Found: 26

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  • Multi-modality machine learning predicting Parkinson's disease.

    Published in:
    NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00288-w
    By:
    • Makarious, Mary B.;
    • Leonard, Hampton L.;
    • Vitale, Dan;
    • Iwaki, Hirotaka;
    • Sargent, Lana;
    • Dadu, Anant;
    • Violich, Ivo;
    • Hutchins, Elizabeth;
    • Saffo, David;
    • Bandres-Ciga, Sara;
    • Kim, Jonggeol Jeff;
    • Song, Yeajin;
    • Maleknia, Melina;
    • Bookman, Matt;
    • Nojopranoto, Willy;
    • Campbell, Roy H.;
    • Hashemi, Sayed Hadi;
    • Botia, Juan A.;
    • Carter, John F.;
    • Craig, David W.
    Publication type:
    Article

  • Large-scale rare variant burden testing in Parkinson's disease.

    Published in:
    Brain: A Journal of Neurology, 2023, v. 146, n. 11, p. 4622, doi. 10.1093/brain/awad214
    By:
    • Makarious, Mary B;
    • Lake, Julie;
    • Pitz, Vanessa;
    • Fu, Allen Ye;
    • Guidubaldi, Joseph L;
    • Solsberg, Caroline Warly;
    • Bandres-Ciga, Sara;
    • Leonard, Hampton L;
    • Kim, Jonggeol Jeffrey;
    • Billingsley, Kimberley J;
    • Grenn, Francis P;
    • Jerez, Pilar Alvarez;
    • Alvarado, Chelsea X;
    • Iwaki, Hirotaka;
    • Ta, Michael;
    • Vitale, Dan;
    • Hernandez, Dena;
    • Torkamani, Ali;
    • Ryten, Mina;
    • Hardy, John
    Publication type:
    Article

  • Genetic risk factor clustering within and across neurodegenerative diseases.

    Published in:
    Brain: A Journal of Neurology, 2023, v. 146, n. 11, p. 4486, doi. 10.1093/brain/awad161
    By:
    • Koretsky, Mathew J;
    • Alvarado, Chelsea;
    • Makarious, Mary B;
    • Vitale, Dan;
    • Levine, Kristin;
    • Bandres-Ciga, Sara;
    • Dadu, Anant;
    • Scholz, Sonja W;
    • Sargent, Lana;
    • Faghri, Faraz;
    • Iwaki, Hirotaka;
    • Blauwendraat, Cornelis;
    • Singleton, Andrew;
    • Nalls, Mike;
    • Leonard, Hampton
    Publication type:
    Article

  • Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

    Published in:
    Brain: A Journal of Neurology, 2020, v. 143, n. 1, p. 234, doi. 10.1093/brain/awz350
    By:
    • Blauwendraat, Cornelis;
    • Reed, Xylena;
    • Krohn, Lynne;
    • Heilbron, Karl;
    • Bandres-Ciga, Sara;
    • Tan, Manuela;
    • Gibbs, J Raphael;
    • Hernandez, Dena G;
    • Kumaran, Ravindran;
    • Langston, Rebekah;
    • Bonet‐Ponce, Luis;
    • Alcalay, Roy N;
    • Hassin-Baer, Sharon;
    • Greenbaum, Lior;
    • Iwaki, Hirotaka;
    • Leonard, Hampton L;
    • Grenn, Francis P;
    • Ruskey, Jennifer A;
    • Sabir, Marya;
    • Ahmed, Sarah
    Publication type:
    Article

  • Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

    Published in:
    2019
    By:
    • Blauwendraat, Cornelis;
    • Reed, Xylena;
    • Krohn, Lynne;
    • Heilbron, Karl;
    • Bandres-Ciga, Sara;
    • Tan, Manuela;
    • Gibbs, J Raphael;
    • Hernandez, Dena G;
    • Kumaran, Ravindran;
    • Langston, Rebekah;
    • Bonet-Ponce, Luis;
    • Alcalay, Roy N;
    • Hassin-Baer, Sharon;
    • Greenbaum, Lior;
    • Iwaki, Hirotaka;
    • Leonard, Hampton L;
    • Grenn, Francis P;
    • Ruskey, Jennifer A;
    • Sabir, Marya;
    • Ahmed, Sarah
    Publication type:
    journal article

