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Dimethylthiazolidine Carboxylic Acid as a Rigid P3 Unit in Inhibitors of Serine Proteases: Application to Two Targets.
Published in:
Chemical Biology & Drug Design, 2009, v. 74, n. 5, p. 517, doi. 10.1111/j.1747-0285.2009.00870.x
By:
- Kawai, Stephen H.;
- Aubry, Norman;
- Duceppe, Jean-Simon;
- Llinàs-Brunet, Montse;
- LaPlante, Steven R.
Publication type:
Article
Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
Published in:
Archives of Toxicology, 2022, v. 96, n. 9, p. 2559, doi. 10.1007/s00204-022-03316-z
By:
- Santos, Marcelo C.;
- Botelho, Fernanda D.;
- Gonçalves, Arlan S.;
- Kitagawa, Daniel A. S.;
- Borges, Caio V. N.;
- Carvalho-Silva, Taynara;
- Bernardo, Leandro B.;
- Ferreira, Cíntia N.;
- Rodrigues, Rafael B.;
- Ferreira Neto, Denise C.;
- Nepovimova, Eugenie;
- Kuča, Kamil;
- LaPlante, Steven R.;
- Lima, Antonio L. S.;
- França, Tanos C. C.;
- Cavalcante, Samir F. A.
Publication type:
Article
Jumping from Fragment to Drug via Smart Scaffolds.
Published in:
ChemMedChem, 2022, v. 17, n. 10, p. 1, doi. 10.1002/cmdc.202200092
By:
- Farahani, Majid D.;
- França, Tanos C. C.;
- Alapour, Saba;
- Shahout, Fatma;
- Boulon, Richard;
- Iddir, Mustapha;
- Maddalena, Michael;
- Ayotte, Yann;
- LaPlante, Steven R.
Publication type:
Article
Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid.
Published in:
ChemMedChem, 2021, v. 16, n. 19, p. 2982, doi. 10.1002/cmdc.202100432
By:
- Mélin, Léa;
- Abdullayev, Shuay;
- Fnaiche, Ahmed;
- Vu, Victoria;
- González Suárez, Narjara;
- Zeng, Hong;
- Szewczyk, Magdalena M.;
- Li, Fengling;
- Senisterra, Guillermo;
- Allali‐Hassani, Abdellah;
- Chau, Irene;
- Dong, Aiping;
- Woo, Simon;
- Annabi, Borhane;
- Halabelian, Levon;
- LaPlante, Steven R.;
- Vedadi, Masoud;
- Barsyte‐Lovejoy, Dalia;
- Santhakumar, Vijayaratnam;
- Gagnon, Alexandre
Publication type:
Article
Front Cover: Fragment‐Based Phenotypic Lead Discovery: Cell‐Based Assay to Target Leishmaniasis (ChemMedChem 14/2018).
Published in:
ChemMedChem, 2018, v. 13, n. 14, p. 1369, doi. 10.1002/cmdc.201800442
By:
- Ayotte, Yann;
- Bilodeau, François;
- Descoteaux, Albert;
- LaPlante, Steven R.
Publication type:
Article
Fragment‐Based Phenotypic Lead Discovery: Cell‐Based Assay to Target Leishmaniasis.
Published in:
ChemMedChem, 2018, v. 13, n. 14, p. 1377, doi. 10.1002/cmdc.201800161
By:
- Ayotte, Yann;
- Bilodeau, François;
- Descoteaux, Albert;
- LaPlante, Steven R.
Publication type:
Article
Molecular modeling study of natural products as potential bioactive compounds against SARS-CoV-2.
Published in:
Journal of Molecular Modeling, 2023, v. 29, n. 6, p. 1, doi. 10.1007/s00894-023-05586-5
By:
- Ribeiro, Rayssa;
- Botelho, Fernanda D.;
- Pinto, Amanda M. V.;
- La Torre, Antonia M. A.;
- Almeida, Joyce S. F. D.;
- LaPlante, Steven R.;
- Franca, Tanos C. C.;
- Veiga-Junior, Valdir F.;
- dos Santos, Marcelo C.
Publication type:
Article
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19.
Published in:
Journal of Molecular Modeling, 2022, v. 28, n. 12, p. 1, doi. 10.1007/s00894-022-05356-9
By:
- Aghamohammadi, Mohammad;
- Sirouspour, Mehdi;
- Goncalves, Arlan S.;
- França, Tanos Celmar Costa;
- LaPlante, Steven R.;
- Shahdousti, Parvin
Publication type:
Article
Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study.
