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Development of a Biosimilar of Agalsidase Beta for the Treatment of Fabry Disease: Preclinical Evaluation.
Published in:
Drugs in R&D, 2023, v. 23, n. 2, p. 141, doi. 10.1007/s40268-023-00421-x
By:
- van Kuilenburg, André B. P.;
- Hollak, Carla E. M.;
- Travella, Ana;
- Jacobs, Melisa;
- Gentilini, Lucas D.;
- Leen, René;
- der Vlugt, Karen M. M. Ghauharali-van;
- Stet, Femke S. Beers;
- Goorden, Susan M. I.;
- van der Veen, Sanne;
- Criscuolo, Marcelo;
- Papouchado, Mariana
Publication type:
Article
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-12640-5
By:
- Milanese, Chiara;
- Bombardieri, Cíntia R.;
- Sepe, Sara;
- Barnhoorn, Sander;
- Payán-Goméz, César;
- Caruso, Donatella;
- Audano, Matteo;
- Pedretti, Silvia;
- Vermeij, Wilbert P.;
- Brandt, Renata M. C.;
- Gyenis, Akos;
- Wamelink, Mirjam M.;
- de Wit, Annelieke S.;
- Janssens, Roel C.;
- Leen, René;
- van Kuilenburg, André B. P.;
- Mitro, Nico;
- Hoeijmakers, Jan H. J.;
- Mastroberardino, Pier G.
Publication type:
Article
Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy.
Published in:
Cellular & Molecular Life Sciences, 2017, v. 74, n. 6, p. 1133, doi. 10.1007/s00018-016-2401-0
By:
- Weijer, Ruud;
- Clavier, Séverine;
- Zaal, Esther;
- Pijls, Maud;
- Kooten, Robert;
- Vermaas, Klaas;
- Leen, René;
- Jongejan, Aldo;
- Moerland, Perry;
- Kampen, Antoine;
- Kuilenburg, André;
- Berkers, Celia;
- Lemeer, Simone;
- Heger, Michal
Publication type:
Article
Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity.
Published in:
International Journal of Cancer, 2003, v. 103, n. 3, p. 387, doi. 10.1002/ijc.10858
By:
- Bierau, Jörgen;
- van Gennip, Albert H.;
- Leen, René;
- Helleman, Jozien;
- Caron, Huib N.;
- van Kuilenburg, André B.P.
Publication type:
Article
Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-β-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line.
Published in:
International Journal of Cancer, 2002, v. 98, n. 4, p. 616, doi. 10.1002/ijc.10211
By:
- Verschuur, Arnauld C.;
- Van Gennip, Albert H.;
- Leen, René;
- Voûte, P.A.;
- Brinkman, Josanne;
- Van Kuilenburg, André B.P.
Publication type:
Article
Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry.
Published in:
Biomedical Chromatography, 2008, v. 22, n. 12, p. 1368, doi. 10.1002/bmc.1067
By:
- Schimmel, Kirsten;
- Lenthe, Henk van;
- Leen, Rene;
- Kulik, Willem;
- Verschuur, Arnauld;
- Guchelaar, Henk-Jan;
- Kuilenburg, André van
Publication type:
Article
Repeat expansions nested within tandem CNVs: a unique structural change in GLS exemplifies the diagnostic challenges of non-coding pathogenic variation.
Published in:
Human Molecular Genetics, 2023, v. 32, n. 1, p. 46, doi. 10.1093/hmg/ddac173
By:
- Fazal, Sarah;
- Danzi, Matt C;
- Kuilenburg, André B P van;
- Reich, Selina;
- Traschütz, Andreas;
- Bender, Benjamin;
- Leen, René;
- Toro, Camilo;
- Usdin, Karen;
- Hayward, Bruce;
- Adams, David R;
- Karnebeek, Clara D M van;
- Ferreira, Carlos R;
- D'Sousa, Precilla;
- Network, Undiagnosed Diseases;
- Tekin, Mustafa;
- Züchner, Stephan;
- Synofzik, Matthis
Publication type:
Article
Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma.
Published in:
Cellular & Molecular Life Sciences, 2010, v. 67, n. 5, p. 807, doi. 10.1007/s00018-009-0212-2
By:
- Cuperus, Roos;
- Leen, René;
- Tytgat, Godelieve A. M.;
- Caron, Huib N.;
- Van Kuilenburg, André B. P.
Publication type:
Article
Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats.
Published in:
Archives of Toxicology, 2005, v. 79, n. 5, p. 268, doi. 10.1007/s00204-004-0633-5
By:
- Schimmel, Kirsten;
- Bennink, Roel;
- de Bruin, Kora;
- Leen, Rene;
- Sand, Karsten;
- van den Hoff, Maurice;
- x00C9;#van Kuilenburg, Andr&;
- Vanderheyden, Jean-Luc;
- Steinmetz, Neil;
- Pfaffendorf, Martin;
- Verschuur, Arnauld;
- Guchelaar, Henk-Jan
Publication type:
Article
In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia.
Published in:
British Journal of Haematology, 2000, v. 110, n. 1, p. 161, doi. 10.1046/j.1365-2141.2000.02136.x
By:
- Verschuur, Arnauld C.;
- Van Gennip, Albert H.;
- Leen, Rene;
- Meinsma, Rutger;
- Voute, P. A.;
- Van Kuilenburg, André B. P.
Publication type:
Article
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells
Published in:
FEBS Letters, 2002, v. 527, n. 1-3, p. 229, doi. 10.1016/S0014-5793(02)03234-9
By:
- Bierau, Jörgen;
- van Gennip, Albert H.;
- Leen, René;
- Caron, Huib N.;
- van Kuilenburg, André B.P.
Publication type:
Article

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