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Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery.
Published in:
Human Genetics, 2023, v. 142, n. 7, p. 927, doi. 10.1007/s00439-023-02570-0
By:
- Aryal, Sandeep;
- Anand, Deepti;
- Huang, Hongzhan;
- Reddy, Ashok P.;
- Wilmarth, Phillip A.;
- David, Larry L.;
- Lachke, Salil A.
Publication type:
Article
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
Published in:
Human Genetics, 2020, v. 139, n. 12, p. 1541, doi. 10.1007/s00439-020-02195-7
By:
- Aryal, Sandeep;
- Viet, Justine;
- Weatherbee, Bailey A. T.;
- Siddam, Archana D.;
- Hernandez, Francisco G.;
- Gautier-Courteille, Carole;
- Paillard, Luc;
- Lachke, Salil A.
Publication type:
Article
iSyTE 2.0: a database for expression-based gene discovery in the eye.
Published in:
Nucleic Acids Research, 2018, v. 46, n. D1, p. D875, doi. 10.1093/nar/gkx837
By:
- Kakrana, Atul;
- Yang, Andrian;
- Anand, Deepti;
- Djordjevic, Djordje;
- Ramachandruni, Deepti;
- Singh, Abhyudai;
- Huang, Hongzhan;
- Ho, Joshua W K;
- Lachke, Salil A
Publication type:
Article
Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.
Published in:
Nucleic Acids Research, 2013, v. 41, n. 22, p. 10199, doi. 10.1093/nar/gkt824
By:
- Wolf, Louise;
- Harrison, Wilbur;
- Huang, Jie;
- Xie, Qing;
- Xiao, Ningna;
- Sun, Jian;
- Kong, Lingkun;
- Lachke, Salil A.;
- Kuracha, Murali R.;
- Govindarajan, Venkatesh;
- Brindle, Paul K.;
- Ashery-Padan, Ruth;
- Beebe, David C.;
- Overbeek, Paul A.;
- Cvekl, Ales
Publication type:
Article
A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23873-8
By:
- Choquet, Hélène;
- Melles, Ronald B.;
- Anand, Deepti;
- Yin, Jie;
- Cuellar-Partida, Gabriel;
- Wang, Wei;
- Hoffmann, Thomas J.;
- Nair, K. Saidas;
- Hysi, Pirro G.;
- Lachke, Salil A.;
- Jorgenson, Eric
Publication type:
Article
The RNA-binding protein Celf1 post-transcriptionally regulates p27<sup>Kip1</sup> and Dnase2b to control fiber cell nuclear degradation in lens development.
Published in:
PLoS Genetics, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.pgen.1007278
By:
- Siddam, Archana D.;
- Gautier-Courteille, Carole;
- Perez-Campos, Linette;
- Anand, Deepti;
- Kakrana, Atul;
- Dang, Christine A.;
- Legagneux, Vincent;
- Méreau, Agnès;
- Viet, Justine;
- Gross, Jeffrey M.;
- Paillard, Luc;
- Lachke, Salil A.
Publication type:
Article
The regulation of EFG1 in white–opaque switching in Candida albicans involves overlapping promoters.
Published in:
Molecular Microbiology, 2003, v. 48, n. 2, p. 523, doi. 10.1046/j.1365-2958.2003.t01-1-03448.x
By:
- Lachke, Salil A.;
- Srikantha, Thyagarajan;
- Soll, David R.
Publication type:
Article
Pax6- and Six3-Mediated Induction of Lens Cell Fate in Mouse and Human ES Cells.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115106
By:
- Anchan, Raymond M.;
- Lachke, Salil A.;
- Gerami-Naini, Behzad;
- Lindsey, Jennifer;
- Ng, Nicholas;
- Naber, Catherine;
- Nickerson, Michael;
- Cavallesco, Resy;
- Rowan, Sheldon;
- Eaton, Jennifer L.;
- Xi, Qiongchao;
- Maas, Richard L.
