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MetaRanker 2.0: a web server for prioritization of genetic variation data.
Published in:
Nucleic Acids Research, 2013, v. 41, p. W104, doi. 10.1093/nar/gkt387
By:
- Pers, Tune H.;
- Dworzyński, Piotr;
- Thomas, Cecilia Engel;
- Lage, Kasper;
- Brunak, Søren
Publication type:
Article
Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25014-7
By:
- Sun, Jiangming;
- Wang, Yunpeng;
- Folkersen, Lasse;
- Borné, Yan;
- Amlien, Inge;
- Buil, Alfonso;
- Orho-Melander, Marju;
- Børglum, Anders D.;
- Hougaard, David M.;
- Regeneron Genetics Center;
- Lotta, Luca Andrea;
- Jones, Marcus;
- Baras, Aris;
- Melander, Olle;
- Engström, Gunnar;
- Werge, Thomas;
- Lage, Kasper
Publication type:
Article
Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22648-5
By:
- Pintacuda, Greta;
- Lassen, Frederik H.;
- Hsu, Yu-Han H.;
- Kim, April;
- Martín, Jacqueline M.;
- Malolepsza, Edyta;
- Lim, Justin K.;
- Fornelos, Nadine;
- Eggan, Kevin C.;
- Lage, Kasper
Publication type:
Article
Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks.
Published in:
American Journal of Medical Genetics. Part A, 2012, v. 158A, n. 12, p. 3148, doi. 10.1002/ajmg.a.35665
By:
- Longoni, Mauro;
- Lage, Kasper;
- Russell, Meaghan K.;
- Loscertales, Maria;
- Abdul-Rahman, Omar A.;
- Baynam, Gareth;
- Bleyl, Steven B.;
- Brady, Paul D.;
- Breckpot, Jeroen;
- Chen, Chih P.;
- Devriendt, Koenraad;
- Gillessen-Kaesbach, Gabriele;
- Grix, Arthur W.;
- Rope, Alan F.;
- Shimokawa, Osamu;
- Strauss, Bernarda;
- Wieczorek, Dagmar;
- Zackai, Elaine H.;
- Coletti, Caroline M.;
- Maalouf, Faouzi I.
Publication type:
Article
A human phenome-interactome network of protein complexes implicated in genetic disorders.
Published in:
Nature Biotechnology, 2007, v. 25, n. 3, p. 309, doi. 10.1038/nbt1295
By:
- Lage, Kasper;
- Karlberg, E Olof;
- Størling, Zenia M;
- Ólason, Páll Í;
- Pedersen, Anders G;
- Rigina, Olga;
- Hinsby, Anders M;
- Tümer, Zeynep;
- Pociot, Flemming;
- Tommerup, Niels;
- Moreau, Yves;
- Brunak, Søren
Publication type:
Article
Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes.
Published in:
PLoS ONE, 2009, v. 4, n. 7, p. 1, doi. 10.1371/journal.pone.0006250
By:
- Bergholdt, Regine;
- Brorsson, Caroline;
- Lage, Kasper;
- Nielsen, Jens Høiriis;
- Brunak, Søren;
- Pociot, Flemming
Publication type:
Article
Proteome analysis demonstrates profound alterations in human dendritic cell nature by TX527, an analogue of vitamin D.
Published in:
Proteomics, 2009, v. 9, n. 14, p. 3752, doi. 10.1002/pmic.200800848
By:
- Ferreira, Gabriela Bomfim;
- van Etten, Evelyne;
- Lage, Kasper;
- Hansen, Daniel Aaen;
- Moreau, Yves;
- Workman, Christopher T.;
- Waer, Mark;
- Verstuyf, Annemieke;
- Waelkens, Etienne;
- Overbergh, Lut;
- Mathieu, Chantal
Publication type:
Article
Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11953-9
By:
- Tanigawa, Yosuke;
- Li, Jiehan;
- Justesen, Johanne M.;
- Horn, Heiko;
- Aguirre, Matthew;
- DeBoever, Christopher;
- Chang, Chris;
- Narasimhan, Balasubramanian;
- Lage, Kasper;
- Hastie, Trevor;
- Park, Chong Y.;
- Bejerano, Gill;
- Ingelsson, Erik;
- Rivas, Manuel A.
