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Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax.
Published in:
Pharmacology Research & Perspectives, 2015, v. 3, n. 5, p. 1, doi. 10.1002/prp2.178
By:
- Ackler, Scott;
- Oleksijew, Anatol;
- Chen, Jun;
- Chyla, Brenda J.;
- Clarin, Jerry;
- Foster, Kelly;
- McGonigal, Thomas;
- Mishra, Sasmita;
- Schlessinger, Sally;
- Smith, Morey L.;
- Tahir, Stephen K.;
- Leverson, Joel D.;
- Souers, Andrew J.;
- Boghaert, Erwin R.;
- Hickson, Jonathan
Publication type:
Article
Potential mechanisms of resistance to venetoclax and strategies to circumvent it.
Published in:
2017
By:
- Tahir, Stephen K.;
- Smith, Morey L.;
- Hessler, Paul;
- Roberts Rapp, Lisa;
- Idler, Kenneth B.;
- Park, Chang H.;
- Leverson, Joel D.;
- Lam, Lloyd T.;
- Rapp, Lisa Roberts
Publication type:
journal article
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
Published in:
Nature Medicine, 2013, v. 19, n. 2, p. 202, doi. 10.1038/nm.3048
By:
- Souers, Andrew J;
- Leverson, Joel D;
- Boghaert, Erwin R;
- Ackler, Scott L;
- Catron, Nathaniel D;
- Chen, Jun;
- Dayton, Brian D;
- Ding, Hong;
- Enschede, Sari H;
- Fairbrother, Wayne J;
- Huang, David C S;
- Hymowitz, Sarah G;
- Jin, Sha;
- Khaw, Seong Lin;
- Kovar, Peter J;
- Lam, Lloyd T;
- Lee, Jackie;
- Maecker, Heather L;
- Marsh, Kennan C;
- Mason, Kylie D
Publication type:
Article
Genomic analysis and selective small molecule inhibition identifies BCL-X<sub>L</sub> as a critical survival factor in a subset of colorectal cancer.
Published in:
Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0397-y
By:
- Haichao Zhang;
- Xue, John;
- Hessler, Paul;
- Tahir, Stephen K.;
- Chen, Jun;
- Sha Jin;
- Souers, Andrew J.;
- Leverson, Joel D.;
- Lam, Lloyd T.
Publication type:
Article
Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer.
Published in:
Molecular Cancer, 2015, v. 14, n. 1, p. 126, doi. 10.1186/s12943-015-0397-y
By:
- Haichao Zhang;
- Xue, John;
- Hessler, Paul;
- Tahir, Stephen K.;
- Jun Chen;
- Jin, Sha;
- Souers, Andrew J.;
- Leverson, Joel D.;
- Lam, Lloyd T.
Publication type:
Article
Identification of recurrent genomic alterations in the apoptotic machinery in chronic lymphocytic leukemia patients treated with venetoclax monotherapy.
Published in:
American Journal of Hematology, 2022, v. 97, n. 2, p. E47, doi. 10.1002/ajh.26411
By:
- Popovic, Relja;
- Dunbar, Fengjiao;
- Lu, Charles;
- Robinson, Kenneth;
- Quarless, Danjuma;
- Warder, Scott E.;
- Mukherjee, Nabanita;
- Pesko, John;
- Souers, Andrew J.;
- Waring, Jeffrey F.;
- Davids, Matthew S.;
- Tausch, Eugen;
- Stilgenbauer, Stephan;
- Ross, Jeremy A.;
- Leverson, Joel D.;
- Kim, Su Young;
- Chyla, Brenda J.
Publication type:
Article
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.
Published in:
2020
By:
- Zoeller, Jason J.;
- Vagodny, Aleksandr;
- Daniels, Veerle W.;
- Taneja, Krishan;
- Tan, Benjamin Y.;
- DeRose, Yoko S.;
- Fujita, Maihi;
- Welm, Alana L.;
- Letai, Anthony;
- Leverson, Joel D.;
- Blot, Vincent;
- Bronson, Roderick T.;
- Dillon, Deborah A.;
- Brugge, Joan S.
Publication type:
journal article
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA.
Published in:
Cancers, 2021, v. 13, n. 10, p. 2310, doi. 10.3390/cancers13102310
By:
- Fairchild Jr., Carter K.;
- Floros, Konstantinos V.;
- Jacob, Sheeba;
- Coon, Colin M.;
- Puchalapalli, Madhavi;
- Hu, Bin;
- Harada, Hisashi;
- Dozmorov, Mikhail G.;
- Koblinski, Jennifer E.;
- Smith, Steven C.;
- Domson, Gregory;
- Leverson, Joel D.;
- Souers, Andrew J.;
- Takebe, Naoko;
- Ebi, Hiromichi;
- Faber, Anthony C.;
- Boikos, Sosipatros A.;
- Canter, Robert J.;
- Thorpe, Steven W.
Publication type:
Article
Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X<sub>L</sub>–BAX interaction.