Publication type:
Article
An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038568
By:
- Jumlongras, Dolrudee;
- Lachke, Salil A.;
- O'Connell, Daniel J.;
- Aboukhalil, Anton;
- Xiao Li;
- Sung E. Choe;
- Joshua W. K. Ho;
- Turbe-Doan, Annick;
- Robertson, Erin A.;
- Olsen, Bjorn R.;
- Bulyk, Martha L.;
- Amendt, Brad A.;
- Maas, Richard L.
Publication type:
Article
Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate.
Published in:
Birth Defects Research, 2017, v. 109, n. 1, p. 27, doi. 10.1002/bdra.23596
By:
- Liu, Huan;
- Busch, Tamara;
- Eliason, Steven;
- Anand, Deepti;
- Bullard, Steven;
- Gowans, Lord J.J;
- Nidey, Nichole;
- Petrin, Aline;
- Augustine-Akpan, Eno-Abasi;
- Saadi, Irfan;
- Dunnwald, Martine;
- Lachke, Salil A.;
- Zhu, Ying;
- Adeyemo, Adebowale;
- Amendt, Brad;
- Roscioli, Tony;
- Cornell, Robert;
- Murray, Jeffrey;
- Butali, Azeez
Publication type:
Article
MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Published in:
Human Genetics, 2020, v. 139, n. 2, p. 151, doi. 10.1007/s00439-019-02095-5
By:
- Aryal, Sandeep;
- Anand, Deepti;
- Hernandez, Francisco G.;
- Weatherbee, Bailey A. T.;
- Huang, Hongzhan;
- Reddy, Ashok P.;
- Wilmarth, Phillip A.;
- David, Larry L.;
- Lachke, Salil A.
Publication type:
Article
High-throughput transcriptome analysis reveals that the loss of Pten activates a novel NKX6-1/RASGRP1 regulatory module to rescue microphthalmia caused by Fgfr2-deficient lenses.
Published in:
Human Genetics, 2019, v. 138, n. 11/12, p. 1391, doi. 10.1007/s00439-019-02084-8
By:
- Padula, Stephanie L.;
- Anand, Deepti;
- Hoang, Thanh V.;
- Chaffee, Blake R.;
- Liu, Lin;
- Liang, Chun;
- Lachke, Salil A.;
- Robinson, Michael L.
Publication type:
Article
RNA sequencing-based transcriptomic profiles of embryonic lens development for cataract gene discovery.
Published in:
Human Genetics, 2018, v. 137, n. 11/12, p. 941, doi. 10.1007/s00439-018-1958-0
By:
- Anand, Deepti;
- Kakrana, Atul;
- Siddam, Archana D.;
- Huang, Hongzhan;
- Saadi, Irfan;
- Lachke, Salil A.
Publication type:
Article
Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract.
Published in:
Human Genetics, 2017, v. 136, n. 2, p. 205, doi. 10.1007/s00439-016-1747-6
By:
- Patel, Nisha;
- Anand, Deepti;
- Monies, Dorota;
- Maddirevula, Sateesh;
- Khan, Arif;
- Algoufi, Talal;
- Alowain, Mohammed;
- Faqeih, Eissa;
- Alshammari, Muneera;
- Qudair, Ahmed;
- Alsharif, Hadeel;
- Aljubran, Fatimah;
- Alsaif, Hessa;
- Ibrahim, Niema;
- Abdulwahab, Firdous;
- Hashem, Mais;
- Alsedairy, Haifa;
- Aldahmesh, Mohammed;
- Lachke, Salil;
- Alkuraya, Fowzan
Publication type:
Article
Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract.
Published in:
Human Genetics, 2015, v. 134, n. 7, p. 717, doi. 10.1007/s00439-015-1554-5
By:
- Agrawal, Smriti;
- Anand, Deepti;
- Siddam, Archana;
- Kakrana, Atul;
- Dash, Soma;
- Scheiblin, David;
- Dang, Christine;
- Terrell, Anne;
- Waters, Stephanie;
- Singh, Abhyudai;
- Motohashi, Hozumi;
- Yamamoto, Masayuki;
- Lachke, Salil
Publication type:
Article
The cell adhesion gene PVRL3 is associated with congenital ocular defects.
