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Islet transplantation in type 1 diabetes: hype, hope and reality - a clinician's perspective.
Published in:
Diabetes/Metabolism Research & Reviews, 2014, v. 30, n. 2, p. 83, doi. 10.1002/dmrr.2484
By:
- Zinger, Adar;
- Leibowitz, Gil
Publication type:
Article
Abrogation of Autophagy by Chloroquine Alone or in Combination with mTOR Inhibitors Induces Apoptosis in Neuroendocrine Tumor Cells.
Published in:
Neuroendocrinology, 2016, v. 103, n. 6, p. 724, doi. 10.1159/000442589
By:
- Avniel-Polak, Shani;
- Leibowitz, Gil;
- Riahi, Yael;
- Glaser, Benjamin;
- Gross, David J.;
- Grozinsky-Glasberg, Simona
Publication type:
Article
Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29124-8
By:
- Hinden, Liad;
- Ahmad, Majdoleen;
- Hamad, Sharleen;
- Nemirovski, Alina;
- Szanda, Gergő;
- Glasmacher, Sandra;
- Kogot-Levin, Aviram;
- Abramovitch, Rinat;
- Thorens, Bernard;
- Gertsch, Jürg;
- Leibowitz, Gil;
- Tam, Joseph
Publication type:
Article
GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome.
Published in:
2016
By:
- Danielpur, Liron;
- Sohn, Yang-Sung;
- Karmi, Ola;
- Fogel, Chen;
- Zinger, Adar;
- Abu-Libdeh, Abdulsalam;
- Israeli, Tal;
- Riahi, Yael;
- Pappo, Orit;
- Birk, Ruth;
- Zangen, David H;
- Mittler, Ron;
- Cabantchik, Zvi-Ioav;
- Cerasi, Erol;
- Nechushtai, Rachel;
- Leibowitz, Gil
Publication type:
journal article
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production.
Published in:
Diabetologia, 2023, v. 66, n. 10, p. 1925, doi. 10.1007/s00125-023-05967-8
By:
- Riahi, Yael;
- Kogot-Levin, Aviram;
- Kadosh, Liat;
- Agranovich, Bella;
- Malka, Assaf;
- Assa, Michael;
- Piran, Ron;
- Avrahami, Dana;
- Glaser, Benjamin;
- Gottlieb, Eyal;
- Jackson III, Fields;
- Cerasi, Erol;
- Bernal-Mizrachi, Ernesto;
- Helman, Aharon;
- Leibowitz, Gil
Publication type:
Article
The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.
Published in:
Diabetologia, 2022, v. 65, n. 3, p. 490, doi. 10.1007/s00125-021-05630-0
By:
- Grajales, Diana;
- Vázquez, Patricia;
- Ruíz-Rosario, Mónica;
- Tudurí, Eva;
- Mirasierra, Mercedes;
- Ferreira, Vítor;
- Hitos, Ana B.;
- Koller, Dora;
- Zubiaur, Pablo;
- Cigudosa, Juan C.;
- Abad-Santos, Francisco;
- Vallejo, Mario;
- Quesada, Iván;
- Tirosh, Boaz;
- Leibowitz, Gil;
- Valverde, Ángela M.
Publication type:
Article
Erratum to: Autophagy is a major regulator of beta cell insulin homeostasis.
Published in:
2016
By:
- Riahi, Yael;
- Wikstrom, Jakob;
- Bachar-Wikstrom, Etty;
- Polin, Nava;
- Zucker, Hava;
- Lee, Myung-Shik;
- Quan, Wenying;
- Haataja, Leena;
- Liu, Ming;
- Arvan, Peter;
- Cerasi, Erol;
- Leibowitz, Gil
Publication type:
Erratum
Autophagy is a major regulator of beta cell insulin homeostasis.
Published in:
Diabetologia, 2016, v. 59, n. 7, p. 1480, doi. 10.1007/s00125-016-3868-9
By:
- Riahi, Yael;
- Wikstrom, Jakob;
- Bachar-Wikstrom, Etty;
- Polin, Nava;
- Zucker, Hava;
- Lee, Myung-Shik;
- Quan, Wenying;
- Haataja, Leena;
- Liu, Ming;
- Arvan, Peter;
- Cerasi, Erol;
- Leibowitz, Gil
Publication type:
Article
Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes.