Publication type:
Article
Branchio–oto–renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses.
Published in:
European Journal of Human Genetics, 2007, v. 15, n. 11, p. 1121, doi. 10.1038/sj.ejhg.5201900
By:
- Sanggaard, Kirsten Marie;
- Rendtorff, Nanna Dahl;
- Kjaer, Klaus Wilbrandt;
- Eiberg, Hans;
- Johnsen, Torsten;
- Gimsing, Steen;
- Dyrmose, Jørgen;
- Nielsen, Kristian Otto;
- Lage, Kasper;
- Tranebjærg, Lisbeth
Publication type:
Article
Systematic auditing is essential to debiasing machine learning in biology.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01674-5
By:
- Eid, Fatma-Elzahraa;
- Elmarakeby, Haitham A.;
- Chan, Yujia Alina;
- Fornelos, Nadine;
- ElHefnawi, Mahmoud;
- Van Allen, Eliezer M.;
- Heath, Lenwood S.;
- Lage, Kasper
Publication type:
Article
Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells.
Published in:
Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01460-2
By:
- Dubonyte, Ugne;
- Asenjo-Martinez, Andrea;
- Werge, Thomas;
- Lage, Kasper;
- Kirkeby, Agnete
Publication type:
Article
Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
Published in:
Cardiovascular Research, 2022, v. 118, n. 13, p. 2833, doi. 10.1093/cvr/cvab344
By:
- Zhu, Qiuyu Martin;
- MacDonald, Bryan T;
- Mizoguchi, Taiji;
- Chaffin, Mark;
- Leed, Alison;
- Arduini, Alessandro;
- Malolepsza, Edyta;
- Lage, Kasper;
- Kaushik, Virendar K;
- Kathiresan, Sekar;
- Ellinor, Patrick T
Publication type:
Article
Dissecting spatio-temporal protein networks driving human heart development and related disorders.
Published in:
Molecular Systems Biology, 2010, v. 6, n. 1, p. 1, doi. 10.1038/msb.2010.36
By:
- Lage, Kasper;
- Møllgård, Kjeld;
- Greenway, Steven;
- Wakimoto, Hiroko;
- Gorham, Joshua M;
- Workman, Christopher T;
- Bendsen, Eske;
- Hansen, Niclas T;
- Rigina, Olga;
- Roque, Francisco S;
- Wiese, Cornelia;
- Christoffels, Vincent M;
- Roberts, Amy E;
- Smoot, Leslie B;
- Pu, William T;
- Donahoe, Patricia K;
- Tommerup, Niels;
- Brunak, Søren;
- Seidman, Christine E;
- Seidman, Jonathan G
Publication type:
Article
Ubiquitin accumulation in autophagy-deicient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
Published in:
Journal of Cell Biology, 2010, v. 191, n. 3, p. 537, doi. 10.1083/jcb.201005012
By:
- Riley, Brigit E.;
- Kaiser, Stephen E.;
- Shaler, Thomas A.;
- Ng, Aylwin C. Y.;
- Hara, Taichi;
- Hipp, Mark S.;
- Lage, Kasper;
- Xavier, Ramnik J.;
- Kwon-Yul Ryu;
- Taguchi, Keiko;
- Yamamoto, Masayuki;
- Tanaka, Keiji;
- Mizushima, Noboru;
- Komatsu, Masaaki;
- Kopito, Ron R.