Published in:
Human Genetics, 2012, v. 131, n. 2, p. 235, doi. 10.1007/s00439-011-1064-z
By:
- Lachke, Salil;
- Higgins, Anne;
- Inagaki, Maiko;
- Saadi, Irfan;
- Xi, Qiongchao;
- Long, Michelle;
- Quade, Bradley;
- Talkowski, Michael;
- Gusella, James;
- Fujimoto, Atsuko;
- Robinson, Michael;
- Yang, Ying;
- Duong, Quynh;
- Shapira, Irit;
- Motro, Benny;
- Miyoshi, Jun;
- Takai, Yoshimi;
- Morton, Cynthia;
- Maas, Richard
Publication type:
Article
A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression.
Published in:
Journal of Developmental Biology, 2021, v. 9, n. 3, p. 27, doi. 10.3390/jdb9030027
By:
- Blizzard, Lauren E.;
- Menke, Chelsea;
- Patel, Shaili D.;
- Waclaw, Ronald R.;
- Lachke, Salil A.;
- Stottmann, Rolf W.
Publication type:
Article
Identification of differentially expressed transcripts in Tdrd7 null mutant mouse lens (747.1).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.747.1
By:
- Patel, Shaili;
- Barnum, Carrie;
- Lachke, Salil
Publication type:
Article
Characterization of Celf1 function in mouse lens cell lines (746.1).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.746.1
By:
- Dang, Christine;
- Siddam, Archana;
- Lachke, Salil
Publication type:
Article
Modeling ocular lens disease in Xenopus.
Published in:
Developmental Dynamics, 2020, v. 249, n. 5, p. 610, doi. 10.1002/dvdy.147
By:
- Viet, Justine;
- Reboutier, David;
- Hardy, Serge;
- Lachke, Salil A.;
- Paillard, Luc;
- Gautier‐Courteille, Carole
Publication type:
Article
Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly.
Published in:
Developmental Dynamics, 2015, v. 244, n. 10, p. 1313, doi. 10.1002/dvdy.24303
By:
- Dash, Soma;
- Dang, Christine A.;
- Beebe, David C.;
- Lachke, Salil A.
Publication type:
Article
The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 12, p. 2076, doi. 10.1093/hmg/ddaa096
By:
- Barnum, Carrie E;
- Saai, Salma Al;
- Patel, Shaili D;
- Cheng, Catherine;
- Anand, Deepti;
- Xu, Xiaolu;
- Dash, Soma;
- Siddam, Archana D;
- Glazewski, Lisa;
- Paglione, Emily;
- Polson, Shawn W;
- Chuma, Shinichiro;
- Mason, Robert W;
- Wei, Shuo;
- Batish, Mona;
- Fowler, Velia M;
- Lachke, Salil A
Publication type:
Article
The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 4, p. 591, doi. 10.1093/hmg/ddz278
By:
- Dash, Soma;
- Brastrom, Lindy K;
- Patel, Shaili D;
- Scott, C Anthony;
- Slusarski, Diane C;
- Lachke, Salil A
Publication type:
Article
RNA‐binding proteins and their downstream regulatory networks in lens development and cataract.
Published in:
2024
By:
- Lachke, Salil
Publication type:
Abstract
iSyTE: A web resource tool to expedite eye gene discovery.
Published in:
Acta Ophthalmologica (1755375X), 2019, v. 97, p. N.PAG, doi. 10.1111/j.1755-3768.2019.5007
By:
- Lachke, Salil
Publication type:
Article
A Transcriptomics Analysis of the Regulation of Lens Fiber Cell Differentiation in the Absence of FGFRs and PTEN.
Published in:
Cells (2073-4409), 2024, v. 13, n. 14, p. 1222, doi. 10.3390/cells13141222
By:
- Upreti, Anil;
- Padula, Stephanie L.;
- Weaver, Jacob M.;
- Wagner, Brad D.;
- Kneller, Allison M.;
- Petulla, Anthony L.;
- Lachke, Salil A.;
- Robinson, Michael L.
Publication type:
Article
Eye Lens Organoids Made Simple: Characterization of a New Three-Dimensional Organoid Model for Lens Development and Pathology.