Published in:
Biomolecules (2218-273X), 2020, v. 10, n. 2, p. 192, doi. 10.3390/biom10020192
By:
- da Silva, Jorge Alberto Valle;
- Pereira, Ander Francisco;
- LaPlante, Steven R.;
- Kuca, Kamil;
- Ramalho, Teodorico Castro;
- França, Tanos Celmar Costa
Publication type:
Article
The Conformation of a Peptidyl Methyl Ketone Inhibitor Bound to the Human Cytomegalovirus Protease.
Published in:
Angewandte Chemie International Edition, 1998, v. 37, n. 19, p. 2729, doi. 10.1002/(SICI)1521-3773(19981016)37:19<2729::AID-ANIE2729>3.0.CO;2-4
By:
- LaPlante, Steven R.;
- Cameron, Dale R.;
- Aubry, Norman;
- Bonneau, Pierre R.;
- Déziel, Robert;
- Grand-Maître, Chantal;
- Ogilvie, William W.;
- Kawai, Stephen H.
Publication type:
Article
Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors.
Published in:
Toxins, 2020, v. 12, n. 12, p. 746, doi. 10.3390/toxins12120746
By:
- Botelho, Fernanda D.;
- dos Santos, Marcelo C.;
- Gonçalves, Arlan da S.;
- Kuca, Kamil;
- Valis, Martin;
- LaPlante, Steven R.;
- França, Tanos C. C.;
- de Almeida, Joyce S. F. D.
Publication type:
Article
Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics StrategyWe are grateful to Dr. Michael Bös, Dr. Michael Cordingley, and Dr. Paul Anderson for encouragement and support. We also thank Dr. Timothy Stammers, Dr. Nathalie Goudreau, Dr. Marc-André Poupart, Dr. Dale Cameron, and Mr. Jeff O'Meara for comments or critical reading of the manuscript, as well as Ginette McKercher for determining inhibition constants.
Published in:
Angewandte Chemie, 2004, v. 116, n. 33, p. 4406, doi. 10.1002/ange.200460326
By:
- Steven R. LaPlante;
- Araz Jakalian;
- Norman Aubry;
- Yves Bousquet;
- Jean-Marie Ferland;
- James Gillard;
- Sylvain Lefebvre;
- Martin Poirier;
- Youla S. Tsantrizos;
- George Kukolj;
- Pierre L. Beaulieu
Publication type:
Article
corrigendum: An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Published in:
2003
By:
- Lamarre, Daniel;
- Anderson, Paul C.;
- Bailey, Murray;
- Beaulieu, Pierre;
- Bolger, Gordon;
- Bonneau, Pierre;
- Bös, Michael;
- Cameron, Dale R.;
- Goudreau, Mireille;
- Kawai, Stephen H.;
- Kukolj, George;
- Lagacé, Lisette;
- Laplante, Steven R.;
- Narjes, Hans;
- Poupart, Marc-André;
- Rancourt, Jean;
- Sentjens, Roel E.;
- St. George, Roger;
- Simoneau, Bruno
Publication type:
Correction Notice
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Published in:
Nature, 2003, v. 426, n. 6963, p. 186, doi. 10.1038/nature02099
By:
- Lamarre, Daniel;
- Anderson, Paul C.;
- Bailey, Murray;
- Beaulieu, Pierre;
- Bolger, Gordon;
- Bonneau, Pierre;
- Bös, Michael;
- Cameron, Dale R.;
- Cartier, Mireille;
- Cordingley, Michael G.;
- Faucher, Anne-Marie;
- Goudreau, Nathalie;
- Kawai, Stephen H.;
- Kukolj, George;
- Lagacé, Lisette;
- LaPlante, Steven R.;
- Narjes, Hans;
- Poupart, Marc-André;
- Rancourt, Jean;
- Sentjens, Roel E.
Publication type:
Article
Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics StrategyWe are grateful to Dr. Michael Bös, Dr. Michael Cordingley, and Dr. Paul Anderson for encouragement and support. We also thank Dr. Timothy Stammers, Dr. Nathalie Goudreau, Dr. Marc-André Poupart, Dr. Dale Cameron, and Mr. Jeff O'Meara for comments or critical reading of the manuscript, as well as Ginette McKercher for determining inhibition constants.