Published in:
Diabetologia, 2014, v. 57, n. 8, p. 1505, doi. 10.1007/s00125-014-3255-3
By:
- Stienstra, Rinke;
- Haim, Yulia;
- Riahi, Yael;
- Netea, Mihai;
- Rudich, Assaf;
- Leibowitz, Gil
Publication type:
Article
Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival.
Published in:
Scientific Reports, 2016, p. 31222, doi. 10.1038/srep31222
By:
- Malakar, Pushkar;
- Chartarifsky, Lital;
- Hija, Ayat;
- Leibowitz, Gil;
- Glaser, Benjamin;
- Dor, Yuval;
- Karni, Rotem
Publication type:
Article
Normoalbuminuria—is it normal? The association of urinary albumin within the 'normoalbuminuric' range with adverse cardiovascular and mortality outcomes: A systematic review and meta‐analysis.
Published in:
Diabetes, Obesity & Metabolism, 2024, v. 26, n. 10, p. 4225, doi. 10.1111/dom.15752
By:
- Sehtman‐Shachar, Dvora R.;
- Yanuv, Ilan;
- Schechter, Meir;
- Fishkin, Alisa;
- Aharon‐Hananel, Genya;
- Leibowitz, Gil;
- Rozenberg, Aliza;
- Mosenzon, Ofri
Publication type:
Article
Effects of proinsulin misfolding on β‐cell dynamics, differentiation and function in diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2018, v. 20, p. 95, doi. 10.1111/dom.13379
By:
- Riahi, Yael;
- Israeli, Tal;
- Cerasi, Erol;
- Leibowitz, Gil
Publication type:
Article
Hypoglycaemia manifestations and recurrent events: Lessons from the SAVOR-TIMI 53 outcome study.
Published in:
Diabetes, Obesity & Metabolism, 2017, v. 19, n. 7, p. 1045, doi. 10.1111/dom.12903
By:
- Cahn, Avivit;
- Mosenzon, Ofri;
- Bhatt, Deepak L.;
- Leibowitz, Gil;
- Yanuv, Ilan;
- Rozenberg, Aliza;
- Iqbal, Nayyar;
- Hirshberg, Boaz;
- Stahre, Christina;
- Im, KyungAh;
- Kanevsky, Estella;
- Raz, Itamar
Publication type:
Article
AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells.
Published in:
PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028804
By:
- Shaked, Maayan;
- Ketzinel-Gilad, Mali;
- Cerasi, Erol;
- Kaiser, Nurit;
- Leibowitz, Gil
Publication type:
Article
Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1.
Published in:
PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004954
By:
- Bachar, Etti;
- Ariav, Yafa;
- Ketzinel-Gilad, Mali;
- Cerasi, Erol;
- Kaiser, Nurit;
- Leibowitz, Gil
Publication type:
Article
Sporadic phaeochromocytomas are rarely associated with germline mutations in the von Hippel-Lindau and RET genes.
Published in:
Clinical Endocrinology, 1997, v. 47, n. 6, p. 707, doi. 10.1046/j.1365-2265.1997.3251150.x
By:
- Bar, Merav;
- Friedman, Eitan;
- Jakobovitz, Orit;
- Leibowitz, Gil;
- Lerer, Israela;
- Abeliovich, Dvorah;
- Gross, David J.
Publication type:
Article
Fluctuating hyper-hypocortisolaemia: a variant of Cushing's syndrome.
Published in:
Clinical Endocrinology, 1997, v. 46, n. 6, p. 759, doi. 10.1046/j.1365-2265.1997.1210935.x
By:
- Leibowitz, Gil;
- White, Anne;
- Hadani, Moshe;
- Gross, David J.
Publication type:
Article
Pre-clinical Cushing's syndrome: an unexpected frequent cause of poor glycaemic control in obese diabetic patients.
Published in:
Clinical Endocrinology, 1996, v. 44, n. 6, p. 717, doi. 10.1046/j.1365-2265.1996.737558.x
By:
- Leibowitz, Gil;
- Tsur, Anat;
- Chayen, Susan D.;
- Salameh, Mohammad;
- Raz, Itamar;
- Cerasi, Erol;
- Gross, David J.
Publication type:
Article
The Autophagy Inhibitor Chloroquine, Alone or in Combination with mTOR Inhibitors, Displays Anti-Tumor Effects in In Vitro and In Vivo Lung Carcinoid Models.