Published in:
Cells (2073-4409), 2023, v. 12, n. 20, p. 2478, doi. 10.3390/cells12202478
By:
- Duot, Matthieu;
- Viel, Roselyne;
- Viet, Justine;
- Le Goff-Gaillard, Catherine;
- Paillard, Luc;
- Lachke, Salil A.;
- Gautier-Courteille, Carole;
- Reboutier, David
Publication type:
Article
High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.
Published in:
Cells (2073-4409), 2023, v. 12, n. 7, p. 1070, doi. 10.3390/cells12071070
By:
- Siddam, Archana D.;
- Duot, Matthieu;
- Coomson, Sarah Y.;
- Anand, Deepti;
- Aryal, Sandeep;
- Weatherbee, Bailey A. T.;
- Audic, Yann;
- Paillard, Luc;
- Lachke, Salil A.
Publication type:
Article
Lens Epithelial Explants Treated with Vitreous Humor Undergo Alterations in Chromatin Landscape with Concurrent Activation of Genes Associated with Fiber Cell Differentiation and Innate Immune Response.
Published in:
Cells (2073-4409), 2023, v. 12, n. 3, p. 501, doi. 10.3390/cells12030501
By:
- Upreti, Anil;
- Padula, Stephanie L.;
- Tangeman, Jared A.;
- Wagner, Brad D.;
- O'Connell, Michael J.;
- Jaquish, Tycho J.;
- Palko, Raye K.;
- Mantz, Courtney J.;
- Anand, Deepti;
- Lovicu, Frank J.;
- Lachke, Salil A.;
- Robinson, Michael L.
Publication type:
Article
Cover Image, Volume 39, Issue 4.
Published in:
Human Mutation, 2018, v. 39, n. 4, p. i, doi. 10.1002/humu.23414
By:
- Anand, Deepti;
- Agrawal, Smriti A.;
- Slavotinek, Anne;
- Lachke, Salil A.
Publication type:
Article
Mutation update of transcription factor genes <italic>FOXE3</italic>, <italic>HSF4</italic>, <italic>MAF</italic>, and <italic>PITX3</italic> causing cataracts and other developmental ocular defects.
Published in:
Human Mutation, 2018, v. 39, n. 4, p. 471, doi. 10.1002/humu.23395
By:
- Anand, Deepti;
- Agrawal, Smriti A.;
- Slavotinek, Anne;
- Lachke, Salil A.
Publication type:
Article
A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals.
Published in:
Genetic Epidemiology, 2019, v. 43, n. 6, p. 704, doi. 10.1002/gepi.22214
By:
- Carlson, Jenna C.;
- Anand, Deepti;
- Butali, Azeez;
- Buxo, Carmen J.;
- Christensen, Kaare;
- Deleyiannis, Frederic;
- Hecht, Jacqueline T.;
- Moreno, Lina M.;
- Orioli, Ieda M.;
- Padilla, Carmencita;
- Shaffer, John R.;
- Vieira, Alexandre R.;
- Wehby, George L.;
- Weinberg, Seth M.;
- Murray, Jeffrey C.;
- Beaty, Terri H.;
- Saadi, Irfan;
- Lachke, Salil A.;
- Marazita, Mary L.;
- Feingold, Eleanor
Publication type:
Article
RNA-binding proteins in eye development and disease: implication of conserved RNA granule components.
Published in:
Wiley Interdisciplinary Reviews: RNA, 2016, v. 7, n. 4, p. 527, doi. 10.1002/wrna.1355
By:
- Dash, Soma;
- Siddam, Archana D.;
- Barnum, Carrie E.;
- Janga, Sarath Chandra;
- Lachke, Salil A.
Publication type:
Article
Cover Image, Volume 7, Issue 4.
Published in:
Wiley Interdisciplinary Reviews: RNA, 2016, v. 7, n. 4, p. i, doi. 10.1002/wrna.1371
By:
- Dash, Soma;
- Siddam, Archana D.;
- Barnum, Carrie E.;
- Janga, Sarath Chandra;
- Lachke, Salil A.
Publication type:
Article

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