  • Assessing the lack of diversity in genetics research across neurodegenerative diseases: A systematic review of the GWAS Catalog and literature.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 8, p. 5740, doi. 10.1002/alz.13873
    By:
    • Jonson, Caroline;
    • Levine, Kristin S.;
    • Lake, Julie;
    • Hertslet, Linnea;
    • Jones, Lietsel;
    • Patel, Dhairya;
    • Kim, Jeff;
    • Bandres‐Ciga, Sara;
    • Terry, Nancy;
    • Mata, Ignacio F.;
    • Blauwendraat, Cornelis;
    • Singleton, Andrew B.;
    • Nalls, Mike A.;
    • Yokoyama, Jennifer S.;
    • Leonard, Hampton L.
    Publication type:
    Article

  • omicSynth: an open multi‐omic community resource for identifying druggable targets across neurodegenerative diseases.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082359
    By:
    • Alvarado, Chelsea X;
    • Makarious, Mary B;
    • Vitale, Dan;
    • Koretsky, Mathew J;
    • Bandres‐Ciga, Sara;
    • Iwaki, Hirotaka;
    • Levine, Kristin;
    • Singleton, Andrew;
    • Faghri, Faraz;
    • Nalls, Mike A;
    • Leonard, Hampton L
    Publication type:
    Article

  • A Multivariate Genome‐Wide Association Study of the Shared Genetic Architecture Among Modifiable Risk Factors for Dementia: 590 Loci Associated with Brain Health.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 22, p. 1, doi. 10.1002/alz.079738
    By:
    • Foote, Isabelle F;
    • Bandres‐Ciga, Sara;
    • Kim, Jonggeol Jeff;
    • Alvarado, Chelsea X;
    • Leonard, Hampton L;
    • Bothongo, Phazha LK;
    • Grotzinger, Andrew D;
    • Jacobs, Benjamin M;
    • Waters, Sheena;
    • Dobson, Ruth;
    • Noyce, Alastair J;
    • Bhui, Kamaldeep S;
    • Korszun, Ania;
    • Marshall, Charles R
    Publication type:
    Article

  • Lack of genetic evidence for NLRP3 inflammasome involvement in Parkinson's disease pathogenesis.

    Published in:
    NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00744-9
    By:
    • Senkevich, Konstantin;
    • Liu, Lang;
    • Alvarado, Chelsea X.;
    • Leonard, Hampton L.;
    • Nalls, Mike A.;
    • Gan-Or, Ziv
    Publication type:
    Article

  • Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2).

    Published in:
    NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00533-w
    By:
    • Towns, Clodagh;
    • Richer, Madeleine;
    • Jasaityte, Simona;
    • Stafford, Eleanor J.;
    • Joubert, Julie;
    • Antar, Tarek;
    • Martinez-Carrasco, Alejandro;
    • Makarious, Mary B.;
    • Casey, Bradford;
    • Vitale, Dan;
    • Levine, Kristin;
    • Leonard, Hampton;
    • Pantazis, Caroline B.;
    • Screven, Laurel A.;
    • Hernandez, Dena G.;
    • Wegel, Claire E.;
    • Solle, Justin;
    • Nalls, Mike A.;
    • Blauwendraat, Cornelis;
    • Singleton, Andrew B.
    Publication type:
    Article

  • Genome-wide case-only analysis of gene-gene interactions with known Parkinson's disease risk variants reveals link between LRRK2 and SYT10.

    Published in:
    NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00550-9
    By:
    • Aleknonytė-Resch, Milda;
    • Trinh, Joanne;
    • Leonard, Hampton;
    • Delcambre, Sylvie;
    • Leitão, Elsa;
    • Lai, Dongbing;
    • Smajić, Semra;
    • Orr-Urtreger, Avi;
    • Thaler, Avner;
    • Blauwendraat, Cornelis;
    • Sharma, Arunabh;
    • Makarious, Mary B.;
    • Kim, Jonggeol Jeff;
    • Lake, Julie;
    • Rahmati, Pegah;
    • Freitag-Wolf, Sandra;
    • Seibler, Philip;
    • Foroud, Tatiana;
    • Singleton, Andrew B.;
    • Grünewald, Anne
    Publication type:
    Article

  • Author Correction: The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data.