Publication type:
Article
TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 14, p. 2435, doi. 10.1093/hmg/ddaa120
By:
- Davis, Erica E;
- Balasubramanian, Ravikumar;
- Kupchinsky, Zachary A;
- Keefe, David L;
- Plummer, Lacey;
- Khan, Kamal;
- Meczekalski, Blazej;
- Heath, Karen E;
- Lopez-Gonzalez, Vanesa;
- Ballesta-Martinez, Mary J;
- Margabanthu, Gomathi;
- Price, Susan;
- Greening, James;
- Brauner, Raja;
- Valenzuela, Irene;
- Cusco, Ivon;
- Fernandez-Alvarez, Paula;
- Wierman, Margaret E;
- Li, Taibo;
- Lage, Kasper
Publication type:
Article
MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 8, p. 2375, doi. 10.1093/hmg/ddv004
By:
- Xi, Qiongchao J.;
- Quintero-Rivera, Fabiola;
- Keppler-Noreuil, Kim M.;
- Ji Hyun Lee;
- Higgins, Anne W.;
- Anchan, Raymond M.;
- Roberts, Amy E.;
- Ihn Sik Seong;
- Xueping Fan;
- Lage, Kasper;
- Lu, Lily Y.;
- Tao, Joanna;
- Xuchen Hu;
- Berezney, Ronald;
- Gelb, Bruce D.;
- Kamp, Anna;
- Moskowitz, Ivan P.;
- Lacro, Ronald V.;
- Lu, Weining;
- Morton, Cynthia C.
Publication type:
Article
CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.
Published in:
PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0156595
By:
- Sosulski, Amanda;
- Horn, Heiko;
- Zhang, Lihua;
- Coletti, Caroline;
- Vathipadiekal, Vinod;
- Castro, Cesar M.;
- Birrer, Michael J.;
- Nagano, Osamu;
- Saya, Hideyuki;
- Lage, Kasper;
- Donahoe, Patricia K.;
- Pépin, David
Publication type:
Article
Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease.
Published in:
PLoS Genetics, 2015, v. 11, n. 10, p. 1, doi. 10.1371/journal.pgen.1005622
By:
- Won, Hong-Hee;
- Natarajan, Pradeep;
- Dobbyn, Amanda;
- Jordan, Daniel M.;
- Roussos, Panos;
- Lage, Kasper;
- Raychaudhuri, Soumya;
- Stahl, Eli;
- Do, Ron
Publication type:
Article
Pervasive Sharing of Genetic Effects in Autoimmune Disease.
Published in:
PLoS Genetics, 2011, v. 7, n. 8, p. 1, doi. 10.1371/journal.pgen.1002254
By:
- Cotsapas, Chris;
- Voight, Benjamin F.;
- Rossin, Elizabeth;
- Lage, Kasper;
- Neale, Benjamin M.;
- Wallace, Chris;
- Abecasis, Gonçalo R.;
- Barrett, Jeffrey C.;
- Behrens, Timothy;
- Cho, Judy;
- De Jager, Philip L.;
- Elder, James T.;
- Graham, Robert R.;
- Gregersen, Peter;
- Klareskog, Lars;
- Siminovitch, Katherine A.;
- van Heel, David A.;
- Wijmenga, Cisca;
- Worthington, Jane;
- Todd, John A.
Publication type:
Article
Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology.
Published in:
PLoS Genetics, 2011, v. 7, n. 1, p. 1, doi. 10.1371/journal.pgen.1001273
By:
- Rossin, Elizabeth J.;
- Lage, Kasper;
- Raychaudhuri, Soumya;
- Xavier, Ramnik J.;
- Tatar, Diana;
- Benita, Yair;
- Cotsapas, Chris;
- Daly, Mark J.
Publication type:
Article
Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease.