Published in:
Molecular Oncology, 2020, v. 14, n. 10, p. 2504, doi. 10.1002/1878-0261.12761
By:
- Saleh, Tareq;
- Carpenter, Valerie J.;
- Tyutyunyk‐Massey, Liliya;
- Murray, Graeme;
- Leverson, Joel D.;
- Souers, Andrew J.;
- Alotaibi, Moureq R.;
- Faber, Anthony C.;
- Reed, Jason;
- Harada, Hisashi;
- Gewirtz, David A.
Publication type:
Article
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins.
Published in:
EMBO Journal, 2007, v. 26, n. 18, p. 4102, doi. 10.1038/sj.emboj.7601839
By:
- Huaiyu Sun;
- Leverson, Joel D.;
- Hunter, Tony
Publication type:
Article
Statins enhance efficacy of venetoclax in blood cancers.
Published in:
Science Translational Medicine, 2018, v. 10, n. 445, p. 1, doi. 10.1126/scitranslmed.aaq1240
By:
- Lee, J. Scott;
- Roberts, Andrew;
- Juarez, Dennis;
- Vo, Thanh-Trang T.;
- Bhatt, Shruti;
- Herzog, Lee-or;
- Mallya, Sharmila;
- Bellin, Richard J.;
- Agarwal, Suresh K.;
- Salem, Ahmed Hamed;
- Xu, Tu;
- Jia, Jia;
- Li, Lingxiao;
- Hanna, John R.;
- Davids, Matthew S.;
- Fleischman, Angela G.;
- O'Brien, Susan;
- Lam, Lloyd T.;
- Leverson, Joel D.;
- Letai, Anthony
Publication type:
Article
Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells.
Published in:
Science Translational Medicine, 2016, v. 8, n. 355, p. 1, doi. 10.1126/scitranslmed.aag1180
By:
- Carter, Bing Z.;
- Po Yee Mak;
- Hong Mu;
- Hongsheng Zhou;
- Mak, Duncan H.;
- Schober, Wendy;
- Leverson, Joel D.;
- Bin Zhang;
- Bhatia, Ravi;
- Xuelin Huang;
- Cortes, Jorge;
- Kantarjian, Hagop;
- Konopleva, Marina;
- Andreeff, Michael
Publication type:
Article
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Published in:
Science Translational Medicine, 2015, v. 7, n. 279, p. 1, doi. 10.1126/scitranslmed.aaa4642
By:
- Leverson, Joel D.;
- Phillips, Darren C.;
- Mitten, Michael J.;
- Boghaert, Erwin R.;
- Diaz, Dolores;
- Tahir, Stephen K.;
- Belmont, Lisa D.;
- Nimmer, Paul;
- Yu Xiao;
- Xiaoju Max Ma;
- Lowes, Kym N.;
- Kovar, Peter;
- Jun Chen;
- Sha Jin;
- Smith, Morey;
- Xue, John;
- Haichao Zhang;
- Oleksijew, Anatol;
- Magoc, Terrance J.;
- Vaidya, Kedar S.
Publication type:
Article
Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. S282, doi. 10.1016/j.clml.2017.07.064
By:
- Han, Lina;
- Zhang, Qi;
- Shi, Ce;
- Cavazos, Antonio;
- Ruvolo, Vivian R.;
- Leverson, Joel D.;
- Dail, Monique;
- Phillips, Darren C.;
- Chen, Jun;
- Jin, Sha S.;
- Jacamo, Rodrigo;
- Daver, Naval;
- Jabbour, Elias;
- Kantarjian, Hagop M.;
- Andreeff, Michael;
- Sampath, Deepak;
- Konopleva, Marina
Publication type:
Article
Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?
Published in:
Frontiers in Oncology, 2018, p. N.PAG, doi. 10.3389/fonc.2018.00458
By:
- Leverson, Joel D.;
- Cojocari, Dan
Publication type:
Article
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.
Published in:
Cell Death & Disease, 2021, v. 12, n. 11, p. 1, doi. 10.1038/s41419-021-04285-4
By:
- Ludwig, Lindsey M.;
- Hawley, Katrina M.;
- Banks, David B.;
- Thomas-Toth, Anika T.;
- Blazar, Bruce R.;
- McNerney, Megan E.;
- Leverson, Joel D.;
- LaBelle, James L.
Publication type:
Article
Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00263-7
By:
- Zervantonakis, Ioannis K.;
- Iavarone, Claudia;
- Hsing-Yu Chen;
- Selfors, Laura M.;
- Palakurthi, Sangeetha;
- Liu, Joyce F.;
- Drapkin, Ronny;
- Matulonis, Ursula;
- Leverson, Joel D.;
- Sampath, Deepak;
- Mills, Gordon B.;
- Brugge, Joan S.
Publication type:
Article
Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines.
Published in:
Cancer Cell International, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12935-014-0151-3
By:
- Lam, Lloyd T.;
- Haichao Zhang;
- John Xue;
- Leverson, Joel D.;
- Bhathena, Anahita
Publication type:
Article

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