    Published in:
    2023
    By:
    • Leonard, Hampton L.;
    • Murtadha, Ruqaya;
    • Martinez-Carrasco, Alejandro;
    • Jama, Alina;
    • Müller-Nedebock, Amica Corda;
    • Gil-Martinez, Ana-Luisa;
    • Illarionova, Anastasia;
    • Moore, Anni;
    • Bustos, Bernabe I.;
    • Jadhav, Bharati;
    • Huxford, Brook;
    • Storm, Catherine;
    • Towns, Clodagh;
    • Vitale, Dan;
    • Chetty, Devina;
    • Yu, Eric;
    • Grenn, Francis P.;
    • Salazar, Gabriela;
    • Rateau, Geoffrey;
    • Iwaki, Hirotaka
    Publication type:
    Correction Notice

  • The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data.

    Published in:
    NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00472-6
    By:
    • Leonard, Hampton L.;
    • Murtadha, Ruqaya;
    • Martinez-Carrasco, Alejandro;
    • Jama, Alina;
    • Müller-Nedebock, Amica Corda;
    • Gil-Martinez, Ana-Luisa;
    • Illarionova, Anastasia;
    • Moore, Anni;
    • Bustos, Bernabe I.;
    • Jadhav, Bharati;
    • Huxford, Brook;
    • Storm, Catherine;
    • Towns, Clodagh;
    • Vitale, Dan;
    • Chetty, Devina;
    • Yu, Eric;
    • Grenn, Francis P.;
    • Salazar, Gabriela;
    • Rateau, Geoffrey;
    • Iwaki, Hirotaka
    Publication type:
    Article

  • Identification and prediction of Parkinson's disease subtypes and progression using machine learning in two cohorts.

    Published in:
    NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00439-z
    By:
    • Dadu, Anant;
    • Satone, Vipul;
    • Kaur, Rachneet;
    • Hashemi, Sayed Hadi;
    • Leonard, Hampton;
    • Iwaki, Hirotaka;
    • Makarious, Mary B.;
    • Billingsley, Kimberley J.;
    • Bandres‐Ciga, Sara;
    • Sargent, Lana J.;
    • Noyce, Alastair J.;
    • Daneshmand, Ali;
    • Blauwendraat, Cornelis;
    • Marek, Ken;
    • Scholz, Sonja W.;
    • Singleton, Andrew B.;
    • Nalls, Mike A.;
    • Campbell, Roy H.;
    • Faghri, Faraz
    Publication type:
    Article

  • Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors.

    Published in:
    Annals of Neurology, 2022, v. 92, n. 2, p. 270, doi. 10.1002/ana.26416
    By:
    • Liu, Hui;
    • Dehestani, Mohammad;
    • Blauwendraat, Cornelis;
    • Makarious, Mary B.;
    • Leonard, Hampton;
    • Kim, Jonggeol J.;
    • Schulte, Claudia;
    • Noyce, Alastair;
    • Jacobs, Benjamin M.;
    • Foote, Isabelle;
    • Sharma, Manu;
    • Koks, Sulev;
    • Mellick, George D;
    • Pirker, Walter;
    • Zimprich, Alexander;
    • Lang, Anthony E;
    • Rogaeva, Ekaterina;
    • Taba, Pille;
    • Brice, Alexis;
    • Chartier‐Harlin, Marie‐Christine
    Publication type:
    Article

  • Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.