Published in:
Cancers, 2021, v. 13, n. 24, p. 6327, doi. 10.3390/cancers13246327
By:
- Knigin, Adi;
- Avniel-Polak, Shani;
- Leibowitz, Gil;
- Oleinikov, Kira;
- Gross, David J.;
- Grozinsky-Glasberg, Simona
Publication type:
Article
Pathogenesis of diabesity‐induced kidney disease: role of kidney nutrient sensing.
Published in:
FEBS Journal, 2022, v. 289, n. 4, p. 901, doi. 10.1111/febs.15790
By:
- Hinden, Liad;
- Kogot‐Levin, Aviram;
- Tam, Joseph;
- Leibowitz, Gil
Publication type:
Article
Should Patients With Frozen Shoulder Be Screened for Diabetes Mellitus?
Published in:
Orthopaedic Journal of Sports Medicine, 2017, v. 5, n. 7, p. 1, doi. 10.1177/2325967117716450
By:
- Safran, Ori;
- El-Haj, Madi;
- Leibowitz, Gil;
- Beyth, Shaul;
- Furman, Zohar;
- Milgrom, Charles;
- Kandel, Leonid
Publication type:
Article
Glucotoxicity and β-Cell Failure in Type 2 Diabetes Mellitus.
Published in:
Journal of Pediatric Endocrinology & Metabolism, 2003, v. 16, n. 1, p. 5
By:
- Kaiser, Nurit;
- Leibowitz, Gil;
- Nesher, Rafael
Publication type:
Article
Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner.
Published in:
Journal of Cellular & Molecular Medicine, 2015, v. 19, n. 8, p. 1887, doi. 10.1111/jcmm.12561
By:
- Riahi, Yael;
- Kaiser, Nurit;
- Cohen, Guy;
- Abd‐Elrahman, Ihab;
- Blum, Galia;
- Shapira, Oz M.;
- Koler, Tomer;
- Simionescu, Maya;
- Sima, Anca V.;
- Zarkovic, Neven;
- Zarkovic, Kamelija;
- Orioli, Marica;
- Aldini, Giancarlo;
- Cerasi, Erol;
- Leibowitz, Gil;
- Sasson, Shlomo
Publication type:
Article
Response to Mastrototaro and Gross.
Published in:
2003
By:
- Metzger, Muriel;
- Leibowitz, Gil;
- Wainstein, Julio;
- Glaser, Benjamin;
- Raz, Itamar
Publication type:
Letter
Reproducibility of glucose measurements using the glucose sensor.
Published in:
2002
By:
- Metzger, Muriel;
- Leibowitz, Gil;
- Wainstein, Julio;
- Glaser, Benjamin;
- Raz, Itamar
Publication type:
journal article
A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells.
Published in:
Antioxidants, 2021, v. 10, n. 8, p. 1160, doi. 10.3390/antiox10081160
By:
- Karmi, Ola;
- Sohn, Yang-Sung;
- Marjault, Henri-Baptiste;
- Israeli, Tal;
- Leibowitz, Gil;
- Ioannidis, Konstantinos;
- Nahmias, Yaakov;
- Mittler, Ron;
- Cabantchik, Ioav Z.;
- Nechushtai, Rachel
Publication type:
Article
β-Cell failure in type 2 diabetes.
Published in:
Journal of Diabetes Investigation, 2011, v. 2, n. 2, p. 82, doi. 10.1111/j.2040-1124.2010.00094.x
By:
- Leibowitz, Gil;
- Kaiser, Nurit;
- Cerasi, Erol
Publication type:
Article
Upregulation of Mitochondrial Content in Cytochrome c Oxidase Deficient Fibroblasts.
Published in:
PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0165417
By:
- Kogot-Levin, Aviram;
- Saada, Ann;
- Leibowitz, Gil;
- Soiferman, Devorah;
- Douiev, Liza;
- Raz, Itamar;
- Weksler-Zangen, Sarah
Publication type:
Article
mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes.
Published in:
Diabetes, 2008, v. 57, n. 4, p. 945, doi. 10.2337/db07-0922
By:
- Fraenkel, Merav;
- Ketzinel-Gilad, Mali;
- Ariav, Yafa;
- Pappo, Orit;
- Karaca, Melis;
- Castel, Julien;
- Berthault, Marie-France;
- Magnan, Christophe;
- Cerasi, Erol;
- Kaiser, Nurit;
- Leibowitz, Gil
Publication type:
Article
Rapamycin Treatment Exacerbates Nutrition-Induced Diabetes in Psammomys obesus.