Published in:
Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-023-05705-1
By:
- Zhu, Qiuyu Martin;
- Hsu, Yu-Han H.;
- Lassen, Frederik H.;
- MacDonald, Bryan T.;
- Stead, Stephanie;
- Malolepsza, Edyta;
- Kim, April;
- Li, Taibo;
- Mizoguchi, Taiji;
- Schenone, Monica;
- Guzman, Gaelen;
- Tanenbaum, Benjamin;
- Fornelos, Nadine;
- Carr, Steven A.;
- Gupta, Rajat M.;
- Ellinor, Patrick T.;
- Lage, Kasper
Publication type:
Article
Systematic multi-trait AAV capsid engineering for efficient gene delivery.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50555-y
By:
- Eid, Fatma-Elzahraa;
- Chen, Albert T.;
- Chan, Ken Y.;
- Huang, Qin;
- Zheng, Qingxia;
- Tobey, Isabelle G.;
- Pacouret, Simon;
- Brauer, Pamela P.;
- Keyes, Casey;
- Powell, Megan;
- Johnston, Jencilin;
- Zhao, Binhui;
- Lage, Kasper;
- Tarantal, Alice F.;
- Chan, Yujia A.;
- Deverman, Benjamin E.
Publication type:
Article
Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes.
Published in:
Genetic Epidemiology, 2011, v. 35, n. 5, p. 318, doi. 10.1002/gepi.20580
By:
- Pers, Tune H.;
- Hansen, Niclas Tue;
- Lage, Kasper;
- Koefoed, Pernille;
- Dworzynski, Piotr;
- Miller, Martin Lee;
- Flint, Tracey J.;
- Mellerup, Erling;
- Dam, Henrik;
- Andreassen, Ole A.;
- Djurovic, Srdjan;
- Melle, Ingrid;
- Børglum, Anders D.;
- Werge, Thomas;
- Purcell, Shaun;
- Ferreira, Manuel A.;
- Kouskoumvekaki, Irene;
- Workman, Christopher T.;
- Hansen, Torben;
- Mors, Ole
Publication type:
Article
Prediction of cancer driver genes through network-based moment propagation of mutation scores.
Published in:
Bioinformatics, 2020, v. 36, p. i508, doi. 10.1093/bioinformatics/btaa452
By:
- Gumpinger, Anja C.;
- Lage, Kasper;
- Horn, Heiko;
- Borgwardt, Karsten
Publication type:
Article
Protein-induced changes during the maturation process of human dendritic cells: A 2-D DIGE approach.
Published in:
Proteomics - Clinical Applications, 2008, v. 2, n. 9, p. 1349, doi. 10.1002/prca.200800110
By:
- Ferreira, Gabriela Bomfim;
- Overbergh, Lut;
- van Etten, Evelyne;
- Lage, Kasper;
- D'Hertog, Wannes;
- Hansen, Daniel Aaen;
- Maris, Michael;
- Moreau, Yves;
- Workman, Christopher T.;
- Waelkens, Etienne;
- Mathieu, Chantal
Publication type:
Article
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.
Published in:
Genome Medicine, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13073-019-0628-8
By:
- Fernández-Tajes, Juan;
- Gaulton, Kyle J.;
- van de Bunt, Martijn;
- Torres, Jason;
- Thurner, Matthias;
- Mahajan, Anubha;
- Gloyn, Anna L.;
- Lage, Kasper;
- McCarthy, Mark I.
Publication type:
Article
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.
Published in:
Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0497-y
By:
- Nguyen, Hoang T.;
- Bryois, Julien;
- Kim, April;
- Dobbyn, Amanda;
- Huckins, Laura M.;
- Munoz-Manchado, Ana B.;
- Ruderfer, Douglas M.;
- Genovese, Giulio;
- Fromer, Menachem;
- Xinyi Xu;
- Pinto, Dalila;
- Linnarsson, Sten;
- Verhage, Matthijs;
- Smit, August B.;
- Hjerling-Leffler, Jens;
- Buxbaum, Joseph D.;
- Hultman, Christina;
- Sklar, Pamela;
- Purcell, Shaun M.;
- Lage, Kasper
Publication type:
Article

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