    Published in:
    Annals of Neurology, 2021, v. 90, n. 1, p. 35, doi. 10.1002/ana.26090
    By:
    • Blauwendraat, Cornelis;
    • Iwaki, Hirotaka;
    • Makarious, Mary B.;
    • Bandres‐Ciga, Sara;
    • Leonard, Hampton L.;
    • Grenn, Francis P.;
    • Lake, Julie;
    • Krohn, Lynne;
    • Tan, Manuela;
    • Kim, Jonggeol J.;
    • Gibbs, Jesse R.;
    • Hernandez, Dena G.;
    • Ruskey, Jennifer A.;
    • Pihlstrøm, Lasse;
    • Toft, Mathias;
    • Hilten, Jacobus J.;
    • Marinus, Johan;
    • Schulte, Claudia;
    • Brockmann, Kathrin;
    • Sharma, Manu
    Publication type:
    Article

  • Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits.

    Published in:
    Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83450-3
    By:
    • Gouveia, Mateus H.;
    • Bentley, Amy R.;
    • Leonard, Hampton;
    • Meeks, Karlijn A. C.;
    • Ekoru, Kenneth;
    • Chen, Guanjie;
    • Nalls, Michael A.;
    • Simonsick, Eleanor M.;
    • Tarazona-Santos, Eduardo;
    • Lima-Costa, Maria Fernanda;
    • Adeyemo, Adebowale;
    • Shriner, Daniel;
    • Rotimi, Charles N.
    Publication type:
    Article

  • Long‐Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease.

    Published in:
    Movement Disorders, 2023, v. 38, n. 12, p. 2249, doi. 10.1002/mds.29610
    By:
    • Daida, Kensuke;
    • Funayama, Manabu;
    • Billingsley, Kimberley J.;
    • Malik, Laksh;
    • Miano‐Burkhardt, Abigail;
    • Leonard, Hampton L.;
    • Makarious, Mary B.;
    • Iwaki, Hirotaka;
    • Ding, Jinhui;
    • Gibbs, J. Raphael;
    • Ishiguro, Mayu;
    • Yoshino, Hiroyo;
    • Ogaki, Kotaro;
    • Oyama, Genko;
    • Nishioka, Kenya;
    • Nonaka, Risa;
    • Akamatsu, Wado;
    • Blauwendraat, Cornelis;
    • Hattori, Nobutaka
    Publication type:
    Article

  • Genome‐Wide Meta‐Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Parkinson's Disease Cohorts.

    Published in:
    Movement Disorders, 2023, v. 38, n. 9, p. 1697, doi. 10.1002/mds.29511
    By:
    • Ta, Michael;
    • Blauwendraat, Cornelis;
    • Antar, Tarek;
    • Leonard, Hampton L.;
    • Singleton, Andrew B.;
    • Nalls, Mike A.;
    • Iwaki, Hirotaka
    Publication type:
    Article

  • Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.

    Published in:
    Movement Disorders, 2022, v. 37, n. 1, p. 95, doi. 10.1002/mds.28787
    By:
    • Lake, Julie;
    • Reed, Xylena;
    • Langston, Rebekah G.;
    • Nalls, Mike A.;
    • Gan‐Or, Ziv;
    • Cookson, Mark R.;
    • Singleton, Andrew B.;
    • Blauwendraat, Cornelis;
    • Leonard, Hampton L.
    Publication type:
    Article

  • Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.

    Published in:
    Movement Disorders, 2021, v. 36, n. 8, p. 1795, doi. 10.1002/mds.28549
    By:
    • Iwaki, Hirotaka;
    • Leonard, Hampton L.;
    • Makarious, Mary B.;
    • Bookman, Matt;
    • Landin, Barry;
    • Vismer, David;
    • Casey, Bradford;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Blauwendraat, Cornelis;
    • Vitale, Daniel;
    • Song, Yeajin;
    • Kumar, Dinesh;
    • Dalgard, Clifton L.;
    • Sadeghi, Mahdiar;
    • Dong, Xianjun;
    • Misquitta, Leonie;
    • Scholz, Sonja W.;
    • Scherzer, Clemens R.;
    • Nalls, Mike A.
    Publication type:
    Article

  • Differences in the Presentation and Progression of Parkinson's Disease by Sex.