Published in:
Angewandte Chemie International Edition, 2004, v. 43, n. 33, p. 4306, doi. 10.1002/anie.200460326
By:
- Steven R. LaPlante;
- Araz Jakalian;
- Norman Aubry;
- Yves Bousquet;
- Jean-Marie Ferland;
- James Gillard;
- Sylvain Lefebvre;
- Martin Poirier;
- Youla S. Tsantrizos;
- George Kukolj;
- Pierre L. Beaulieu
Publication type:
Article
Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection.
Published in:
Angewandte Chemie International Edition, 2003, v. 42, n. 12, p. 1356, doi. 10.1002/anie.200390347
By:
- Tsantrizos, Youla S.;
- Bolger, Gordon;
- Bonneau, Pierre;
- Cameron, Dale R.;
- Goudreau, Nathalie;
- Kukolj, George;
- LaPlante, Steven R.;
- Llinàs-Brunet, Montse;
- Nar, Herbert;
- Lamarre, Daniel
Publication type:
Article
A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus.
Published in:
Applied Biochemistry & Biotechnology, 2024, v. 196, n. 4, p. 2137, doi. 10.1007/s12010-023-04604-9
By:
- Ali, Zeeshan;
- Cardoza, Jyothsna Volisha;
- Basak, Srijita;
- Narsaria, Utkarsh;
- Bhattacharjee, Surjit;
- G., Unnati Meher;
- Isaac, Samuel Paul;
- Franca, Tanos C. C.;
- LaPlante, Steven R.;
- George, Sudhan S.
Publication type:
Article
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48269-2
By:
- Mistretta, Maxime;
- Cimino, Mena;
- Campagne, Pascal;
- Volant, Stevenn;
- Kornobis, Etienne;
- Hebert, Olivier;
- Rochais, Christophe;
- Dallemagne, Patrick;
- Lecoutey, Cédric;
- Tisnerat, Camille;
- Lepailleur, Alban;
- Ayotte, Yann;
- LaPlante, Steven R.;
- Gangneux, Nicolas;
- Záhorszká, Monika;
- Korduláková, Jana;
- Vichier-Guerre, Sophie;
- Bonhomme, Frédéric;
- Pokorny, Laura;
- Albert, Marvin
Publication type:
Article
Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities.
Published in:
Nature Protocols, 2021, v. 16, n. 11, p. 5250, doi. 10.1038/s41596-021-00612-3
By:
- LaPlante, Steven R.;
- Roux, Valérie;
- Shahout, Fatma;
- LaPlante, Gabriela;
- Woo, Simon;
- Denk, Maria M.;
- Larda, Sacha T.;
- Ayotte, Yann
Publication type:
Article
Revealing Atropisomer Axial Chirality in Drug Discovery.
Published in:
ChemMedChem, 2011, v. 6, n. 3, p. 505, doi. 10.1002/cmdc.201000485
By:
- LaPlante, Steven R.;
- Edwards, Paul J.;
- Fader, Lee D.;
- Jakalian, Araz;
- Hucke, Oliver
Publication type:
Article
Cover Picture: Revealing Atropisomer Axial Chirality in Drug Discovery (ChemMedChem 3/2011).
Published in:
ChemMedChem, 2011, v. 6, n. 3, p. 381, doi. 10.1002/cmdc.201190005
By:
- LaPlante, Steven R.;
- Edwards, Paul J.;
- Fader, Lee D.;
- Jakalian, Araz;
- Hucke, Oliver
Publication type:
Article
The Use of Chemical Double-Mutant Cycles in Biomolecular Recognition Studies: Application to HCV NS3 Protease Inhibitors.
Published in:
ChemMedChem, 2008, v. 3, n. 11, p. 1654, doi. 10.1002/cmdc.200800214
By:
- Kawai, Stephen H.;
- Bailey, Murray D.;
- Halmos, Ted;
- Forgione, Pat;
- LaPlante, Steven R.;
- Llinàs-Brunet, Montse;
- Naud, Julie;
- Goudreau, Natalie
Publication type:
Article
The Challenge of Atropisomerism in Drug Discovery.
Published in:
Angewandte Chemie International Edition, 2009, v. 48, n. 35, p. 6398, doi. 10.1002/anie.200901719
By:
- Clayden, Jonathan;
- Moran, Wesley J.;
- Edwards, Paul J.;
- LaPlante, Steven R.
Publication type:
Article

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