Found: 22
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Discovery of Dual TRPA1 and TRPV1 Antagonists as Novel Therapeutic Agents for Pain.
- Published in:
- Pharmaceuticals (14248247), 2024, v. 17, n. 9, p. 1209, doi. 10.3390/ph17091209
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- Publication type:
- Article
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 7, p. 962, doi. 10.3390/ph16070962
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- Article
Discovery of Novel Dual Adenosine A 2A and A 1 Receptor Antagonists with 1 H -Pyrazolo[3,4 -d ]pyrimidin-6-amine Core Scaffold as Anti-Parkinson's Disease Agents.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 8, p. 922, doi. 10.3390/ph15080922
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- Article
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30389-2
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- Article
Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells.
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- Journal of Biochemical & Molecular Toxicology, 2005, v. 19, n. 4, p. 266, doi. 10.1002/jbt.20084
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- Article
Chiral 2‐phenyl‐3‐hydroxypropyl esters as PKC‐alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies.
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- Chirality, 2022, v. 34, n. 3, p. 498, doi. 10.1002/chir.23406
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- Article
Functional Group-Dependent Induction of Astrocytogenesis and Neurogenesis by Flavone Derivatives.
- Published in:
- Biomolecules (2218-273X), 2019, v. 9, n. 12, p. 812, doi. 10.3390/biom9120812
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- Article
A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer.
- Published in:
- 2020
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- Publication type:
- Letter
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2008, v. 377, n. 2, p. 149, doi. 10.1007/s00210-007-0258-3
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- Publication type:
- Article
Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis.
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- FASEB Journal, 2014, v. 28, n. 7, p. 3197, doi. 10.1096/fj.13-247148
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- Publication type:
- Article
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies.
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- Journal of Computer-Aided Molecular Design, 2011, v. 25, n. 4, p. 317, doi. 10.1007/s10822-011-9421-5
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- Publication type:
- Article
Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer's agent, in rats.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2011, v. 38, n. 5, p. 637, doi. 10.1007/s10928-011-9212-6
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- Publication type:
- Article
The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells.
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- Cell Death Discovery, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41420-021-00743-2
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- Publication type:
- Article
Design and synthesis of bioisosteres of ultrapotent protein kinase C (PKC) ligand, 5-Acetoxymethyl-5-hydroxymethyl-3-alkylidene tetrahydro-2-furanone.
- Published in:
- Archives of Pharmacal Research, 1998, v. 21, n. 4, p. 452, doi. 10.1007/BF02974642
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- Publication type:
- Article
Synthesis and biological activity of 5-hydroxy-4-quinolones and 5-methoxy-4-quinolones as truncated acridones.
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- Archives of Pharmacal Research, 1998, v. 21, n. 4, p. 445, doi. 10.1007/BF02974641
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- Publication type:
- Article
Conformationally constrained analogues of diacylglycerol having a perhydrofuro[3,4-c]furan-1,4-dione bis-γ-butyrolactone skeleton.
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- Archives of Pharmacal Research, 1998, v. 21, n. 2, p. 164, doi. 10.1007/BF02974022
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- Publication type:
- Article
Synthesis and antiviral activity of fluoro sugar nucleosides 2: Synthesis and biological evaluations of 2′, 3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl nucleosides.
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- Archives of Pharmacal Research, 1996, v. 19, n. 3, p. 243, doi. 10.1007/BF02976899
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- Publication type:
- Article
Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors.
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- Journal of Molecular Medicine, 2014, v. 92, n. 10, p. 1083, doi. 10.1007/s00109-014-1168-8
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- Publication type:
- Article
Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-42581-4
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- Publication type:
- Article
Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-32196-6
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- Publication type:
- Article
The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer.
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- Theranostics, 2024, v. 14, n. 6, p. 2442, doi. 10.7150/thno.93236
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- Publication type:
- Article
A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects.
- Published in:
- Theranostics, 2022, v. 12, n. 1, p. 105, doi. 10.7150/thno.63788
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- Publication type:
- Article