Published in:
Diabetes, 2007, v. 56, p. A514
By:
- Fraenkel, Merav;
- Gilad, Mali Ketzinel;
- Karaca, Melis;
- Castel, Julien;
- Magnan, Christophe;
- Ceraci, Erol;
- Kaiser, Nurit;
- Leibowitz, Gil
Publication type:
Article
Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.
Published in:
2005
By:
- Kaiser, Nurit;
- Nesher, Rafael;
- Donath, Marc Y.;
- Fraenkel, Merav;
- Behar, Vered;
- Magnan, Christophe;
- Ktorza, Alain;
- Cerasi, Erol;
- Leibowitz, Gil
Publication type:
journal article
Insulin does not mediate glucose stimulation of proinsulin biosynthesis.
Published in:
2003
By:
- Leibowitz, Gil;
- Oprescu, Andrei I.;
- Üçkaya, Gökhan;
- Gross, David J.;
- Cerasi, Erol;
- Kaiser, Nurit;
- Uçkaya, Gökhan
Publication type:
journal article
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes.
Published in:
2001
By:
- Leibowitz, Gil;
- Ferber, Sarah;
- Apelqvist, Asa;
- Edlund, Helena;
- Gross, David J.;
- Cerasi, Erol;
- Melloul, Danielle;
- Kaiser, Nerd;
- Leibowitz, G;
- Ferber, S;
- Apelqvist A;
- Edlund, H;
- Gross, D J;
- Cerasi, E;
- Melloul, D;
- Kaiser, N
Publication type:
journal article
Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes.
Published in:
2001
By:
- Leibowitz, Gil;
- Leibowitz, G;
- Melloul, D;
- Yuli, M;
- Gross, D J;
- Apelqvist, A;
- Edlund, H;
- Cerasi, E;
- Kaiser, N
Publication type:
journal article
beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.
Published in:
2001
By:
- Leibowitz, Gil;
- Yuli, Michal;
- Donath, Marc Y.;
- Nesher, Rafael;
- Melloul, Danielle;
- Cerasi, Erol;
- Gross, David J.;
- Kaiser, Nurit;
- Leibowitz, G;
- Yuli, M;
- Donath, M Y;
- Nesher, R;
- Melloul, D;
- Cerasi, E;
- Gross, D J;
- Kaiser, N
Publication type:
journal article
Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.
Published in:
1999
By:
- Marshak, Sonya;
- Leibowitz, Gil;
- Bertuzzi, Federico;
- Socci, Carlo;
- Kaiser, Nurit;
- Gross, David J.;
- Cerasi, Erol;
- Melloul, Danielle;
- Marshak, S;
- Leibowitz, G;
- Bertuzzi, F;
- Socci, C;
- Kaiser, N;
- Gross, D J;
- Cerasi, E;
- Melloul, D
Publication type:
journal article
Sustained proliferation of PDX-1+ cells derived from human islets.
Published in:
1999
By:
- Beattie, Gillian M.;
- Itkin-Ansari, Pamela;
- Cirulli, Vincenzo;
- Leibowitz, Gil;
- Lopez, Ana D.;
- Bossie, Stuart;
- Mally, Martin I.;
- Levine, Fred;
- Hayek, Alberto;
- Beattie, G M;
- Itkin-Ansari, P;
- Cirulli, V;
- Leibowitz, G;
- Lopez, A D;
- Bossie, S;
- Mally, M I;
- Levine, F;
- Hayek, A
Publication type:
journal article
Gene transfer to human pancreatic endocrine cells using viral vectors.
Published in:
1999
By:
- Leibowitz, Gil;
- Beattie, Gillian M.;
- Kafri, Tal;
- Cirulli, Vincenzo;
- Lopez, Ana D.;
- Hayek, Alberto;
- Levine, Fred;
- Leibowitz, G;
- Beattie, G M;
- Kafri, T;
- Cirulli, V;
- Lopez, A D;
- Hayek, A;
- Levine, F
Publication type:
journal article
Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial.
Published in:
2017
By:
- Mosenzon, Ofri;
- Leibowitz, Gil;
- Bhatt, Deepak L.;
- Cahn, Avivit;
- Hirshberg, Boaz;
- Wei, Cheryl;
- KyungAh Im;
- Rozenberg, Aliza;
- Yanuv, Ilan;
- Stahre, Christina;
- Ray, Kausik K.;
- Iqbal, Nayyar;
- Braunwald, Eugene;
- Scirica, Benjamin M.;
- Raz, Itamar;
- Im, KyungAh
Publication type:
journal article
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications.