    Published in:
    2021
    By:
    • Iwaki, Hirotaka;
    • Blauwendraat, Cornelis;
    • Leonard, Hampton L.;
    • Makarious, Mary B.;
    • Kim, Jonggeol J.;
    • Liu, Ganqiang;
    • Maple‐Grødem, Jodi;
    • Corvol, Jean‐Christophe;
    • Pihlstrøm, Lasse;
    • Nimwegen, Marlies;
    • Smolensky, Luba;
    • Amondikar, Ninad;
    • Hutten, Samantha J.;
    • Frasier, Mark;
    • Nguyen, Khanh‐Dung H.;
    • Rick, Jacqueline;
    • Eberly, Shirley;
    • Faghri, Faraz;
    • Auinger, Peggy;
    • Scott, Kirsten M.
    Publication type:
    journal article

  • The Parkinson's Disease Genome‐Wide Association Study Locus Browser.

    Published in:
    Movement Disorders, 2020, v. 35, n. 11, p. 2056, doi. 10.1002/mds.28197
    By:
    • Grenn, Francis P.;
    • Kim, Jonggeol J.;
    • Makarious, Mary B.;
    • Iwaki, Hirotaka;
    • Illarionova, Anastasia;
    • Brolin, Kajsa;
    • Kluss, Jillian H.;
    • Schumacher‐Schuh, Artur F.;
    • Leonard, Hampton;
    • Faghri, Faraz;
    • Billingsley, Kimberley;
    • Krohn, Lynne;
    • Hall, Ashley;
    • Diez‐Fairen, Monica;
    • Periñán, Maria Teresa;
    • Foo, Jia Nee;
    • Sandor, Cynthia;
    • Webber, Caleb;
    • Fiske, Brian K.;
    • Gibbs, J. Raphael
    Publication type:
    Article

  • Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score.

    Published in:
    2020
    By:
    • Iwaki, Hirotaka;
    • Blauwendraat, Cornelis;
    • Makarious, Mary B.;
    • Bandrés‐Ciga, Sara;
    • Leonard, Hampton L.;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Scholz, Sonja W.;
    • Faghri, Faraz;
    • Nalls, Mike A.;
    • Singleton, Andrew B.;
    • Noyce, Alastair J;
    • Kaiyrzhanov, Rauan;
    • Middlehurst, Ben;
    • Kia, Demis A;
    • Tan, Manuela;
    • Houlden, Henry;
    • Morris, Huw R;
    • Plun‐Favreau, Helene;
    • Holmans, Peter
    Publication type:
    journal article

  • Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.

    Published in:
    2019
    By:
    • Iwaki, Hirotaka;
    • Blauwendraat, Cornelis;
    • Leonard, Hampton L.;
    • Kim, Jonggeol J.;
    • Liu, Ganqiang;
    • Maple‐Grødem, Jodi;
    • Corvol, Jean‐Christophe;
    • Pihlstrøm, Lasse;
    • Nimwegen, Marlies;
    • Hutten, Samantha J.;
    • Nguyen, Khanh‐Dung H.;
    • Rick, Jacqueline;
    • Eberly, Shirley;
    • Faghri, Faraz;
    • Auinger, Peggy;
    • Scott, Kirsten M.;
    • Wijeyekoon, Ruwani;
    • Van Deerlin, Vivianna M.;
    • Hernandez, Dena G.;
    • Gibbs, J. Raphael
    Publication type:
    journal article

  • Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

    Published in:
    2019
    By:
    • Blauwendraat, Cornelis;
    • Heilbron, Karl;
    • Vallerga, Costanza L.;
    • Bandres‐Ciga, Sara;
    • von Coelln, Rainer;
    • Pihlstrøm, Lasse;
    • Simón‐Sánchez, Javier;
    • Schulte, Claudia;
    • Sharma, Manu;
    • Krohn, Lynne;
    • Siitonen, Ari;
    • Iwaki, Hirotaka;
    • Leonard, Hampton;
    • Noyce, Alastair J.;
    • Tan, Manuela;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Scholz, Sonja W.;
    • Jankovic, Joseph;
    • Shulman, Lisa M.
    Publication type:
    journal article