-Ching;
- Schutt, Leah;
- Kamath, Amrita V.;
- Ovacik, Meric A.
Publication type:
Article
The Development and Characterization of a Highly Sensitive Mature TGFβ3 Assay to Evaluate Anti-TGFβ3 Target Engagement.
Published in:
AAPS Journal, 2023, v. 25, n. 1, p. 1, doi. 10.1208/s12248-023-00785-7
By:
- Setiadi, A. Francesca;
- Sperinde, Gizette;
- Cheu, Melissa;
- Liang, Wei-Ching;
- Lin, WeiYu;
- Mahood, Connie;
- Fischer, Saloumeh K.
Publication type:
Article
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
Published in:
Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02019
By:
- Lin, WeiYu;
- Xu, Daqi;
- Austin, Cary D.;
- Caplazi, Patrick;
- Senger, Kate;
- Sun, Yonglian;
- Jeet, Surinder;
- Young, Judy;
- Delarosa, Donnie;
- Suto, Eric;
- Huang, Zhiyu;
- Zhang, Juan;
- Yan, Donghong;
- Corzo, Cesar;
- Barck, Kai;
- Rajan, Sharmila;
- Looney, Carrie;
- Gandham, Vineela;
- Lesch, Justin;
- Liang, Wei-Ching
Publication type:
Article
Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology.
Published in:
PLoS ONE, 2020, v. 15, n. 12, p. 1, doi. 10.1371/journal.pone.0244158
By:
- Lin, WeiYu;
- Liang, Wei-Ching;
- Nguy, Trung;
- Maia, Mauricio;
- Tyagi, Tulika;
- Chiu, Cecilia;
- Hoi, Kam Hon;
- Chen, Yongmei;
- Wu, Yan
Publication type:
Article
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
Published in:
Nature, 2006, v. 444, n. 7122, p. 1083, doi. 10.1038/nature05313
By:
- Ridgway, John;
- Zhang, Gu;
- Wu, Yan;
- Stawicki, Scott;
- Liang, Wei-Ching;
- Chanthery, Yvan;
- Kowalski, Joe;
- Watts, Ryan J.;
- Callahan, Christopher;
- Kasman, Ian;
- Singh, Mallika;
- Chien, May;
- Tan, Christine;
- Hongo, Jo-Anne S.;
- de Sauvage, Fred;
- Plowman, Greg;
- Yan, Minhong
Publication type:
Article
EphB4 forward signalling regulates lymphatic valve development.
Published in:
Nature Communications, 2015, v. 6, n. 4, p. 6625, doi. 10.1038/ncomms7625
By:
- Zhang, Gu;
- Brady, John;
- Liang, Wei-Ching;
- Wu, Yan;
- Henkemeyer, Mark;
- Yan, Minhong
Publication type:
Article
A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 20, p. 3836, doi. 10.1111/bph.16258
By:
- Janezic, Eric M.;
- Doan, Alexander;
- Mai, Elaine;
- Bravo, Daniel D.;
- Wang, Jianyong;
- Kim, Hok Seon;
- Spiess, Christoph;
- Bewley, Kathryn;
- ElSohly, Adel;
- Liang, Wei‐Ching;
- Koerber, James T.;
- Richalet, Pascale;
- Vanhove, Marc;
- Comps‐Agrar, Laetitia
Publication type:
Article
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.
Published in:
Science Translational Medicine, 2021, v. 13, n. 605, p. 1, doi. 10.1126/scitranslmed.abe0407
By:
- Sun, Tianhe;
- Huang, Zhiyu;
- Liang, Wei-Ching;
- Yin, Jianping;
- Lin, Wei Yu;
- Wu, Jia;
- Vernes, Jean-Michel;
- Lutman, Jeff;
- Caplazi, Patrick;
- Jeet, Surinder;
- Wong, Tiffany;
- Wong, Manda;
- DePianto, Daryle J.;
- Morshead, Katrina B.;
- Sun, Kai-Hui;
- Modrusan, Zora;
- Vander Heiden, Jason A.;
- Abbas, Alexander R.;
- Zhang, Hua;
- Xu, Min
Publication type:
Article
A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys.
Published in:
Toxicological Sciences, 2020, v. 175, n. 1, p. 24, doi. 10.1093/toxsci/kfaa024
By:
- Mitra, Mayur S;
- Lancaster, Karla;
- Adedeji, Adeyemi O;
- Palanisamy, Gopinath S;
- Dave, Rutwij A;
- Zhong, Fiona;
- Holdren, Matthew S;
- Turley, Shannon J;
- Liang, Wei-Ching;
- Wu, Yan;
- Meng, Y Gloria;
- Vernes, Jean-Michel;
- Schutten, Melissa M
Publication type:
Article
Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans.
Published in:
Pharmaceutical Research, 2012, v. 29, n. 9, p. 2512, doi. 10.1007/s11095-012-0781-x
By:
- Xin, Yan;
- Bai, Shuang;
- Damico-Beyer, Lisa;
- Jin, Denise;
- Liang, Wei-Ching;
- Wu, Yan;
- Theil, Frank-Peter;
- Joshi, Amita;
- Lu, Yanmei;
- Lowe, John;
- Maia, Mauricio;
- Brachmann, Rainer;
- Xiang, Hong
Publication type:
Article

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