Published in:
2016
By:
- Pollack, Rena M.;
- Donath, Marc Y.;
- LeRoith, Derek;
- Leibowitz, Gil
Publication type:
journal article
Predisposing Factors for Any and Major Hypoglycemia With Saxagliptin Versus Placebo and Overall: Analysis From the SAVOR-TIMI 53 Trial.
Published in:
2016
By:
- Cahn, Avivit;
- Raz, Itamar;
- Mosenzon, Ofri;
- Leibowitz, Gil;
- Yanuv, Ilan;
- Rozenberg, Aliza;
- Iqbal, Nayyar;
- Hirshberg, Boaz;
- Sjostrand, Mikaela;
- Stahre, Christina;
- KyungAh Im;
- Kanevsky, Estella;
- Scirica, Benjamin M.;
- Bhatt, Deepak L.;
- Braunwald, Eugene;
- Im, KyungAh
Publication type:
journal article
Decreased Serum Concentrations of 25-Hydroxycholecalciferol Are Associated With Increased Risk of Progression to Impaired Fasting Glucose and Diabetes.
Published in:
Diabetes Care, 2013, v. 36, n. 5, p. 1361, doi. 10.2337/dc12-1050
By:
- TSUR, ANAT;
- FELDMAN, BECCA S.;
- FELDHAMMER, ILAN;
- HOSHEN, MOSHE B.;
- LEIBOWITZ, GIL;
- BALICER, RAN D.
Publication type:
Article
Scanning Electron Microscopic Analysis of Intramyocellular Lipid Droplets in an Animal Model of Type 2 Diabetes.
Published in:
Obesity (19307381), 2008, v. 16, n. 3, p. 695, doi. 10.1038/oby.2007.105
By:
- Fraenkel, Merav;
- Weiss, Ram;
- Leizerman, Ilit;
- Anaby, Debbie;
- Golomb, Eliahu;
- Leibowitz, Gil;
- Kaiser, Nurit
Publication type:
Article
A rare frameshift mutation in the AGPAT2 gene in a family from gaza with congenital generalized lipodystrophy.
Published in:
Clinical Endocrinology, 2020, v. 93, n. 2, p. 212, doi. 10.1111/cen.14223
By:
- Gorin, Kobi;
- Golomb, Mordechai;
- Spitzen, Shoshi;
- Leitersdorf, Eran;
- Schurr, Daniel;
- Haj‐Yahia, Arin;
- Weiss, Ram;
- Leibowitz, Gil;
- Durst, Ronen
Publication type:
Article
Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy.
Published in:
2022
By:
- Israeli, Tal;
- Riahi, Yael;
- Garzon, Perla;
- Louzada, Ruy Andrade;
- Werneck-de-Castro, Joao Pedro;
- Blandino-Rosano, Manuel;
- Yeroslaviz-Stolper, Roni;
- Kadosh, Liat;
- Tornovsky-Babeay, Sharona;
- Hacker, Gilad;
- Israeli, Nitzan;
- Agmon, Orly;
- Tirosh, Boaz;
- Cerasi, Erol;
- Bernal-Mizrachi, Ernesto;
- Leibowitz, Gil
Publication type:
journal article
Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.
Published in:
2017
By:
- Dahan, Tehila;
- Ziv, Oren;
- Horwitz, Elad;
- Zemmour, Hai;
- Lavi, Judith;
- Swisa, Avital;
- Leibowitz, Gil;
- Ashcroft, Frances M.;
- In't Veld, Peter;
- Glaser, Benjamin;
- Dor, Yuval
Publication type:
journal article
Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.
Published in:
2013
By:
- Bachar-Wikstrom, Etty;
- Wikstrom, Jakob D;
- Ariav, Yafa;
- Tirosh, Boaz;
- Kaiser, Nurit;
- Cerasi, Erol;
- Leibowitz, Gil
Publication type:
journal article
Stimulation of Autophagy Improves Endoplasmic Reticulum Stress--Induced Diabetes.
Published in:
Diabetes, 2013, v. 62, n. 4, p. 1227, doi. 10.2337/db12-1474
By:
- Bachar-Wikstrom, Etty;
- Wikstrom, Jakob D.;
- Ariav, Yafa;
- Tirosh, Boaz;
- Kaiser, Nurit;
- Cerasi, Erol;
- Leibowitz, Gil
Publication type:
Article

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